LOCUS       NM_001164310            1054 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ciliary microtubule inner protein 2B (CIMIP2B),
            transcript variant 1, mRNA.
ACCESSION   NM_001164310
VERSION     NM_001164310.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1054)
  AUTHORS   Leung,M.R., Zeng,J., Wang,X., Roelofs,M.C., Huang,W., Zenezini
            Chiozzi,R., Hevler,J.F., Heck,A.J.R., Dutcher,S.K., Brown,A.,
            Zhang,R. and Zeev-Ben-Mordehai,T.
  TITLE     Structural specializations of the sperm tail
  JOURNAL   Cell 186 (13), 2880-2896 (2023)
   PUBMED   37327785
REFERENCE   2  (bases 1 to 1054)
  AUTHORS   Gui,M., Croft,J.T., Zabeo,D., Acharya,V., Kollman,J.M.,
            Burgoyne,T., Hoog,J.L. and Brown,A.
  TITLE     SPACA9 is a lumenal protein of human ciliary singlet and doublet
            microtubules
  JOURNAL   Proc Natl Acad Sci U S A 119 (41), e2207605119 (2022)
   PUBMED   36191189
REFERENCE   3  (bases 1 to 1054)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC146928.1, AI383111.1 and CB241755.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001164310.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279832.10523.1, BC146928.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399742.7/ ENSP00000382646.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-937               BC146928.1         22-958
            938-975             AI383111.1         84-121              c
            976-1054            CB241755.1         18-96               c
FEATURES             Location/Qualifiers
     source          1..1054
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..1054
                     /gene="CIMIP2B"
                     /gene_synonym="FAM166B"
                     /note="ciliary microtubule inner protein 2B"
                     /db_xref="GeneID:730112"
                     /db_xref="HGNC:HGNC:34242"
     exon            1..112
                     /gene="CIMIP2B"
                     /gene_synonym="FAM166B"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..878
                     /gene="CIMIP2B"
                     /gene_synonym="FAM166B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM166B; family with sequence similarity 166
                     member B"
                     /codon_start=1
                     /product="ciliary microtubule inner protein 2B isoform 1"
                     /protein_id="NP_001157782.1"
                     /db_xref="CCDS:CCDS56572.1"
                     /db_xref="GeneID:730112"
                     /db_xref="HGNC:HGNC:34242"
                     /translation="MAVASTFIPGLNPQNPHYIPGYTGHCPLLRFSVGQTYGQVTGQL
                     LRGPPGLAWPPVHRTLLPPIRPPRSPEVPRESLPVRRGQERLSSSMIPGYTGFVPRAQ
                     FIFAKNCSQVWAEALSDFTHLHEKQGSEELPKEAKGRKDTEKDQVPEPEGQLEEPTLE
                     VVEQASPYSMDDRDPRKFFMSGFTGYVPCARFLFGSSFPVLTNQALQEFGQKHSPGSA
                     QDPKHLPPLPRTYPQNLGLLPNYGGYVPGYKFQFGHTFGHLTHDALGLSTFQKQLLA"
     exon            113..336
                     /gene="CIMIP2B"
                     /gene_synonym="FAM166B"
                     /inference="alignment:Splign:2.1.0"
     exon            337..542
                     /gene="CIMIP2B"
                     /gene_synonym="FAM166B"
                     /inference="alignment:Splign:2.1.0"
     exon            543..594
                     /gene="CIMIP2B"
                     /gene_synonym="FAM166B"
                     /inference="alignment:Splign:2.1.0"
     exon            595..789
                     /gene="CIMIP2B"
                     /gene_synonym="FAM166B"
                     /inference="alignment:Splign:2.1.0"
     exon            790..1054
                     /gene="CIMIP2B"
                     /gene_synonym="FAM166B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1033..1038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIMIP2B"
                     /gene_synonym="FAM166B"
                     /note="hexamer: AATAAA"
     polyA_site      1054
                     /gene="CIMIP2B"
                     /gene_synonym="FAM166B"
                     /note="major polyA site"
ORIGIN      
        1 agaccagagc cttggctcaa aggcaaacaa aaggaaatgc ccggctcccc atggctgtgg
       61 ccagcacctt cataccaggg ctcaaccctc agaaccctca ttatatccca gggtacactg
      121 gacactgccc actacttcgg ttcagcgtgg gccagaccta tgggcaggtg actggtcagc
      181 tacttcgagg ccctcctggc ctagcctggc cccctgtcca ccgcacactt ctgcctccca
      241 ttcggcctcc aagatctcct gaggttccca gggagagtct acctgtcagg cgtgggcaag
      301 aaaggctcag ctccagcatg atccctgggt acacaggttt tgtaccccgg gcacagttca
      361 tctttgccaa gaactgcagc caggtctggg ccgaggctct gagtgacttt actcacttgc
      421 atgaaaagca agggagtgaa gagctaccaa aggaggccaa gggaagaaag gacacagaga
      481 aggaccaggt gccagagccg gaggggcagc tggaggagcc gacactggag gtggtggaac
      541 aagcttctcc ctactccatg gatgacaggg accctcggaa gttcttcatg tcaggcttca
      601 ctggctatgt gccctgcgcc cgcttcctct tcggctccag ctttcctgtg ctcaccaacc
      661 aggcactgca ggaatttggg cagaagcact caccaggcag tgcccaggac cccaaacatc
      721 tccccccact tcccagaaca taccctcaga acctgggtct tttacctaac tatgggggct
      781 acgtgccagg gtataagttc cagtttggcc acacatttgg ccatctcacc catgatgctc
      841 tgggcctcag caccttccag aagcagctct tggcttaggc cactggacat caagttccct
      901 tcccttttca tcctatccca gccatccttt tggaagggag agaggtgggt gggagggtgg
      961 gagggtgggg gaacacaaag agaaaatggt ttggaggctg agcacctttt ttattaatag
     1021 gtataataaa taaataaata aatacataaa caga
//
