LOCUS       NM_001110533            1690 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens ciliary microtubule associated protein 2 (CIMAP2),
            transcript variant 2, mRNA.
ACCESSION   NM_001110533
VERSION     NM_001110533.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1690)
  AUTHORS   Leung,M.R., Zeng,J., Wang,X., Roelofs,M.C., Huang,W., Zenezini
            Chiozzi,R., Hevler,J.F., Heck,A.J.R., Dutcher,S.K., Brown,A.,
            Zhang,R. and Zeev-Ben-Mordehai,T.
  TITLE     Structural specializations of the sperm tail
  JOURNAL   Cell 186 (13), 2880-2896 (2023)
   PUBMED   37327785
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK097520.1, AC096536.2, BC039109.1 and BU633253.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001110533.1.
            
            Transcript Variant: This variant (2) differs in the 3' coding
            region and 3' UTR, compared to variant 1. The encoded isoform (2)
            has a longer and distinct C-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039109.1, SRR5189667.404810.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371273.4/ ENSP00000360320.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AK097520.1         1-38
            39-39               AC096536.2         22814-22814
            40-429              AK097520.1         40-429
            430-1265            BC039109.1         391-1226
            1266-1690           BU633253.1         30-454              c
FEATURES             Location/Qualifiers
     source          1..1690
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..1690
                     /gene="CIMAP2"
                     /gene_synonym="C1orf177; LEM; LEXM"
                     /note="ciliary microtubule associated protein 2"
                     /db_xref="GeneID:163747"
                     /db_xref="HGNC:HGNC:26854"
                     /db_xref="MIM:616446"
     exon            1..158
                     /gene="CIMAP2"
                     /gene_synonym="C1orf177; LEM; LEXM"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1311
                     /gene="CIMAP2"
                     /gene_synonym="C1orf177; LEM; LEXM"
                     /note="isoform 2 is encoded by transcript variant 2;
                     lymphocyte expansion molecule"
                     /codon_start=1
                     /product="ciliary microtubule-associated protein 2 isoform
                     2"
                     /protein_id="NP_001104003.1"
                     /db_xref="CCDS:CCDS44153.1"
                     /db_xref="GeneID:163747"
                     /db_xref="HGNC:HGNC:26854"
                     /db_xref="MIM:616446"
                     /translation="MRESQDAAGAHGWNRVGSTATKWFTGAPFGVQSHRFDISAVYPN
                     WKKFSTFTEAPYSTRYSTQVSHIGPGTYSSKETCFSKKKLMKEVDTGWAKAQEATRLT
                     QLPHFQYQAIMKEKRLKEQKLGPGSYNLKDFLEQLREKPCSTRGLLSSGEVRFRGLTG
                     NYYPGPGNYGEKGNPYTKLEENAWNRSHSEGLMCRMSNKPHPRPHQGSGLGPGTYFFK
                     SDLETYVARSVGTRGPYDTFSGDRSKPLPYGHYSMQKKKPRELMNFKSFVEELNSHHN
                     KKHGVFSKLPRNPKTPTERIYWANLSQCPRTLATSGPSFWLPQEKKCKPVNQPPFLLT
                     SKGSGAKACQMIMGSWNPVGVGRYLNTWLMETKDRRQRYRSLFLSGSKRYLSDLARDM
                     LMQERITPFTKGKCPPTVDYNSDPTP"
     exon            159..246
                     /gene="CIMAP2"
                     /gene_synonym="C1orf177; LEM; LEXM"
                     /inference="alignment:Splign:2.1.0"
     exon            247..411
                     /gene="CIMAP2"
                     /gene_synonym="C1orf177; LEM; LEXM"
                     /inference="alignment:Splign:2.1.0"
     exon            412..534
                     /gene="CIMAP2"
                     /gene_synonym="C1orf177; LEM; LEXM"
                     /inference="alignment:Splign:2.1.0"
     exon            535..672
                     /gene="CIMAP2"
                     /gene_synonym="C1orf177; LEM; LEXM"
                     /inference="alignment:Splign:2.1.0"
     exon            673..816
                     /gene="CIMAP2"
                     /gene_synonym="C1orf177; LEM; LEXM"
                     /inference="alignment:Splign:2.1.0"
     exon            817..978
                     /gene="CIMAP2"
                     /gene_synonym="C1orf177; LEM; LEXM"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1104
                     /gene="CIMAP2"
                     /gene_synonym="C1orf177; LEM; LEXM"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1238
                     /gene="CIMAP2"
                     /gene_synonym="C1orf177; LEM; LEXM"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1690
                     /gene="CIMAP2"
                     /gene_synonym="C1orf177; LEM; LEXM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1672..1677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIMAP2"
                     /gene_synonym="C1orf177; LEM; LEXM"
                     /note="hexamer: ATTAAA"
     polyA_site      1690
                     /gene="CIMAP2"
                     /gene_synonym="C1orf177; LEM; LEXM"
                     /note="major polyA site"
ORIGIN      
        1 acaaggcccg ggttgccgtg gcagcagcgg aggcgggcag cgcgcaggcc tgccatgagg
       61 gaaagccagg atgccgccgg agctcatggc tggaaccgcg tcggctccac ggccaccaag
      121 tggttcaccg gggcgccctt cggggtgcag agccacaggt ttgacatctc tgctgtttat
      181 cccaactgga agaagttcag caccttcact gaggccccat actccacgcg ttattctacc
      241 caagtgtccc acataggccc tgggacttac agctccaaag agacctgctt cagcaagaag
      301 aagctgatga aggaggtgga cacaggctgg gccaaggccc aggaagccac gcggctgacc
      361 cagctacccc acttccagta ccaggccatc atgaaagaga agcggctgaa ggagcaaaag
      421 ctgggccccg gctcctacaa cctcaaagac ttcttagaac agctgcggga gaaaccatgt
      481 agcacccggg ggctgctcag ctctggggag gttcgcttcc gaggactcac tgggaactac
      541 tatccaggcc ctggaaatta tggggagaag ggtaacccat acaccaagct ggaggagaat
      601 gcctggaacc ggtctcattc cgagggcctc atgtgcagga tgagcaacaa gccacacccc
      661 cggcctcatc aggggagtgg tctgggaccc ggcacctact tcttcaaaag cgaccttgag
      721 acatatgtgg cacgatccgt cggcacccgc ggcccctatg acactttctc tggtgatcgg
      781 agcaagccac tgccttatgg gcactactcc atgcagaaaa aaaagcccag ggaactgatg
      841 aatttcaaga gctttgtaga agaacttaac tcacatcaca ataagaagca tggggttttt
      901 tctaaacttc cccgaaaccc gaaaacccct acagagagga tttactgggc caacctcagc
      961 cagtgccccc gcacactggc cacatctggc cccagtttct ggcttccaca agagaagaaa
     1021 tgcaaacccg tcaaccagcc cccattcctg ttgacctcca aggggtcagg tgcaaaggcc
     1081 tgccagatga ttatgggaag ctggaaccca gtaggtgtgg gccgctacct caacacctgg
     1141 ctgatggaga caaaggacag gcggcagcga tatcgatccc tattcctgag tggatccaaa
     1201 cgctacctct cagacctggc ccgggacatg ctcatgcagg aaaggatcac accatttact
     1261 aagggaaagt gccctccaac tgtggattac aattcagatc ctactcctta aagccacatg
     1321 cgaaggacag cctgcagtga ccagagagcc caaaggcctg aagacaaatc tgggggtgac
     1381 agcatgggca tgggagtggg gtgtcttaga gaaaggacac atgggcttgg gagaggggag
     1441 agatgtatgg ggatcacctt tgccagagct gcatacctga aggtcacagt gtcttccggg
     1501 acagctgggg acaggtatct tttgttgcag gagatcaatt atcctgagaa ctcaactcag
     1561 ccagtgacat gaacatgggg gccagagagc agatggactg aagggatggg acgtagttga
     1621 cacttgtggg accctttcta ttctaaagcc agagtgcttg gctccttgtt tattaaagtt
     1681 cagaaagtgg
//
