LOCUS       NM_144697               2011 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens circadian associated repressor of transcription
            (CIART), transcript variant 1, mRNA.
ACCESSION   NM_144697
VERSION     NM_144697.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2011)
  AUTHORS   Tang,X., Xue,D., Zhang,T., Nilsson-Payant,B.E., Carrau,L., Duan,X.,
            Gordillo,M., Tan,A.Y., Qiu,Y., Xiang,J., Schwartz,R.E.,
            tenOever,B.R., Evans,T. and Chen,S.
  TITLE     A multi-organoid platform identifies CIART as a key factor for
            SARS-CoV-2 infection
  JOURNAL   Nat Cell Biol 25 (3), 381-389 (2023)
   PUBMED   36918693
  REMARK    GeneRIF: A multi-organoid platform identifies CIART as a key factor
            for SARS-CoV-2 infection.
REFERENCE   2  (bases 1 to 2011)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2011)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2011)
  AUTHORS   Hatanaka,F. and Takumi,T.
  TITLE     CHRONO integrates behavioral stress and epigenetic control of
            metabolism
  JOURNAL   Ann Med 49 (4), 352-356 (2017)
   PUBMED   28010116
  REMARK    GeneRIF: Study shows that:1- Chrono is a circadian clock gene whose
            transcription exhibits a robust circadian oscillation. 2- Is is a
            repressor of circadian transcriptional/translational feedback
            loops. 3- It may function to link epigenetic control mechanisms to
            stress responses. [review]
            Review article
REFERENCE   5  (bases 1 to 2011)
  AUTHORS   Anafi,R.C., Lee,Y., Sato,T.K., Venkataraman,A., Ramanathan,C.,
            Kavakli,I.H., Hughes,M.E., Baggs,J.E., Growe,J., Liu,A.C., Kim,J.
            and Hogenesch,J.B.
  TITLE     Machine learning helps identify CHRONO as a circadian clock
            component
  JOURNAL   PLoS Biol 12 (4), e1001840 (2014)
   PUBMED   24737000
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2011)
  AUTHORS   Goriki,A., Hatanaka,F., Myung,J., Kim,J.K., Yoritaka,T., Tanoue,S.,
            Abe,T., Kiyonari,H., Fujimoto,K., Kato,Y., Todo,T., Matsubara,A.,
            Forger,D. and Takumi,T.
  TITLE     A novel protein, CHRONO, functions as a core component of the
            mammalian circadian clock
  JOURNAL   PLoS Biol 12 (4), e1001839 (2014)
   PUBMED   24736997
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2011)
  AUTHORS   Annayev,Y., Adar,S., Chiou,Y.Y., Lieb,J.D., Sancar,A. and Ye,R.
  TITLE     Gene model 129 (Gm129) encodes a novel transcriptional repressor
            that modulates circadian gene expression
  JOURNAL   J Biol Chem 289 (8), 5013-5024 (2014)
   PUBMED   24385426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EB388133.1, AC242988.1, BC047238.1 and CK904668.1.
            
            On Nov 22, 2018 this sequence version replaced NM_144697.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.996580.1,
                                           SRR1803615.159664.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290363.6/ ENSP00000290363.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-623               EB388133.1         22-644
            624-624             AC242988.1         159364-159364
            625-1905            BC047238.1         360-1640
            1906-2011           CK904668.1         8-113               c
FEATURES             Location/Qualifiers
     source          1..2011
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..2011
                     /gene="CIART"
                     /gene_synonym="C1orf51; CHRONO; GM129"
                     /note="circadian associated repressor of transcription"
                     /db_xref="GeneID:148523"
                     /db_xref="HGNC:HGNC:25200"
                     /db_xref="MIM:615782"
     exon            1..1080
                     /gene="CIART"
                     /gene_synonym="C1orf51; CHRONO; GM129"
                     /inference="alignment:Splign:2.1.0"
     CDS             715..1872
                     /gene="CIART"
                     /gene_synonym="C1orf51; CHRONO; GM129"
                     /note="isoform a is encoded by transcript variant 1;
                     circadian-associated transcriptional repressor;
                     chIP-derived repressor of network oscillator;
                     computationally highlighted repressor of the network
                     oscillator"
                     /codon_start=1
                     /product="circadian-associated transcriptional repressor
                     isoform a"
                     /protein_id="NP_653298.1"
                     /db_xref="CCDS:CCDS949.1"
                     /db_xref="GeneID:148523"
                     /db_xref="HGNC:HGNC:25200"
                     /db_xref="MIM:615782"
                     /translation="MDSPSSVSSYSSYSLSSSFPTSPVNSDFGFPSDSEREDKGAHGP
                     RPDTVGQRGGSRPSPGPIRCRHRSKVSGNQHTPSHPKQRGSASPMAGSGAKRSRDGEL
                     ETSLNTQGCTTEGDLLFAQKCKELQGFIPPLTDLLNGLKMGRFERGLSSFQQSVAMDR
                     IQRIVGVLQKPQMGERYLGTLLQVEGMLKTWFPQIAAQKSSLGGGKHQLTKHFPSHHS
                     DSAASSPASPMEKMDQTQLGHLALKPKQPWHLTQWPAMNLTWIHTTPICNPPLSSPGT
                     ISFSHGPLGTGTGIGVILFLQHGVQPFTHSAPTTPVPPTTASPVIPGEPMKLSGEGPR
                     CYSLPVTLPSDWSYTLSPPSLPTLARKMTIGHREQQRSHPPVAADAHLLNL"
     exon            1081..1156
                     /gene="CIART"
                     /gene_synonym="C1orf51; CHRONO; GM129"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1235
                     /gene="CIART"
                     /gene_synonym="C1orf51; CHRONO; GM129"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1347
                     /gene="CIART"
                     /gene_synonym="C1orf51; CHRONO; GM129"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..2011
                     /gene="CIART"
                     /gene_synonym="C1orf51; CHRONO; GM129"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1990..1995
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIART"
                     /gene_synonym="C1orf51; CHRONO; GM129"
                     /note="hexamer: AAGAAA"
     polyA_site      2011
                     /gene="CIART"
                     /gene_synonym="C1orf51; CHRONO; GM129"
                     /note="major polyA site"
ORIGIN      
        1 agatagaccc ggagagacgg cgaaggagct ggaaaccgag ccagggctga gccggctgac
       61 aacaggtaag gagattcgga ggacaaagcg agctgttagg gagtatttgg gagtggattt
      121 gggggctgaa tgcagatctt ggtattggga gggtttgcat cacgtggcag gtgcgagccc
      181 agagagaccg gcgcagggat cctgatcttg aaagattggg agagggcagg aggccagtct
      241 ctatgggggc ggttcccgta ggatcaccag gtgggttcgc gtgcccagat tgactgcttg
      301 tgggtggcat ggcctcaggt ggagaggctt gctgcggact caggctggcg aatagccctg
      361 gcgaacaacg ggcggagggg aaggtgtctt tcaagtcggt atttactctg aactgaggga
      421 agaaaagaac ggaggccgcg tcagaccgag agctgctctg cggcggccag agagggaatc
      481 ccaagctctt aatgggcggg ggtgggggta gaaatgtctt tttctattgt gtttgagacc
      541 ggtaatattg gggaggggga gaacaagtat tatcccacgc agtacacccc aatctcccag
      601 ttcatttcct aatccttaaa ctctggtttc aaactccctc gctttgctct tcagttgcag
      661 gttccgatct ttgggtactc caggagctgt tctatagccc ctgcttctgg acctatggat
      721 tctccatcta gcgtttcttc ctattcctcc tactctctct cttcgtcttt tcccacctcc
      781 ccagtgaaca gtgactttgg cttcccctct gatagtgaga gggaggacaa gggggcccat
      841 gggcccaggc cagacactgt tgggcagagg ggaggttcac ggcccagccc gggtcctatc
      901 cgctgcaggc atcgatcgaa ggtttccggt aaccagcata caccatctca tccgaaacag
      961 cggggttcgg cttctcctat ggcaggatct ggggcgaaaa gatcaagaga tggtgaactg
     1021 gagaccagtc taaacaccca aggttgtacc acagagggag acctgctgtt tgcccagaag
     1081 tgtaaagaac tccaaggatt tatacctcct ctcacagacc tactcaatgg gctgaagatg
     1141 ggtcgttttg agagaggatt aagcagtttt cagcagagtg tggcaatgga caggatccag
     1201 cgtattgtag gtgttttgca gaagccacag atgggggaac gttacctagg aaccttgcta
     1261 caggtagaag ggatgttaaa gacttggttt ccacaaatag ctgcccagaa gtcatcattg
     1321 ggtggtggca agcatcagct gaccaagcat tttccaagcc accacagtga ttcagctgct
     1381 tcctctcctg catctcctat ggaaaagatg gaccagacac agctaggaca tctagcttta
     1441 aaaccaaagc agccttggca cctcacacaa tggccagcta tgaacctcac ctggatccac
     1501 accactccaa tttgcaaccc ccctctcagc tccccaggta ctatctcctt tagccatggt
     1561 cctttaggca ctggaaccgg cattggcgtc attcttttcc tccagcatgg agtgcaaccc
     1621 ttcacccact ctgccccaac caccccagtc ccacctacta cagcatctcc tgtcatccct
     1681 ggtgagccta tgaaactatc tggagagggt cctcgttgct acagtttgcc agtaactctg
     1741 ccatcagact ggagctatac cctatcccct cccagtctac ccaccttggc cagaaagatg
     1801 accataggac accgggagca gcagagaagc catcctccag ttgctgctga tgctcatctt
     1861 ctcaacctct agcccagggc atacagctgt ccactgtgac ttctaatttg tgtaaatatt
     1921 tatgtatata tgtattttta ctattaatgt gtgcatttgt gttgagggaa gataaatcct
     1981 ttctgattaa agaaattttt ttatacctaa a
//
