LOCUS       NM_001371321            7902 bp    mRNA    linear   PRI 16-FEB-2025
DEFINITION  Homo sapiens ciliary microtubule inner protein 5 (CIMIP5),
            transcript variant 3, mRNA.
ACCESSION   NM_001371321
VERSION     NM_001371321.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7902)
  AUTHORS   Andersen,J.S., Vijayakumaran,A., Godbehere,C., Lorentzen,E.,
            Mennella,V. and Schou,K.B.
  TITLE     Uncovering structural themes across cilia microtubule inner
            proteins with implications for human cilia function
  JOURNAL   Nat Commun 15 (1), 2687 (2024)
   PUBMED   38538594
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7902)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 7902)
  AUTHORS   Luykx,J.J., Bakker,S.C., Lentjes,E., Neeleman,M., Strengman,E.,
            Mentink,L., DeYoung,J., de Jong,S., Sul,J.H., Eskin,E., van
            Eijk,K., van Setten,J., Buizer-Voskamp,J.E., Cantor,R.M., Lu,A.,
            van Amerongen,M., van Dongen,E.P., Keijzers,P., Kappen,T.,
            Borgdorff,P., Bruins,P., Derks,E.M., Kahn,R.S. and Ophoff,R.A.
  TITLE     Genome-wide association study of monoamine metabolite levels in
            human cerebrospinal fluid
  JOURNAL   Mol Psychiatry 19 (2), 228-234 (2014)
   PUBMED   23319000
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC062028.6 and AC018463.11.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK057872.1, SRR14038192.1502615.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381585.8/ ENSP00000370997.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-464               AC062028.6         39843-40306
            465-504             AC062028.6         47225-47264
            505-7504            AC062028.6         50635-57634
            7505-7902           AC018463.11        1-398
FEATURES             Location/Qualifiers
     source          1..7902
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.1"
     gene            1..7902
                     /gene="CIMIP5"
                     /gene_synonym="C2orf50"
                     /note="ciliary microtubule inner protein 5"
                     /db_xref="GeneID:130813"
                     /db_xref="HGNC:HGNC:26324"
     exon            1..464
                     /gene="CIMIP5"
                     /gene_synonym="C2orf50"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..696
                     /gene="CIMIP5"
                     /gene_synonym="C2orf50"
                     /note="uncharacterized protein C2orf50"
                     /codon_start=1
                     /product="ciliary microtubule inner protein 5"
                     /protein_id="NP_001358250.1"
                     /db_xref="CCDS:CCDS1678.1"
                     /db_xref="GeneID:130813"
                     /db_xref="HGNC:HGNC:26324"
                     /translation="MGSHPTPGLQRTTSAGYRLPPTRPPASVSPAARGGPMASRGLAG
                     GCQAPQALKAQRVAQGAACDGVQQDQLWRELLEAERRGQQRWIQNWSFLKDYDPMGNK
                     KEPEKLPDHVPLFSDTVPSSTNQVVGSRLDTPLGQTLIRMDFFFTEGARKKKLEDQMQ
                     PI"
     exon            465..504
                     /gene="CIMIP5"
                     /gene_synonym="C2orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            505..7902
                     /gene="CIMIP5"
                     /gene_synonym="C2orf50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7881..7886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIMIP5"
                     /gene_synonym="C2orf50"
                     /note="hexamer: AATAAA"
     polyA_site      7902
                     /gene="CIMIP5"
                     /gene_synonym="C2orf50"
                     /note="major polyA site"
ORIGIN      
        1 caaatgctct ccccagcccg gagagccctg tccccatcgg ccactctgag ctcgaggcct
       61 aaagggacag tgaggaggac cctgcccagg ctctcccggg gttaggaggg acagagtgtt
      121 ccaggaggag gtttgagctg agctcaggca caggtctctc tctctctctc tctgacacaa
      181 gcgcacacac acacacacac ttgcaccatg gggagccacc ccacccctgg gctccagaga
      241 accacatcag ctgggtaccg attgcccccc accaggccac cagcctcggt ctccccagct
      301 gcccggggtg gccctatggc cagcaggggt cttgctggtg gctgccaggc cccccaggct
      361 ctgaaggcgc agcgggtggc tcagggagct gcctgcgatg gcgtgcagca ggaccagctg
      421 tggcgggagc tcctggaggc cgagcggcgg ggccagcagc gctggattca gaactggagt
      481 ttcctgaaag actatgaccc aatgggcaac aagaaggagc ctgagaagtt gccagaccat
      541 gtgcctctct tttcggacac agttcccagt tccacgaacc aggttgtggg cagcaggctg
      601 gacacacccc tgggacagac tctcatccgc atggacttct tcttcacaga aggggcccgg
      661 aagaagaagc tggaggacca gatgcagccc atctaggagc aaggagggct gggctggcct
      721 tccccaggtg ggtgtgggtg gggacaagag acccagccca caacagcacc agtcagctcc
      781 ccacacaagg cagcttgggt ctgcactgtc tgtaagctgc aggacactct tccaggggac
      841 ccaaggggtc actcttacac actttttaca cgtaagattc agaggagtca gtaactggtc
      901 cacggccgta caatccccag cccttccagc ttgggaactc atgggtgccc catgaaaggg
      961 accctgcatt gtggtcagga gcactgaatg cctgggttca aatccagctt gtgaccctga
     1021 tgagctgtgg gaccttgagc tggctgctgc aacactctgt gcctccgtct cccctcctgc
     1081 gattcagtgt gttcactcct tgcagctgct gtgacaagtg agcacaaact gcatagctta
     1141 aaacaacaca aacgtatcat cttacagctc tgaagatcac aactctgaca tgggtgacat
     1201 gttgcagagc tgtgctcttt taggagtatc tggggaagaa tctatttcca cattttttcc
     1261 agtttctcaa ggcagcctgt attccttagt tggcagctcc ttactccgtc tttgaagcca
     1321 gcatcctagc atcttcaaat cagtctctat cgcttgctct ctcctgcctc actccttcat
     1381 cttttctttc tttctctctc tctctctttt ttttttagag acagtgtctt actctgtcac
     1441 ctaggctaga gggcagtgat gcaattataa atcattgtag ccttgaactc ccgggctcaa
     1501 gcaatcctcc cacctcagcc tcccaagtag ctagggatac agacacatgg caacatgcct
     1561 ggctaatttt ttttttattt ttattccaga cagagtctcg cactgtcgcc taggctggag
     1621 tgcaacagtg tgatcttggc tcaccgcaac ctccgcctcc taggtccagg caattctcct
     1681 gcttctgcct cctgagtagc tggaattaca ggcatgtgcc gccatgcctg gctaattttt
     1741 tgtattttta gtagagatgg ggtttctcca tgttggtcag gctggtctga aactcccaac
     1801 ttcaggtgat ccgcctgcct cagcctccca aagtgctggg attacaggtg tgagccactg
     1861 cgcccggcca tgcctggcta atttttaaaa ttttatgtag agatagggtc tcactatgtt
     1921 gaccaggctg gtcttgaact tttgggctca aatgatcctc ccaccttggc ctcccaaagc
     1981 actgggatta caggcatctg gtttcacttc ctccaccttt taaggaccct tgtgattata
     2041 tcacaacctt tatatttaag caaaaaaatg cagaaaaggc ttagttcctc tttgttggtt
     2101 aaaacacaaa tggattcatt ctttcaaaca tccgcattct cctcttcttc ctgggtgctc
     2161 tgccaggctg tggtttccct tggtttgggt ggagcatgtg acagagccat ggccagtgga
     2221 atgggagcaa aaaccctagg tctcccttcc aggcctggtc catgagacac tccaggtatt
     2281 ggcttgttct cctttcccca tcagctgaag aagggagagg acttggagga tgcagggaag
     2341 agaggggcac aagatggagg gagcatgtca ggaccaagcc tggagccctg agtgagctcg
     2401 tggagcagaa tctcccgaca cccacactga cacacaaaca aaataaacaa aaactggcca
     2461 aaacaaaaac aatagcccac acttctaggg taaagcattt taaatttatt ttctcaacaa
     2521 cccaagagaa tcaacaggca gggatttcgt attcatttaa tacaggcaaa acctgagatt
     2581 cagagaggtg aaataaaatc ccgaacatac attaatgcca ggcctcaagc ttgaagccca
     2641 gtgttctctg caggacccca gccgtggcct ccagaaaaga gagaaaaatg gggcaggggc
     2701 tgaaatgact gctctgtctt tgatgcttgc ttgggtctta ttcggcagta gctaaatgtc
     2761 actgttattt gcatgcatta actcatttaa tcctctcagc aaccctatga gatagatact
     2821 cctataaatg aggcaactaa agcgcagaga ggttaagtca cttgcccaag gtcacacagc
     2881 tggcaagtgg tgaagctggg gttcagactc agcagttgag tctggctcca aggactatat
     2941 acttaagcat tatgctatat gggtcccctt taatcctcaa tgaattgatt cccccaaatt
     3001 tagcaaatta caggattttt ctgcttaaag aaagtctctt gattcttgag aaaggaaaaa
     3061 ctgatttttc caatctctgg gatccctact accatcaaga atagatcatc ggtgtttcca
     3121 ggagttacac aggacaggac acgttatttc catgcaacag cccctgtgtt tcatgccata
     3181 ccctggccct gagcgactgt gtgatggagc agaccaggcc cagtgtgact tggccaggaa
     3241 gaggcccaac ccttcctact tggatctgga ggccaccgcc ttctttctca gtgtctgaca
     3301 tggaagctgg gctccctctc cactctgaga tcatcagctg ggtaaaggtc agtggccagg
     3361 acagccaggg gtcctggtca catcctggct gcatcccatg aaggtcaagt gctcgtcctt
     3421 aggctgggtg ggtacaaaga tgctggaggc tccttaaaga cccaatctac gtttttgccc
     3481 tgagcctgcc ttatattatt ctcacactca aaataaagaa gatttccatt tgagggaggg
     3541 agaggcacaa gaaaagtcaa ggttaaggat ggctgcaagt ggtcaggcct gtgcagaggg
     3601 gagagaatca ctgagtgccc tggagggcag tgaggagggc cagggaccag cgccggttct
     3661 gccactcctg gaagcacagc cacttacaga caatgcaacc tataagcaca gactctgggc
     3721 ttggcacatt acccacattg tgtcttttgc acgtattaga attgtcacca tttgagaggt
     3781 ttggaaacta agccgaacac ttcattcaat ctggtcaggg tctcacaact agtgaagagc
     3841 caggatccat ctcatgtgtg acttctccat gctgccttcc ccgctccagg cctcagtctc
     3901 cacagttata aaatggcgcg ggagggaaga agacagattt aagggcatct ccagctccag
     3961 gattctcttc tttgagcatt cagggagtac tgaagaagaa aggggtttga gttcttttac
     4021 agagtgcatt agtcagctgt gataatgctg tgtaacaaaa cacccccttc cttgctcaca
     4081 ggtctgcatg tagctggggc tcagctgatt ttggctgggc ttggctagac ttgcctccac
     4141 acttcaggtt aggttcaagt tttttgtgca tgtctctcat tctcttggac tgaaagcctc
     4201 ctggggcatg tttttctcat ggcacatcac aagggtgcaa gggcccaaca gaactgtgca
     4261 ggcacactga tggcttctgc atgcagaact gctttctgta ctctgcaatg acctgtcatc
     4321 acgccaaatc cctcacaacc agccccaccc accctctgct ccttgccaca tctgccttct
     4381 tttcaagaag acgcctgctt ctaaccttcc ccatctcacc cactgggagc ccagaaaacc
     4441 aggacagagg ggcatctgca gtgaagtccc aaggccagcc tttcagctcg tttgggccag
     4501 aacaagggag ggtggatggg ccaggaggtc atgaagaagt gggcaccaag cctgcagggt
     4561 cagtgccagc aaaaggaaat gggggcatta cctataaaga gatgggcact tggagaccaa
     4621 gggccaggag acagcagggc ttcaggaaag gaagaatcaa gacctgagag ccatagcaag
     4681 cctggaggga tgcttgcttc acattttttt tttttttgag atggagtttc gccagcttgt
     4741 cgcccaagct ggagtgcaat ggtacgatct cagctcacca caacctccgc ctaccaggtt
     4801 caagcgattc tcctgcctca gcctcctgag tagctgggat tacaagcatg caccaccaca
     4861 cccggctaat tttgcatttt tagtagagac atggtttctc catgttggtc aggctgttct
     4921 caaactcccg acctcaggtg atccacctgc ctcggcctcc caaagtgctg ggattacagg
     4981 catgagccac tgcgcccagc caactttcca catgataaaa aatgacttct atccacggaa
     5041 agtacaaggc gagcctggag caacttcctg tgccagaaac taagaaaaat tcaaaaagtg
     5101 atgaaaatat ggaaaaggga tacaaggacc agcctaaatt tgggacaata tgagcatcga
     5161 aatgaagaac agtaataggc caccctgacc acgcccatgc ccacccccag ccagtgccac
     5221 aagccccacc aaataacatt aataataata acaataacaa ataatccatg ggttcatacc
     5281 aataattttt ttaaatttta agtactaatg aaaactcttt tttttttttt tttttttgag
     5341 atgaagtctc gctctcgtcc cccaggctgg agtgcgatag tgcgatctcg ctcactgcaa
     5401 ccttcgcctc ctgggttcaa gcgattctcc tgcctcggcc tccaagtagc taggattaca
     5461 ggcacccgcc accatgcctg gctaattttt gtatttttag tagagacggg ggttcaccat
     5521 gttggccaag ctggtctcga actcctgacc gcaggtgatc cgcccgcctc ggcctcccaa
     5581 agtgctggga ttacagacat gagccactgc gcctggccat gaaaactctt ttctattgaa
     5641 gaatgcagaa taaatgataa cagaaaaatc agcatttaat gactcagcaa taactgactt
     5701 aggcaagaat caataaaaga cactaaaacg actgagtgaa agattcttag agaacggtaa
     5761 atgctgaaat ctagaagata ctgccttaac caaactatta agccaaacct caccaataac
     5821 aggacagctg acaccgtgct cccctggtgt ggttcactga ggacaacgct acctacttac
     5881 ctaggaagca ctcttgccaa aaaaaaaaaa agtaactaga atataatcag gaagaaactc
     5941 ctggcaaacc caaattgaga aatattctgc caaagagttg gccttgattc ttcaaaaatg
     6001 tcaatgtctg ccaggcgctg tgactcacgc ccataatgcc ggcactttgg gaggccgagg
     6061 taaaagtatc gcttgagctc aggagtttga gaccagcctg tacaacatgc tgaaaccgca
     6121 tctctgctaa aaatacaaaa aattagccag gtgtggtgat gcaggcctat agtcccagct
     6181 acttgggagg ctgagatggg agaatcacct gagcccagga agtcaaggct gcagtgattt
     6241 atgatctgat cactgccttc cagcctgggt gacagaatga gaccctatct caaaaaaaat
     6301 taattaatta attaaaataa aataaaaata aaaaaagtca atgtcataaa agacaaagaa
     6361 aggctgaaga agtgattcag cccgtgatcc ttgactggat cctgggtgaa agcaaaagca
     6421 gctctaaagg acactttgca gactaaatgt tagctaacac cattgtatca gtgagaaagt
     6481 gcagagtgtg gtgagtccat tgaggctctg tagaagaaag tccttgttct ttttgtttgt
     6541 ttgtttttga gacggcgtct caccccattg cccaggttgg agtacaatgg cacaatcttg
     6601 gctcactgca aacctccacc tcccgggttc aagcgattct cctgcctcag cctcccgagt
     6661 agctgggatt acgggtgcgt gccaccatgc ccagctaatt ttttgtatct ttagtagaga
     6721 cggggtttca ccattctggc cgggctggtc tcgaacctcg tgatccactc gcctcaacct
     6781 cccaaagtgc tgggattaca ggcgtgagcc actgtgccca gccgaaagcc cttgttctta
     6841 ggaggtgttt gctgaaaagt cccatgatgt atataacaaa cttgcaagtg gcttaacgaa
     6901 aaatttgtgt ttaggatttt ttttcttttt tttttgagat ggagtctcgc tctatcaccc
     6961 aggctggagt gcagtggtgc catcttggct cactgcagcc tccgcttccc aggttcaagc
     7021 aattctcctg cctcagcctc ccgagtagct gggatgacat gcacctgcca ccatgcccgg
     7081 ctaatttttg tatttttgta gagacagggt ttcaccacat tggccaggct ggtcttgaac
     7141 tcttgacctc aggtgatctg ccagcctcag cctcccaaag tgctgggatt acaggtgtga
     7201 gccaccgtgc ccggtggttt aggaattttt ttttttaatg aaggtggggg aatggccact
     7261 gtgaaagaaa aataaatctc aactccaaaa tcactaagct aagggaaaag tcaagctggg
     7321 aacctgcctc ccattttaat tcctgaataa gatggctata aagataaaac agctacatgc
     7381 ctccctcaca atttgcccac aaggaaattc cttgtgggcc tcaagatctt taccctactc
     7441 aggatcatgc caagaattaa aaaaaaaaac aaaaaacaaa actttaccct gaaacatttc
     7501 tgttgaattc atcctggcaa tgtaaactga tagctgatct taacaggtgc aggacagaaa
     7561 atcattcctc tgctcacctg agagaaatgc ttatctgatt gcttcctcag acctactgtg
     7621 tatgtaaaaa tgaagattca ctgagccaga ctagattgtg aattcactga aaggctgatc
     7681 aaggactcaa aagaatgcaa gcttttgtct cttatctacc tatgacctgg aagcccccct
     7741 cttcgagttg tcctgtgtta ctggatggaa ccaaagtata tcttacatat attaattgat
     7801 gtctcaggtc tccctaaaat gcacaaaagc aagctgtacc ccagccacct tggggacgtg
     7861 tcgtcaggac ctgttggcaa aataaacttt taaattgctt ga
//
