LOCUS       NM_198491               1862 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens CBY1 interacting BAR domain containing 2 (CIBAR2),
            transcript variant 1, mRNA.
ACCESSION   NM_198491 XM_290728
VERSION     NM_198491.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1862)
  AUTHORS   Li,F.Q., Chen,X., Fisher,C., Siller,S.S., Zelikman,K., Kuriyama,R.
            and Takemaru,K.I.
  TITLE     BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To
            Facilitate Ciliogenesis
  JOURNAL   Mol Cell Biol 36 (21), 2668-2680 (2016)
   PUBMED   27528616
  REMARK    GeneRIF: FAM92 proteins interact with Cby1 to promote ciliogenesis
            via regulation of membrane-remodeling processes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1862)
  AUTHORS   Amre,D.K., Mack,D.R., Israel,D., Krupoves,A., Costea,I.,
            Lambrette,P., Grimard,G., Dong,J. and Levy,E.
  TITLE     NELL1, NCF4, and FAM92B genes are not major susceptibility genes
            for Crohn's disease in Canadian children and young adults
  JOURNAL   Inflamm Bowel Dis 18 (3), 529-535 (2012)
   PUBMED   21472827
  REMARK    GeneRIF: Genome-wide association studies-reported associations
            between the NELL1, NCF4, and FAM92B genes and susceptibility to
            Crohn's disease could not be replicated in Canadian children and
            young adults.
REFERENCE   3  (bases 1 to 1862)
  AUTHORS   Glas,J., Seiderer,J., Pasciuto,G., Tillack,C., Diegelmann,J.,
            Pfennig,S., Konrad,A., Schmechel,S., Wetzke,M., Torok,H.P.,
            Stallhofer,J., Jurgens,M., Griga,T., Klein,W., Epplen,J.T.,
            Schiemann,U., Mussack,T., Lohse,P., Goke,B., Ochsenkuhn,T.,
            Folwaczny,M., Muller-Myhsok,B. and Brand,S.
  TITLE     rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and
            FAM92B are not major genetic risk factors for susceptibility to
            Crohn's disease in the German population
  JOURNAL   Am J Gastroenterol 104 (3), 665-672 (2009)
   PUBMED   19262523
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   4  (bases 1 to 1862)
  AUTHORS   Roberts,R.L., Hollis-Moffatt,J.E., Gearry,R.B., Kennedy,M.A.,
            Barclay,M.L. and Merriman,T.R.
  TITLE     Confirmation of association of IRGM and NCF4 with ileal Crohn's
            disease in a population-based cohort
  JOURNAL   Genes Immun 9 (6), 561-565 (2008)
   PUBMED   18580884
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK126284.1, AC026469.8 and BU680724.1.
            
            On Nov 23, 2018 this sequence version replaced NM_198491.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK126284.1, BC093665.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158569 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000539556.6/ ENSP00000443411.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-962               AK126284.1         37-998
            963-1827            AC026469.8         59012-59876
            1828-1862           BU680724.1         24-58               c
FEATURES             Location/Qualifiers
     source          1..1862
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.1"
     gene            1..1862
                     /gene="CIBAR2"
                     /gene_synonym="FAM92B"
                     /note="CBY1 interacting BAR domain containing 2"
                     /db_xref="GeneID:339145"
                     /db_xref="HGNC:HGNC:24781"
                     /db_xref="MIM:617274"
     exon            1..140
                     /gene="CIBAR2"
                     /gene_synonym="FAM92B"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1035
                     /gene="CIBAR2"
                     /gene_synonym="FAM92B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM92B; family with sequence similarity 92 member
                     B; CBY1-interacting BAR domain-containing protein 2"
                     /codon_start=1
                     /product="CBY1-interacting BAR domain-containing protein 2
                     isoform 1"
                     /protein_id="NP_940893.1"
                     /db_xref="CCDS:CCDS32500.1"
                     /db_xref="GeneID:339145"
                     /db_xref="HGNC:HGNC:24781"
                     /db_xref="MIM:617274"
                     /translation="MNIVFSRDSQVRVMENTVANTEKYFGQFCSLLAAYTRKTARLRD
                     KADQLVKQLIDFANSENPELRATMRGFAEDLAKVQDYRQAQVERLETKVVNPLKLYGA
                     QIKQTRAEIKKFKHVQNHEIKQLEKLEKLRQKSPSDQQMISQAETRVQRAAVDSSRTT
                     LQLEETVDGFQRQKLKDLQKFFCDFVTIEMVFHAKAVEVYSSAFQTLEKYDLERDLLD
                     FRAKMQGVYGHYDTRLLANTSPPPSVLQSLASQGTLQVQLSRANEDPEHPHANHGRFS
                     LCEWVVKGQPAHCVCGQGGHLMLPGHSL"
     exon            141..375
                     /gene="CIBAR2"
                     /gene_synonym="FAM92B"
                     /inference="alignment:Splign:2.1.0"
     exon            376..444
                     /gene="CIBAR2"
                     /gene_synonym="FAM92B"
                     /inference="alignment:Splign:2.1.0"
     exon            445..546
                     /gene="CIBAR2"
                     /gene_synonym="FAM92B"
                     /inference="alignment:Splign:2.1.0"
     exon            547..552
                     /gene="CIBAR2"
                     /gene_synonym="FAM92B"
                     /inference="alignment:Splign:2.1.0"
     exon            553..657
                     /gene="CIBAR2"
                     /gene_synonym="FAM92B"
                     /inference="alignment:Splign:2.1.0"
     exon            658..771
                     /gene="CIBAR2"
                     /gene_synonym="FAM92B"
                     /inference="alignment:Splign:2.1.0"
     exon            772..873
                     /gene="CIBAR2"
                     /gene_synonym="FAM92B"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1862
                     /gene="CIBAR2"
                     /gene_synonym="FAM92B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1841..1846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIBAR2"
                     /gene_synonym="FAM92B"
                     /note="hexamer: AATAAA"
     polyA_site      1862
                     /gene="CIBAR2"
                     /gene_synonym="FAM92B"
                     /note="major polyA site"
ORIGIN      
        1 gtcccttgag cccaggccac acagctgcac ccagccctgc ccggctcctc ccaggcctgc
       61 aggacccctg gggccctgtc cttattcccc agcaccggga cagccaaagc tctggtcaca
      121 atgaacatcg tcttctccag ggacagccag gtgagggtga tggagaatac cgtggccaac
      181 accgagaagt actttgggca gttctgctcg ctgctggccg cctacacgcg caagacggcc
      241 cggctgcggg acaaggcgga ccagctggtc aagcagctca tcgactttgc caactccgag
      301 aaccccgagc tgcgggccac catgaggggc ttcgctgagg acctggccaa agtgcaggat
      361 taccggcagg cccaggtcga gaggctggag accaaggtgg tcaaccccct gaagctctac
      421 ggggcacaga tcaagcagac acgggctgag atcaagaaat tcaaacatgt ccaaaatcat
      481 gagatcaaac aactggaaaa actggagaaa ctgaggcaga agtcaccctc ggatcagcaa
      541 atgatctccc aggcagagac cagagtgcag agggccgctg tggactccag ccgcaccacc
      601 ctccagctgg aggagactgt ggatggcttc cagaggcaga agctcaagga cctgcagaaa
      661 tttttttgtg actttgtaac tattgagatg gttttccatg ccaaagcggt ggaggtgtat
      721 tctagcgcct tccagaccct ggagaagtat gacctggaga gggatctact ggattttaga
      781 gccaagatgc aaggagttta tgggcattat gacactcggc tgcttgccaa caccagcccc
      841 cctccatctg ttcttcagtc tctcgccagc cagggaactc tgcaggtcca gctgagtagg
      901 gcaaatgaag accctgaaca tcctcatgcc aatcatggca ggtttagtct ctgtgagtgg
      961 gtggttaagg ggcagccagc ccactgtgtg tgtgggcagg gtgggcatct catgcttcca
     1021 ggacattctc tctaacgacg tagggtaagt gcaatcccaa gccgtttaaa ataatcccag
     1081 actgcctgga ggctttgttc ttattttctg attctttttt ctttgtcttt gttggattgt
     1141 gttaattcaa agaccttgtc ttcaagctct gaatttcctt cttctacttg ttcaattctg
     1201 ttgctgagac tttccagagc attttgcatt tctgtgagtg tatccaatgt ttcctgaagt
     1261 tttgattgtt tttctttatg ctatctattt cttggtccga gcccactgct cccggcggtg
     1321 tgaccttggg aaagtctcct agcctctctg tgccttagag tcctcgcctg cagagtggct
     1381 tagaacagta acctccgtgt agggctgtgc tgagtatcag atgaacagat ctatacgaag
     1441 cacagaaaac ccggcctgtt gcgcaacaaa cacttgagac ttgttgctgc cattatcatt
     1501 actgatgttg ctgtcgtttt attattatta ttatttagag tgctcagagc accatatgga
     1561 gcccaggaaa agaaggggag gagagtgagg acaactccat ggaggaggcc cccgtggagg
     1621 acctcagggc actggggcag ggaccccata agagagaact gcccacaaca gtcagaagaa
     1681 cttagctggc cttggatcct caggtgggct ctgctgtgtg ccctcaggca agccacgtgt
     1741 cctctgagcc tcagtttcct catctgtaca acagggccaa tatcactcac ttcacaggtt
     1801 gctctggggg atcgctgtgc ctggcatata gtaggtgttc aataaatgcc ctgtgactct
     1861 ca
//
