LOCUS       NM_001386298            8299 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens capicua transcriptional repressor (CIC), transcript
            variant 7, mRNA.
ACCESSION   NM_001386298 XM_011526660
VERSION     NM_001386298.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8299)
  AUTHORS   Makise,N. and Yoshida,A.
  TITLE     CIC-Rearranged Sarcoma
  JOURNAL   Surg Pathol Clin 17 (1), 141-151 (2024)
   PUBMED   38278603
  REMARK    GeneRIF: CIC-Rearranged Sarcoma.
            Review article
REFERENCE   2  (bases 1 to 8299)
  AUTHORS   Linos,K., Dermawan,J.K., Bale,T., Rosenblum,M.K., Singer,S.,
            Tap,W., Dickson,M.A., Hornick,J.L. and Antonescu,C.R.
  TITLE     Expanding the Molecular Diversity of CIC-Rearranged Sarcomas With
            Novel and Very Rare Partners
  JOURNAL   Mod Pathol 36 (5), 100103 (2023)
   PUBMED   36788092
  REMARK    GeneRIF: Expanding the Molecular Diversity of CIC-Rearranged
            Sarcomas With Novel and Very Rare Partners.
REFERENCE   3  (bases 1 to 8299)
  AUTHORS   Palmerini,E., Gambarotti,M., Italiano,A., Nathenson,M.J., Ratan,R.,
            Dileo,P., Provenzano,S., Jones,R.L., DuBois,S.G., Martin-Broto,J.,
            de Alava,E., Baldi,G.G., Grignani,G., Ferraresi,V., Brunello,A.,
            Paoluzzi,L., Bertulli,R., Hindi,N., Montemurro,M., Rothermundt,C.,
            Cocchi,S., Salguero-Aranda,C., Donati,D., Martin,J.D., Abdelhamid
            Ahmed,A.H., Mazzocca,A., Carretta,E., Cesari,M., Pierini,M.,
            Righi,A., Sbaraglia,M., Laginestra,M.A., Scotlandi,K., Dei
            Tos,A.P., Ibrahim,T., Stacchiotti,S. and Vincenzi,B.
  TITLE     A global collaboRAtive study of CIC-rearranged,
            BCOR::CCNB3-rearranged and other ultra-rare unclassified
            undifferentiated small round cell sarcomas (GRACefUl)
  JOURNAL   Eur J Cancer 183, 11-23 (2023)
   PUBMED   36791667
  REMARK    GeneRIF: A global collaboRAtive study of CIC-rearranged,
            BCOR::CCNB3-rearranged and other ultra-rare unclassified
            undifferentiated small round cell sarcomas (GRACefUl).
REFERENCE   4  (bases 1 to 8299)
  AUTHORS   Jimenez,G., Shvartsman,S.Y. and Paroush,Z.
  TITLE     The Capicua repressor--a general sensor of RTK signaling in
            development and disease
  JOURNAL   J Cell Sci 125 (Pt 6), 1383-1391 (2012)
   PUBMED   22526417
  REMARK    Review article
REFERENCE   5  (bases 1 to 8299)
  AUTHORS   Bettegowda,C., Agrawal,N., Jiao,Y., Sausen,M., Wood,L.D.,
            Hruban,R.H., Rodriguez,F.J., Cahill,D.P., McLendon,R., Riggins,G.,
            Velculescu,V.E., Oba-Shinjo,S.M., Marie,S.K., Vogelstein,B.,
            Bigner,D., Yan,H., Papadopoulos,N. and Kinzler,K.W.
  TITLE     Mutations in CIC and FUBP1 contribute to human oligodendroglioma
  JOURNAL   Science 333 (6048), 1453-1455 (2011)
   PUBMED   21817013
  REMARK    GeneRIF: CIC gene was mutated in 6 oligodendrogliomas and FUBP1
            gene was mutated in 2; 27 additional oligodendrogliomas showed 12
            and 3 more tumors with mutations of CIC and FUBP1; results suggest
            role of these genes in biology and pathology of oligodendrocytes
REFERENCE   6  (bases 1 to 8299)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 8299)
  AUTHORS   Lim,J., Crespo-Barreto,J., Jafar-Nejad,P., Bowman,A.B., Richman,R.,
            Hill,D.E., Orr,H.T. and Zoghbi,H.Y.
  TITLE     Opposing effects of polyglutamine expansion on native protein
            complexes contribute to SCA1
  JOURNAL   Nature 452 (7188), 713-718 (2008)
   PUBMED   18337722
REFERENCE   8  (bases 1 to 8299)
  AUTHORS   Lam,Y.C., Bowman,A.B., Jafar-Nejad,P., Lim,J., Richman,R.,
            Fryer,J.D., Hyun,E.D., Duvick,L.A., Orr,H.T., Botas,J. and
            Zoghbi,H.Y.
  TITLE     ATAXIN-1 interacts with the repressor Capicua in its native complex
            to cause SCA1 neuropathology
  JOURNAL   Cell 127 (7), 1335-1347 (2006)
   PUBMED   17190598
REFERENCE   9  (bases 1 to 8299)
  AUTHORS   Lee,C.J., Chan,W.I. and Scotting,P.J.
  TITLE     CIC, a gene involved in cerebellar development and ErbB signaling,
            is significantly expressed in medulloblastomas
  JOURNAL   J Neurooncol 73 (2), 101-108 (2005)
   PUBMED   15981098
  REMARK    GeneRIF: Medulloblastomas exhibited the highest level of CIC
            expression, although the level of expression varied between
            different medulloblastoma subtypes. Expression was most common in
            tumors of the CNS in general.
REFERENCE   10 (bases 1 to 8299)
  AUTHORS   Lee,C.J., Chan,W.I., Cheung,M., Cheng,Y.C., Appleby,V.J., Orme,A.T.
            and Scotting,P.J.
  TITLE     CIC, a member of a novel subfamily of the HMG-box superfamily, is
            transiently expressed in developing granule neurons
  JOURNAL   Brain Res Mol Brain Res 106 (1-2), 151-156 (2002)
   PUBMED   12393275
  REMARK    GeneRIF: Results describe the identification and characterization
            of a new gene, Cic, in both human and mouse genomes, that is
            implicated in granule cell development.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006486.1.
            
            On Aug 19, 2020 this sequence version replaced XM_011526660.2.
            
            Summary: The protein encoded by this gene is an ortholog of the
            Drosophila melanogaster capicua gene, and is a member of the high
            mobility group (HMG)-box superfamily of transcriptional repressors.
            This protein contains a conserved HMG domain that is involved in
            DNA binding and nuclear localization, and a conserved C-terminus.
            Studies suggest that the N-terminal region of this protein
            interacts with Atxn1 (GeneID:6310), to form a transcription
            repressor complex, and in vitro studies suggest that
            polyglutamine-expansion of ATXN1 may alter the repressor activity
            of this complex. Mutations in this gene have been associated with
            olidogdendrogliomas (PMID:21817013). In addition, translocation
            events resulting in gene fusions of this gene with both DUX4
            (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated
            with round cell sarcomas. There are multiple pseudogenes of this
            gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Feb 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.3034135.1,
                                           SRR11853563.17095.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000681038.1/ ENSP00000505728.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               AC006486.1         61107-61236
            131-2934            AC006486.1         63629-66432
            2935-3084           AC006486.1         78626-78775
            3085-3319           AC006486.1         78861-79095
            3320-3449           AC006486.1         79175-79304
            3450-3632           AC006486.1         79400-79582
            3633-3798           AC006486.1         79665-79830
            3799-4001           AC006486.1         80743-80945
            4002-4227           AC006486.1         81036-81261
            4228-4331           AC006486.1         81703-81806
            4332-5565           AC006486.1         82088-83321
            5566-5753           AC006486.1         83413-83600
            5754-5875           AC006486.1         83941-84062
            5876-6042           AC006486.1         84155-84321
            6043-6336           AC006486.1         84421-84714
            6337-6662           AC006486.1         84811-85136
            6663-6907           AC006486.1         85447-85691
            6908-7062           AC006486.1         85790-85944
            7063-7194           AC006486.1         86028-86159
            7195-7326           AC006486.1         86459-86590
            7327-8299           AC006486.1         86679-87651
FEATURES             Location/Qualifiers
     source          1..8299
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..8299
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /note="capicua transcriptional repressor"
                     /db_xref="GeneID:23152"
                     /db_xref="HGNC:HGNC:14214"
                     /db_xref="MIM:612082"
     exon            1..130
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /inference="alignment:Splign:2.1.0"
     exon            131..2934
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..7694
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /note="isoform CIC-L is encoded by transcript variant 7;
                     protein capicua homolog"
                     /codon_start=1
                     /product="protein capicua homolog isoform CIC-L"
                     /protein_id="NP_001373227.1"
                     /db_xref="CCDS:CCDS92632.1"
                     /db_xref="GeneID:23152"
                     /db_xref="HGNC:HGNC:14214"
                     /db_xref="MIM:612082"
                     /translation="MKPMKKACTGLSGPGSGSKSPPATRAKALRRRGAGEGDKPEEED
                     DEAQQPQPQSGPEEAEEGEEEEAERGPGAEGPPLELHPGDPAPGPAEDPKGDGEAGRW
                     EPSLSRKTATFKSRAPKKKYVEEHGAGSSGVAGAPEERVRTPEEASGLGVPPRPPTST
                     RSSSTDTASEHSADLEDEPAEACGPGPWPPGSTSGSYDLRQLRSQRVLARRGDGLFLP
                     AVVRQVRRSQDLGVQFPGDRALTFYEGVPGAGVDVVLDATPPPGALVVGTAVCTCVEP
                     GVAAYREGVVVEVATKPAAYKVRLSPGPSSQPGLPGSLPQPPQPLHREPEEAVWVARS
                     SLRLLRPPWEPETMLRKPPTGPEEEQAEPGATLPPCPAALDPKQPEDAEVSKISFGGN
                     LGTHCEEGEEKHPPALGTPALLPLPPPQLLSPPPKSPAFVGPGRPGEQPSPCQEGSQG
                     GSRSSSVASLEKGTAPAARARTPLTAAQQKYKKGDVVCTPSGIRKKFNGKQWRRLCSR
                     DGCMKESQRRGYCSRHLSMRTKEMEGLADSGPGGAGRPAAVAAREGSTEFDWGDETSR
                     DSEASSVAARGDSRPRLVAPADLSRFEFDECEAAVMLVSLGSSRSGTPSFSPVSTQSP
                     FSPAPSPSPSPLFGFRPANFSPINASPVIQRTAVRSRHLSASTPKAGVLTPPDLGPHP
                     PPPAPRERHSSGILPTFQTNLTFTVPISPGRRKTELLPHPGALGAPGAGGGGAAPDFP
                     KSDSLDSGVDSVSHTPTPSTPAGFRAVSPAVPFSRSRQPSPLLLLPPPAGLTSDPGPS
                     VRRVPAVQRDSPVIVRNPDVPLPSKFPGEVGTAGEVRAGGPGRGCRETPVPPGVASGK
                     PGLPPPLPAPVPITVPPAAPTAVAQPMPAFGLASSPFQPVAFHPSPAALLPVLVPSSY
                     TSHPAPKKEVIMGRPGTVWTNVEPRSVAVFPWHSLVPFLAPSQPDPSVQPSEAQQPAS
                     HPVASNQSKEPAESAAVAHERPPGGTGSADPERPPGATCPESPGPGPPHPLGVVESGK
                     GPPPTTEEEASGPPGEPRLDSETESDHDDAFLSIMSPEIQLPLPPGKRRTQSLSALPK
                     ERDSSSEKDGRSPNKREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEW
                     WYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKKSSSEAKPTSLGLAGGHKET
                     RERSMSETGTAAAPGVSSELLSVAAQTLLSSDTKAPGSSSCGAERLHTVGGPGSARPR
                     AFSHSGVHSLDGGEVDSQALQELTQMVSGPASYSGPKPSTQYGAPGPFAAPGEGGALA
                     ATGRPPLLPTRASRSQRAASEDMTSDEERMVICEEEGDDDVIADDGFGTTDIDLKCKE
                     RVTDSESGDSSGEDPEGNKGFGRKVFSPVIRSSFTHCRPPLDPEPPGPPDPPVAFGKG
                     YGSAPSSSASSPASSSASAATSFSLGSGTFKAQESGQGSTAGPLRPPPPGAGGPATPS
                     KATRFLPMDPATFRRKRPESVGGLEPPGPSVIAAPPSGGGNILQTLVLPPNKEEQEGG
                     GARVPSAPAPSLAYGAPAAPLSRPAATMVTNVVRPVSSTPVPIASKPFPTSGRAEASP
                     NDTAGARTEMGTGSRVPGGSPLGVSLVYSDKKSAAATSPAPHLVAGPLLGTVGKAPAT
                     VTNLLVGTPGYGAPAPPAVQFIAQGAPGGGTTAGSGAGAGSGPNGPVPLGILQPGALG
                     KAGGITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPSGPAPTTSIRFTLPPGTSTNGK
                     VLAATAPTPGIPILQSVPSAPPPKAQSVSPVQAPPPGGSAQLLPGKVLVPLAAPSMSV
                     RGGGAGQPLPLVSPPFSVPVQNGAQPPSKIIQLTPVPVSTPSGLVPPLSPATLPGPTS
                     QPQKVLLPSSTRITYVQSAGGHALPLGTSPASSQAGTVTSYGPTSSVALGFTSLGPSG
                     PAFVQPLLSAGQAPLLAPGQVGVSPVPSPQLPPACAAPGGPVITAFYSGSPAPTSSAP
                     LAQPSQAPPSLVYTVATSTTPPAATILPKGPPAPATATPAPTSPFPSATAGSMTYSLV
                     APKAQRPSPKAPQKVKAAIASIPVGSFEAGASGRPGPAPRQPLEPGPVREPTAPESEL
                     EGQPTPPAPPPLPETWTPTARSSPPLPPPAEERTSAKGPETMASKFPSSSSDWRVPGQ
                     GLENRGEPPTPPSPAPAPAVAPGGSSESSSGRAAGDTPERKEAAGTGKKVKVRPPPLK
                     KTFDSVDNRVLSEVDFEERFAELPEFRPEEVLPSPTLQSLATSPRAILGSYRKKRKNS
                     TDLDSAPEDPTSPKRKMRRRSSCSSEPNTPKSAKCEGDIFTFDRTGTEAEDVLGELEY
                     DKVPYSSLRRTLDQRRALVMQLFQDHGFFPSAQATAAFQARYADIFPSKVCLQLKIRE
                     VRQKIMQAATPTEQPPGAEAPLPVPPPTGTAAAPAPTPSPAGGPDPTSPSSDSGTAQA
                     APPLPPPPESGPGQPGWEGAPQPSPPPPGPSTAATGR"
     exon            2935..3084
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..3319
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /inference="alignment:Splign:2.1.0"
     exon            3320..3449
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /inference="alignment:Splign:2.1.0"
     exon            3450..3632
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /inference="alignment:Splign:2.1.0"
     exon            3633..3798
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /inference="alignment:Splign:2.1.0"
     exon            3799..4001
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /inference="alignment:Splign:2.1.0"
     exon            4002..4227
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /inference="alignment:Splign:2.1.0"
     exon            4228..4331
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /inference="alignment:Splign:2.1.0"
     exon            4332..5565
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /inference="alignment:Splign:2.1.0"
     exon            5566..5753
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /inference="alignment:Splign:2.1.0"
     exon            5754..5875
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /inference="alignment:Splign:2.1.0"
     exon            5876..6042
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /inference="alignment:Splign:2.1.0"
     exon            6043..6336
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /inference="alignment:Splign:2.1.0"
     exon            6337..6662
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /inference="alignment:Splign:2.1.0"
     exon            6663..6907
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /inference="alignment:Splign:2.1.0"
     exon            6908..7062
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /inference="alignment:Splign:2.1.0"
     exon            7063..7194
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /inference="alignment:Splign:2.1.0"
     exon            7195..7326
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /inference="alignment:Splign:2.1.0"
     exon            7327..8299
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8281..8286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /note="hexamer: ATTAAA"
     polyA_site      8299
                     /gene="CIC"
                     /gene_synonym="MRD45"
                     /note="major polyA site"
ORIGIN      
        1 accattttgt gtgttggagt aaaaaaaaaa gggagaatcg agagggagag ccggaggggg
       61 ggcggggagg gaccggaccg gaccgagccg gggccacggc cccccgcccc gaaaccccgc
      121 cgagcccaag gtggacaaaa atgaagccaa tgaagaaggc atgcactggc ctttcaggtc
      181 ctggcagtgg cagcaagtcc cccccagcca ccagggccaa ggctctgagg cggcgagggg
      241 ctggggaggg tgacaagcca gaggaggagg atgacgaggc acagcagccg caaccacagt
      301 ccgggcccga agaggctgag gaaggggagg aggaggaggc tgagcggggc cctggggctg
      361 aaggtcctcc actggagctg caccctggcg acccggctcc aggcccagca gaggacccca
      421 aaggggatgg ggaggcaggc cgctgggagc cctcactcag ccgcaagaca gccacgttca
      481 agtctcgagc gcccaagaag aagtatgtgg aggagcacgg agctggcagc agtggggtgg
      541 ctggggcccc tgaagagcgg gtgcggaccc ctgaggaggc cagtggcctg ggggtgcctc
      601 cacggccacc cacctccact cgttcctcct ccactgacac agccagcgag cactcggcgg
      661 acctggagga tgagccggct gaggcttgtg gtccaggccc ttggccccct ggcagcacca
      721 gtggcagcta tgacctgcgg cagctgcggt cccagcgggt gctggctcgg cgtggtgatg
      781 gccttttcct gccggctgtg gtgcgccagg tgcgccgaag ccaggacctg ggcgtgcagt
      841 tccctggtga ccgagccctg actttctatg agggggtgcc aggcgctggt gtggatgtag
      901 ttttggatgc cacaccccca ccaggtgccc tggtggtggg cacagctgtc tgtacctgtg
      961 tggagcccgg cgtggctgcc taccgggaag gtgtggtggt ggaggtggcc accaagccag
     1021 ctgcctacaa ggtccgtctc agccctggcc ccagctccca gccaggccta ccaggcagcc
     1081 tcccgcagcc cccacagcca ctgcaccgtg agccagagga ggctgtgtgg gtggcccgct
     1141 ccagcctacg cctgctgcgc cccccctggg aacctgagac catgctgagg aagcccccta
     1201 caggccctga ggaagagcag gcagagcctg gggccaccct gccaccctgc cctgctgccc
     1261 tggaccccaa acagcccgag gatgctgagg tctctaagat cagctttggt ggcaacctgg
     1321 gtactcactg tgaggagggc gaggagaagc accctccagc cctgggtacc ccagccctgc
     1381 tcccactgcc cccaccccag ctcctgtcac caccacccaa gtctccagcc tttgtgggcc
     1441 ccggccgccc tggcgagcag ccctcgccct gccaggaggg gagccagggc ggcagccgca
     1501 gcagcagcgt ggcctccctg gaaaagggga cagcaccggc agcccgggcc cgcacgccac
     1561 tgacagccgc ccagcagaag tacaagaagg gcgatgtggt ctgcacaccc agcggaatac
     1621 gaaagaagtt caacggcaag cagtggcgcc ggctgtgctc acgagatggc tgcatgaagg
     1681 agtcacagcg gcgaggctac tgctcacgcc acctgtccat gcgaaccaaa gagatggaag
     1741 gcctggcaga cagtgggcct ggcggggcgg gccggcccgc ggccgtggca gcccgtgagg
     1801 gcagcacgga gtttgactgg ggtgatgaga cgtcgaggga cagtgaggcc agcagtgtgg
     1861 cggctcgtgg agactcacgg ccacgcctgg tggcccctgc tgacttgtca cgctttgagt
     1921 tcgacgagtg tgaggcggcc gtgatgctgg tgtcgctggg cagctcgcgc tcaggcacgc
     1981 cctccttctc acccgtctcc actcaatcgc ccttctcgcc agccccatca ccctcaccct
     2041 caccactctt cggcttccgc cctgccaact ttagccccat caatgcctca ccagtcatcc
     2101 agcgcactgc agtccgcagt cgccacctga gcgccagcac ccctaaggca ggcgtgctga
     2161 cgccaccaga cctgggcccc cacccaccgc cacctgcccc ccgagagcgc cactcctctg
     2221 gaatcctacc caccttccag accaacctga ccttcaccgt gcccatcagc cctgggcgac
     2281 ggaagacaga gctgttgccg catccagggg ccttgggggc ccctggcgca gggggtggag
     2341 gagccgcccc agactttccc aagagtgaca gcttagactc tggtgtggac tcagtgtccc
     2401 acacacctac accctccacg ccggctggct tccgggccgt gtcccctgct gtgcccttct
     2461 ctcgctcccg ccagccctca ccattgctgc tgttgccacc ccctgccggc ctgacctcgg
     2521 atccagggcc ctctgtgcgc agggtgcctg ctgtgcagcg ggactcacct gttattgtcc
     2581 gcaaccctga tgtgccactg ccctccaaat tccctgggga ggtgggcact gctggtgagg
     2641 tgcgggctgg gggacctggg cggggctgcc gtgaaacccc agtgccccct ggggtggcca
     2701 gtgggaagcc tggcctgccc ccacctctgc cagcccccgt gcccatcacc gtgcctccag
     2761 ctgcaccaac tgccgtggcc cagccgatgc ccgcctttgg cctggcttct tcaccctttc
     2821 agcctgtggc cttccacccc tcacctgctg ccctgttgcc cgttttggtg cccagcagct
     2881 ataccagcca ccctgccccc aagaaggaag tcatcatggg ccggcctgga acagtgtgga
     2941 cgaatgtgga acctcgctct gtggctgtgt tcccttggca ctccttagtc cccttcctgg
     3001 cacccagcca gcctgacccc tccgtgcagc cgagcgaggc ccagcaacct gccagccacc
     3061 cagtggcctc caaccagagc aaagaacctg ctgagtcggc agctgttgct catgaacggc
     3121 caccaggtgg gacagggagt gctgaccctg agcggccccc tggagccaca tgccctgaga
     3181 gcccaggacc cggaccccca caccctttgg gggtggtgga atctggtaag ggtccgcctc
     3241 ccaccacgga ggaggaggcc tccggccccc caggagagcc ccggctggac agtgagacag
     3301 agagtgacca tgatgatgcc ttcctctcca tcatgtctcc tgagatccag ttgcctctac
     3361 cgcccggaaa acgtcggacc cagtccctca gtgccctacc caaggaacgg gactcatctt
     3421 ctgagaagga tggacgcagc cccaacaagc gggagaagga ccacatccgg cggcccatga
     3481 atgccttcat gatcttcagc aagcggcacc gggccctggt ccaccagcgt catcccaacc
     3541 aggacaaccg gaccgtcagc aagatcctgg gcgagtggtg gtatgccctg gggcccaagg
     3601 agaagcagaa gtaccacgac ctggccttcc aggtgaagga ggcccacttc aaggcccacc
     3661 cagattggaa gtggtgcaac aaggaccgaa agaagtccag ctcagaggcc aagcccacga
     3721 gcctggggct ggcaggaggg cacaaggaga cgcgggagcg gagcatgtcg gagacgggca
     3781 ctgctgctgc ccctggggtg tcctctgagc tcctgtccgt tgcagcccag acactcctga
     3841 gctcagacac caaggctccg gggagcagct cctgtggggc agaacggcta cacacagttg
     3901 ggggacctgg ctcagcccgg ccccgagctt tctcccacag cggggtacac agcctggacg
     3961 gcggagaagt agacagtcag gcgctacagg aactgacgca gatggtgtct ggccctgcat
     4021 cgtactctgg cccaaagcct tctacccagt atggagctcc aggacccttt gcagcccctg
     4081 gtgagggagg tgccttggcg gccactgggc ggcccccgct gctgcccacc cgagcttctc
     4141 gttctcagcg tgcggccagt gaggacatga cgagtgatga ggagcgcatg gtcatctgtg
     4201 aggaggaagg ggatgatgat gtcattgctg acgatggctt cggcaccact gacattgatc
     4261 tcaagtgcaa ggagcgggtg accgacagcg agagtgggga cagctctggg gaggacccag
     4321 agggcaacaa gggctttggt cggaaggtgt tttcacctgt gatccgttcc tcctttaccc
     4381 actgccgccc cccactggac cctgagcccc cagggccccc ggatcctcct gtagcctttg
     4441 gcaaaggcta tggttccgcc ccatcctcct ctgcgtcctc gcctgcttcc tcctcagcct
     4501 cggcagccac ctccttctca ctgggctcag gaaccttcaa ggcccaggag tctggtcagg
     4561 gcagcacagc gggcccccta cggcccccac cccctggggc tgggggtcca gcgacacctt
     4621 ccaaggcaac ccggttcctc ccaatggatc ctgccacctt ccggcgcaag agacccgaaa
     4681 gtgtgggtgg cctggagcca ccaggcccct cagtcatcgc ggcccctccc agcggaggag
     4741 gaaacatcct gcagacactg gtgctgcccc caaacaagga ggagcaagag ggcggcggag
     4801 ccagagtgcc ctccgccccc gccccatcac tggcctatgg ggccccagca gctcccctgt
     4861 cccgtcctgc cgccaccatg gtcaccaatg tggtgcggcc tgtcagcagc actcctgtgc
     4921 ccatcgcctc taagcccttc cccacctctg gccgggctga ggcgtctcca aatgacacag
     4981 caggtgccag gactgaaatg ggcactgggt ctcgggtgcc tgggggctcc ccgctgggtg
     5041 tcagcttagt gtattcggac aagaagtcgg cagcagccac ctcaccagcc ccacacttgg
     5101 tggctggacc cctgctgggc actgtgggga aggcgcctgc cactgtcact aacctactgg
     5161 tgggcacccc ggggtatggg gcccctgcgc cccctgctgt ccagttcatt gcccaggggg
     5221 cccctggtgg tgggaccact gcgggctcag gagcaggtgc tgggagtggc cccaatgggc
     5281 cagtacccct gggcatcctg caaccaggtg ccctgggcaa ggctggggga atcacccagg
     5341 tacagtacat cctgcccacg ctgccccagc agcttcaggt ggcacctgcc ccagcaccag
     5401 cccctgggac caaggcagcg gctcccagcg gccctgcacc caccaccagc atccgtttca
     5461 ccctcccacc gggcacttcc accaacggca aagtcctggc tgccactgca cccactcctg
     5521 gcatccccat cctgcagtct gtaccctccg ccccaccccc caaagcccag tcagtttctc
     5581 ccgtgcaggc cccgcccccg ggtggctcag cccagctgct gcctgggaag gtcctagtgc
     5641 ctctggccgc ccctagcatg tcagtgcggg gtggaggggc cggccagcca ctgccactgg
     5701 tgagcccgcc cttctcagta cctgtgcaga atggtgccca gccccccagc aagatcatcc
     5761 agctgacccc ggtgcctgtg agcacaccca gcggcctggt gccgcccctg agcccagcca
     5821 cactccctgg acccacctct cagcctcaga aggtcctgtt gccctcctcc accagaatca
     5881 cctatgtgca gtcagcgggc gggcacgcgc tgcccctggg taccagccct gcgtccagcc
     5941 aggctggaac agtcacctcg tacgggccca cgagctctgt agctctaggc ttcacctcgc
     6001 tggggcccag cggccccgcc ttcgtgcagc ccctgctctc agcaggccaa gccccactgc
     6061 tggctcccgg tcaggtgggc gtgtcacctg tgcccagtcc ccagctgccg cctgcctgtg
     6121 cagcccccgg aggtcctgtc ataacagcat tttactctgg cagccctgca cccacctcct
     6181 cagcacccct ggcccagcca tcccaggccc ccccaagcct ggtctacact gtggccacca
     6241 gcacaacccc acctgcagcc accattctgc ccaagggccc gccagcccct gccactgcca
     6301 ccccagcccc gactagccct ttccccagcg ccacagcagg ttccatgacc tacagcttag
     6361 tggcccccaa ggcccagcgg cccagcccga aggcccccca gaaagtgaag gcagccatcg
     6421 ccagcattcc cgtggggtcc tttgaggcag gtgcctctgg gcggcctggc cctgcacccc
     6481 ggcagcctct ggagcctggc ccagtccgag agccaactgc cccagagtct gagcttgagg
     6541 ggcagcccac accaccagcc cctccacccc tgccagagac ctggactccc acggcccgga
     6601 gcagcccccc actgccccca cctgctgagg agcggaccag cgccaagggc cctgagacca
     6661 tggccagcaa attccccagc tcatcttcag actggcgcgt ccctgggcag ggcctggaga
     6721 atcgtgggga gcctcccact cctcccagcc cggccccagc tccagctgta gcccctggtg
     6781 gcagcagcga gagcagcagt gggcgggcag ccggggacac cccggagcgc aaggaggcgg
     6841 ctggtactgg caagaaggtg aaggtgcggc ccccgcccct gaagaagacc tttgactctg
     6901 tggacaacag ggtcctgtca gaagtggact tcgaagagcg ctttgctgag ttgcctgagt
     6961 ttcggcctga ggaggtgctg ccctccccca ccctgcagtc tctggccacc tcaccccggg
     7021 ccatcctggg ctcttaccgc aagaagagga agaactccac ggacctggat tcagcacccg
     7081 aggaccccac ctcgcccaag cgcaagatga gaagacgctc cagctgcagc tcggagccca
     7141 acacccccaa gagtgccaag tgcgaggggg acatcttcac ctttgaccgt acaggtacag
     7201 aagccgagga cgtgcttggg gagctagagt atgacaaggt gccatactcc tccctgcggc
     7261 gcaccctgga ccagcgccgg gccctggtca tgcagctctt tcaggaccat ggcttcttcc
     7321 cgtcagccca ggccacagcc gccttccagg cccgctatgc agacatcttt ccctccaagg
     7381 tttgtctgca gttgaagatc cgtgaggtgc gccagaagat catgcaggct gccactccca
     7441 cggagcagcc ccctggagct gaggctcctc tccctgtacc gccccccact ggcaccgctg
     7501 ctgcccctgc ccccactccc agccccgcag ggggccctga ccccacctca cccagctcgg
     7561 actctggcac ggcccaggct gccccgccac tgcctccacc cccagagtcg gggcctggac
     7621 agcctggctg ggagggggct ccccagccct cccccccacc cccaggtccc tccacagctg
     7681 ccacaggcag gtgagggacc cctgagaaga tgccaggact tatagtaccc cctcaggaca
     7741 tggacagtat gtgggggcag gaaggttatc tcctcccggg taaagccatt tcgtcctctc
     7801 cagtttgggg cggaatgagg cctgctcctc ttgtaaatac ccccttccct cgaagctccc
     7861 tcccggtgct ggggggcagc tgaggggctg caggggcagt ctccctcctc caagcccctg
     7921 tacataacct ggagcgtgtg accttcagag cttttcactt tatgcaaaat ggctcctgtg
     7981 agggctgcaa gctggagggt ggtgcaggcc ttgggccaca gggaggcgcc tgtggaatag
     8041 ggggagttca tgcacccctt ttttccccag aggggctgga ctcaggttag tttgggggtg
     8101 ggggctcctg cactttgcca caggcacggg gagggttttc tcctcacccc ctctgccctc
     8161 ccaacttggg ttgtactttc taagaaggtg attccccctg cccttgcccc cttccccaga
     8221 acaaaacatg ttgatcatgt gcaatatttc ttactgtgcc gagaagccgc aatgagcgag
     8281 attaaagctg tttaacaca
//
