LOCUS       NM_001001710            1091 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens ciliary microtubule inner protein 2A (CIMIP2A), mRNA.
ACCESSION   NM_001001710 XM_497085
VERSION     NM_001001710.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1091)
  AUTHORS   Leung,M.R., Zeng,J., Wang,X., Roelofs,M.C., Huang,W., Zenezini
            Chiozzi,R., Hevler,J.F., Heck,A.J.R., Dutcher,S.K., Brown,A.,
            Zhang,R. and Zeev-Ben-Mordehai,T.
  TITLE     Structural specializations of the sperm tail
  JOURNAL   Cell 186 (13), 2880-2896 (2023)
   PUBMED   37327785
REFERENCE   2  (bases 1 to 1091)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1091)
  AUTHORS   Sigg,M.A., Menchen,T., Lee,C., Johnson,J., Jungnickel,M.K.,
            Choksi,S.P., Garcia,G. 3rd, Busengdal,H., Dougherty,G.W.,
            Pennekamp,P., Werner,C., Rentzsch,F., Florman,H.M., Krogan,N.,
            Wallingford,J.B., Omran,H. and Reiter,J.F.
  TITLE     Evolutionary Proteomics Uncovers Ancient Associations of Cilia with
            Signaling Pathways
  JOURNAL   Dev Cell 43 (6), 744-762 (2017)
   PUBMED   29257953
REFERENCE   4  (bases 1 to 1091)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY604177.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001001710.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY604177.1, BC132918.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2142680 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344774.6/ ENSP00000344729.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1091              AY604177.1         20-1110
FEATURES             Location/Qualifiers
     source          1..1091
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..1091
                     /gene="CIMIP2A"
                     /gene_synonym="FAM166A; HSD46"
                     /note="ciliary microtubule inner protein 2A"
                     /db_xref="GeneID:401565"
                     /db_xref="HGNC:HGNC:33818"
     exon            1..92
                     /gene="CIMIP2A"
                     /gene_synonym="FAM166A; HSD46"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..990
                     /gene="CIMIP2A"
                     /gene_synonym="FAM166A; HSD46"
                     /note="protein FAM166A; family with sequence similarity
                     166 member A"
                     /codon_start=1
                     /product="ciliary microtubule inner protein 2A"
                     /protein_id="NP_001001710.1"
                     /db_xref="CCDS:CCDS35186.1"
                     /db_xref="GeneID:401565"
                     /db_xref="HGNC:HGNC:33818"
                     /translation="MTTTQKHDLFTPEPHYVPGYAGFFPQLRYQVGNTYGRTTGQLLT
                     DPSVQKSPCSVLSPMSKPKFIEDFSQSKPPRVPCQDLTEPYIPHYTSLKPSKNFEILG
                     QLPPLEVDAQEPPGVENIPRQILLPAGFTPDTPHPPCPPGRKGDSRDLGHPVYGEEAW
                     KSATPVCEAPRQHQLYHCQRDEYPPPARRQQETLDVGSFQRLPQLDHPNLIQRKAISG
                     YAGFIPRFTWVMGLNYRDGVMQAMDEFDKSQFLFRNPHCDLGEKLPGTHWPSNHIYSS
                     QGLIPFYMGFIPAMQDNYALTFGNSTRRAYWKEWAKRNHTL"
     exon            93..307
                     /gene="CIMIP2A"
                     /gene_synonym="FAM166A; HSD46"
                     /inference="alignment:Splign:2.1.0"
     exon            308..558
                     /gene="CIMIP2A"
                     /gene_synonym="FAM166A; HSD46"
                     /inference="alignment:Splign:2.1.0"
     exon            559..688
                     /gene="CIMIP2A"
                     /gene_synonym="FAM166A; HSD46"
                     /inference="alignment:Splign:2.1.0"
     exon            689..783
                     /gene="CIMIP2A"
                     /gene_synonym="FAM166A; HSD46"
                     /inference="alignment:Splign:2.1.0"
     exon            784..901
                     /gene="CIMIP2A"
                     /gene_synonym="FAM166A; HSD46"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1091
                     /gene="CIMIP2A"
                     /gene_synonym="FAM166A; HSD46"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1091
                     /gene="CIMIP2A"
                     /gene_synonym="FAM166A; HSD46"
                     /note="major polyA site"
ORIGIN      
        1 agggactgga gccagcaagg ccagagtgaa agcaaaatga caactactca gaaacacgat
       61 ctcttcacgc cggagcctca ctatgtccct ggctatgccg gcttctttcc gcagctgcgc
      121 taccaggtgg ggaacaccta tgggcgtacc acggggcagc tgctcacaga ccccagtgtg
      181 cagaagagcc cctgctctgt gctgtccccc atgtccaaac ccaagttcat tgaggacttc
      241 agccagtcca agcccccgag ggttccctgc caagacctga cggagcccta catcccccac
      301 tacaccagtc tgaagccctc taagaacttt gagattctgg gccagctccc acccttggag
      361 gtggacgccc aggagccgcc aggggtagag aacataccca gacagattct gctgcctgca
      421 ggcttcacgc ccgacacccc gcaccctccg tgcccaccag gcaggaaggg agactccaga
      481 gacttgggac acccagtata cggggaagag gcctggaaga gcgccactcc tgtttgcgag
      541 gcccccaggc agcaccagct gtaccactgc cagagggatg agtacccacc ccccgcccgc
      601 cgccagcagg agacgctaga tgtgggcagc ttccagcggc tgccgcagct ggaccaccct
      661 aacctaatcc aacgcaaggc catctcaggc tatgctggct tcattccccg tttcacctgg
      721 gtaatggggt tgaattaccg agacggcgtc atgcaagcca tggacgaatt cgacaagagc
      781 cagttcctgt ttagaaaccc ccactgtgac ctgggcgaga agctgcctgg aacacactgg
      841 cccagcaacc acatctacag cagccaaggc ctgatcccct tctacatggg gttcatcccc
      901 gccatgcagg acaactacgc cctgacattc ggcaacagca cccggagggc ctactggaag
      961 gaatgggcaa agcgaaacca cacactatga aaatgcttta atggtggtgt ctgtacagca
     1021 tggatgtgga cagggaaaac agcaagtgca cacagtggga caggccacag gacaggctgg
     1081 gagtgaataa a
//
