LOCUS       NM_001029881             768 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens calcium and integrin binding family member 4 (CIB4),
            mRNA.
ACCESSION   NM_001029881 XM_059399
VERSION     NM_001029881.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 768)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 768)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 768)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 768)
  AUTHORS   Huang,H., Bogstie,J.N. and Vogel,H.J.
  TITLE     Biophysical and structural studies of the human calcium- and
            integrin-binding protein family: understanding their functional
            similarities and differences
  JOURNAL   Biochem Cell Biol 90 (5), 646-656 (2012)
   PUBMED   22779914
  REMARK    GeneRIF: CIB4, as binding partners for the integrin alphaIIb
            subunit, which suggests that they are potentially involved in
            regulating integrin alphaIIb subunit activation.
REFERENCE   5  (bases 1 to 768)
  AUTHORS   Divaris,K., Monda,K.L., North,K.E., Olshan,A.F., Lange,E.M.,
            Moss,K., Barros,S.P., Beck,J.D. and Offenbacher,S.
  TITLE     Genome-wide association study of periodontal pathogen colonization
  JOURNAL   J Dent Res 91 (7 Suppl), 21S-28S (2012)
   PUBMED   22699663
REFERENCE   6  (bases 1 to 768)
  AUTHORS   Gentry,H.R., Singer,A.U., Betts,L., Yang,C., Ferrara,J.D.,
            Sondek,J. and Parise,L.V.
  TITLE     Structural and biochemical characterization of CIB1 delineates a
            new family of EF-hand-containing proteins
  JOURNAL   J Biol Chem 280 (9), 8407-8415 (2005)
   PUBMED   15574431
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC127684.1, AC015977.9 and AW138422.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001029881.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.395462.1,
                                           SRR5189658.11248.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000288861.5/ ENSP00000288861.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-622               BC127684.1         3-624
            623-623             AC015977.9         12947-12947         c
            624-667             BC127684.1         626-669
            668-768             AW138422.1         21-121              c
FEATURES             Location/Qualifiers
     source          1..768
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..768
                     /gene="CIB4"
                     /gene_synonym="KIP4"
                     /note="calcium and integrin binding family member 4"
                     /db_xref="GeneID:130106"
                     /db_xref="HGNC:HGNC:33703"
                     /db_xref="MIM:610646"
     exon            1..106
                     /gene="CIB4"
                     /gene_synonym="KIP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..610
                     /gene="CIB4"
                     /gene_synonym="KIP4"
                     /codon_start=1
                     /product="calcium and integrin-binding family member 4"
                     /protein_id="NP_001025052.1"
                     /db_xref="CCDS:CCDS33160.1"
                     /db_xref="GeneID:130106"
                     /db_xref="HGNC:HGNC:33703"
                     /db_xref="MIM:610646"
                     /translation="MGQCLRYQMHWEDLEEYQALTFLTRNEILCIHDTFLKLCPPGKY
                     YKEATLTMDQVSSLPALRVNPFRDRICRVFSHKGMFSFEDVLGMASVFSEQACPSLKI
                     EYAFRIYDFNENGFIDEEDLQRIILRLLNSDDMSEDLLMDLTNHVLSESDLDNDNMLS
                     FSEFEHAMAKSPDFMNSFRIHFWGC"
     exon            107..141
                     /gene="CIB4"
                     /gene_synonym="KIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            142..238
                     /gene="CIB4"
                     /gene_synonym="KIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            239..380
                     /gene="CIB4"
                     /gene_synonym="KIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            381..490
                     /gene="CIB4"
                     /gene_synonym="KIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            491..579
                     /gene="CIB4"
                     /gene_synonym="KIP4"
                     /inference="alignment:Splign:2.1.0"
     exon            580..768
                     /gene="CIB4"
                     /gene_synonym="KIP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      750..755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIB4"
                     /gene_synonym="KIP4"
                     /note="hexamer: AAGAAA"
     polyA_site      768
                     /gene="CIB4"
                     /gene_synonym="KIP4"
                     /note="major polyA site"
ORIGIN      
        1 gagtccttga ggctgaggtt ctactgctgg cagacagaaa ggtgtggttg gcatggggca
       61 atgcttgagg tatcagatgc actgggagga cctggaagag taccaggccc tgaccttcct
      121 gaccagaaat gaaattctgt gcatccatga caccttcctg aagctctgcc ctcctgggaa
      181 gtactacaag gaggcaacgc tcaccatgga ccaggtcagc tccctgccag ctctgcgggt
      241 caaccctttc agagaccgta tctgcagagt gttctcccac aaaggcatgt tctcctttga
      301 ggatgtgctg ggcatggcat ctgtgttcag cgagcaggcc tgcccaagcc tgaagattga
      361 gtatgccttt cgcatctatg attttaatga gaatggcttc attgatgagg aggatctgca
      421 gaggatcatc ctgcgactgc tgaacagtga tgacatgtct gaggacctcc tgatggacct
      481 cacgaaccac gtcctgagtg agtcggatct ggacaatgac aacatgctgt ccttctcaga
      541 gtttgaacat gcaatggcca agtctccaga tttcatgaac tcctttcgga ttcacttctg
      601 gggatgctga tgtagcggca aacacctgac atggcagcct cgagggagac cacaggaatc
      661 gaaccccctc cagcactgga gggagctggt ttgaagtatg actttgtact gggcccacac
      721 tcacctctag aatattgttt attagataaa agaaaaagct tttcctta
//
