LOCUS       NM_053280               1284 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens ciliary microtubule associated protein 1A (CIMAP1A),
            transcript variant 1, mRNA.
ACCESSION   NM_053280
VERSION     NM_053280.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1284)
  AUTHORS   Leung,M.R., Zeng,J., Wang,X., Roelofs,M.C., Huang,W., Zenezini
            Chiozzi,R., Hevler,J.F., Heck,A.J.R., Dutcher,S.K., Brown,A.,
            Zhang,R. and Zeev-Ben-Mordehai,T.
  TITLE     Structural specializations of the sperm tail
  JOURNAL   Cell 186 (13), 2880-2896 (2023)
   PUBMED   37327785
REFERENCE   2  (bases 1 to 1284)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1284)
  AUTHORS   Shameer,K., Denny,J.C., Ding,K., Jouni,H., Crosslin,D.R., de
            Andrade,M., Chute,C.G., Peissig,P., Pacheco,J.A., Li,R.,
            Bastarache,L., Kho,A.N., Ritchie,M.D., Masys,D.R., Chisholm,R.L.,
            Larson,E.B., McCarty,C.A., Roden,D.M., Jarvik,G.P. and Kullo,I.J.
  TITLE     A genome- and phenome-wide association study to identify genetic
            variants influencing platelet count and volume and their
            pleiotropic effects
  JOURNAL   Hum Genet 133 (1), 95-109 (2014)
   PUBMED   24026423
REFERENCE   4  (bases 1 to 1284)
  AUTHORS   Petit,F.M., Serres,C., Bourgeon,F., Pineau,C. and Auer,J.
  TITLE     Identification of sperm head proteins involved in zona pellucida
            binding
  JOURNAL   Hum Reprod 28 (4), 852-865 (2013)
   PUBMED   23355646
REFERENCE   5  (bases 1 to 1284)
  AUTHORS   Ghafouri-Fard,S., Ghafouri-Fard,S. and Modarressi,M.H.
  TITLE     Expression of splice variants of cancer-testis genes ODF3 and ODF4
            in the testis of a prostate cancer patient
  JOURNAL   Genet Mol Res 11 (4), 3642-3648 (2012)
   PUBMED   23096689
  REMARK    GeneRIF: Two alternative splice variants of ODF3 and ODF4, were
            found.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1284)
  AUTHORS   Cha,P.C., Takahashi,A., Hosono,N., Low,S.K., Kamatani,N., Kubo,M.
            and Nakamura,Y.
  TITLE     A genome-wide association study identifies three loci associated
            with susceptibility to uterine fibroids
  JOURNAL   Nat Genet 43 (5), 447-450 (2011)
   PUBMED   21460842
REFERENCE   7  (bases 1 to 1284)
  AUTHORS   Egydio de Carvalho,C., Tanaka,H., Iguchi,N., Ventela,S., Nojima,H.
            and Nishimune,Y.
  TITLE     Molecular cloning and characterization of a complementary DNA
            encoding sperm tail protein SHIPPO 1
  JOURNAL   Biol Reprod 66 (3), 785-795 (2002)
   PUBMED   11870087
  REMARK    GeneRIF: cloning and sequence analysis of h-shippo 1 an orthologue
            of mouse shippo 1
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC069287.7.
            
            On Nov 22, 2019 this sequence version replaced NM_053280.4.
            
            Summary: ODF3 is a component of sperm flagella outer dense fibers,
            which add stiffness, elastic recoil, and protection against
            shearing forces during sperm movement.[supplied by OMIM, Apr 2004].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB067774.1, AY713299.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325113.9/ ENSP00000325868.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               AC069287.7         62442-62727         c
            287-403             AC069287.7         62075-62191         c
            404-604             AC069287.7         61727-61927         c
            605-706             AC069287.7         61188-61289         c
            707-828             AC069287.7         60903-61024         c
            829-969             AC069287.7         59979-60119         c
            970-1284            AC069287.7         59230-59544         c
FEATURES             Location/Qualifiers
     source          1..1284
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..1284
                     /gene="CIMAP1A"
                     /gene_synonym="CT135; ODF3; SHIPPO1; TISP50"
                     /note="ciliary microtubule associated protein 1A"
                     /db_xref="GeneID:113746"
                     /db_xref="HGNC:HGNC:19905"
                     /db_xref="MIM:608356"
     exon            1..286
                     /gene="CIMAP1A"
                     /gene_synonym="CT135; ODF3; SHIPPO1; TISP50"
                     /inference="alignment:Splign:2.1.0"
     exon            287..403
                     /gene="CIMAP1A"
                     /gene_synonym="CT135; ODF3; SHIPPO1; TISP50"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..1059
                     /gene="CIMAP1A"
                     /gene_synonym="CT135; ODF3; SHIPPO1; TISP50"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cancer/testis antigen 135; sperm tail protein SHIPPO1;
                     outer dense fiber protein 3; transcript induced in
                     spermiogenesis protein 50; outer dense fiber of sperm
                     tails 3"
                     /codon_start=1
                     /product="ciliary microtubule associated protein 1A
                     isoform 1"
                     /protein_id="NP_444510.2"
                     /db_xref="CCDS:CCDS7688.1"
                     /db_xref="GeneID:113746"
                     /db_xref="HGNC:HGNC:19905"
                     /db_xref="MIM:608356"
                     /translation="MTEEVWMGTWRPHRPRGPIMALYSSPGPKYLIPPTTGFMKHTPT
                     KLRAPAYSFRGAPMLLAENCSPGPRYNVNPKILRTGKDLGPAYSILGRYQTKTMLTPG
                     PGDYFPEKSTKYVFDSAPSHSISARTKAFRVDSTPGPAAYMLPMVMGPNTVGKASQPS
                     FSIKGRSKLGGFSDDLHKTPGPAAYRQTDVRVTKFKAPQYTMAARVEPPGDKTLKPGP
                     GAHSPEKVTLTKPCAPVVTFGIKHSDYMTPLLVDVE"
     exon            404..604
                     /gene="CIMAP1A"
                     /gene_synonym="CT135; ODF3; SHIPPO1; TISP50"
                     /inference="alignment:Splign:2.1.0"
     exon            605..706
                     /gene="CIMAP1A"
                     /gene_synonym="CT135; ODF3; SHIPPO1; TISP50"
                     /inference="alignment:Splign:2.1.0"
     exon            707..828
                     /gene="CIMAP1A"
                     /gene_synonym="CT135; ODF3; SHIPPO1; TISP50"
                     /inference="alignment:Splign:2.1.0"
     exon            829..969
                     /gene="CIMAP1A"
                     /gene_synonym="CT135; ODF3; SHIPPO1; TISP50"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1284
                     /gene="CIMAP1A"
                     /gene_synonym="CT135; ODF3; SHIPPO1; TISP50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1265..1270
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIMAP1A"
                     /gene_synonym="CT135; ODF3; SHIPPO1; TISP50"
                     /note="hexamer: AATAAA"
     polyA_site      1284
                     /gene="CIMAP1A"
                     /gene_synonym="CT135; ODF3; SHIPPO1; TISP50"
                     /note="major polyA site"
ORIGIN      
        1 cctctcccca attctgtaag cccatgagga gagaggaagg cctttctctc catgctcctt
       61 ttgcgggaac tccctggcac caaggccagg ggggaaagga cagtctctga tgaggatggg
      121 tctctaggct gctctgagtg ctgtccctgc actgaagaag ttatagttcc ctcccaggcg
      181 gccccctccc tgcccctcag ctcagcctca atcaagaagt tccccatctt tgaccactcc
      241 aagtaggaga aaccggccca gggctccctt agagccgaga acagtgagct ggccatgacg
      301 gaggaggtat ggatgggtac ctggaggccc catcgccccc ggggacccat catggccctc
      361 tacagcagcc ctggacccaa gtacctgatt ccaccaacaa caggcttcat gaagcacacg
      421 cccaccaagc tgcgtgcacc ggcctacagc ttccgtgggg cccccatgct cctggcagag
      481 aactgctccc cagggccccg ttacaatgta aaccccaaga tactgaggac tggcaaggac
      541 cttggccctg cctactccat cctggggcgc taccaaacca agaccatgct gactcctggt
      601 ccaggtgact actttccaga gaaatccacc aagtacgtgt tcgactcagc acccagccac
      661 tccatctctg cccggacaaa ggcattccga gtggacagca ccccaggccc cgctgcgtac
      721 atgctgccca tggtaatggg gcccaatacc gtcggcaagg cctcccagcc ctccttttcc
      781 atcaagggcc gcagcaagct gggcggcttc agcgacgacc tacacaagac cccaggtccc
      841 gcagcctacc gccaaactga tgtgcgggtg accaagttca aggctccgca gtacaccatg
      901 gctgcccgtg tggagccccc aggggacaag accctcaagc caggaccagg cgcccacagc
      961 cctgagaagg tgaccctgac caagccctgc gccccagttg tcaccttcgg catcaaacac
     1021 tctgattaca tgactcccct gctggttgat gtggaataac gccagccctg ctgtgcccca
     1081 tcacacccgg catctacaca agatccgccg ggccacagag ctcgaggctg tcttcaccag
     1141 ctgggctggg ccagcctggc cctgcagggc agagcacgct tgtttgggca attgtaatca
     1201 gttacttttt ttctatgcta ttttaccatt ttttaatctt gttttctgct gtgcccaaat
     1261 tattaataaa tcagattgca ttaa
//
