LOCUS       NM_178456                805 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens ciliary microtubule inner protein 1 (CIMIP1), mRNA.
ACCESSION   NM_178456
VERSION     NM_178456.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 805)
  AUTHORS   Leung,M.R., Zeng,J., Wang,X., Roelofs,M.C., Huang,W., Zenezini
            Chiozzi,R., Hevler,J.F., Heck,A.J.R., Dutcher,S.K., Brown,A.,
            Zhang,R. and Zeev-Ben-Mordehai,T.
  TITLE     Structural specializations of the sperm tail
  JOURNAL   Cell 186 (13), 2880-2896 (2023)
   PUBMED   37327785
REFERENCE   2  (bases 1 to 805)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 805)
  AUTHORS   Coan,M., Rampioni Vinciguerra,G.L., Cesaratto,L., Gardenal,E.,
            Bianchet,R., Dassi,E., Vecchione,A., Baldassarre,G., Spizzo,R. and
            Nicoloso,M.S.
  TITLE     Exploring the Role of Fallopian Ciliated Cells in the Pathogenesis
            of High-Grade Serous Ovarian Cancer
  JOURNAL   Int J Mol Sci 19 (9), 2512 (2018)
   PUBMED   30149579
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 805)
  AUTHORS   Chandra,V., Choi,Y.B., Hwang,H.L., Lee,J.H., Park,S.Y., Kim,H.K.,
            Poojan,S., Koh,J.S., Kim,H.S. and Hong,K.M.
  TITLE     Immunohistochemical localization of LLC1 in human tissues and its
            limited expression in non-small cell lung cancer
  JOURNAL   Histol Histopathol 30 (9), 1111-1120 (2015)
   PUBMED   25786037
  REMARK    GeneRIF: our findings suggest that LLC1 is not a tumor suppressor,
            and that it is localized in the cilia of the normal lung epithelium
            but is absent in most non-small cell lung cancer cases
REFERENCE   5  (bases 1 to 805)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   6  (bases 1 to 805)
  AUTHORS   Hong,K.M., Yang,S.H., Chowdhuri,S.R., Player,A., Hames,M.,
            Fukuoka,J., Meerzaman,D., Dracheva,T., Sun,Z., Yang,P. and Jen,J.
  TITLE     Inactivation of LLC1 gene in nonsmall cell lung cancer
  JOURNAL   Int J Cancer 120 (11), 2353-2358 (2007)
   PUBMED   17304513
  REMARK    GeneRIF: inactivation of LLC1 by means of promoter methylation is a
            frequent event in nonsmall cell lung cancer and may play a role in
            lung tumorigenesis.
REFERENCE   7  (bases 1 to 805)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL354776.15, BX093883.1 and BC035405.1.
            
            On May 17, 2019 this sequence version replaced NM_178456.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138524.1231382.1,
                                           DRR138524.274124.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371168.4/ ENSP00000360210.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AL354776.15        37787-37811
            26-63               BX093883.1         1-38
            64-785              BC035405.1         28-749
            786-805             AL354776.15        48016-48035
FEATURES             Location/Qualifiers
     source          1..805
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.32"
     gene            1..805
                     /gene="CIMIP1"
                     /gene_synonym="bA196N14.1; C20orf85; LLC1"
                     /note="ciliary microtubule inner protein 1"
                     /db_xref="GeneID:128602"
                     /db_xref="HGNC:HGNC:16216"
                     /db_xref="MIM:619277"
     exon            1..131
                     /gene="CIMIP1"
                     /gene_synonym="bA196N14.1; C20orf85; LLC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..477
                     /gene="CIMIP1"
                     /gene_synonym="bA196N14.1; C20orf85; LLC1"
                     /note="low in lung cancer 1; uncharacterized protein
                     C20orf85"
                     /codon_start=1
                     /product="ciliary microtubule inner protein 1"
                     /protein_id="NP_848551.1"
                     /db_xref="CCDS:CCDS13465.1"
                     /db_xref="GeneID:128602"
                     /db_xref="HGNC:HGNC:16216"
                     /db_xref="MIM:619277"
                     /translation="MAQKPLSTAAAERMNLVGQDEIWKYRLKAESEARQNWPQNWGFL
                     TTPFEELIKCEEDLPTPKPKIELPERFRIRPVTPVEKYIKVFPSPPVPQTTQGFIGWR
                     SAVPGLNKCLELDDAIRSCKGAFARELCWPKQGVH"
     exon            132..213
                     /gene="CIMIP1"
                     /gene_synonym="bA196N14.1; C20orf85; LLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            214..315
                     /gene="CIMIP1"
                     /gene_synonym="bA196N14.1; C20orf85; LLC1"
                     /inference="alignment:Splign:2.1.0"
     exon            316..805
                     /gene="CIMIP1"
                     /gene_synonym="bA196N14.1; C20orf85; LLC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      763..768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIMIP1"
                     /gene_synonym="bA196N14.1; C20orf85; LLC1"
                     /note="hexamer: AATAAG"
     polyA_site      785
                     /gene="CIMIP1"
                     /gene_synonym="bA196N14.1; C20orf85; LLC1"
                     /note="major polyA site"
ORIGIN      
        1 aggagacgcg agacgctgag cccagggcca gagcttgcgg ggcgcacaga gcccccaggc
       61 ctcatggcgc agaaacctct cagcaccgcg gcggctgaac gcatgaacct tgtgggtcag
      121 gatgagatct ggaaataccg tctgaaggct gaatcggaag cacggcagaa ctggccccag
      181 aactgggggt ttttaacaac cccttttgag gagttgatca agtgtgaaga agatctcccc
      241 accccaaagc ccaaaatcga gcttcctgag cgtttccgca tccggccggt gaccccagtg
      301 gagaagtaca tcaaggtctt tccatccccc ccagtcccac agaccaccca gggcttcatc
      361 ggctggagat ctgcagtgcc aggcctgaac aagtgcctag agctcgacga tgcgatcaga
      421 agctgcaaag gtgcttttgc acgagagctg tgctggccca agcagggcgt gcactgaatc
      481 cagacggagt tctgcccagg ggtgctgcat atcggtcacc aggcacccag ggccatgcca
      541 gggaaaggaa gagctcccct gaatcccgag gacacagtcc cctgcgtact tgctcatggg
      601 atgttgcaaa gaacacaaag tgtgccttag acattctcaa gtcatcagcg tcacccttcc
      661 agaatgttca cgtccacacc cattcttggc taatgtaatg aataaggctt ctctcatttg
      721 tttttgatac cttgggaatt tctatgcagg gctttaaaaa aaaataagtg attcaatttt
      781 aaaaatattt gtctaggtcc ttcaa
//
