LOCUS       NM_153221               4199 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens cartilage intermediate layer protein 2 (CILP2), mRNA.
ACCESSION   NM_153221
VERSION     NM_153221.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4199)
  AUTHORS   Wang,J., Du,J., Wang,Y., Song,Y., Wu,J., Wang,T., Yu,Z. and Song,B.
  TITLE     CILP2 promotes hypertrophic scar through Snail acetylation by
            interaction with ACLY
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167202 (2024)
   PUBMED   38670440
  REMARK    GeneRIF: CILP2 promotes hypertrophic scar through Snail acetylation
            by interaction with ACLY.
REFERENCE   2  (bases 1 to 4199)
  AUTHORS   Ha,Y.J., Park,S.H., Tak,K.H., Lee,J.L., Kim,C.W., Kim,J.H.,
            Kim,S.Y., Kim,S.K. and Yoon,Y.S.
  TITLE     CILP2 is a potential biomarker for the prediction and therapeutic
            target of peritoneal metastases in colorectal cancer
  JOURNAL   Sci Rep 14 (1), 12487 (2024)
   PUBMED   38816545
  REMARK    GeneRIF: CILP2 is a potential biomarker for the prediction and
            therapeutic target of peritoneal metastases in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4199)
  AUTHORS   Torga,T., Suutre,S., Kisand,K., Aunapuu,M. and Arend,A.
  TITLE     Expression of CILP-2 and DDR2 and ultrastructural changes in the
            articular cartilage of patients with knee osteoarthritis undergoing
            total knee arthroplasty: a pilot morphological study
  JOURNAL   Med Mol Morphol 56 (1), 46-57 (2023)
   PUBMED   36370214
  REMARK    GeneRIF: Expression of CILP-2 and DDR2 and ultrastructural changes
            in the articular cartilage of patients with knee osteoarthritis
            undergoing total knee arthroplasty: a pilot morphological study.
REFERENCE   4  (bases 1 to 4199)
  AUTHORS   Hu,W., Li,K., Han,H., Geng,S., Zhou,B., Fan,X., Xu,S., Yang,M.,
            Liu,H., Yang,G. and Liu,Y.
  TITLE     Circulating Levels of CILP2 Are Elevated in Coronary Heart Disease
            and Associated with Atherosclerosis
  JOURNAL   Oxid Med Cell Longev 2020, 1871984 (2020)
   PUBMED   33204392
  REMARK    GeneRIF: Circulating Levels of CILP2 Are Elevated in Coronary Heart
            Disease and Associated with Atherosclerosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4199)
  AUTHORS   Boonvisut,S., Nakayama,K., Makishima,S., Watanabe,K., Miyashita,H.,
            Lkhagvasuren,M., Kagawa,Y. and Iwamoto,S.
  TITLE     Replication analysis of genetic association of the NCAN-CILP2
            region with plasma lipid levels and non-alcoholic fatty liver
            disease in Asian and Pacific ethnic groups
  JOURNAL   Lipids Health Dis 15, 8 (2016)
   PUBMED   26758378
  REMARK    GeneRIF: This study aims to analyze the influences of
            single-nucleotide polymorphism in the NCAN-CILP2 region on
            non-alcoholic fatty liver disease and plasma lipid levels in the
            Asian and Pacific ethnic groups.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4199)
  AUTHORS   Tai,E.S., Sim,X.L., Ong,T.H., Wong,T.Y., Saw,S.M., Aung,T.,
            Kathiresan,S., Orho-Melander,M., Ordovas,J.M., Tan,J.T. and
            Seielstad,M.
  TITLE     Polymorphisms at newly identified lipid-associated loci are
            associated with blood lipids and cardiovascular disease in an Asian
            Malay population
  JOURNAL   J Lipid Res 50 (3), 514-520 (2009)
   PUBMED   18987386
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4199)
  AUTHORS   Kathiresan,S., Willer,C.J., Peloso,G.M., Demissie,S., Musunuru,K.,
            Schadt,E.E., Kaplan,L., Bennett,D., Li,Y., Tanaka,T., Voight,B.F.,
            Bonnycastle,L.L., Jackson,A.U., Crawford,G., Surti,A., Guiducci,C.,
            Burtt,N.P., Parish,S., Clarke,R., Zelenika,D., Kubalanza,K.A.,
            Morken,M.A., Scott,L.J., Stringham,H.M., Galan,P., Swift,A.J.,
            Kuusisto,J., Bergman,R.N., Sundvall,J., Laakso,M., Ferrucci,L.,
            Scheet,P., Sanna,S., Uda,M., Yang,Q., Lunetta,K.L., Dupuis,J., de
            Bakker,P.I., O'Donnell,C.J., Chambers,J.C., Kooner,J.S.,
            Hercberg,S., Meneton,P., Lakatta,E.G., Scuteri,A., Schlessinger,D.,
            Tuomilehto,J., Collins,F.S., Groop,L., Altshuler,D., Collins,R.,
            Lathrop,G.M., Melander,O., Salomaa,V., Peltonen,L.,
            Orho-Melander,M., Ordovas,J.M., Boehnke,M., Abecasis,G.R.,
            Mohlke,K.L. and Cupples,L.A.
  TITLE     Common variants at 30 loci contribute to polygenic dyslipidemia
  JOURNAL   Nat Genet 41 (1), 56-65 (2009)
   PUBMED   19060906
REFERENCE   8  (bases 1 to 4199)
  AUTHORS   Kathiresan,S., Melander,O., Guiducci,C., Surti,A., Burtt,N.P.,
            Rieder,M.J., Cooper,G.M., Roos,C., Voight,B.F., Havulinna,A.S.,
            Wahlstrand,B., Hedner,T., Corella,D., Tai,E.S., Ordovas,J.M.,
            Berglund,G., Vartiainen,E., Jousilahti,P., Hedblad,B.,
            Taskinen,M.R., Newton-Cheh,C., Salomaa,V., Peltonen,L., Groop,L.,
            Altshuler,D.M. and Orho-Melander,M.
  TITLE     Six new loci associated with blood low-density lipoprotein
            cholesterol, high-density lipoprotein cholesterol or triglycerides
            in humans
  JOURNAL   Nat Genet 40 (2), 189-197 (2008)
   PUBMED   18193044
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Erratum:[Nat Genet. 2008 Nov;40(11):1384]
REFERENCE   9  (bases 1 to 4199)
  AUTHORS   Willer,C.J., Sanna,S., Jackson,A.U., Scuteri,A., Bonnycastle,L.L.,
            Clarke,R., Heath,S.C., Timpson,N.J., Najjar,S.S., Stringham,H.M.,
            Strait,J., Duren,W.L., Maschio,A., Busonero,F., Mulas,A., Albai,G.,
            Swift,A.J., Morken,M.A., Narisu,N., Bennett,D., Parish,S., Shen,H.,
            Galan,P., Meneton,P., Hercberg,S., Zelenika,D., Chen,W.M., Li,Y.,
            Scott,L.J., Scheet,P.A., Sundvall,J., Watanabe,R.M., Nagaraja,R.,
            Ebrahim,S., Lawlor,D.A., Ben-Shlomo,Y., Davey-Smith,G.,
            Shuldiner,A.R., Collins,R., Bergman,R.N., Uda,M., Tuomilehto,J.,
            Cao,A., Collins,F.S., Lakatta,E., Lathrop,G.M., Boehnke,M.,
            Schlessinger,D., Mohlke,K.L. and Abecasis,G.R.
  TITLE     Newly identified loci that influence lipid concentrations and risk
            of coronary artery disease
  JOURNAL   Nat Genet 40 (2), 161-169 (2008)
   PUBMED   18193043
REFERENCE   10 (bases 1 to 4199)
  AUTHORS   Johnson,K., Farley,D., Hu,S.I. and Terkeltaub,R.
  TITLE     One of two chondrocyte-expressed isoforms of cartilage
            intermediate-layer protein functions as an insulin-like growth
            factor 1 antagonist
  JOURNAL   Arthritis Rheum 48 (5), 1302-1314 (2003)
   PUBMED   12746903
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA328640.1, AF542080.1 and BC018939.2.
            
            On Apr 25, 2007 this sequence version replaced NM_153221.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068256.1, AF542080.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467143, SAMEA2467144
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291495.5/ ENSP00000291495.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                DA328640.1         1-41
            42-2151             AF542080.1         10-2119
            2152-4199           BC018939.2         560-2607
FEATURES             Location/Qualifiers
     source          1..4199
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..4199
                     /gene="CILP2"
                     /gene_synonym="CLIP-2"
                     /note="cartilage intermediate layer protein 2"
                     /db_xref="GeneID:148113"
                     /db_xref="HGNC:HGNC:24213"
                     /db_xref="MIM:612419"
     exon            1..149
                     /gene="CILP2"
                     /gene_synonym="CLIP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..3556
                     /gene="CILP2"
                     /gene_synonym="CLIP-2"
                     /note="cartilage intermediate layer protein-like protein
                     2; CILP-2"
                     /codon_start=1
                     /product="cartilage intermediate layer protein 2
                     precursor"
                     /protein_id="NP_694953.2"
                     /db_xref="CCDS:CCDS12405.1"
                     /db_xref="GeneID:148113"
                     /db_xref="HGNC:HGNC:24213"
                     /db_xref="MIM:612419"
                     /translation="MASLLPLLCLCVVAAHLAGARDATPTEEPMATALGLERRSVYTG
                     QPSPALEDWEEASEWTSWFNVDHPGGDGDFESLAAIRFYYGPARVCPRPLALEARTTD
                     WALPSAVGERVHLNPTRGFWCLNREQPRGRRCSNYHVRFRCPLEASWGAWGPWGPCSG
                     SCGPGRRLRRRHCPSPAGDACPGRPLEAQKCVRPRCPGCSLDTCECPDHILLGSVVTP
                     SGQPLLGARVSLRDQPGTVATSDAHGTFRVPGVCADSRANIRAQMDGFSAGEAQAQAN
                     GSISVVTIILDKLEKPYLVKHPESRVREAGQNVTFCCKASGTPMPKKYSWFHNGTLLD
                     RRAHGYGAHLELRGLRPDQAGIYHCKAWNEAGAVRSGTARLTVLAPGQPACDPRPREY
                     LIKLPEDCGQPGSGPAYLDVGLCPDTRCPSLAGSSPRCGDASSRCCSVRRLERREIHC
                     PGYVLPVKVVAECGCQKCLPPRGLVRGRVVAADSGEPLRFARILLGQEPIGFTAYQGD
                     FTIEVPPSTQRLVVTFVDPSGEFMDAVRVLPFDPRGAGVYHEVKAMRKKAPVILHTSQ
                     SNTIPLGELEDEAPLGELVLPSGAFRRADGKPYSGPVEARVTFVDPRDLTSAASAPSD
                     LRFVDSDGELAPLRTYGMFSVDLRAPGSAEQLQVGPVAVRVAASQIHMPGHVEALKLW
                     SLNPETGLWEEESGFRREGSSGPRVRREERVFLVGNVEIRERRLFNLDVPERRRCFVK
                     VRAYANDKFTPSEQVEGVVVTLVNLEPAPGFSANPRAWGRFDSAVTGPNGACLPAFCD
                     ADRPDAYTALVTATLGGEELEPAPSLPRPLPATVGVTQPYLDRLGYRRTDHDDPAFKR
                     NGFRINLAKPRPGDPAEANGPVYPWRSLRECQGAPVTASHFRFARVEADKYEYNVVPF
                     REGTPASWTGDLLAWWPNPQEFRACFLKVKIQGPQEYMVRSHNAGGSHPRTRGQLYGL
                     RDARSVRDPERPGTSAACVEFKCSGMLFDQRQVDRTLVTIMPQGSCRRVAVNGLLRDY
                     LTRHPPPVPAEDPAAFSMLAPLDPLGHNYGVYTVTDQSPRLAKEIAIGRCFDGSSDGF
                     SREMKADAGTAVTFQCREPPAGRPSLFQRLLESPATALGDIRREMSEAAQAQARASGP
                     LRTRRGRVRQ"
     exon            150..248
                     /gene="CILP2"
                     /gene_synonym="CLIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            249..521
                     /gene="CILP2"
                     /gene_synonym="CLIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            522..677
                     /gene="CILP2"
                     /gene_synonym="CLIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            678..953
                     /gene="CILP2"
                     /gene_synonym="CLIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1062
                     /gene="CILP2"
                     /gene_synonym="CLIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1220
                     /gene="CILP2"
                     /gene_synonym="CLIP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..4199
                     /gene="CILP2"
                     /gene_synonym="CLIP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4178..4183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CILP2"
                     /gene_synonym="CLIP-2"
                     /note="hexamer: ATTAAA"
     polyA_site      4199
                     /gene="CILP2"
                     /gene_synonym="CLIP-2"
                     /note="major polyA site"
ORIGIN      
        1 agtcccagcg gccgccagac ccgccggagt tggacccgag cacgccgcgg agcccggacc
       61 ctccctcgga cgctctgccc cggccatggc gtcgctgctg ccactgctct gtctctgtgt
      121 cgtcgctgcg cacctggcgg gggcccgaga cgccaccccc accgaggagc caatggcgac
      181 tgcactgggc ctggaaagac ggtccgtgta caccggccag ccctcaccag ccctggagga
      241 ctgggaagag gccagcgagt ggacgtcctg gttcaacgtg gaccaccccg gaggcgacgg
      301 cgacttcgag agcctggctg ccatccgctt ctactacggg ccagcgcgcg tgtgcccgcg
      361 accgctggcg ctggaagcgc gcaccacgga ctgggccctg ccgtccgccg tcggcgagcg
      421 cgtgcacttg aaccccacgc gcggcttctg gtgcctcaac cgcgagcaac cgcgtggccg
      481 ccgctgctcc aactaccacg tgcgcttccg ctgcccacta gaagcctcgt ggggcgcgtg
      541 gggcccgtgg ggtccctgct cggggagctg tgggccaggc cgtcgcttgc gccgccgcca
      601 ctgcccaagc cccgctgggg atgcgtgtcc cgggcgtcct ctggaggcgc agaagtgcgt
      661 gcggcctcgg tgtccagggt gcagccttga cacctgtgaa tgcccggacc acatcctcct
      721 gggctcggtg gtcaccccat ctgggcaacc actgctagga gccagggtct ccctgcgaga
      781 ccagcctggc actgtggcca ccagcgatgc tcacggaacc ttccgggtgc ctggtgtctg
      841 tgctgacagc cgcgccaaca tcagggccca gatggatggc ttctctgcag gggaggccca
      901 ggcccaggcc aacggatcca tctctgtggt caccatcatc cttgataagt tggagaagcc
      961 gtacctggtg aaacaccctg agtcccgagt gcgagaggct ggccagaatg tgactttctg
     1021 ctgcaaagcc tccgggaccc ccatgcccaa gaaatactcc tggttccaca atgggaccct
     1081 gctggacagg cgagctcatg ggtacggggc ccacctggag ctgcggggac tgcgcccaga
     1141 ccaggctggc atctaccact gcaaggcatg gaatgaggcg ggtgccgtgc gctcgggcac
     1201 tgcccggctc actgtacttg ccccaggcca gccagcctgc gacccccggc cccgagagta
     1261 cctgatcaag ctccctgagg actgtggtca gccaggtagt ggccctgcct acctggatgt
     1321 gggcctctgt cccgacaccc gctgccccag cctggcaggc tccagccccc gctgcgggga
     1381 cgccagctcc cgctgctgct ctgtgcgccg tctggagaga agggagattc actgccctgg
     1441 ctacgtcctc ccagtgaagg tggtggcaga gtgtggctgc cagaagtgtc tgccccctcg
     1501 ggggctggtc cggggccgtg ttgtggctgc tgactccggg gagccgctac gcttcgccag
     1561 gattctgctg ggccaggagc ccatcggctt caccgcctac cagggcgact ttaccattga
     1621 ggtgccgccc tccacccagc ggctggtggt gacttttgtg gaccccagcg gtgagttcat
     1681 ggacgctgtc cgggtcttgc cttttgatcc tcgaggtgcc ggcgtgtacc acgaggtcaa
     1741 ggccatgcgg aagaaagccc cggtcatttt acataccagc cagagcaaca cgatccccct
     1801 gggcgagctg gaagatgagg cgcccctggg cgagctggtc ctgccttctg gcgctttccg
     1861 cagagccgac ggcaaaccct actcggggcc tgtggaggcc cgggtgacgt tcgtggaccc
     1921 ccgagacctc acctcggcgg cgtctgcccc cagtgacctg cgcttcgtgg acagcgacgg
     1981 cgagctggct ccactgcgca cctacggcat gttctccgtg gacctccgtg cgcccggctc
     2041 cgcggagcag ctgcaggtgg ggccggtggc cgtgcgggtg gccgccagcc agatccacat
     2101 gccaggccac gtggaggccc tcaagctgtg gtcgctgaac cccgagaccg gcttgtggga
     2161 ggaggagagc ggcttccggc gcgaggggtc ctcgggcccc cgggtgcgcc gggaggagcg
     2221 cgtcttcctg gtgggcaacg tggagatccg ggagcggcgc ctgttcaatc tggacgtgcc
     2281 tgagcgccgc cgctgcttcg tgaaggtgcg cgcctacgcc aacgacaagt tcacccccag
     2341 cgagcaggtg gagggcgtgg tggtcacgct ggtcaatctg gagcccgccc ccggcttctc
     2401 cgccaacccc cgtgcctggg gccgctttga cagcgcggtc accggcccca atggcgcctg
     2461 cctccccgcc ttctgcgacg ccgacaggcc agacgcctac accgccctgg tcaccgccac
     2521 cctgggcggc gaggagctgg agccggcccc ttccttgccc cgcccactcc cggccaccgt
     2581 gggcgtcacc cagccctacc tggacaggct ggggtaccgt cggacggacc acgacgatcc
     2641 cgccttcaag cgtaacggct tccgcatcaa cctcgccaag cccaggccag gtgaccccgc
     2701 cgaggccaat gggcctgtgt acccgtggcg cagcctgcgg gaatgccagg gggccccggt
     2761 gactgccagc cacttccgct tcgccagggt ggaggcggac aagtacgagt acaacgtggt
     2821 ccccttccga gagggcacac ctgcctcctg gactggcgat ctcctggcct ggtggcccaa
     2881 cccgcaggag ttccgggcct gcttcctcaa ggtgaagatc cagggtcccc aggagtatat
     2941 ggtccgctcc cacaacgcag ggggcagcca cccacgcacc cgcggccagc tctacggact
     3001 tcgggatgcc cggagtgtgc gagaccccga gcgtccgggc acctcggcag cctgcgtgga
     3061 gttcaagtgc agcgggatgc tgttcgacca gcggcaggtg gacaggacgc tggtgaccat
     3121 tatgccccag ggcagctgcc ggcgcgtggc cgtcaacgga ctccttcggg attacctgac
     3181 ccggcacccc ccaccggtgc ccgcggagga cccagctgcc ttctccatgc tggcccccct
     3241 agaccctctg ggccacaact atggcgtcta cactgtcact gaccagagcc cacgcttggc
     3301 caaggagatc gccattggcc gctgctttga tggttcctct gacggcttct ccagagagat
     3361 gaaggctgat gccggcacag ccgtcacctt ccagtgccgg gagccaccgg ccggacgacc
     3421 cagcctcttc cagaggctgc tggagtcccc ggcgacagca cttggtgaca tccgcaggga
     3481 gatgagcgag gcggcgcagg cacaggcccg ggcctcaggt cccctccgca cccgccgggg
     3541 tagggtccgg cagtgacctg ggcaggggcc tcgctttccc acctccctcc agactccttt
     3601 gaccccagga agttttgccc ctccttcttc tccagacagc cccctcccca ggtgtctggg
     3661 tcccctttcc cgcccctttc cagaactcag agtcagacaa gaacccagag catccgatgg
     3721 tagaaacacc aggaagacaa ttgttgctgt gtggtatgga atggagtttg cggtgactct
     3781 ggggccagca cccaggggac gacgttcaac cctagcctga agggacccgc tcccagctca
     3841 gaagccgtct ctgacttctc gtgcgtattt tgaccctgat ttcaatcttc tacccttggg
     3901 agttctggcg tttggcacaa agtcccctct gcctgtttgg agctcagtgc tagaccaggt
     3961 cccctgcccc gagctttgtt tttggggtta tttattgaaa caaagtgtgg ggagctggtt
     4021 gtgggtgtga gtgggggtgt ggggtccagg ctgggcccag tgaaaaggag gaaggggttc
     4081 ccatgcgggg gaggctctgg ggctgagggg aacaattctc acgtgtttgg tgcttagaga
     4141 cctgcccggg gcgttgggca ggccctccgg gggctgaatt aaaaatgctt tatttccaa
//
