LOCUS       NM_014920               6146 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens ciliogenesis associated kinase 1 (CILK1), transcript
            variant 1, mRNA.
ACCESSION   NM_014920
VERSION     NM_014920.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6146)
  AUTHORS   He,Y., Zhang,X., Pan,W., Zhang,J., Zhu,W., Zhang,J. and Shi,J.
  TITLE     Ciliogenesis-associated Kinase 1 Promotes Breast Cancer Cell
            Proliferation and Chemoresistance via Phosphorylating ERK1
  JOURNAL   Int J Biol Sci 20 (7), 2403-2421 (2024)
   PUBMED   38725848
  REMARK    GeneRIF: Ciliogenesis-associated Kinase 1 Promotes Breast Cancer
            Cell Proliferation and Chemoresistance via Phosphorylating ERK1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6146)
  AUTHORS   Turner,J.S., McCabe,E.A., Kuang,K.W., Gailey,C.D., Brautigan,D.L.,
            Limerick,A., Wang,E.X. and Fu,Z.
  TITLE     The Scaffold Protein KATNIP Enhances CILK1 Control of Primary Cilia
  JOURNAL   Mol Cell Biol 43 (9), 472-480 (2023)
   PUBMED   37665596
  REMARK    GeneRIF: The Scaffold Protein KATNIP Enhances CILK1 Control of
            Primary Cilia.
REFERENCE   3  (bases 1 to 6146)
  AUTHORS   Satoda,Y., Noguchi,T., Fujii,T., Taniguchi,A., Katoh,Y. and
            Nakayama,K.
  TITLE     BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36
            contributes to intraflagellar transport turnaround involving
            ICK/CILK1
  JOURNAL   Mol Biol Cell 33 (9), ar79 (2022)
   PUBMED   35609210
  REMARK    GeneRIF: BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36
            contributes to intraflagellar transport turnaround involving
            ICK/CILK1.
REFERENCE   4  (bases 1 to 6146)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 6146)
  AUTHORS   Nakamura,K., Noguchi,T., Takahara,M., Omori,Y., Furukawa,T.,
            Katoh,Y. and Nakayama,K.
  TITLE     Anterograde trafficking of ciliary MAP kinase-like ICK/CILK1 by the
            intraflagellar transport machinery is required for intraciliary
            retrograde protein trafficking
  JOURNAL   J Biol Chem 295 (38), 13363-13376 (2020)
   PUBMED   32732286
  REMARK    GeneRIF: Anterograde trafficking of ciliary MAP kinase-like
            ICK/CILK1 by the intraflagellar transport machinery is required for
            intraciliary retrograde protein trafficking.
REFERENCE   6  (bases 1 to 6146)
  AUTHORS   Fu,Z., Schroeder,M.J., Shabanowitz,J., Kaldis,P., Togawa,K.,
            Rustgi,A.K., Hunt,D.F. and Sturgill,T.W.
  TITLE     Activation of a nuclear Cdc2-related kinase within a
            mitogen-activated protein kinase-like TDY motif by
            autophosphorylation and cyclin-dependent protein kinase-activating
            kinase
  JOURNAL   Mol Cell Biol 25 (14), 6047-6064 (2005)
   PUBMED   15988018
  REMARK    GeneRIF: ICK is the prototype for a new group of MAPK-like kinases
            requiring dual phosphorylation at TDY motifs.
REFERENCE   7  (bases 1 to 6146)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   8  (bases 1 to 6146)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   9  (bases 1 to 6146)
  AUTHORS   Yang,T., Jiang,Y. and Chen,J.
  TITLE     The identification and subcellular localization of human MRK
  JOURNAL   Biomol Eng 19 (1), 1-4 (2002)
   PUBMED   12103360
REFERENCE   10 (bases 1 to 6146)
  AUTHORS   Togawa,K., Yan,Y.X., Inomoto,T., Slaugenhaupt,S. and Rustgi,A.K.
  TITLE     Intestinal cell kinase (ICK) localizes to the crypt region and
            requires a dual phosphorylation site found in map kinases
  JOURNAL   J Cell Physiol 183 (1), 129-139 (2000)
   PUBMED   10699974
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031178.1 and AL162581.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 25, 2019 this sequence version replaced NM_014920.4.
            
            Summary: Eukaryotic protein kinases are enzymes that belong to a
            very extensive family of proteins which share a conserved catalytic
            core common with both serine/threonine and tyrosine protein
            kinases. This gene encodes an intestinal serine/threonine kinase
            harboring a dual phosphorylation site found in mitogen-activating
            protein (MAP) kinases. The protein localizes to the intestinal
            crypt region and is thought to be important in intestinal
            epithelial cell proliferation and differentiation. Alternative
            splicing has been observed at this locus and two variants, encoding
            the same isoform, have been identified. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC152464.1, AB023153.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000676107.1/ ENSP00000501692.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-229               AL031178.1         38426-38654         c
            230-502             AL031178.1         17966-18238         c
            503-557             AL031178.1         14769-14823         c
            558-679             AL031178.1         9363-9484           c
            680-759             AL031178.1         7895-7974           c
            760-892             AL162581.11        29950-30082         c
            893-1064            AL162581.11        29053-29224         c
            1065-1232           AL162581.11        26806-26973         c
            1233-1553           AL162581.11        24385-24705         c
            1554-1744           AL162581.11        22760-22950         c
            1745-1893           AL162581.11        22492-22640         c
            1894-2022           AL162581.11        20162-20290         c
            2023-2145           AL162581.11        17038-17160         c
            2146-6146           AL162581.11        12026-16026         c
FEATURES             Location/Qualifiers
     source          1..6146
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.1"
     gene            1..6146
                     /gene="CILK1"
                     /gene_synonym="ECO; EJM10; hICK; ICK; LCK2; MRK"
                     /note="ciliogenesis associated kinase 1"
                     /db_xref="GeneID:22858"
                     /db_xref="HGNC:HGNC:21219"
                     /db_xref="MIM:612325"
     exon            1..229
                     /gene="CILK1"
                     /gene_synonym="ECO; EJM10; hICK; ICK; LCK2; MRK"
                     /inference="alignment:Splign:2.1.0"
     exon            230..502
                     /gene="CILK1"
                     /gene_synonym="ECO; EJM10; hICK; ICK; LCK2; MRK"
                     /inference="alignment:Splign:2.1.0"
     CDS             402..2300
                     /gene="CILK1"
                     /gene_synonym="ECO; EJM10; hICK; ICK; LCK2; MRK"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     MAK-related kinase; serine/threonine-protein kinase ICK;
                     serine/threonine protein kinase; laryngeal cancer kinase
                     2; intestinal cell kinase; iciliogenesis associated kinase
                     1; intestinal cell (MAK-like) kinase"
                     /codon_start=1
                     /product="serine/threonine-protein kinase ICK isoform 1"
                     /protein_id="NP_055735.1"
                     /db_xref="CCDS:CCDS4949.1"
                     /db_xref="GeneID:22858"
                     /db_xref="HGNC:HGNC:21219"
                     /db_xref="MIM:612325"
                     /translation="MNRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEE
                     CMNLREVKSLKKLNHANVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAI
                     RNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSKPPYTDYV
                     STRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGT
                     PKKTDWPEGYQLSSAMNFRWPQCVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTAS
                     QALRYPYFQVGHPLGSTTQNLQDSEKPQKGILEKAGPPPYIKPVPPAQPPAKPHTRIS
                     SRQHQASQPPLHLTYPYKAEVSRTDHPSHLQEDKPSPLLFPSLHNKHPQSKITAGLEH
                     KNGEIKPKSRRRWGLISRSTKDSDDWADLDDLDFSPSLSRIDLKNKKRQSDDTLCRFE
                     SVLDLKPSEPVGTGNSAPTQTSYQRRDTPTLRSAAKQHYLKHSRYLPGISIRNGILSN
                     PGKEFIPPNPWSSSGLSGKSSGTMSVISKVNSVGSSSTSSSGLTGNYVPSFLKKEIGS
                     AMQRVHLAPIPDPSPGYSSLKAMRPHPGRPFFHTQPRSTPGLIPRPPAAQPVHGRTDW
                     ASKYASRR"
     exon            503..557
                     /gene="CILK1"
                     /gene_synonym="ECO; EJM10; hICK; ICK; LCK2; MRK"
                     /inference="alignment:Splign:2.1.0"
     exon            558..679
                     /gene="CILK1"
                     /gene_synonym="ECO; EJM10; hICK; ICK; LCK2; MRK"
                     /inference="alignment:Splign:2.1.0"
     exon            680..759
                     /gene="CILK1"
                     /gene_synonym="ECO; EJM10; hICK; ICK; LCK2; MRK"
                     /inference="alignment:Splign:2.1.0"
     exon            760..892
                     /gene="CILK1"
                     /gene_synonym="ECO; EJM10; hICK; ICK; LCK2; MRK"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1064
                     /gene="CILK1"
                     /gene_synonym="ECO; EJM10; hICK; ICK; LCK2; MRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1232
                     /gene="CILK1"
                     /gene_synonym="ECO; EJM10; hICK; ICK; LCK2; MRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1553
                     /gene="CILK1"
                     /gene_synonym="ECO; EJM10; hICK; ICK; LCK2; MRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1744
                     /gene="CILK1"
                     /gene_synonym="ECO; EJM10; hICK; ICK; LCK2; MRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1893
                     /gene="CILK1"
                     /gene_synonym="ECO; EJM10; hICK; ICK; LCK2; MRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2022
                     /gene="CILK1"
                     /gene_synonym="ECO; EJM10; hICK; ICK; LCK2; MRK"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2145
                     /gene="CILK1"
                     /gene_synonym="ECO; EJM10; hICK; ICK; LCK2; MRK"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..6146
                     /gene="CILK1"
                     /gene_synonym="ECO; EJM10; hICK; ICK; LCK2; MRK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6123..6128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CILK1"
                     /gene_synonym="ECO; EJM10; hICK; ICK; LCK2; MRK"
                     /note="hexamer: AATAAA"
     polyA_site      6146
                     /gene="CILK1"
                     /gene_synonym="ECO; EJM10; hICK; ICK; LCK2; MRK"
                     /note="major polyA site"
ORIGIN      
        1 gtttgttttc ctgccggagg ctggaaaacg gccgggttcc tgctgcacta ccatgcgccg
       61 tgcggcccgt gcgactcgcc ggacctcgcg ggcgtccctg tacggagccc tcggccggtc
      121 ctagcaggga ttgtccccat ttccagctcc ggagcgggcg gctgcgcccc gctcgtcgag
      181 gagctgcgct cacctcaggg gcgggccccc gcctgcgttc gcggcgccag cagaagactg
      241 atttttggaa atatgtattt gggagacagt cacgtcctat tgaatacctt gtgctggtgc
      301 tgccatcgaa aaatctggtt acactctggg gaggactgct accactgcag aactgaacca
      361 cttcggccgt gagatgagtg tccggcctga gcaggcacac catgaataga tacacaacaa
      421 tcaggcagct cggggatgga acctacggtt ccgtcctgct gggaagaagc attgagtctg
      481 gggagctgat cgctattaaa aaaatgaaaa gaaaatttta ttcctgggag gaatgcatga
      541 accttcggga ggttaagtct ttaaagaagc tcaaccatgc caatgtagtc aaattaaaag
      601 aagttatcag ggaaaatgat catctttatt ttatcttcga gtacatgaag gaaaatcttt
      661 accagctcat taaagagaga aataagttgt ttcctgagtc tgctataagg aatatcatgt
      721 atcagatatt acaaggactc gcatttattc acaaacacgg cttctttcat cgagacttaa
      781 agcctgagaa cctcctctgc atgggaccag aacttgtgaa aattgcagac tttggtttgg
      841 cccgagaaat acgatcaaaa cctccatata cagattatgt atctaccaga tggtacaggg
      901 ctccagaagt actcctgagg tctaccaact acagctcccc cattgacgtc tgggcggtgg
      961 gctgcatcat ggcagaagtt tacaccctca ggccactctt ccctggagcc agtgaaattg
     1021 acacaatatt caaaatttgc caagtgctgg ggacaccaaa aaagactgac tggcctgaag
     1081 gctatcaact ttcaagtgca atgaacttcc gttggccaca gtgtgtaccc aataacttaa
     1141 agaccttgat tcccaatgct agcagtgaag cagtccagct cctgagagac atgcttcagt
     1201 gggatcccaa gaaacgacca acagctagtc aggcacttcg atatccttac ttccaagttg
     1261 gacacccact aggcagcacc acacaaaacc ttcaggattc agaaaaacca cagaaaggca
     1321 tcctggaaaa ggcaggccca cctccttata ttaagccagt cccacctgcc cagccaccag
     1381 ccaagccaca cacacgaatt tcttcacgac agcatcaagc cagccagccc cctctgcatc
     1441 tcacgtaccc ctacaaagca gaggtctcca ggacagatca cccaagccat ctccaggagg
     1501 acaagccaag cccgttgctt ttcccatccc tccacaacaa gcatccacag tcgaaaatca
     1561 cagctggcct ggagcacaaa aatggtgaga taaagccaaa gagtaggaga aggtggggtc
     1621 ttatttccag gtcaacaaag gattcagatg attgggctga cttggatgac ttggatttca
     1681 gtccatccct cagcaggatt gacctgaaaa acaagaaaag acagagtgat gacactctct
     1741 gcaggtttga gagtgttttg gacctgaagc cctctgagcc tgtgggcaca ggaaacagtg
     1801 cccccaccca gacgtcatat cagcggcgag acacgcccac cctgagatct gcagccaagc
     1861 agcactattt gaagcactct cgatacttgc ctgggatcag tataagaaat ggcatactct
     1921 cgaatccagg caaggaattt attccaccta atccatggtc tagttctggc ttgtctggaa
     1981 aatcttcagg gacaatgtca gtaatcagca aagtaaattc agttggttcc agctctacaa
     2041 gttctagtgg actgactgga aactatgtcc cttcctttct gaaaaaagaa atcggttctg
     2101 ctatgcagag ggtacaccta gcacctattc cagacccttc ccctggttat tcctccctga
     2161 aggccatgag acctcatcct gggcgaccat tcttccacac ccagcctaga agcactcctg
     2221 ggttgatacc acggcctcca gccgcccagc cagtgcatgg ccggacagac tgggcttcca
     2281 agtacgcatc tcggcgatga ctgtctgcct tggtgatgaa tctcttccta gggagaagca
     2341 ggatactttc cctcagctga ctggtgttct acctgcaaga tgtgcagagg gcataaaagc
     2401 aaatcaacac tttatagtta ttcttctgaa ctaagacatg tcaatattct tttttaaagt
     2461 ttttttttaa aatattgatt tgaatgcagt aggctttttt gtataaaatt attttattct
     2521 aaaactgggt cccattattt tcttaaacaa cagcattttg tatatatgga ttatgtttta
     2581 gcattttata cagtcaactt tgtaatgaac tttttaaaaa ttaattgatt ttcctttggg
     2641 gttccagata atattttcta cagattttga aaaatgtaat aatattaatg cagtattgca
     2701 acaggggtgc aatttaaggc tatgtgatag agggttattt actcagtgtg tgcagatatt
     2761 tatgaagtgg tgaaatttca agtgtggctc actaggtact tcaggccttc ttggactgtt
     2821 gttagaaaag tgatcctctg cttttcttag taggtcattg gtttgatttt tggataccac
     2881 tctgctgttc taaaaggact attatattat ataattcact ttgttttact tttgttcccc
     2941 agatgaaaga actctaagta aatacatttt aaaaaatttt tctgacaccc tttaatgtgg
     3001 ttgcagatct cagatgaaac caagcttaat tatactatgc cattatattc taatttattc
     3061 catttttgaa atcaagttgt atgtgtacca ataaaagaga tttctgcttc aaaaggctct
     3121 caacatgaag gttaacacag tcaatcaaac ttacattcct gccaagatgc atggccaaaa
     3181 aactaagtat caaagcagca gaaggttttt gattatagta actgagatgg aattttgtgc
     3241 ctagctcagt tctccagatc tggctaggag cagtcaatga ctaatgttct gtcctagcca
     3301 aattctcagg acaatttggg gagcagaaag agttatggca gaggttccac tcatctacaa
     3361 agtcacagtc acatgccaca tttgatctcc taaccctggt gtagtttctt tcaagagtga
     3421 gaactttatt tgttgggcag aggctgttcc attgagagga atgtttacag cagtttcaaa
     3481 aatgacaaag tcagtttgga gacagaaaaa gacaaaaggt ccagtctcat ccatctctat
     3541 atggtacatt tgcctcactt atggttgcct taaaggcaag agggaaggtc accatcagtg
     3601 aacgcaatgc aatctcaaca gtgtattgat tcatattctc ctagggctca aactactctc
     3661 tattggttcc aggataatga caaattgaac catatgtaag taatctttta ttttttattt
     3721 tttttttgag acagagtctc actctgtcac ccaggctgga gtgcagtggc gcgatcttag
     3781 ctctctgcaa cctctgcctc ccaggttcaa gcctcctgag taactgggac tacaggcgcc
     3841 cgccaccacg cccagctaat tttttgtatt tttagtagag acggggtttc actgtgttag
     3901 ccaggacggc ctcgatctcc tgacctcgtg atccaccctc ctccacctcc caaagtactg
     3961 ggattacagg catgagccac tgcacccagc caagtgatca tttttatagg ttaaaatgat
     4021 aggtgaaatg aatatagaca ctttcatatg gttcaaccta atgacttggt aaattattgc
     4081 cttggtgtat taataatatg ttgcattctg aacaaataac catggcttcc aaagggccct
     4141 aacctaaaat cggagagtaa tttatgcttt ggagaatttg actcaaatat atacttgacc
     4201 aagcaccatg atccctaggg gcatgagaaa agcacataat ggatgtggat gtgataggtg
     4261 gtcttttcct gttaacaagc tggcagcaaa gcttcagaaa atatatatgc aagcacaact
     4321 tgaagctgaa ttcatttctg tattatattc tcaactcgtt atctaaagca tcagaacatg
     4381 tgttttcaga gatgagtcct ttactataag gttaatattt attttcattt tctgtattat
     4441 atatgaaaag taaattaatg tgaaacctgg cccagcttgc tggaaagcag gttttaaatt
     4501 gtaaatattc cttagaggag caaatggatt gtttaatacc atagtctcag taatctagct
     4561 tatataaggt cattacattt tttaactgaa aaacctagtt acctgattat tgcacattat
     4621 aaaattgttt ttctaatact ttatagggcc caacttcaga aaatacttcg cttttttctt
     4681 tttatgcttt cgtttgttta ccagcaagca acttccctgg ggaagccaaa cacatattca
     4741 taaaaaaaat caagtagctg atgtgcagtt gagaaaacta gaggactgaa aaaacaaatt
     4801 ttaactagca aatgctgtga attactcttc ctccccttct ctgaaatggg taaaggacaa
     4861 attgtgtaaa aaaacctatg cactatagaa gggaatagta accatttctt ttgtctctct
     4921 gtttctgttc tgactgagaa cctgcagcca tttcttgtta catgaaaaca aaatgctact
     4981 tgttacctct attttttgtt actatacaat tatgaaatgt aatgtaagac accaacagaa
     5041 atgatatacc tgtaactgta cctatcagga ctatacctca tttacagtca gaaagcttac
     5101 tgggatgtca ggaaatgata cagggttggt tctcatttcg tgccgaaatg agacagaaat
     5161 tcagtgacga aggtgcgttg taggggtatt gatgtgcccc aggtagtgcc agcagagtag
     5221 ggaaaactgc atttgcataa aaactactct tgacatgatt gttcatttta caaaaaaatt
     5281 ccattaatta ccaagccctc acccagccca tgtgtgatag gatttatgta ggaagaaact
     5341 tgattttcaa ataatttttt aaatgtatct cttgcctaaa ggactatata catctaataa
     5401 agtaacactg tgtcatcttc tggagttatc aaaaattgta tacaatcaag acaacacaag
     5461 aattatttta tttttgagtg caaatacagg tactgttgga gttgatgggc accatgcttt
     5521 ctcatgaagt agcatttccc taccatcaag ccattgtttt gtgccattca ggagaggaaa
     5581 aaaaggaatt tatgctgtac atttcagttc agtgtatgac caaaagcaat atgtttataa
     5641 gaagatgttt gacatactaa ttattttata tcatttaaac catactgtag caacataata
     5701 tatggagcta atttgtagaa ttatttttac gatttccaaa caaatgtact gtactgttat
     5761 ataatttatt gtgaggacct tctcatggaa gccattagga aaacaaacta gaggtaaata
     5821 tcacattaat ctgtattatc aatttctcat agacactgtg ctaatgtgaa ttttaaatga
     5881 cctgcatcaa gtcttctgat ctcagataac tcagtacaga tagcaattag tcagctgatt
     5941 tgattacaat ggagtaaccg acaatatatt tatttataaa gcacatattc ataataacga
     6001 gaagaattca gaaaaccact taagcaagac ccttctgaaa taaaaaatgt tgctttttaa
     6061 atagtttgtc ctaaggtgtt taaaacatgt caaccttatg taaggaaaaa tttcctggtc
     6121 caaataaagt tgaagtttaa gaaaaa
//
