LOCUS       XM_047434117            5278 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens class II major histocompatibility complex
            transactivator (CIITA), transcript variant X8, mRNA.
ACCESSION   XM_047434117
VERSION     XM_047434117.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000016.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5278
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
     gene            1..5278
                     /gene="CIITA"
                     /gene_synonym="C2TA; CIITAIV; MHC2D1; MHC2TA; NLRA"
                     /note="class II major histocompatibility complex
                     transactivator; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 1 mRNA, 52 ESTs, 61 long
                     SRA reads, 2 Proteins, and 99% coverage of the annotated
                     genomic feature by RNAseq alignments, including 59 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:4261"
                     /db_xref="HGNC:HGNC:7067"
                     /db_xref="MIM:600005"
     CDS             97..3420
                     /gene="CIITA"
                     /gene_synonym="C2TA; CIITAIV; MHC2D1; MHC2TA; NLRA"
                     /codon_start=1
                     /product="MHC class II transactivator isoform X5"
                     /protein_id="XP_047290073.1"
                     /db_xref="GeneID:4261"
                     /db_xref="HGNC:HGNC:7067"
                     /db_xref="MIM:600005"
                     /translation="MELGPLEGGYLELLNSDADPLCLYHFYDQMDLAGEEEIELYSEP
                     DTDTINCDQFSRLLCDMEGDEETREAYANIAELDQYVFQDSQLEGLSKDIFIEHIGPD
                     EVIGESMEMPAEVGQKSQKRPFPEELPADLKHWKPAEPPTVVTGSLLVGPVSDCSTLP
                     CLPLPALFNQEPASGQMRLEKTDQIPMPFSSSSLSCLNLPEGPIQFVPTISTLPHGLW
                     QISEAGTGVSSIFIYHGEVPQASQVPPPSGFTVHGLPTSPDRPGSTSPFAPSATDLPS
                     MPEPALTSRANMTEHKTSPTQCPAAGEVSNKLPKWPEPVEQFYRSLQDTYGAEPAGPD
                     GILVEVDLVQARLERSSSKSLERELATPDWAERQLAQGGLAEVLLAAKEHRRPRETRV
                     IAVLGKAGQGKSYWAGAVSRAWACGRLPQYDFVFSVPCHCLNRPGDAYGLQDLLFSLG
                     PQPLVAADEVFSHILKRPDRVLLILDGFEELEAQDGFLHSTCGPAPAEPCSLRGLLAG
                     LFQKKLLRGCTLLLTARPRGRLVQSLSKADALFELSGFSMEQAQAYVMRYFESSGMTE
                     HQDRALTLLRDRPLLLSHSHSPTLCRAVCQLSEALLELGEDAKLPSTLTGLYVGLLGR
                     AALDSPPGALAELAKLAWELGRRHQSTLQEDQFPSADVRTWAMAKGLVQHPPRAAESE
                     LAFPSFLLQCFLGALWLALSGEIKDKELPQYLALTPRKKRPYDNWLEGVPRFLAGLIF
                     QPPARCLGALLGPSAAASVDRKQKVLARYLKRLQPGTLRARQLLELLHCAHEAEEAGI
                     WQHVVQELPGRLSFLGTRLTPPDAHVLGKALEAAGQDFSLDLRSTGICPSGLGSLVGL
                     SCVTRFRAALSDTVALWESLQQHGETKLLQAAEEKFTIEPFKAKSLKDVEDLGKLVQT
                     QRTRSSSEDTAGELPAVRDLKKLEFALGPVSGPQAFPKLVRILTAFSSLQHLDLDALS
                     ENKIGDEGVSQLSATFPQLKSLETLNLSQNNITDLGAYKLAEALPSLAASLLRLSLYN
                     NCICDVGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRRCPHVETLAMWTPT
                     IPFSVQEHLQQQDSRISLR"
     polyA_site      5278
                     /gene="CIITA"
                     /gene_synonym="C2TA; CIITAIV; MHC2D1; MHC2TA; NLRA"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 acagacttgc cgcggcccca gagctggcgg gagggagagg ccaccagcag cgcgcgcggg
       61 agcccgggga acagcggcag ctcacagtgt gccaccatgg agttggggcc cctagaaggt
      121 ggctacctgg agcttcttaa cagcgatgct gaccccctgt gcctctacca cttctatgac
      181 cagatggacc tggctggaga agaagagatt gagctctact cagaacccga cacagacacc
      241 atcaactgcg accagttcag caggctgttg tgtgacatgg aaggtgatga agagaccagg
      301 gaggcttatg ccaatatcgc ggaactggac cagtatgtct tccaggactc ccagctggag
      361 ggcctgagca aggacatttt catagagcac ataggaccag atgaagtgat cggtgagagt
      421 atggagatgc cagcagaagt tgggcagaaa agtcagaaaa gacccttccc agaggagctt
      481 ccggcagacc tgaagcactg gaagccagct gagcccccca ctgtggtgac tggcagtctc
      541 ctagtgggac cagtgagcga ctgctccacc ctgccctgcc tgccactgcc tgcgctgttc
      601 aaccaggagc cagcctccgg ccagatgcgc ctggagaaaa ccgaccagat tcccatgcct
      661 ttctccagtt cctcgttgag ctgcctgaat ctccctgagg gacccatcca gtttgtcccc
      721 accatctcca ctctgcccca tgggctctgg caaatctctg aggctggaac aggggtctcc
      781 agtatattca tctaccatgg tgaggtgccc caggccagcc aagtaccccc tcccagtgga
      841 ttcactgtcc acggcctccc aacatctcca gaccggccag gctccaccag ccccttcgct
      901 ccatcagcca ctgacctgcc cagcatgcct gaacctgccc tgacctcccg agcaaacatg
      961 acagagcaca agacgtcccc cacccaatgc ccggcagctg gagaggtctc caacaagctt
     1021 ccaaaatggc ctgagccggt ggagcagttc taccgctcac tgcaggacac gtatggtgcc
     1081 gagcccgcag gcccggatgg catcctagtg gaggtggatc tggtgcaggc caggctggag
     1141 aggagcagca gcaagagcct ggagcgggaa ctggccaccc cggactgggc agaacggcag
     1201 ctggcccaag gaggcctggc tgaggtgctg ttggctgcca aggagcaccg gcggccgcgt
     1261 gagacacgag tgattgctgt gctgggcaaa gctggtcagg gcaagagcta ttgggctggg
     1321 gcagtgagcc gggcctgggc ttgtggccgg cttccccagt acgactttgt cttctctgtc
     1381 ccctgccatt gcttgaaccg tccgggggat gcctatggcc tgcaggatct gctcttctcc
     1441 ctgggcccac agccactcgt ggcggccgat gaggttttca gccacatctt gaagagacct
     1501 gaccgcgttc tgctcatcct agacggcttc gaggagctgg aagcgcaaga tggcttcctg
     1561 cacagcacgt gcggaccggc accggcggag ccctgctccc tccgggggct gctggccggc
     1621 cttttccaga agaagctgct ccgaggttgc accctcctcc tcacagcccg gccccggggc
     1681 cgcctggtcc agagcctgag caaggccgac gccctatttg agctgtccgg cttctccatg
     1741 gagcaggccc aggcatacgt gatgcgctac tttgagagct cagggatgac agagcaccaa
     1801 gacagagccc tgacgctcct ccgggaccgg ccacttcttc tcagtcacag ccacagccct
     1861 actttgtgcc gggcagtgtg ccagctctca gaggccctgc tggagcttgg ggaggacgcc
     1921 aagctgccct ccacgctcac gggactctat gtcggcctgc tgggccgtgc agccctcgac
     1981 agcccccccg gggccctggc agagctggcc aagctggcct gggagctggg ccgcagacat
     2041 caaagtaccc tacaggagga ccagttccca tccgcagacg tgaggacctg ggcgatggcc
     2101 aaaggcttag tccaacaccc accgcgggcc gcagagtccg agctggcctt ccccagcttc
     2161 ctcctgcaat gcttcctggg ggccctgtgg ctggctctga gtggcgaaat caaggacaag
     2221 gagctcccgc agtacctagc attgacccca aggaagaaga ggccctatga caactggctg
     2281 gagggcgtgc cacgctttct ggctgggctg atcttccagc ctcccgcccg ctgcctggga
     2341 gccctactcg ggccatcggc ggctgcctcg gtggacagga agcagaaggt gcttgcgagg
     2401 tacctgaagc ggctgcagcc ggggacactg cgggcgcggc agctgctgga gctgctgcac
     2461 tgcgcccacg aggccgagga ggctggaatt tggcagcacg tggtacagga gctccccggc
     2521 cgcctctctt ttctgggcac ccgcctcacg cctcctgatg cacatgtact gggcaaggcc
     2581 ttggaggcgg cgggccaaga cttctccctg gacctccgca gcactggcat ttgcccctct
     2641 ggattgggga gcctcgtggg actcagctgt gtcacccgtt tcagggctgc cttgagcgac
     2701 acggtggcgc tgtgggagtc cctgcagcag catggggaga ccaagctact tcaggcagca
     2761 gaggagaagt tcaccatcga gcctttcaaa gccaagtccc tgaaggatgt ggaagacctg
     2821 ggaaagcttg tgcagactca gaggacgaga agttcctcgg aagacacagc tggggagctc
     2881 cctgctgttc gggacctaaa gaaactggag tttgcgctgg gccctgtctc aggcccccag
     2941 gctttcccca aactggtgcg gatcctcacg gccttttcct ccctgcagca tctggacctg
     3001 gatgcgctga gtgagaacaa gatcggggac gagggtgtct cgcagctctc agccaccttc
     3061 ccccagctga agtccttgga aaccctcaat ctgtcccaga acaacatcac tgacctgggt
     3121 gcctacaaac tcgccgaggc cctgccttcg ctcgctgcat ccctgctcag gctaagcttg
     3181 tacaataact gcatctgcga cgtgggagcc gagagcttgg ctcgtgtgct tccggacatg
     3241 gtgtccctcc gggtgatgga cgtccagtac aacaagttca cggctgccgg ggcccagcag
     3301 ctcgctgcca gccttcggag gtgtcctcat gtggagacgc tggcgatgtg gacgcccacc
     3361 atcccattca gtgtccagga acacctgcaa caacaggatt cacggatcag cctgagatga
     3421 tcccagctgt gctctggaca gggacaagcg agaatccccc aaaagccaag gtcatcatca
     3481 agccaggatg aggactggag gaggagctga cagctctgcc tcaaatggat ttgggagcga
     3541 aggctttttc cataagcttt gggggtaagt cacagagcta ccccaaatgt aacttagtct
     3601 cggggtctcc ttccttttca ccagctgtcc cctttgctgg aggaagcttt ccagcccaaa
     3661 cgaagggctt aagaggagtc tggccattcc tggcatccag ttagacctgg aggaggtgaa
     3721 cggaggagaa gcctgaggga ggggtgtgta tccggcctgg gaattcctcc ctctcccttg
     3781 ctagcgcccc aacccgccct catcctgttc agagagggca cttacaggcc tcggaggcag
     3841 gggagggtct cctcctgggg aaccatcccc gtccagatgg tgcccccaac cagctgcggc
     3901 ggcatgatct gggcggctgg tccagggcat gggttgcgga tcgtgtaggg aagaggggaa
     3961 cagcagtcga gaccctactc caagtacgca tcaaagacgt cgagctccga gtcagcatcg
     4021 taaaggcccg agccggggtc ggagagcacg ccgaggtcca cgagcgcctg gtccatgtcc
     4081 tcgggcagga agacgaggcc cacgttgagg acgatgtact ccatgaggaa ggcgtagtac
     4141 aggatcagca cattgacgaa gaacaggccc acgtagaaca tagagggcag cagcggcggc
     4201 ggcacgtagg ggaccagggg gcccagtgcg tccaggtggg ccgcgacccg ggcgccgagc
     4261 atgcagcggg tggcaagggc ggcggcccgg cgatcccggc gaactcagcc gctgcggcgc
     4321 ccgggcggcc ggcgagggca cagcgcagcc atccaggggt accctggagc ccgacagaag
     4381 cagggccggg ctccagatgt cccctggcaa ttgcgccccg acccccgaaa tgcgccgggc
     4441 gggtcaccgc accccgagat gtgcccccaa ggatctctcg accgcccggg cggcgaggcg
     4501 ggcccccctg aagtggcccg cggctgcccg gctccctcgt ggcgcctccc tggcgctcgc
     4561 agggcctcgc agagccggtg gggatcccac cgcggctcag tgtctagggc cggtcccggc
     4621 agccttctct cccgccccgc cccgcaggtc ctcgcgcacc ccccgcgccc ccgcaggccc
     4681 agcacccatg gctgcggccg ccgcgtagcc ctcccggtgg cgctcggagc tccgcctccc
     4741 gaggggcccc gagctcattg gcaggccgcc ccctgcacgc gctaattggc cggctcaacg
     4801 cccgcgctga ttggctccgg ccgccagggg gcgggtaccg cttcgctccg cccctcgggg
     4861 ccctagcgtc tgagttgctt tcctggttcg ggtctgccct cagatctcaa atcgaattcg
     4921 ctctgcgtat cgaatagggg gaggtaaaag agactgaaca cagttcaaac ctagacataa
     4981 tgctaaggcc gcaaaagccg aaggaaaccc gggctaccgc tgcaccttgc tgcatgcctc
     5041 tttgggactc cgtttctcct ttaaaaggag gcggggtcgg ggaggggcga cggacggttg
     5101 ccctggaaat tttggacatt cccaaagcgc caattttcat ggtggagatc caccagtgtc
     5161 cccttcgctt ctccaaactc tggttgctgg aaggtccgcc cactacggaa cctgcatcct
     5221 agagttaagg aacacctgaa taaagagatt ccgaggtagt tcagatcttc aaccataa
//
