LOCUS       NM_145269               4198 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens CBY1 interacting BAR domain containing 1 (CIBAR1),
            transcript variant 1, mRNA.
ACCESSION   NM_145269 XM_001126414 XM_931181 XM_943013
VERSION     NM_145269.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4198)
  AUTHORS   Wang,Z. and Mim,C.
  TITLE     Optimizing purification of the peripheral membrane protein FAM92A1
            fused to a modified spidroin tag
  JOURNAL   Protein Expr Purif 189, 105992 (2022)
   PUBMED   34648955
  REMARK    GeneRIF: Optimizing purification of the peripheral membrane protein
            FAM92A1 fused to a modified spidroin tag.
REFERENCE   2  (bases 1 to 4198)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4198)
  AUTHORS   Zhi Ruan,X., Rong Guo,X., Bin Wang,X. and Yun Ji,F.
  TITLE     BARMR1/FAM92A1, a novel gene encoding BAR domain protein with
            multi-functions
  JOURNAL   Gene 765, 145074 (2021)
   PUBMED   32891772
  REMARK    GeneRIF: BARMR1/FAM92A1, a novel gene encoding BAR domain protein
            with multi-functions.
            Review article
REFERENCE   4  (bases 1 to 4198)
  AUTHORS   Guo,X.R., Shan,M.Y., Huang,Y., Zhang,Z.L., Yuan,Y., Dai,L.J.,
            Wang,J., Zhou,X.P., Ji,F.Y., Tang,J.M., Meng,Z.J. and Ruan,X.Z.
  TITLE     BARMR1-mediated sorafenib resistance is derived through stem-like
            property acquisition by activating integrin-FAK signaling pathways
  JOURNAL   Signal Transduct Target Ther 5 (1), 97 (2020)
   PUBMED   32532973
  REMARK    GeneRIF: BARMR1-mediated sorafenib resistance is derived through
            stem-like property acquisition by activating integrin-FAK signaling
            pathways.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4198)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4198)
  AUTHORS   Li,F.Q., Chen,X., Fisher,C., Siller,S.S., Zelikman,K., Kuriyama,R.
            and Takemaru,K.I.
  TITLE     BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To
            Facilitate Ciliogenesis
  JOURNAL   Mol Cell Biol 36 (21), 2668-2680 (2016)
   PUBMED   27528616
  REMARK    GeneRIF: FAM92 proteins interact with Cby1 to promote ciliogenesis
            via regulation of membrane-remodeling processes.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4198)
  AUTHORS   Gui,H., Guo,X.R., Fang,J., Ma,S.N., Wu,G., Shen,J.H., Tu,H.J.,
            Li,D.S., Dai,L.J. and Ruan,X.Z.
  TITLE     The Tumor-promoting Effects of FAM92A1-289 in Cervical Carcinoma
            Cells
  JOURNAL   Anticancer Res 36 (10), 5197-5204 (2016)
   PUBMED   27798880
  REMARK    GeneRIF: FAM92A1-289 retains many oncogenic properties evidenced by
            facilitating cell migration, boosting cell proliferation and
            promoting colony formation in vitro and tumor growth in vivo,
            providing evidence for use as as a therapeutic target for cancer
            treatment.
REFERENCE   8  (bases 1 to 4198)
  AUTHORS   Service,S.K., Verweij,K.J., Lahti,J., Congdon,E., Ekelund,J.,
            Hintsanen,M., Raikkonen,K., Lehtimaki,T., Kahonen,M., Widen,E.,
            Taanila,A., Veijola,J., Heath,A.C., Madden,P.A., Montgomery,G.W.,
            Sabatti,C., Jarvelin,M.R., Palotie,A., Raitakari,O., Viikari,J.,
            Martin,N.G., Eriksson,J.G., Keltikangas-Jarvinen,L., Wray,N.R. and
            Freimer,N.B.
  TITLE     A genome-wide meta-analysis of association studies of Cloninger's
            Temperament Scales
  JOURNAL   Transl Psychiatry 2 (5), e116 (2012)
   PUBMED   22832960
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4198)
  AUTHORS   Liang,S., Gong,F., Zhao,X., Wang,X., Shen,G., Xu,Y., Yang,H.,
            Ruan,X. and Wei,Y.
  TITLE     Prokaryotic expression, purification of a new tumor-relative
            protein FAM92A1-289 and its characterization in renal cell
            carcinoma
  JOURNAL   Cancer Lett 276 (1), 81-87 (2009)
   PUBMED   19059705
  REMARK    GeneRIF: FAM92A1-289 is a new tumor-related gene with oncogenic
            potentials to probably play roles in renal carcinogenesis.
REFERENCE   10 (bases 1 to 4198)
  AUTHORS   Ruan,X.Z., Yan,F., Zhao,X.Y., Wang,C.T., Song,M., Yang,H.S.,
            Deng,H.X. and Wei,Y.Q.
  TITLE     Identification and characterization of two novel variants of the
            DUF1208 protein FAM92A1
  JOURNAL   Mol Cells 23 (3), 391-397 (2007)
   PUBMED   17646714
  REMARK    GeneRIF: FAM92A1 has different splicing variants, and that it may
            take part in regulating cell proliferation and apoptosis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC108707.1, AC010834.19 and CR627475.1.
            
            On May 17, 2019 this sequence version replaced NM_145269.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.259690.1,
                                           SRR1660809.33224.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000518322.6/ ENSP00000429367.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1117              BC108707.1         6-1122
            1118-1509           AC010834.19        79793-80184
            1510-1921           CR627475.1         2592-3003
            1922-4198           AC010834.19        80597-82873
FEATURES             Location/Qualifiers
     source          1..4198
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.1"
     gene            1..4198
                     /gene="CIBAR1"
                     /gene_synonym="BARMR1; FAM92A; FAM92A1; PAPA9"
                     /note="CBY1 interacting BAR domain containing 1"
                     /db_xref="GeneID:137392"
                     /db_xref="HGNC:HGNC:30452"
                     /db_xref="MIM:617273"
     exon            1..124
                     /gene="CIBAR1"
                     /gene_synonym="BARMR1; FAM92A; FAM92A1; PAPA9"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..968
                     /gene="CIBAR1"
                     /gene_synonym="BARMR1; FAM92A; FAM92A1; PAPA9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM92A1; family with sequence similarity 92 member
                     A1; CBY1-interacting BAR domain-containing protein 1"
                     /codon_start=1
                     /product="CBY1-interacting BAR domain-containing protein 1
                     isoform 1"
                     /protein_id="NP_660312.2"
                     /db_xref="CCDS:CCDS47892.1"
                     /db_xref="GeneID:137392"
                     /db_xref="HGNC:HGNC:30452"
                     /db_xref="MIM:617273"
                     /translation="MMRRTLENRNAQTKQLQTAVSNVEKHFGELCQIFAAYVRKTARL
                     RDKADLLVNEINAYAATETPHLKLGLMNFADEFAKLQDYRQAEVERLEAKVVEPLKTY
                     GTIVKMKRDDLKATLTARNREAKQLTQLERTRQRNPSDRHVISQAETELQRAAMDASR
                     TSRHLEETINNFERQKMKDIKTIFSEFITIEMLFHGKALEVYTAAYQNIQNIDEDEDL
                     EVFRNSLYAPDYSSRLDIVRANSKSPLQRSLSAKCVSGTGQVSTCRLRKDQQAEDDED
                     DELDVTEEENFLK"
     exon            125..359
                     /gene="CIBAR1"
                     /gene_synonym="BARMR1; FAM92A; FAM92A1; PAPA9"
                     /inference="alignment:Splign:2.1.0"
     exon            360..428
                     /gene="CIBAR1"
                     /gene_synonym="BARMR1; FAM92A; FAM92A1; PAPA9"
                     /inference="alignment:Splign:2.1.0"
     exon            429..530
                     /gene="CIBAR1"
                     /gene_synonym="BARMR1; FAM92A; FAM92A1; PAPA9"
                     /inference="alignment:Splign:2.1.0"
     exon            531..536
                     /gene="CIBAR1"
                     /gene_synonym="BARMR1; FAM92A; FAM92A1; PAPA9"
                     /inference="alignment:Splign:2.1.0"
     exon            537..641
                     /gene="CIBAR1"
                     /gene_synonym="BARMR1; FAM92A; FAM92A1; PAPA9"
                     /inference="alignment:Splign:2.1.0"
     exon            642..755
                     /gene="CIBAR1"
                     /gene_synonym="BARMR1; FAM92A; FAM92A1; PAPA9"
                     /inference="alignment:Splign:2.1.0"
     exon            756..875
                     /gene="CIBAR1"
                     /gene_synonym="BARMR1; FAM92A; FAM92A1; PAPA9"
                     /inference="alignment:Splign:2.1.0"
     exon            876..4198
                     /gene="CIBAR1"
                     /gene_synonym="BARMR1; FAM92A; FAM92A1; PAPA9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1090..1095
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIBAR1"
                     /gene_synonym="BARMR1; FAM92A; FAM92A1; PAPA9"
                     /note="hexamer: ATTAAA"
     polyA_site      1117
                     /gene="CIBAR1"
                     /gene_synonym="BARMR1; FAM92A; FAM92A1; PAPA9"
                     /note="major polyA site"
     regulatory      1898..1903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIBAR1"
                     /gene_synonym="BARMR1; FAM92A; FAM92A1; PAPA9"
                     /note="hexamer: AATAAA"
     polyA_site      1921
                     /gene="CIBAR1"
                     /gene_synonym="BARMR1; FAM92A; FAM92A1; PAPA9"
                     /note="major polyA site"
     regulatory      2227..2232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIBAR1"
                     /gene_synonym="BARMR1; FAM92A; FAM92A1; PAPA9"
                     /note="hexamer: AATAAA"
     polyA_site      2255
                     /gene="CIBAR1"
                     /gene_synonym="BARMR1; FAM92A; FAM92A1; PAPA9"
     regulatory      4054..4059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIBAR1"
                     /gene_synonym="BARMR1; FAM92A; FAM92A1; PAPA9"
                     /note="hexamer: ATTAAA"
     polyA_site      4077
                     /gene="CIBAR1"
                     /gene_synonym="BARMR1; FAM92A; FAM92A1; PAPA9"
ORIGIN      
        1 aggctcccgg cggctgcttg cgccccagcg cgcgcccagg cgccttggaa tccccgtcct
       61 tgggcccccg caaggtcccc ggccgtgcgc gaggcagcat gatgaggcgc accctggaaa
      121 accggaacgc tcaaacgaaa caactgcaaa cagctgtctc aaatgtggag aagcattttg
      181 gagaactgtg ccaaatcttc gctgcctatg tgcggaaaac tgccaggctg agagacaaag
      241 cagacctcct ggtgaatgaa attaacgcgt atgctgctac agagaccccg catttaaagc
      301 tgggcctgat gaactttgca gatgagtttg ccaaacttca ggattatcga caagcagagg
      361 ttgaaagact tgaagccaaa gtagttgaac ccttgaaaac ttatgggacc attgtgaaaa
      421 tgaaacggga tgacctcaaa gcaacactca cagcaaggaa tcgagaagct aagcaattaa
      481 ctcagttaga aagaacacgt cagcgaaacc catctgatcg acatgttatt tcacaggcag
      541 aaacggaatt acagagagct gcaatggatg ctagccgaac aagtcgtcat ctggaggaaa
      601 ctattaacaa ctttgaaagg cagaaaatga aggatataaa gactatattt tctgaattta
      661 tcacaatcga aatgttattt cacggcaaag ctttagaggt ctacactgct gcctaccaga
      721 atatacaaaa cattgatgaa gatgaagatt tagaggtttt ccgaaattct ctgtatgcac
      781 cagattattc atctcgttta gatattgtaa gagcaaattc aaagtcacct cttcagagat
      841 cactgtcagc taagtgtgta tctggaacag gacaggtatc cacttgtcga ctaagaaagg
      901 atcaacaagc agaagatgat gaggatgacg agttagatgt tacagaagaa gaaaattttc
      961 ttaagtaaac tacacatttc cattttcatc ataaatgact tgaaatccac aatgactaaa
     1021 ttgtagaact ttatactcac tttgctatgt taagcctcaa agtgaagtcc aactggaaac
     1081 agaaaaataa ttaaaggaaa cttatgctga ccaaaaatga aggctttaaa aaatattgca
     1141 taccagtcat ttcaacatcc tacctagtgt tacatgattt ttgtgtaagt gccttttttt
     1201 ttaaagatgg tgtatttcaa agtatttcat attaatgtac tatatctact tgaagttcca
     1261 atagtacatt atgacagaaa ccaaaagatc taacaattct gcttagcttt ttggttaaga
     1321 ctccatgctt tcattaccag aaaagggtct tacgtagtca ttatgattca tggaattcta
     1381 ttccatgaag ccttaagaaa aaaaactttt tttaactttc cctgaaactt tatcatttga
     1441 taagtaaatt tacttttcaa gaagagtata accaaagagt aaagataatg tgacactaag
     1501 ttatcaatgt tttatgaata cacataaggc ataaatttca gctgtaaaaa agctacattc
     1561 aatctgactc tggttttaaa acaaaactgc tgtcataatt atacatgata ctgcaacttt
     1621 tggaaggcta atttggtgga atgttgcctc atcatagaac accatagatc attaaaaatt
     1681 ctataaaaat tttaccaagc taccatatag ttaataaaag ggtatacagt cacttttatt
     1741 tctgaaaata taaaacattg agcctttcag tgtatctgat gcttctcttt tggtaaggaa
     1801 tacttttatt tcatggatcc caggcaggca tataaaagtt acggaattta taaaatcatt
     1861 tgggataatt agaaaatgca attattcata acagaaaaat aaagactttc tagaaagctt
     1921 ctgactttgt caatcatggc tctgttctta acaaagcact ccttcctgag aatagtccta
     1981 agtgacaaag ttgtttcagt acttttttgt aaaatattta aaacatttta aaaccctaaa
     2041 ttgatattct taagaaactc aagatatcat tggatattta ctgcttcctc actcagtatt
     2101 taaatttggt tgtacttcgg gggaaaacaa cagagttatt attttgctgc ttactaaata
     2161 gcaacttctc ttgagcatta tttgccttgt ttgtaaagtt aaaactgcgt aaaacagtaa
     2221 ttctggaata aaacatacat tctgcctacc tcaaagaaat attctaagaa caaaaggaat
     2281 actatccatg aaaatacttt cattaatgta aaattttcat tatttagacc agcctaggtt
     2341 ggcaaacttc ttaaagggcc agatagcaaa tactgttatt cttcgtgggt ttaggcaaat
     2401 tcaagactat tatacaggta actatgtaac catgtaagac ttaagtacac ttaaaaaatg
     2461 tgaaaaacca ttcctagctt ccactacaac aacaacaaaa aacaggcaac caatccaacc
     2521 aacccagcct gtaagtctcc atctcttatc tccaaaatag gaatacaaat tgagtatcct
     2581 ttatctgaag tgcttgggac cagaagtatt taagactttg gatttcttca gattttggag
     2641 tatttgcatt ataccagttc aacattccta acccaaaaat ctgaaatctt aaatgctgca
     2701 atgagcattt tctttgagca tcatgttggc actcaaaaag tttgtgattt tcggagcatg
     2761 tgaaatttca gattaccaga ttaggaatac tcaacctgta gtacatttac taggattatc
     2821 agaattaaat gatagttaat tcatacataa ttatacatca tatagtatct aatacagctc
     2881 aataaacaac agctaatatt tactgcaaaa acagaggcag caaggtcact acttaacagg
     2941 tgatatatgg atcaagaatc actgctctta acagtgatct cagtaaatta atagaaatgc
     3001 actcctaaca tgatttttac ctatctcttg gttgtgggat tgactttcta gacatgatct
     3061 acattttttt agataatttc tagacaaaaa tgtttggctt taagacaaat gccactgggt
     3121 atcaggctag agaatacacc tccagtgtac ctggtatacc ttgaggatag gagaggaaaa
     3181 actggctatg agacgacaat tactgaagct gagtgatgtg tacatgaaaa tttactattc
     3241 tttttttata tttgaaattg atgaggtgct gggaagctgg ctttctgagg ggacaacagg
     3301 aggggaattc cttgatttgc tgcatttatc actttccatg gtgtaaaata ctcctgccat
     3361 ggccaatttg ttattgacat atcactaaag gcagagttgg agagagatgt gcaaagatgg
     3421 ctcccaacta gaagatacca ctttctgtaa tcaacttttt ataatgaagt ttaaaaatat
     3481 taagccctga tacattatag ggtaaaagga aatattcata taaattaatt taaaaatcaa
     3541 aatacaaggc tgggcacagt ggctcacacc tgtaatccca acacattctg ggagaccaag
     3601 gagtgaggat tgcttgaggc cagaaatttg agaacagcct gggcaacaca gtgagactct
     3661 gtctctacaa ataataaaaa atttagccag acaaggtggc acacacctgt agtcccagct
     3721 ctcaggaggc tgaggcagga agacagcttg agcccaggag ttagaagctg cagtgaacca
     3781 ttatcagacc actgcactcc agcctggcca gcagaacaag actctgactc ttaaaataat
     3841 aaaactacaa agcttatgtt tactctagct ggcctcttat ctaccaccac catcccacct
     3901 cagcccagtt tgaaatgcaa ttccacagta agtaatccct cacgttaagc ttcatcttag
     3961 ctttattcct ttgtatctga gaagcatttt ttaactttcc atatattatt caaaatgggt
     4021 gaccaaatga accatctata caatctttgc tcaattaaaa atatcatttc tactttcttc
     4081 attgtgcttg gtttggatat tccaaacaat caatttaaca ttatcctagc tacttacaag
     4141 cttatacttt aaagaatcat actgaggtgc tttttcatat caaatttacc tgtttatt
//
