LOCUS       NM_020313               2021 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cytokine induced apoptosis inhibitor 1 (CIAPIN1),
            transcript variant 1, mRNA.
ACCESSION   NM_020313
VERSION     NM_020313.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2021)
  AUTHORS   Yuan,H., Zhong,M., Liu,J., Tang,S., Zhu,H., Wei,Q., Pu,B. and Li,Y.
  TITLE     Downregulation of CIAPIN1 regulates the proliferation, migration
            and glycolysis of breast cancer cells via inhibition of STAT3
            pathway
  JOURNAL   Sci Rep 14 (1), 20794 (2024)
   PUBMED   39242716
  REMARK    GeneRIF: Downregulation of CIAPIN1 regulates the proliferation,
            migration and glycolysis of breast cancer cells via inhibition of
            STAT3 pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2021)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2021)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2021)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2021)
  AUTHORS   Wang,J., Zhou,Y., Ma,L., Cao,S., Gao,W., Xiong,Q., Wang,K. and
            Yang,L.
  TITLE     CIAPIN1 Targeted NHE1 and ERK1/2 to Suppress NSCLC Cells'
            Metastasis and Predicted Good Prognosis in NSCLC Patients Receiving
            Pulmonectomy
  JOURNAL   Oxid Med Cell Longev 2019, 1970818 (2019)
   PUBMED   31093311
  REMARK    GeneRIF: NHE1 (Na+/H+ exchanger 1) expression and ERK1/2
            phosphorylation decreased along with CIAPIN1 upregulation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2021)
  AUTHORS   Hao,Z., Li,X., Qiao,T. and Fan,D.
  TITLE     Successful expression and purification of human CIAPIN1 in
            baculovirus-insect cell system and application of this system to
            investigation of its potential methyltransferase activity
  JOURNAL   Int J Biol Macromol 42 (1), 27-32 (2008)
   PUBMED   17935775
  REMARK    GeneRIF: CIAPIN1 might be a DNA or RNA methyltransferase.
REFERENCE   7  (bases 1 to 2021)
  AUTHORS   Hao,Z., Li,X., Qiao,T., Du,R., Zhang,G. and Fan,D.
  TITLE     Subcellular localization of CIAPIN1
  JOURNAL   J Histochem Cytochem 54 (12), 1437-1444 (2006)
   PUBMED   16957168
  REMARK    GeneRIF: CIAPIN1 was localized in both the cytoplasm and the
            nucleus and was accumulated in the nucleolus. Bioinformatic
            prediction disclosed a putative nuclear localization signal and a
            putative nuclear export signal within human CIAPIN1.
REFERENCE   8  (bases 1 to 2021)
  AUTHORS   Hao,Z., Li,X., Qiao,T., Du,R., Hong,L. and Fan,D.
  TITLE     CIAPIN1 confers multidrug resistance by upregulating the expression
            of MDR-1 and MRP-1 in gastric cancer cells
  JOURNAL   Cancer Biol Ther 5 (3), 261-266 (2006)
   PUBMED   16410721
  REMARK    GeneRIF: it is concluded that CIAPIN1 confers multidrug resistance
            in gastric cancer cells, likely by upregulating MDR-1 and MRP-1
REFERENCE   9  (bases 1 to 2021)
  AUTHORS   Shibayama,H., Takai,E., Matsumura,I., Kouno,M., Morii,E.,
            Kitamura,Y., Takeda,J. and Kanakura,Y.
  TITLE     Identification of a cytokine-induced antiapoptotic molecule
            anamorsin essential for definitive hematopoiesis
  JOURNAL   J Exp Med 199 (4), 581-592 (2004)
   PUBMED   14970183
REFERENCE   10 (bases 1 to 2021)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC024196.2, BC067303.1 and AF248964.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020313.3.
            
            Summary: CIAPIN1 is a cytokine-induced inhibitor of apoptosis with
            no relation to apoptosis regulatory molecules of the BCL2 (MIM
            151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is
            dependent on growth factor stimulation (Shibayama et al., 2004
            [PubMed 14970183]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1163755.1, AF248964.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394391.9/ ENSP00000377914.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-908               BC024196.2         25-932
            909-1660            BC067303.1         1052-1803
            1661-2021           AF248964.1         1708-2068
FEATURES             Location/Qualifiers
     source          1..2021
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..2021
                     /gene="CIAPIN1"
                     /gene_synonym="Anamorsin; CIAE2; DRE2; PRO0915"
                     /note="cytokine induced apoptosis inhibitor 1"
                     /db_xref="GeneID:57019"
                     /db_xref="HGNC:HGNC:28050"
                     /db_xref="MIM:608943"
     exon            1..44
                     /gene="CIAPIN1"
                     /gene_synonym="Anamorsin; CIAE2; DRE2; PRO0915"
                     /inference="alignment:Splign:2.1.0"
     exon            45..256
                     /gene="CIAPIN1"
                     /gene_synonym="Anamorsin; CIAE2; DRE2; PRO0915"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1038
                     /gene="CIAPIN1"
                     /gene_synonym="Anamorsin; CIAE2; DRE2; PRO0915"
                     /note="isoform 1 is encoded by transcript variant 1;
                     predicted protein of HQ0915; fe-S cluster assembly protein
                     DRE2 homolog"
                     /codon_start=1
                     /product="anamorsin isoform 1"
                     /protein_id="NP_064709.2"
                     /db_xref="CCDS:CCDS10781.2"
                     /db_xref="GeneID:57019"
                     /db_xref="HGNC:HGNC:28050"
                     /db_xref="MIM:608943"
                     /translation="MADFGISAGQFVAVVWDKSSPVEALKGLVDKLQALTGNEGRVSV
                     ENIKQLLQSAHKESSFDIILSGLVPGSTTLHSAEILAEIARILRPGGCLFLKEPVETA
                     VDNNSKVKTASKLCSALTLSGLVEVKELQREPLTPEEVQSVREHLGHESDNLLFVQIT
                     GKKPNFEVGSSRQLKLSITKKSSPSVKPAVDPAAAKLWTLSANDMEDDSMDLIDSDEL
                     LDPEDLKKPDPASLRAASCGEGKKRKACKNCTCGLAEELEKEKSREQMSSQPKSACGN
                     CYLGDAFRCASCPYLGMPAFKPGEKVLLSDSNLHDA"
     exon            257..409
                     /gene="CIAPIN1"
                     /gene_synonym="Anamorsin; CIAE2; DRE2; PRO0915"
                     /inference="alignment:Splign:2.1.0"
     exon            410..486
                     /gene="CIAPIN1"
                     /gene_synonym="Anamorsin; CIAE2; DRE2; PRO0915"
                     /inference="alignment:Splign:2.1.0"
     exon            487..655
                     /gene="CIAPIN1"
                     /gene_synonym="Anamorsin; CIAE2; DRE2; PRO0915"
                     /inference="alignment:Splign:2.1.0"
     exon            656..729
                     /gene="CIAPIN1"
                     /gene_synonym="Anamorsin; CIAE2; DRE2; PRO0915"
                     /inference="alignment:Splign:2.1.0"
     exon            730..845
                     /gene="CIAPIN1"
                     /gene_synonym="Anamorsin; CIAE2; DRE2; PRO0915"
                     /inference="alignment:Splign:2.1.0"
     exon            846..927
                     /gene="CIAPIN1"
                     /gene_synonym="Anamorsin; CIAE2; DRE2; PRO0915"
                     /inference="alignment:Splign:2.1.0"
     exon            928..2021
                     /gene="CIAPIN1"
                     /gene_synonym="Anamorsin; CIAE2; DRE2; PRO0915"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1634..1639
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIAPIN1"
                     /gene_synonym="Anamorsin; CIAE2; DRE2; PRO0915"
                     /note="hexamer: ATTAAA"
     polyA_site      1660
                     /gene="CIAPIN1"
                     /gene_synonym="Anamorsin; CIAE2; DRE2; PRO0915"
                     /note="major polyA site"
     regulatory      2002..2007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CIAPIN1"
                     /gene_synonym="Anamorsin; CIAE2; DRE2; PRO0915"
                     /note="hexamer: AATAAA"
     polyA_site      2021
                     /gene="CIAPIN1"
                     /gene_synonym="Anamorsin; CIAE2; DRE2; PRO0915"
                     /note="major polyA site"
ORIGIN      
        1 gagtcgacgg ctggagagaa gccgggagcg agcccaggcg gcagtcttga ttcccttttg
       61 gccagcagtt tttaggtctg tcagtactgc actgcaagaa tggcagattt tgggatctct
      121 gctggccagt ttgtggcagt ggtctgggat aagtcatccc cagtggaggc tctgaaaggt
      181 ctggtggata agcttcaagc gttaaccggc aatgagggcc gcgtgtctgt ggaaaacatc
      241 aagcagctgt tgcaatctgc ccacaaagaa tccagctttg acattatttt gtcaggttta
      301 gtcccaggaa gcaccactct gcacagtgct gagattttgg ctgaaatcgc ccggatcctt
      361 cggcctggtg gatgtctttt tctgaaggag ccagtagaga cagctgtaga taacaatagc
      421 aaagtgaaga cagcatctaa gctgtgttca gccctgactc tttctggtct tgtggaagtg
      481 aaagagctgc agcgggagcc cctaacccct gaggaagtac agtctgttcg agaacacctt
      541 ggtcatgaaa gtgacaacct gctgtttgtt cagatcacag gcaaaaaacc aaactttgaa
      601 gtgggttctt ctaggcagct taagctttcc atcaccaaga agtcttctcc ttcagtgaaa
      661 cctgctgtgg accctgctgc tgccaagctg tggaccctct cagccaacga tatggaggac
      721 gacagcatgg atctcattga ctcagatgag ctgctggatc cagaagattt gaagaagcca
      781 gatccagctt ccctgcgggc tgcttcttgt ggggaaggga aaaagaggaa ggcctgtaag
      841 aactgcacct gtggccttgc cgaagaactg gaaaaagaga agtcaaggga acagatgagc
      901 tcccaaccca agtcagcttg tggaaactgc tacctgggcg atgccttccg ctgtgccagc
      961 tgcccctacc ttgggatgcc agccttcaaa cctggggaaa aggtgcttct gagtgatagc
     1021 aatcttcatg atgcctagga ggttcctgac atgggaccca tctgctcctc cagccaactc
     1081 ctgtccctca catcccacca tggtggctcc tcccacctcc tctggatttg ttcactctga
     1141 gatctgtttg cagagtgggt gcttagcaga cagagtgaag ctggctgggg ggcacagtgg
     1201 tgtgtagtgc tgctgtgtat caaaagacca aggtattatg ggacctggtt tcagaatggg
     1261 atgggtttct tcacctcatg ttaagagaag ggagtgtgtc ctgaagaagc ccttcttctg
     1321 atgttaaaat gctgaccaga acgctcttga gcccaggcat cgttgagcat taacactctg
     1381 tgacagagct gcagacccct gccttgagtc tcatctcagc aatgctgcca ccctcttgtc
     1441 tttcagagtt gttagtttac tccattcttt gtgacacgag tcaagtggct cacaacctcc
     1501 tcagggcacc agaggactca ctcactggtt gctgtgatga tatccagtgt ccctctgccc
     1561 ccttccatcc ccaaccacat ttgactgtag cattgcatct gtgtcctgtt gtcatttatg
     1621 ttaaccttca ggtattaaac ttgctgcata tcttgacata tcttgagatt ctgcatgtct
     1681 tgtaaagaga ggggatgtgc atttgtgtgt gatgttggat agtcatccac gctcagtttg
     1741 gaccattgga ggaacttagt gtcacgcaca aatggggcta ttcctacgct tagaataggg
     1801 cttgtctgcc cactttagaa gagtccaggt tggtgagcat ttagagggaa gcagggcaga
     1861 actctgaacg acaatacgtc tctctgagca gagacccctt tgttcttgtt atccacccat
     1921 atggacttgg aatcaatctt gccaaatatt tggagagatt gtgtggattt aagagacctg
     1981 gatttttata ttttaccagt aaataaaagt tttcattgat a
//
