LOCUS       NM_001014440             872 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens ciliary microtubule associated protein 1B (CIMAP1B),
            transcript variant 3, mRNA.
ACCESSION   NM_001014440 XM_496534
VERSION     NM_001014440.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 872)
  AUTHORS   Leung,M.R., Zeng,J., Wang,X., Roelofs,M.C., Huang,W., Zenezini
            Chiozzi,R., Hevler,J.F., Heck,A.J.R., Dutcher,S.K., Brown,A.,
            Zhang,R. and Zeev-Ben-Mordehai,T.
  TITLE     Structural specializations of the sperm tail
  JOURNAL   Cell 186 (13), 2880-2896 (2023)
   PUBMED   37327785
REFERENCE   2  (bases 1 to 872)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 872)
  AUTHORS   Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
            Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
            Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
            Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
            Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
            Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
            Kastenmuller,G., Spector,T.D. and Soranzo,N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   4  (bases 1 to 872)
  AUTHORS   van der Harst,P., Zhang,W., Mateo Leach,I., Rendon,A., Verweij,N.,
            Sehmi,J., Paul,D.S., Elling,U., Allayee,H., Li,X.,
            Radhakrishnan,A., Tan,S.T., Voss,K., Weichenberger,C.X.,
            Albers,C.A., Al-Hussani,A., Asselbergs,F.W., Ciullo,M., Danjou,F.,
            Dina,C., Esko,T., Evans,D.M., Franke,L., Gogele,M., Hartiala,J.,
            Hersch,M., Holm,H., Hottenga,J.J., Kanoni,S., Kleber,M.E.,
            Lagou,V., Langenberg,C., Lopez,L.M., Lyytikainen,L.P., Melander,O.,
            Murgia,F., Nolte,I.M., O'Reilly,P.F., Padmanabhan,S., Parsa,A.,
            Pirastu,N., Porcu,E., Portas,L., Prokopenko,I., Ried,J.S.,
            Shin,S.Y., Tang,C.S., Teumer,A., Traglia,M., Ulivi,S., Westra,H.J.,
            Yang,J., Zhao,J.H., Anni,F., Abdellaoui,A., Attwood,A., Balkau,B.,
            Bandinelli,S., Bastardot,F., Benyamin,B., Boehm,B.O., Cookson,W.O.,
            Das,D., de Bakker,P.I., de Boer,R.A., de Geus,E.J., de Moor,M.H.,
            Dimitriou,M., Domingues,F.S., Doring,A., Engstrom,G.,
            Eyjolfsson,G.I., Ferrucci,L., Fischer,K., Galanello,R.,
            Garner,S.F., Genser,B., Gibson,Q.D., Girotto,G., Gudbjartsson,D.F.,
            Harris,S.E., Hartikainen,A.L., Hastie,C.E., Hedblad,B., Illig,T.,
            Jolley,J., Kahonen,M., Kema,I.P., Kemp,J.P., Liang,L.,
            Lloyd-Jones,H., Loos,R.J., Meacham,S., Medland,S.E., Meisinger,C.,
            Memari,Y., Mihailov,E., Miller,K., Moffatt,M.F., Nauck,M.,
            Novatchkova,M., Nutile,T., Olafsson,I., Onundarson,P.T.,
            Parracciani,D., Penninx,B.W., Perseu,L., Piga,A., Pistis,G.,
            Pouta,A., Puc,U., Raitakari,O., Ring,S.M., Robino,A., Ruggiero,D.,
            Ruokonen,A., Saint-Pierre,A., Sala,C., Salumets,A., Sambrook,J.,
            Schepers,H., Schmidt,C.O., Sillje,H.H., Sladek,R., Smit,J.H.,
            Starr,J.M., Stephens,J., Sulem,P., Tanaka,T., Thorsteinsdottir,U.,
            Tragante,V., van Gilst,W.H., van Pelt,L.J., van Veldhuisen,D.J.,
            Volker,U., Whitfield,J.B., Willemsen,G., Winkelmann,B.R.,
            Wirnsberger,G., Algra,A., Cucca,F., d'Adamo,A.P., Danesh,J.,
            Deary,I.J., Dominiczak,A.F., Elliott,P., Fortina,P., Froguel,P.,
            Gasparini,P., Greinacher,A., Hazen,S.L., Jarvelin,M.R., Khaw,K.T.,
            Lehtimaki,T., Maerz,W., Martin,N.G., Metspalu,A., Mitchell,B.D.,
            Montgomery,G.W., Moore,C., Navis,G., Pirastu,M., Pramstaller,P.P.,
            Ramirez-Solis,R., Schadt,E., Scott,J., Shuldiner,A.R., Smith,G.D.,
            Smith,J.G., Snieder,H., Sorice,R., Spector,T.D., Stefansson,K.,
            Stumvoll,M., Tang,W.H., Toniolo,D., Tonjes,A., Visscher,P.M.,
            Vollenweider,P., Wareham,N.J., Wolffenbuttel,B.H., Boomsma,D.I.,
            Beckmann,J.S., Dedoussis,G.V., Deloukas,P., Ferreira,M.A.,
            Sanna,S., Uda,M., Hicks,A.A., Penninger,J.M., Gieger,C.,
            Kooner,J.S., Ouwehand,W.H., Soranzo,N. and Chambers,J.C.
  TITLE     Seventy-five genetic loci influencing the human red blood cell
  JOURNAL   Nature 492 (7429), 369-375 (2012)
   PUBMED   23222517
REFERENCE   5  (bases 1 to 872)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   6  (bases 1 to 872)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 872)
  AUTHORS   Ganesh,S.K., Zakai,N.A., van Rooij,F.J., Soranzo,N., Smith,A.V.,
            Nalls,M.A., Chen,M.H., Kottgen,A., Glazer,N.L., Dehghan,A.,
            Kuhnel,B., Aspelund,T., Yang,Q., Tanaka,T., Jaffe,A., Bis,J.C.,
            Verwoert,G.C., Teumer,A., Fox,C.S., Guralnik,J.M., Ehret,G.B.,
            Rice,K., Felix,J.F., Rendon,A., Eiriksdottir,G., Levy,D.,
            Patel,K.V., Boerwinkle,E., Rotter,J.I., Hofman,A., Sambrook,J.G.,
            Hernandez,D.G., Zheng,G., Bandinelli,S., Singleton,A.B., Coresh,J.,
            Lumley,T., Uitterlinden,A.G., Vangils,J.M., Launer,L.J.,
            Cupples,L.A., Oostra,B.A., Zwaginga,J.J., Ouwehand,W.H.,
            Thein,S.L., Meisinger,C., Deloukas,P., Nauck,M., Spector,T.D.,
            Gieger,C., Gudnason,V., van Duijn,C.M., Psaty,B.M., Ferrucci,L.,
            Chakravarti,A., Greinacher,A., O'Donnell,C.J., Witteman,J.C.,
            Furth,S., Cushman,M., Harris,T.B. and Lin,J.P.
  TITLE     Multiple loci influence erythrocyte phenotypes in the CHARGE
            Consortium
  JOURNAL   Nat Genet 41 (11), 1191-1198 (2009)
   PUBMED   19862010
REFERENCE   8  (bases 1 to 872)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Behal,A., Touchman,J.W.,
            Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human lens for the NEIBank
            Project: over 2000 non-redundant transcripts, novel genes and
            splice variants
  JOURNAL   Mol Vis 8, 171-184 (2002)
   PUBMED   12107413
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 872)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   10 (bases 1 to 872)
  AUTHORS   Usuki,K., Gonez,L.J., Wernstedt,C., Moren,A., Miyazono,K.,
            Claesson-Welsh,L. and Heldin,C.H.
  TITLE     Structural properties of 3.0 kb and 3.2 kb transcripts encoding
            platelet-derived endothelial cell growth factor/thymidine
            phosphorylase in A431 cells
  JOURNAL   Biochim Biophys Acta 1222 (3), 411-414 (1994)
   PUBMED   8038210
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AW291097.1, BG149596.1 and BC127935.1.
            
            On May 19, 2020 this sequence version replaced NM_001014440.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.4280738.1,
                                           DRR138524.284305.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329363.9/ ENSP00000382804.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AW291097.1         1-194               c
            195-686             BG149596.1         9-500
            687-872             BC127935.1         597-782
FEATURES             Location/Qualifiers
     source          1..872
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..872
                     /gene="CIMAP1B"
                     /gene_synonym="FAP123; ODF3B; ODF3L3"
                     /note="ciliary microtubule associated protein 1B"
                     /db_xref="GeneID:440836"
                     /db_xref="HGNC:HGNC:34388"
     exon            1..22
                     /gene="CIMAP1B"
                     /gene_synonym="FAP123; ODF3B; ODF3L3"
                     /inference="alignment:Splign:2.1.0"
     exon            23..165
                     /gene="CIMAP1B"
                     /gene_synonym="FAP123; ODF3B; ODF3L3"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..818
                     /gene="CIMAP1B"
                     /gene_synonym="FAP123; ODF3B; ODF3L3"
                     /note="isoform 3 is encoded by transcript variant 3; orf2
                     5' to PD-ECGF/TP; outer dense fiber protein 3B; outer
                     dense fiber protein 3-like protein 3; outer dense fiber of
                     sperm tails 3B"
                     /codon_start=1
                     /product="ciliary microtubule associated protein 1B
                     isoform 3"
                     /protein_id="NP_001014440.2"
                     /db_xref="CCDS:CCDS43039.1"
                     /db_xref="GeneID:440836"
                     /db_xref="HGNC:HGNC:34388"
                     /translation="MGSDAWVGLWRPHRPRGPIAAHYGGPGPKYKLPPNTGYALHDPS
                     RPRAPAFTFGARFPTQQTTCGPGPGHLVPARMTVRGTDGAPAYSIYGRPRRSAPFLTP
                     GPGRYFPERAGNATYPSAPRHTIAPRNWGVQAEQQSPGPAAYTVPSLLGPRVIGKVSA
                     PTCSIYGRRAAGSFFEDLSKTPGPCAYQVVSPGVYKSRAPQFTILARTSLPQDNTRKP
                     GPAAYNVDQHRKPRGWSFGIRHSDYLAPLVTDADN"
     exon            166..369
                     /gene="CIMAP1B"
                     /gene_synonym="FAP123; ODF3B; ODF3L3"
                     /inference="alignment:Splign:2.1.0"
     exon            370..474
                     /gene="CIMAP1B"
                     /gene_synonym="FAP123; ODF3B; ODF3L3"
                     /inference="alignment:Splign:2.1.0"
     exon            475..596
                     /gene="CIMAP1B"
                     /gene_synonym="FAP123; ODF3B; ODF3L3"
                     /inference="alignment:Splign:2.1.0"
     exon            597..737
                     /gene="CIMAP1B"
                     /gene_synonym="FAP123; ODF3B; ODF3L3"
                     /inference="alignment:Splign:2.1.0"
     exon            738..872
                     /gene="CIMAP1B"
                     /gene_synonym="FAP123; ODF3B; ODF3L3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      872
                     /gene="CIMAP1B"
                     /gene_synonym="FAP123; ODF3B; ODF3L3"
                     /note="major polyA site"
ORIGIN      
        1 acgctaggag ctaccacaac aggtgctgcg agccgtaagc gccccccacc cgcgctatgg
       61 gctcggacgc ctgggtgggc ctttggcggc cacaccggcc ccgcggcccc atcgcggcgc
      121 actacggagg ccccgggccc aaatacaagc tgccgcccaa caccggctac gccctgcatg
      181 acccgtcgcg gccgcgcgcc cccgccttca ccttcggcgc gcgcttcccc acgcagcaga
      241 cgacgtgcgg ccccgggcca ggccacctgg tgcccgctcg catgaccgtg cgcggcaccg
      301 acggcgcccc cgcctactcc atctacggcc gcccacgccg ctcagcgccc ttcctcactc
      361 cgggacctgg caggtacttc ccggagcgag cggggaacgc gacgtacccc agtgcgcctc
      421 ggcacaccat tgctccccga aactggggtg tccaggcgga acagcagagc ccaggtcccg
      481 cggcctatac ggtgccctcg ctcttgggtc cgcgcgtcat cggcaaagtc tccgccccaa
      541 cttgctccat ctacggccgc agagcggctg gcagtttctt cgaggacctc agcaagaccc
      601 cgggcccctg cgcctatcag gtcgtgagtc caggggtcta caagtcccgg gccccccagt
      661 tcacgattct ggcgcggact tcgctccccc aagacaacac tcggaagcca gggcccgcgg
      721 cctacaacgt ggatcagcac cggaagcccc gcggctggag tttcgggatc cggcactcgg
      781 actacctggc cccgctggtg accgacgcgg acaactgacc cgccaggcgg gagcggcccc
      841 acacgtgttt gcttaaagtc tgcgagtccg ca
//
