LOCUS       NM_001279               1008 bp    mRNA    linear   PRI 28-APR-2025
DEFINITION  Homo sapiens cell death inducing DFFA like effector a (CIDEA),
            transcript variant 1, mRNA.
ACCESSION   NM_001279
VERSION     NM_001279.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1008)
  AUTHORS   Tarabra,E., Nouws,J., Vash-Margita,A., Hellerstein,M.,
            Shabanova,V., McCollum,S., Pierpont,B., Zhao,D., Shulman,G.I. and
            Caprio,S.
  TITLE     CIDEA expression in SAT from adolescent girls with obesity and
            unfavorable patterns of abdominal fat distribution
  JOURNAL   Obesity (Silver Spring) 29 (12), 2068-2080 (2021)
   PUBMED   34672413
  REMARK    GeneRIF: CIDEA expression in SAT from adolescent girls with obesity
            and unfavorable patterns of abdominal fat distribution.
REFERENCE   2  (bases 1 to 1008)
  AUTHORS   Sans,A., Bonnafous,S., Rousseau,D., Patouraux,S., Canivet,C.M.,
            Leclere,P.S., Tran-Van-Nhieu,J., Luci,C., Bailly-Maitre,B., Xu,X.,
            Lee,A.H., Minehira,K., Anty,R., Tran,A., Iannelli,A. and Gual,P.
  TITLE     The Differential Expression of Cide Family Members is Associated
            with Nafld Progression from Steatosis to Steatohepatitis
  JOURNAL   Sci Rep 9 (1), 7501 (2019)
   PUBMED   31097771
  REMARK    GeneRIF: The Differential Expression of Cide Family Members is
            Associated with Nafld Progression from Steatosis to
            Steatohepatitis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1008)
  AUTHORS   Fischer,A.W., Shabalina,I.G., Mattsson,C.L., Abreu-Vieira,G.,
            Cannon,B., Nedergaard,J. and Petrovic,N.
  TITLE     UCP1 inhibition in Cidea-overexpressing mice is physiologically
            counteracted by brown adipose tissue hyperrecruitment
  JOURNAL   Am J Physiol Endocrinol Metab 312 (1), E72-E87 (2017)
   PUBMED   27923808
  REMARK    GeneRIF: Cidea, unexpectedly, functions molecularly as an indirect
            inhibitor of thermogenesis via inhibition of UCP1 activity.
REFERENCE   4  (bases 1 to 1008)
  AUTHORS   Abreu-Vieira,G., Fischer,A.W., Mattsson,C., de Jong,J.M.,
            Shabalina,I.G., Ryden,M., Laurencikiene,J., Arner,P., Cannon,B.,
            Nedergaard,J. and Petrovic,N.
  TITLE     Cidea improves the metabolic profile through expansion of adipose
            tissue
  JOURNAL   Nat Commun 6, 7433 (2015)
   PUBMED   26118629
  REMARK    GeneRIF: These data establish a functional role for Cidea and
            suggest that, in humans, the association between Cidea levels in
            white fat and metabolic health is not only correlative but also
            causative.
            Erratum:[Nat Commun. 2016 Aug 04;7:12395. doi: 10.1038/ncomms12395.
            PMID: 27488677]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1008)
  AUTHORS   Feldo,M., Kocki,J., Feldo,J., Lukasik,S., Bogucki,J.,
            Skwarzynski,A., Wronski,J., Kesik,J. and Zubilewicz,T.
  TITLE     CIDE-A gene expression in patients with obesity qualified for
            endovascular treatment of abdominal aorta aneurysm
  JOURNAL   Pol Przegl Chir 86 (10), 473-478 (2015)
   PUBMED   25720106
  REMARK    GeneRIF: The lowest mean relative of the gene expression for CIDE-A
            was observed in the group of obese patients with aortic aneurysm
            and lipid disorders
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1008)
  AUTHORS   Dahlman,I., Kaaman,M., Jiao,H., Kere,J., Laakso,M. and Arner,P.
  TITLE     The CIDEA gene V115F polymorphism is associated with obesity in
            Swedish subjects
  JOURNAL   Diabetes 54 (10), 3032-3034 (2005)
   PUBMED   16186410
  REMARK    GeneRIF: results support a role for cell death-inducing DFFA (DNA
            fragmentation factor-alpha)-like effector A (CIDEA) alleles in
            human obesity
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1008)
  AUTHORS   Nordstrom,E.A., Ryden,M., Backlund,E.C., Dahlman,I., Kaaman,M.,
            Blomqvist,L., Cannon,B., Nedergaard,J. and Arner,P.
  TITLE     A human-specific role of cell death-inducing DFFA (DNA
            fragmentation factor-alpha)-like effector A (CIDEA) in adipocyte
            lipolysis and obesity
  JOURNAL   Diabetes 54 (6), 1726-1734 (2005)
   PUBMED   15919794
  REMARK    GeneRIF: We propose an important and human-specific role for CIDEA
            in lipolysis regulation and metabolic complications of obesity.
REFERENCE   8  (bases 1 to 1008)
  AUTHORS   Zhou,Z., Yon Toh,S., Chen,Z., Guo,K., Ng,C.P., Ponniah,S.,
            Lin,S.C., Hong,W. and Li,P.
  TITLE     Cidea-deficient mice have lean phenotype and are resistant to
            obesity
  JOURNAL   Nat Genet 35 (1), 49-56 (2003)
   PUBMED   12910269
REFERENCE   9  (bases 1 to 1008)
  AUTHORS   Chen,Z., Guo,K., Toh,S.Y., Zhou,Z. and Li,P.
  TITLE     Mitochondria localization and dimerization are required for CIDE-B
            to induce apoptosis
  JOURNAL   J Biol Chem 275 (30), 22619-22622 (2000)
   PUBMED   10837461
REFERENCE   10 (bases 1 to 1008)
  AUTHORS   Inohara,N., Koseki,T., Chen,S., Wu,X. and Nunez,G.
  TITLE     CIDE, a novel family of cell death activators with homology to the
            45 kDa subunit of the DNA fragmentation factor
  JOURNAL   EMBO J 17 (9), 2526-2533 (1998)
   PUBMED   9564035
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from R73455.1, BQ718688.1 and
            BC031896.1.
            
            On May 17, 2019 this sequence version replaced NM_001279.3.
            
            Summary: This gene encodes the homolog of the mouse protein Cidea
            that has been shown to activate apoptosis. This activation of
            apoptosis is inhibited by the DNA fragmentation factor DFF45 but
            not by caspase inhibitors. Mice that lack functional Cidea have
            higher metabolic rates, higher lipolysis in brown adipose tissue
            and higher core body temperatures when subjected to cold. These
            mice are also resistant to diet-induced obesity and diabetes. This
            suggests that in mice this gene product plays a role in
            thermogenesis and lipolysis. Alternatively spliced transcripts have
            been identified. [provided by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (1) encodes the shorter isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG674879.1, AY364639.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320477.10/ ENSP00000320209.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                R73455.1           43-52
            11-615              BQ718688.1         1-605
            616-1008            BC031896.1         723-1115
FEATURES             Location/Qualifiers
     source          1..1008
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.21"
     gene            1..1008
                     /gene="CIDEA"
                     /gene_synonym="CIDE-A"
                     /note="cell death inducing DFFA like effector a"
                     /db_xref="GeneID:1149"
                     /db_xref="HGNC:HGNC:1976"
                     /db_xref="MIM:604440"
     exon            1..61
                     /gene="CIDEA"
                     /gene_synonym="CIDE-A"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..683
                     /gene="CIDEA"
                     /gene_synonym="CIDE-A"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     death activator CIDE-A; lipid transferase CIDEA"
                     /codon_start=1
                     /product="lipid transferase CIDEA isoform 1"
                     /protein_id="NP_001270.1"
                     /db_xref="CCDS:CCDS11856.1"
                     /db_xref="GeneID:1149"
                     /db_xref="HGNC:HGNC:1976"
                     /db_xref="MIM:604440"
                     /translation="MEAARDYAGALIRPLTFMGSQTKRVLFTPLMHPARPFRVSNHDR
                     SSRRGVMASSLQELISKTLDALVIATGLVTLVLEEDGTVVDTEEFFQTLGDNTHFMIL
                     EKGQKWMPGSQHVPTCSPPKRSGIARVTFDLYRLNPKDFIGCLNVKATMYEMYSVSYD
                     IRCTGLKGLLRSLLRFLSYSAQVTGQFLIYLGTYMLRVLDDKEERPSLRSQAKGRFTC
                     G"
     exon            62..206
                     /gene="CIDEA"
                     /gene_synonym="CIDE-A"
                     /inference="alignment:Splign:2.1.0"
     exon            207..353
                     /gene="CIDEA"
                     /gene_synonym="CIDE-A"
                     /inference="alignment:Splign:2.1.0"
     exon            354..535
                     /gene="CIDEA"
                     /gene_synonym="CIDE-A"
                     /inference="alignment:Splign:2.1.0"
     exon            536..1008
                     /gene="CIDEA"
                     /gene_synonym="CIDE-A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      980..985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIDEA"
                     /gene_synonym="CIDE-A"
                     /note="hexamer: AATAAA"
     polyA_site      1008
                     /gene="CIDEA"
                     /gene_synonym="CIDE-A"
                     /note="major polyA site"
ORIGIN      
        1 aggcccgcta ggggatccgc gccatggagg ccgcccggga ctatgcagga gccctcatca
       61 ggcccctgac atttatggga tcacagacta agcgagtcct gttcaccccg ctcatgcatc
      121 cagctcgccc tttccgggtc tccaaccatg acaggagcag ccggcgtggg gtgatggcaa
      181 gcagcctgca ggagctcatc agcaagactc tggatgccct cgtcatcgct accggactgg
      241 tcactctggt gctggaggaa gatggcaccg tggtggacac agaagagttc tttcagacct
      301 tgggagacaa cacgcatttc atgatcttgg aaaaaggaca gaagtggatg ccgggcagcc
      361 agcacgtccc cacttgctcg ccgccgaaga ggtcgggaat agcgagagtc accttcgact
      421 tgtacaggct gaaccccaag gacttcatcg gctgccttaa cgtgaaggcc accatgtatg
      481 agatgtactc cgtgtcctac gacatccggt gcacgggact caagggcctg ctgaggagtc
      541 tgctgcggtt cctgtcctac tccgcccagg tgacgggaca gtttctcatc tatctgggca
      601 catacatgct ccgggtgctg gatgacaagg aagagcggcc atccctccgg tcacaagcca
      661 agggcaggtt cacgtgtgga tagggatgca ggctgtcgcc ggctcttgag ccaaacactg
      721 tgtttcgttt ggctcaatga cgaatgttga agatgctttt atgttctgag ccacatgcac
      781 ttggaggccg ctggtcacgc tgctcaggag tggtgcccag aaaaggaaag ggcttggtgg
      841 tacatgaagt gggggcagtg ggcagggtgc cctggggggg aggcatagag ggccctgggg
      901 gtcatgggaa gcgagcacgc agcaggcgtg cccaggagcg tgtgcatgtg tcagagccat
      961 ttggtccatc atctcctgca ataaacccat cgcaagaatg accttcaa
//
