LOCUS       NM_006384               1141 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens calcium and integrin binding 1 (CIB1), transcript
            variant b, mRNA.
ACCESSION   NM_006384
VERSION     NM_006384.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1141)
  AUTHORS   Xu,M.H., Zheng,Y.M., Liang,B.G., Xu,W.X., Cao,J., Wang,P.,
            Dong,Z.Y., Zhou,C.H., Sun,H.C., Ren,N., Ke,A.W. and Shen,Y.H.
  TITLE     Deubiquitination of CIB1 by USP14 promotes lenvatinib resistance
            via the PAK1-ERK1/2 axis in hepatocellular carcinoma
  JOURNAL   Int J Biol Sci 20 (9), 3269-3284 (2024)
   PUBMED   38993552
  REMARK    GeneRIF: Deubiquitination of CIB1 by USP14 promotes lenvatinib
            resistance via the PAK1-ERK1/2 axis in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1141)
  AUTHORS   Wang,C., Felli,E., Selicean,S., Nulan,Y., Lozano,J.J.,
            Guixe-Muntet,S., Bosch,J., Berzigotti,A. and Gracia-Sancho,J.
  TITLE     Role of calcium integrin-binding protein 1 in the mechanobiology of
            the liver endothelium
  JOURNAL   J Cell Physiol 239 (5), e31198 (2024)
   PUBMED   38451745
  REMARK    GeneRIF: Role of calcium integrin-binding protein 1 in the
            mechanobiology of the liver endothelium.
REFERENCE   3  (bases 1 to 1141)
  AUTHORS   Ma,J., Song,Y., Zhuang,T., Yang,H., Yang,X., Zheng,J., Luo,J.,
            Xia,Y., Fei,X., Chan,D.W., Wu,D., Xu,P., Ni,P., Dai,J., Xu,D. and
            Hu,Y.
  TITLE     Identification of calcium and integrin-binding protein 1 as a
            reprogrammed glucose metabolism mediator to restrict immune cell
            infiltration in the stromal compartment of pancreatic ductal
            adenocarcinoma
  JOURNAL   Front Immunol 14, 1158964 (2023)
   PUBMED   37187730
  REMARK    GeneRIF: Identification of calcium and integrin-binding protein 1
            as a reprogrammed glucose metabolism mediator to restrict immune
            cell infiltration in the stromal compartment of pancreatic ductal
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1141)
  AUTHORS   Hu,G., Ding,X., Gao,F. and Li,J.
  TITLE     Calcium and integrin binding protein 1 (CIB1) induces myocardial
            fibrosis in myocardial infarction via regulating the PI3K/Akt
            pathway
  JOURNAL   Exp Anim 71 (1), 1-13 (2022)
   PUBMED   34349085
  REMARK    GeneRIF: Calcium and integrin binding protein 1 (CIB1) induces
            myocardial fibrosis in myocardial infarction via regulating the
            PI3K/Akt pathway.
REFERENCE   5  (bases 1 to 1141)
  AUTHORS   Jacob,S., Bosch,F., Schoenberg,M.B., Pretzsch,E., Lampert,C.,
            Haoyu,R., Renz,B.W., Michl,M., Kumbrink,J., Kirchner,T., Werner,J.,
            Angele,M.K. and Neumann,J.
  TITLE     Expression of CIB1 correlates with colorectal liver metastases but
            not with peritoneal carcinomatosis
  JOURNAL   BMC Cancer 21 (1), 1243 (2021)
   PUBMED   34794407
  REMARK    GeneRIF: Expression of CIB1 correlates with colorectal liver
            metastases but not with peritoneal carcinomatosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1141)
  AUTHORS   Armacki,M., Joodi,G., Nimmagadda,S.C., de Kimpe,L., Pusapati,G.V.,
            Vandoninck,S., Van Lint,J., Illing,A. and Seufferlein,T.
  TITLE     A novel splice variant of calcium and integrin-binding protein 1
            mediates protein kinase D2-stimulated tumour growth by regulating
            angiogenesis
  JOURNAL   Oncogene 33 (9), 1167-1180 (2014)
   PUBMED   23503467
  REMARK    GeneRIF: CIB1a is a novel mediator of PKD2-driven carcinogenesis.
REFERENCE   7  (bases 1 to 1141)
  AUTHORS   Stabler,S.M., Ostrowski,L.L., Janicki,S.M. and Monteiro,M.J.
  TITLE     A myristoylated calcium-binding protein that preferentially
            interacts with the Alzheimer's disease presenilin 2 protein
  JOURNAL   J Cell Biol 145 (6), 1277-1292 (1999)
   PUBMED   10366599
REFERENCE   8  (bases 1 to 1141)
  AUTHORS   Seki,N., Hayashi,A., Abe,M., Araki,R., Fujimori,A., Fukumura,R.,
            Hattori,A., Kozuma,S., Ohhira,M., Hori,T. and Saito,T.
  TITLE     Chromosomal assignment of the gene for human DNA-PKcs interacting
            protein (KIP) on chromosome 15q25.3-q26.1 by somatic hybrid
            analysis and fluorescence in situ hybridization
  JOURNAL   J Hum Genet 43 (4), 275-277 (1998)
   PUBMED   9852683
REFERENCE   9  (bases 1 to 1141)
  AUTHORS   Wu,X. and Lieber,M.R.
  TITLE     Interaction between DNA-dependent protein kinase and a novel
            protein, KIP
  JOURNAL   Mutat Res 385 (1), 13-20 (1997)
   PUBMED   9372844
REFERENCE   10 (bases 1 to 1141)
  AUTHORS   Naik,U.P., Patel,P.M. and Parise,L.V.
  TITLE     Identification of a novel calcium-binding protein that interacts
            with the integrin alphaIIb cytoplasmic domain
  JOURNAL   J Biol Chem 272 (8), 4651-4654 (1997)
   PUBMED   9030514
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD622547.1, U82226.1,
            AA769426.1 and AC091167.19.
            
            On May 17, 2019 this sequence version replaced NM_006384.3.
            
            Summary: This gene encodes a member of the EF-hand
            domain-containing calcium-binding superfamily. The encoded protein
            interacts with many other proteins, including the platelet integrin
            alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal
            adhesion kinase, p21 activated kinase, and protein kinase D. The
            encoded protein may be involved in cell survival and proliferation,
            and is associated with several disease states including cancer and
            Alzheimer's disease. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Apr 2013].
            
            Transcript Variant: This variant (b) uses an alternate splice site
            in the coding region, compared to variant a. The encoded isoform
            (b, also known as CIB1) is shorter, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.570233.1,
                                           SRR7346977.191440.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328649.11/ ENSP00000333873.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                CD622547.1         114-123
            11-865              U82226.1           1-855
            866-871             AA769426.1         19-24               c
            872-1141            AC091167.19        108429-108698
FEATURES             Location/Qualifiers
     source          1..1141
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..1141
                     /gene="CIB1"
                     /gene_synonym="CIB; CIBP; EV3; KIP1; PRKDCIP; SIP2-28"
                     /note="calcium and integrin binding 1"
                     /db_xref="GeneID:10519"
                     /db_xref="HGNC:HGNC:16920"
                     /db_xref="MIM:602293"
     exon            1..107
                     /gene="CIB1"
                     /gene_synonym="CIB; CIBP; EV3; KIP1; PRKDCIP; SIP2-28"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..632
                     /gene="CIB1"
                     /gene_synonym="CIB; CIBP; EV3; KIP1; PRKDCIP; SIP2-28"
                     /note="isoform b is encoded by transcript variant b;
                     DNA-dependent protein kinase interacting protein;
                     DNA-PKcs-interacting protein; SNK-interacting protein
                     2-28; testicular secretory protein Li 9; DNA-PK
                     interaction protein; calcium and integrin binding 1
                     (calmyrin)"
                     /codon_start=1
                     /product="calcium and integrin-binding protein 1 isoform
                     b"
                     /protein_id="NP_006375.2"
                     /db_xref="CCDS:CCDS10360.1"
                     /db_xref="GeneID:10519"
                     /db_xref="HGNC:HGNC:16920"
                     /db_xref="MIM:602293"
                     /translation="MGGSGSRLSKELLAEYQDLTFLTKQEILLAHRRFCELLPQEQRS
                     VESSLRAQVPFEQILSLPELKANPFKERICRVFSTSPAKDSLSFEDFLDLLSVFSDTA
                     TPDIKSHYAFRIFDFDDDGTLNREDLSRLVNCLTGEGEDTRLSASEMKQLIDNILEES
                     DIDRDGTINLSEFQHVISRSPDFASSFKIVL"
     exon            108..142
                     /gene="CIB1"
                     /gene_synonym="CIB; CIBP; EV3; KIP1; PRKDCIP; SIP2-28"
                     /inference="alignment:Splign:2.1.0"
     exon            143..251
                     /gene="CIB1"
                     /gene_synonym="CIB; CIBP; EV3; KIP1; PRKDCIP; SIP2-28"
                     /inference="alignment:Splign:2.1.0"
     exon            252..402
                     /gene="CIB1"
                     /gene_synonym="CIB; CIBP; EV3; KIP1; PRKDCIP; SIP2-28"
                     /inference="alignment:Splign:2.1.0"
     exon            403..521
                     /gene="CIB1"
                     /gene_synonym="CIB; CIBP; EV3; KIP1; PRKDCIP; SIP2-28"
                     /inference="alignment:Splign:2.1.0"
     exon            522..610
                     /gene="CIB1"
                     /gene_synonym="CIB; CIBP; EV3; KIP1; PRKDCIP; SIP2-28"
                     /inference="alignment:Splign:2.1.0"
     exon            611..1141
                     /gene="CIB1"
                     /gene_synonym="CIB; CIBP; EV3; KIP1; PRKDCIP; SIP2-28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      846..851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIB1"
                     /gene_synonym="CIB; CIBP; EV3; KIP1; PRKDCIP; SIP2-28"
                     /note="hexamer: AATAAA"
     polyA_site      866
                     /gene="CIB1"
                     /gene_synonym="CIB; CIBP; EV3; KIP1; PRKDCIP; SIP2-28"
                     /note="major polyA site"
     regulatory      1121..1126
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIB1"
                     /gene_synonym="CIB; CIBP; EV3; KIP1; PRKDCIP; SIP2-28"
                     /note="hexamer: AGTAAA"
     polyA_site      1141
                     /gene="CIB1"
                     /gene_synonym="CIB; CIBP; EV3; KIP1; PRKDCIP; SIP2-28"
ORIGIN      
        1 gagaaagttg tctgcgtctc gaggcgagtt ggcggagctg tgcgcgcggc ggggcgatgg
       61 ggggctcggg cagtcgcctg tccaaggagc tgctggccga gtaccaggac ttgacgttcc
      121 tgacgaagca ggagatcctc ctagcccaca ggcggttttg tgagctgctt ccccaggagc
      181 agcggagcgt ggagtcgtca cttcgggcac aagtgccctt cgagcagatt ctcagccttc
      241 cagagctcaa ggccaacccc ttcaaggagc gaatctgcag ggtcttctcc acatccccag
      301 ccaaagacag ccttagcttt gaggacttcc tggatctcct cagtgtgttc agtgacacag
      361 ccacgccaga catcaagtcc cattatgcct tccgcatctt tgactttgat gatgacggaa
      421 ccttgaacag agaagacctg agccggctgg tgaactgcct cacgggagag ggcgaggaca
      481 cacggcttag tgcgtctgag atgaagcagc tcatcgacaa catcctggag gagtctgaca
      541 ttgacaggga tggaaccatc aacctctctg agttccagca cgtcatctcc cgttctccag
      601 actttgccag ctcctttaag attgtcctgt gacagcagcc ccagcgtgtg tcctggcacc
      661 ctgtccaaga acctttctac tgctgagctg tggccaaggt caagcctgtg ttgccagtgc
      721 gggccaagct ggcccagcct ggagctggcg ctgtgcagcc tcaccccggg caggggcggc
      781 cctcgttgtc agggcctctc ctcactgctg ttgtcattgc tccgtttgtg tttgtactaa
      841 tcagtaataa aggtttagaa gtttgaccct atgtgtgaca tgagatacac tggtatgagg
      901 aaggactgga cttctcttct aagagccttc aatcatccta ggaataagca gcatatcgag
      961 cagaggccag cgggaagtca agccgcaccc acgctggctg tccccgtggg agggtgtgag
     1021 gatgaagggg cagcaggagg tgtgggactc gcctgtatcc tgattggggt ggtggttaga
     1081 tgagtctctg catgcatcaa aatgtaaaga accgtacatc agtaaagtct attttactgc
     1141 a
//
