LOCUS       NP_064709                312 aa            linear   PRI 27-APR-2025
DEFINITION  anamorsin isoform 1 [Homo sapiens].
ACCESSION   NP_064709
VERSION     NP_064709.2
DBSOURCE    REFSEQ: accession NM_020313.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 312)
  AUTHORS   Yuan,H., Zhong,M., Liu,J., Tang,S., Zhu,H., Wei,Q., Pu,B. and Li,Y.
  TITLE     Downregulation of CIAPIN1 regulates the proliferation, migration
            and glycolysis of breast cancer cells via inhibition of STAT3
            pathway
  JOURNAL   Sci Rep 14 (1), 20794 (2024)
   PUBMED   39242716
  REMARK    GeneRIF: Downregulation of CIAPIN1 regulates the proliferation,
            migration and glycolysis of breast cancer cells via inhibition of
            STAT3 pathway.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 312)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (residues 1 to 312)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 312)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 312)
  AUTHORS   Wang,J., Zhou,Y., Ma,L., Cao,S., Gao,W., Xiong,Q., Wang,K. and
            Yang,L.
  TITLE     CIAPIN1 Targeted NHE1 and ERK1/2 to Suppress NSCLC Cells'
            Metastasis and Predicted Good Prognosis in NSCLC Patients Receiving
            Pulmonectomy
  JOURNAL   Oxid Med Cell Longev 2019, 1970818 (2019)
   PUBMED   31093311
  REMARK    GeneRIF: NHE1 (Na+/H+ exchanger 1) expression and ERK1/2
            phosphorylation decreased along with CIAPIN1 upregulation.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 312)
  AUTHORS   Hao,Z., Li,X., Qiao,T. and Fan,D.
  TITLE     Successful expression and purification of human CIAPIN1 in
            baculovirus-insect cell system and application of this system to
            investigation of its potential methyltransferase activity
  JOURNAL   Int J Biol Macromol 42 (1), 27-32 (2008)
   PUBMED   17935775
  REMARK    GeneRIF: CIAPIN1 might be a DNA or RNA methyltransferase.
REFERENCE   7  (residues 1 to 312)
  AUTHORS   Hao,Z., Li,X., Qiao,T., Du,R., Zhang,G. and Fan,D.
  TITLE     Subcellular localization of CIAPIN1
  JOURNAL   J Histochem Cytochem 54 (12), 1437-1444 (2006)
   PUBMED   16957168
  REMARK    GeneRIF: CIAPIN1 was localized in both the cytoplasm and the
            nucleus and was accumulated in the nucleolus. Bioinformatic
            prediction disclosed a putative nuclear localization signal and a
            putative nuclear export signal within human CIAPIN1.
REFERENCE   8  (residues 1 to 312)
  AUTHORS   Hao,Z., Li,X., Qiao,T., Du,R., Hong,L. and Fan,D.
  TITLE     CIAPIN1 confers multidrug resistance by upregulating the expression
            of MDR-1 and MRP-1 in gastric cancer cells
  JOURNAL   Cancer Biol Ther 5 (3), 261-266 (2006)
   PUBMED   16410721
  REMARK    GeneRIF: it is concluded that CIAPIN1 confers multidrug resistance
            in gastric cancer cells, likely by upregulating MDR-1 and MRP-1
REFERENCE   9  (residues 1 to 312)
  AUTHORS   Shibayama,H., Takai,E., Matsumura,I., Kouno,M., Morii,E.,
            Kitamura,Y., Takeda,J. and Kanakura,Y.
  TITLE     Identification of a cytokine-induced antiapoptotic molecule
            anamorsin essential for definitive hematopoiesis
  JOURNAL   J Exp Med 199 (4), 581-592 (2004)
   PUBMED   14970183
REFERENCE   10 (residues 1 to 312)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC024196.2, BC067303.1 and AF248964.1.
            
            On Mar 9, 2006 this sequence version replaced NP_064709.1.
            
            Summary: CIAPIN1 is a cytokine-induced inhibitor of apoptosis with
            no relation to apoptosis regulatory molecules of the BCL2 (MIM
            151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is
            dependent on growth factor stimulation (Shibayama et al., 2004
            [PubMed 14970183]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1163755.1, AF248964.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394391.9/ ENSP00000377914.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..312
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     Protein         1..312
                     /product="anamorsin isoform 1"
                     /note="predicted protein of HQ0915; fe-S cluster assembly
                     protein DRE2 homolog"
                     /calculated_mol_wt=33451
     Region          3..95
                     /region_name="Methyltransf_11"
                     /note="Methyltransferase domain; pfam08241"
                     /db_xref="CDD:462406"
     Region          6..172
                     /region_name="N-terminal SAM-like domain.
                     /evidence=ECO:0000255|HAMAP-Rule:MF_03115"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6FI81.2)"
     Site            136
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q6FI81.2)"
     Region          173..224
                     /region_name="Linker.
                     /evidence=ECO:0000255|HAMAP-Rule:MF_03115"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6FI81.2)"
     Site            177
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q6FI81.2)"
     Site            182
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19690332; propagated from
                     UniProtKB/Swiss-Prot (Q6FI81.2)"
     Site            183
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19690332,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q6FI81.2)"
     Site            215
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (Q6FI81.2)"
     Region          237..251
                     /region_name="Fe-S binding site A.
                     /evidence=ECO:0000255|HAMAP-Rule:MF_03115"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6FI81.2)"
     Region          240..304
                     /region_name="CIAPIN1"
                     /note="Cytokine-induced anti-apoptosis inhibitor 1, Fe-S
                     biogenesis; pfam05093"
                     /db_xref="CDD:398662"
     Site            272
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8WTY4; propagated from
                     UniProtKB/Swiss-Prot (Q6FI81.2)"
     Region          274..288
                     /region_name="Fe-S binding site B.
                     /evidence=ECO:0000255|HAMAP-Rule:MF_03115"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6FI81.2)"
     Region          274..277
                     /region_name="Cx2C motif 1.
                     /evidence=ECO:0000255|HAMAP-Rule:MF_03115"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6FI81.2)"
     Region          285..288
                     /region_name="Cx2C motif 2.
                     /evidence=ECO:0000255|HAMAP-Rule:MF_03115"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6FI81.2)"
     Site            305
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231,
                     ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (Q6FI81.2)"
     Site            307
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163;
                     propagated from UniProtKB/Swiss-Prot (Q6FI81.2)"
     CDS             1..312
                     /gene="CIAPIN1"
                     /gene_synonym="Anamorsin; CIAE2; DRE2; PRO0915"
                     /coded_by="NM_020313.4:100..1038"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS10781.2"
                     /db_xref="GeneID:57019"
                     /db_xref="HGNC:HGNC:28050"
                     /db_xref="MIM:608943"
ORIGIN      
        1 madfgisagq fvavvwdkss pvealkglvd klqaltgneg rvsvenikql lqsahkessf
       61 diilsglvpg sttlhsaeil aeiarilrpg gclflkepve tavdnnskvk tasklcsalt
      121 lsglvevkel qrepltpeev qsvrehlghe sdnllfvqit gkkpnfevgs srqlklsitk
      181 ksspsvkpav dpaaaklwtl sandmeddsm dlidsdelld pedlkkpdpa slraascgeg
      241 kkrkacknct cglaeeleke ksreqmssqp ksacgncylg dafrcascpy lgmpafkpge
      301 kvllsdsnlh da
//
