LOCUS       NM_001105519             718 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens ciliary microtubule inner protein 2C (CIMIP2C),
            transcript variant 1, mRNA.
ACCESSION   NM_001105519 XM_496547 XM_940593
VERSION     NM_001105519.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 718)
  AUTHORS   Leung,M.R., Zeng,J., Wang,X., Roelofs,M.C., Huang,W., Zenezini
            Chiozzi,R., Hevler,J.F., Heck,A.J.R., Dutcher,S.K., Brown,A.,
            Zhang,R. and Zeev-Ben-Mordehai,T.
  TITLE     Structural specializations of the sperm tail
  JOURNAL   Cell 186 (13), 2880-2896 (2023)
   PUBMED   37327785
REFERENCE   2  (bases 1 to 718)
  AUTHORS   Gui,M., Croft,J.T., Zabeo,D., Acharya,V., Kollman,J.M.,
            Burgoyne,T., Hoog,J.L. and Brown,A.
  TITLE     SPACA9 is a lumenal protein of human ciliary singlet and doublet
            microtubules
  JOURNAL   Proc Natl Acad Sci U S A 119 (41), e2207605119 (2022)
   PUBMED   36191189
REFERENCE   3  (bases 1 to 718)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108070.2 and AC015977.9.
            
            On Nov 22, 2018 this sequence version replaced NM_001105519.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.348008.1,
                                           ERR279859.2077.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329615.4/ ENSP00000332875.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AC108070.2         84297-84396
            101-374             AC015977.9         7499-7772
            375-487             AC015977.9         9113-9225
            488-718             AC015977.9         10891-11121
FEATURES             Location/Qualifiers
     source          1..718
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..718
                     /gene="CIMIP2C"
                     /gene_synonym="C2orf70; FAM166C"
                     /note="ciliary microtubule inner protein 2C"
                     /db_xref="GeneID:339778"
                     /db_xref="HGNC:HGNC:27938"
     exon            1..100
                     /gene="CIMIP2C"
                     /gene_synonym="C2orf70; FAM166C"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..632
                     /gene="CIMIP2C"
                     /gene_synonym="C2orf70; FAM166C"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0573 protein C2orf70; protein FAM166C; family with
                     sequence similarity 166 member C"
                     /codon_start=1
                     /product="ciliary microtubule inner protein 2C isoform 1"
                     /protein_id="NP_001098989.1"
                     /db_xref="CCDS:CCDS42661.1"
                     /db_xref="GeneID:339778"
                     /db_xref="HGNC:HGNC:27938"
                     /translation="MASRSAGTLLTEFNAAYVPPGLMPGYQGHVPTVAFSFGAPYGTT
                     TLKYFQDHRNRAMEKSHTPFSQGGHFPTIFSTNPNLLLMERASTRDRWLHKPSYTRFN
                     LDSHRSTELTNFYQMVQQHRKYYQDKTGTVPRVPYFAMPVREPERYPLPTVLPPLCPK
                     KKWHLLRLAPENLKTYQTFPSGKRVSPQERKKRDCYFEFRA"
     exon            101..374
                     /gene="CIMIP2C"
                     /gene_synonym="C2orf70; FAM166C"
                     /inference="alignment:Splign:2.1.0"
     exon            375..487
                     /gene="CIMIP2C"
                     /gene_synonym="C2orf70; FAM166C"
                     /inference="alignment:Splign:2.1.0"
     exon            488..718
                     /gene="CIMIP2C"
                     /gene_synonym="C2orf70; FAM166C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      699..704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIMIP2C"
                     /gene_synonym="C2orf70; FAM166C"
                     /note="hexamer: AATAAA"
     polyA_site      718
                     /gene="CIMIP2C"
                     /gene_synonym="C2orf70; FAM166C"
                     /note="major polyA site"
ORIGIN      
        1 aggctcgctg tactcgcgca cccaccatgg cctcccgcag cgcgggcacc ctactgaccg
       61 agttcaatgc cgcctacgtg ccccctggac tcatgcccgg gtaccagggc cacgtcccca
      121 ctgtggcctt ctcctttggc gctccctacg gcaccaccac cctcaagtac ttccaggacc
      181 accgcaacag agccatggag aagagccaca ctcccttcag ccaaggcggc catttcccca
      241 ccatcttctc caccaacccc aacctcctgc tgatggagcg cgccagcacc cgggaccgct
      301 ggctgcacaa gcccagctac actcgcttca acctggacag ccatcgctcc acagagctta
      361 cgaatttcta ccagatggtc cagcagcatc ggaagtacta tcaagacaag acgggcacag
      421 tgcctcgagt cccctacttt gcgatgcccg tgagggagcc ggaacggtac cccctcccca
      481 ccgtcctgcc tcctctgtgc ccaaagaaga agtggcacct tttaagacta gcccccgaga
      541 acctgaagac ctaccagacc ttcccatcag ggaagagggt ctctccacag gagcggaaaa
      601 agagagactg ctactttgag ttcagagcat gagactttta gttcagagca gagcctgatg
      661 cctgagatcc tgggtcgtga ccagcctggc ttgcttggaa taaaatcttt agccatga
//
