LOCUS       NM_054113                711 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens calcium and integrin binding family member 3 (CIB3),
            transcript variant 1, mRNA.
ACCESSION   NM_054113
VERSION     NM_054113.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 711)
  AUTHORS   Wijeratne,S.S., Marchan,M.F., Tresback,J.S. and Subramanian,R.
  TITLE     Atomic force microscopy reveals distinct protofilament-scale
            structural dynamics in depolymerizing microtubule arrays
  JOURNAL   Proc Natl Acad Sci U S A 119 (5) (2022)
   PUBMED   35101922
  REMARK    GeneRIF: Atomic force microscopy reveals distinct
            protofilament-scale structural dynamics in depolymerizing
            microtubule arrays.
REFERENCE   2  (bases 1 to 711)
  AUTHORS   Liang,X., Qiu,X., Dionne,G., Cunningham,C.L., Pucak,M.L., Peng,G.,
            Kim,Y.H., Lauer,A., Shapiro,L. and Muller,U.
  TITLE     CIB2 and CIB3 are auxiliary subunits of the mechanotransduction
            channel of hair cells
  JOURNAL   Neuron 109 (13), 2131-2149 (2021)
   PUBMED   34089643
  REMARK    GeneRIF: CIB2 and CIB3 are auxiliary subunits of the
            mechanotransduction channel of hair cells.
REFERENCE   3  (bases 1 to 711)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 711)
  AUTHORS   Huang,H., Bogstie,J.N. and Vogel,H.J.
  TITLE     Biophysical and structural studies of the human calcium- and
            integrin-binding protein family: understanding their functional
            similarities and differences
  JOURNAL   Biochem Cell Biol 90 (5), 646-656 (2012)
   PUBMED   22779914
  REMARK    GeneRIF: CIB3, as binding partners for the integrin alphaIIb
            subunit, which suggests that they are potentially involved in
            regulating integrin alphaIIb subunit activation.
REFERENCE   5  (bases 1 to 711)
  AUTHORS   Gentry,H.R., Singer,A.U., Betts,L., Yang,C., Ferrara,J.D.,
            Sondek,J. and Parise,L.V.
  TITLE     Structural and biochemical characterization of CIB1 delineates a
            new family of EF-hand-containing proteins
  JOURNAL   J Biol Chem 280 (9), 8407-8415 (2005)
   PUBMED   15574431
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC112200.1, AB050868.1 and
            AW295492.1.
            
            On May 17, 2019 this sequence version replaced NM_054113.3.
            
            Summary: This gene product shares a high degree of sequence
            similarity with DNA-dependent protein kinase catalytic
            subunit-interacting protein 2 in human and mouse, and like them may
            bind the catalytic subunit of DNA-dependent protein kinases. The
            exact function of this gene is not known. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jul
            2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC113591.1, AB050868.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269878.8/ ENSP00000269878.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BC112200.1         1-50
            51-685              AB050868.1         1-635
            686-711             AW295492.1         15-40               c
FEATURES             Location/Qualifiers
     source          1..711
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..711
                     /gene="CIB3"
                     /gene_synonym="KIP3"
                     /note="calcium and integrin binding family member 3"
                     /db_xref="GeneID:117286"
                     /db_xref="HGNC:HGNC:24580"
                     /db_xref="MIM:610645"
     exon            1..101
                     /gene="CIB3"
                     /gene_synonym="KIP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..614
                     /gene="CIB3"
                     /gene_synonym="KIP3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DNA-dependent protein kinase catalytic subunit-interacting
                     protein 3"
                     /codon_start=1
                     /product="calcium and integrin-binding family member 3
                     isoform 1"
                     /protein_id="NP_473454.1"
                     /db_xref="CCDS:CCDS12340.1"
                     /db_xref="GeneID:117286"
                     /db_xref="HGNC:HGNC:24580"
                     /db_xref="MIM:610645"
                     /translation="MGNKQTVFTHEQLEAYQDCTFFTRKEIMRLFYRYQDLAPQLVPL
                     DYTTCPDVKVPYELIGSMPELKDNPFRQRIAQVFSEDGDGHMTLDNFLDMFSVMSEMA
                     PRDLKAYYAFKIYDFNNDDYICAWDLEQTVTKLTRGGLSAEEVSLVCEKVLDEADGDH
                     DGRLSLEDFQNMILRAPDFLSTFHIRI"
     exon            102..136
                     /gene="CIB3"
                     /gene_synonym="KIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            137..248
                     /gene="CIB3"
                     /gene_synonym="KIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            249..396
                     /gene="CIB3"
                     /gene_synonym="KIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            397..592
                     /gene="CIB3"
                     /gene_synonym="KIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            593..711
                     /gene="CIB3"
                     /gene_synonym="KIP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      687..692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIB3"
                     /gene_synonym="KIP3"
                     /note="hexamer: AATAAA"
     polyA_site      711
                     /gene="CIB3"
                     /gene_synonym="KIP3"
                     /note="major polyA site"
ORIGIN      
        1 agctgggagc ctttggggtg catccccaag tctgggctgt ggttcacacc atgggcaaca
       61 agcagacagt cttcacacac gagcagctgg aagcgtatca ggactgcaca tttttcacaa
      121 ggaaggagat catgaggctc ttctatcgct accaggacct ggccccacag ctcgtgcccc
      181 tcgactatac cacctgcccc gatgtgaagg tgccctacga gctcattggc agcatgcccg
      241 agctgaagga caaccccttc cgccagagga ttgcccaggt attctctgag gatggggatg
      301 gccacatgac cctggacaac tttttggaca tgttttccgt gatgagtgaa atggctcccc
      361 gcgacctcaa ggcttactat gcttttaaaa tttatgattt taacaacgac gactacattt
      421 gtgcgtggga cctggagcag acggtgacca aactgacgcg gggggggctg agtgccgagg
      481 aggtgagcct ggtatgtgag aaggtgctgg atgaggctga tggagaccat gatgggcggc
      541 tgtccctgga agatttccag aacatgatcc tccgggcacc agacttcctc agcaccttcc
      601 acatccgaat ctgatggcac cacagaggag ccgagctata ggagggcggg gtgacccctc
      661 acccgctgtg gactctggtt tctgagaata aacacaagtc actgagtcac a
//
