LOCUS       NM_181643               2293 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens ciliary microtubule associated protein 3 (CIMAP3),
            transcript variant 1, mRNA.
ACCESSION   NM_181643
VERSION     NM_181643.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2293)
  AUTHORS   Leung,M.R., Zeng,J., Wang,X., Roelofs,M.C., Huang,W., Zenezini
            Chiozzi,R., Hevler,J.F., Heck,A.J.R., Dutcher,S.K., Brown,A.,
            Zhang,R. and Zeev-Ben-Mordehai,T.
  TITLE     Structural specializations of the sperm tail
  JOURNAL   Cell 186 (13), 2880-2896 (2023)
   PUBMED   37327785
REFERENCE   2  (bases 1 to 2293)
  AUTHORS   Kinzel,D., Boldt,K., Davis,E.E., Burtscher,I., Trumbach,D.,
            Diplas,B., Attie-Bitach,T., Wurst,W., Katsanis,N., Ueffing,M. and
            Lickert,H.
  TITLE     Pitchfork regulates primary cilia disassembly and left-right
            asymmetry
  JOURNAL   Dev Cell 19 (1), 66-77 (2010)
   PUBMED   20643351
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC101501.1, BC050319.1 and BU686257.1.
            
            On Nov 23, 2018 this sequence version replaced NM_181643.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK074433.1, SRR1803617.55482.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369738.9/ ENSP00000358753.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-673               BC101501.1         51-723
            674-2144            BC050319.1         2159-3629
            2145-2293           BU686257.1         17-165              c
FEATURES             Location/Qualifiers
     source          1..2293
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..2293
                     /gene="CIMAP3"
                     /gene_synonym="C1orf88; PIFO; pitchfork"
                     /note="ciliary microtubule associated protein 3"
                     /db_xref="GeneID:128344"
                     /db_xref="HGNC:HGNC:27009"
                     /db_xref="MIM:614234"
     exon            1..50
                     /gene="CIMAP3"
                     /gene_synonym="C1orf88; PIFO; pitchfork"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..607
                     /gene="CIMAP3"
                     /gene_synonym="C1orf88; PIFO; pitchfork"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein pitchfork; primary cilia formation"
                     /codon_start=1
                     /product="ciliary microtubule-associated protein 3 isoform
                     1"
                     /protein_id="NP_857594.2"
                     /db_xref="CCDS:CCDS833.1"
                     /db_xref="GeneID:128344"
                     /db_xref="HGNC:HGNC:27009"
                     /db_xref="MIM:614234"
                     /translation="MCFSRADAADNYPFGTCQQRKLFPHFHPPNLIGNKFVPLRGSPH
                     RGPGCYFSDGYGLAYDLSKIPTSIKGYTLGARTAVRFKPIQKEMTPHAGRYQKVSPQQ
                     EKHKQNFAPFNVLVPRFKNYPKDTYYPSPGAYNPEKKPPPKIAWPMKFGSPDWAQVPC
                     LQKRTLKAELSTDKDFRKHRNRVAYLSLYYN"
     exon            51..190
                     /gene="CIMAP3"
                     /gene_synonym="C1orf88; PIFO; pitchfork"
                     /inference="alignment:Splign:2.1.0"
     exon            191..289
                     /gene="CIMAP3"
                     /gene_synonym="C1orf88; PIFO; pitchfork"
                     /inference="alignment:Splign:2.1.0"
     exon            290..420
                     /gene="CIMAP3"
                     /gene_synonym="C1orf88; PIFO; pitchfork"
                     /inference="alignment:Splign:2.1.0"
     exon            421..538
                     /gene="CIMAP3"
                     /gene_synonym="C1orf88; PIFO; pitchfork"
                     /inference="alignment:Splign:2.1.0"
     exon            539..2293
                     /gene="CIMAP3"
                     /gene_synonym="C1orf88; PIFO; pitchfork"
                     /inference="alignment:Splign:2.1.0"
     regulatory      760..765
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIMAP3"
                     /gene_synonym="C1orf88; PIFO; pitchfork"
                     /note="hexamer: CATAAA"
     polyA_site      783
                     /gene="CIMAP3"
                     /gene_synonym="C1orf88; PIFO; pitchfork"
                     /note="major polyA site"
     regulatory      2271..2276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIMAP3"
                     /gene_synonym="C1orf88; PIFO; pitchfork"
                     /note="hexamer: AATAAA"
     polyA_site      2293
                     /gene="CIMAP3"
                     /gene_synonym="C1orf88; PIFO; pitchfork"
ORIGIN      
        1 agtacacaag tgctagccct agcagctcgc gatgtgcttc agcagagcag acgctgcgga
       61 taactaccct tttggaacat gtcaacagag gaaacttttt cctcacttcc atcccccgaa
      121 tttgattggg aacaagtttg tccctcttag gggatcaccc cacagagggc ctgggtgtta
      181 tttttcagat ggatatggct tggcatacga cttatctaag atcccaacca gtataaaagg
      241 atatactttg ggagccagaa cagctgtgag gtttaagcca atacagaagg aaatgacacc
      301 tcatgcaggc aggtaccaga aagtaagtcc tcagcaggaa aaacacaaac aaaattttgc
      361 tccatttaat gtcttggtgc ctcgatttaa gaactaccca aaggacactt actatcccag
      421 ccctggtgca tacaacccag agaagaagcc accgccaaaa attgcctggc caatgaaatt
      481 tggatctcca gactgggctc aggttccatg tctacagaaa agaaccctaa aagctgagct
      541 gtccacagac aaagacttta gaaagcatcg gaaccgtgtg gcctacctaa gcctgtatta
      601 taattgagcg gctgtaacta ccttcacgtg ctcctcttat acacagactc tccaggactg
      661 aggacagagc tgctcttctt cttctacgtt actgtggccc tcttgtctgg cagcctggag
      721 cccagggagg gacaggggct tatagctgct gtatgagaac ataaagacta gtgcacagtg
      781 ctatctccat ctactgactt gtggtgtaca cgtgcatgtc tgggtctgtg ggtttctgtt
      841 gggtgctgag ttgggtgatt tcattttagt gaaatatttg tgggcccctg ctctctagtt
      901 ctaattccca ggagccaatt ttatatattc taccactagc cctggtcata ggaggctgtt
      961 agcctataca tgtcaagggt ttggatggga tttgggcttg ctagatacag aaaacactta
     1021 aggcagatta aaacatgtat tggagctctc ccaattgtgt tgctcagtgt ggagtgggaa
     1081 ggtcttgatt tggttgactt tcccagattg acataaaact caaaaaccaa aaaattgccc
     1141 ctttcctatg acatcatcca tttagtctgt gagtcaacat atatactgag gtcctactat
     1201 gtgttgagca gagcagtaag cactggggat atggcaggaa tcaaaataaa cttatctact
     1261 aagtccttgg gcctggcctg aagtcagagg aggactcccc agggcagcta ggggattggg
     1321 tctgccctcc aatctgaatg accccctaga accttacaag tcattctggg gttataaaga
     1381 tcataacatt tatagcccca gactgacttg taagcagctg catttaaagt acttactcag
     1441 acactcaggc ctgagagata gacccctttc tttccagcac tagctgaaat aatcaagtat
     1501 atagtttgtt caggattggc actaaatgtg atttaatctt ttaataaaag ggtccttttg
     1561 tacccactta ggcttcttcg taattaccag aaaggtgata agcctgcatg tgtctggaca
     1621 ccaaagattg agaagctgcc agtggctgca agagagccta ctgtaaccct catggccacc
     1681 ccctgatgag tgttacctgg ggaaagggct agcaagaggt gaagcctcct ggtcatatga
     1741 tgctgggggt gcctaattcc ttaaaggcca aggtcttctg aaataataat ggtgaaggac
     1801 agaaaagtct ttatgagaaa tcacatagga tatattaaga taatgataaa gatacctcag
     1861 caagaacata cctaatatat acacttcttt taatctgatg acttaatgat ttctgttatc
     1921 aagaagtatt tatgacttga gataagtcag gattaactgt tatcacctct cctgtacacc
     1981 tccctccttt ttctcctttg tacccacatg tgcagatttt ttcagaggtg acaatttagc
     2041 atttaatgtt tttttttctg cttcaagttc ttaggtccct ttggaggata ttgatggggg
     2101 tggaggtggg gatagaacat ctttcacact gtttggtaca gagacgctca aagcttttcc
     2161 cagggaaagg aactctctaa aatagtaatc tgatttgatg aaagataaaa ttttaatata
     2221 gcttcagtta accttcagga tactttaaat gctacattgt atataaaagt aataaagtac
     2281 aaatgaacac gaa
//
