LOCUS       NM_001386928            3518 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens churchill domain containing 1 (CHURC1), transcript
            variant 2, mRNA.
ACCESSION   NM_001386928
VERSION     NM_001386928.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3518)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3518)
  AUTHORS   Griswold,A.J., Ma,D., Sacharow,S.J., Robinson,J.L., Jaworski,J.M.,
            Wright,H.H., Abramson,R.K., Lybaek,H., Oyen,N., Cuccaro,M.L.,
            Gilbert,J.R. and Pericak-Vance,M.A.
  TITLE     A de novo 1.5 Mb microdeletion on chromosome 14q23.2-23.3 in a
            patient with autism and spherocytosis
  JOURNAL   Autism Res 4 (3), 221-227 (2011)
   PUBMED   21360829
  REMARK    GeneRIF: This is the first implication of chr14q23.2-23.3 in the
            etiology of autism and points to MTHFD1, PLEKHG3, and CHURC1 as
            potential candidate genes contributing to autism risk.
REFERENCE   3  (bases 1 to 3518)
  AUTHORS   Lee,B.M., Buck-Koehntop,B.A., Martinez-Yamout,M.A., Dyson,H.J. and
            Wright,P.E.
  TITLE     Embryonic neural inducing factor churchill is not a DNA-binding
            zinc finger protein: solution structure reveals a solvent-exposed
            beta-sheet and zinc binuclear cluster
  JOURNAL   J Mol Biol 371 (5), 1274-1289 (2007)
   PUBMED   17610897
  REMARK    GeneRIF: Embryonic neural inducing factor churchill is not a
            DNA-binding zinc finger protein: solution structure reveals a
            solvent-exposed beta-sheet and zinc binuclear cluster
REFERENCE   4  (bases 1 to 3518)
  AUTHORS   Sheng,G., dos Reis,M. and Stern,C.D.
  TITLE     Churchill, a zinc finger transcriptional activator, regulates the
            transition between gastrulation and neurulation
  JOURNAL   Cell 115 (5), 603-613 (2003)
   PUBMED   14651851
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL135745.5 and AL139022.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.64589.1,
                                           SRR14038193.1661812.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000549115.7/ ENSP00000448050.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AL135745.5         3982-4061           c
            81-216              AL139022.4         182057-182192       c
            217-287             AL139022.4         180103-180173       c
            288-3518            AL139022.4         170815-174045       c
FEATURES             Location/Qualifiers
     source          1..3518
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.3"
     gene            1..3518
                     /gene="CHURC1"
                     /gene_synonym="C14orf52; chch; My015"
                     /note="churchill domain containing 1"
                     /db_xref="GeneID:91612"
                     /db_xref="HGNC:HGNC:20099"
                     /db_xref="MIM:608577"
     exon            1..80
                     /gene="CHURC1"
                     /gene_synonym="C14orf52; chch; My015"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..380
                     /gene="CHURC1"
                     /gene_synonym="C14orf52; chch; My015"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein Churchill"
                     /codon_start=1
                     /product="protein Churchill isoform 2"
                     /protein_id="NP_001373857.1"
                     /db_xref="CCDS:CCDS55921.2"
                     /db_xref="GeneID:91612"
                     /db_xref="HGNC:HGNC:20099"
                     /db_xref="MIM:608577"
                     /translation="MCGDCVEKEYPNRGNTCLENGSFLLNFTGCAVCSKRDFMLITNK
                     SLKEEDGEEIVTYDHLCKNCHHVIARHEYTFSIMDEFQEYTMLCLLCGKAEDTISILP
                     DDPRQMTLLF"
     exon            81..216
                     /gene="CHURC1"
                     /gene_synonym="C14orf52; chch; My015"
                     /inference="alignment:Splign:2.1.0"
     exon            217..287
                     /gene="CHURC1"
                     /gene_synonym="C14orf52; chch; My015"
                     /inference="alignment:Splign:2.1.0"
     exon            288..3518
                     /gene="CHURC1"
                     /gene_synonym="C14orf52; chch; My015"
                     /inference="alignment:Splign:2.1.0"
     regulatory      425..430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHURC1"
                     /gene_synonym="C14orf52; chch; My015"
                     /note="hexamer: AATACA"
     polyA_site      470
                     /gene="CHURC1"
                     /gene_synonym="C14orf52; chch; My015"
                     /note="major polyA site"
     polyA_site      3142
                     /gene="CHURC1"
                     /gene_synonym="C14orf52; chch; My015"
                     /note="major polyA site"
     regulatory      3493..3498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHURC1"
                     /gene_synonym="C14orf52; chch; My015"
                     /note="hexamer: AATAAA"
     polyA_site      3518
                     /gene="CHURC1"
                     /gene_synonym="C14orf52; chch; My015"
ORIGIN      
        1 cccggaagcg ttggaggaca ttccctgttg actgcgtcgc gatgtgtggc gactgtgtgg
       61 agaaggaata tcccaaccgg ggtaatacct gcctggagaa tggatctttc ttactgaact
      121 ttacaggctg tgcagtgtgc agtaagcggg attttatgct gatcacaaac aaatccttga
      181 aagaagaaga tggagaagaa atagttacct atgatcattt gtgtaagaat tgtcatcatg
      241 taatagccag acatgagtat acattcagta tcatggatga atttcaggag tataccatgc
      301 tgtgtctgtt atgcggcaaa gccgaagata ctatcagtat tctccctgat gacccccgac
      361 aaatgactct cttattctaa ggatccttct acagatctgt tataactata ttgtgttggt
      421 ttacaataca gcaagcctga tggtttgtct tatttcattc atactgaaaa ttctttgcat
      481 attttttttc tgcttagact tacttattct ttgaggaaaa aaggtaatgt aggagctcat
      541 tgttctctag agctgagctc ttctgctaaa gttcaaagtt cacatcagtg tagccagagt
      601 gaagcatctt tgttagcagt tatgtggtca gaaaacaact agaatgggag cacacctggt
      661 gcccagattt tggtttccaa taaaaggaac caggactcct tagaaaatga actgattcta
      721 gaactgggat atgaactgta caagatgagc ctagagtatc ttgtgccaca gaaaaatgaa
      781 gtactgaaat taaaaaaaaa aaatcatagt gattgggagt atgtcagcat gatcgaactg
      841 aaggatctct gaaaggccac agctggagca atttgagtaa caaaataaag tagtattggg
      901 ttataaccca aactatataa taaatattta caagcccaaa ctaatataaa tgattgaatg
      961 ggaacaaatc tcttgtgcag aagaatttca aataatttat gtagatactc cccacttagt
     1021 gggctctgca tagtgacttc cttgcagagt ataatatgga aaggggggaa aagagtaact
     1081 ttacagtgga gaaatctgac agacaccagc tcagccaggt gattgaggtt aacatcatcc
     1141 atgataagcc cttttgatag catgtatcct tgatagcatc acatcataca gaatgtgata
     1201 agaatggcac tttacctctg tggtcctcct ccccagaact cagaacccaa gtctgatcag
     1261 gagaaaaaca tcacacaaat tccaattgag aagcattctt taaaatacct aaccagtact
     1321 tctcaaaact atcaaggcca taaaaaacaa ggaaaatctg agacatggtc acagccaaga
     1381 ggagcctgag aagacatgac tgctagatgt aatgtggtat cctacatgga attatatacc
     1441 acgaaaagaa aaaaaggtca tttggtagaa actagggaaa tctgaataca gtgtggactt
     1501 cagttaatat aaatgagaaa atggtttcat tggctttaaa gggattttag aatatcttac
     1561 tttgcatagt ttcatgagca ctggccagga ggttataaac tggcatttag gcctctctgc
     1621 catttagtag cagtatagtc attaagcaaa gcattactct ggactttatt gtcctgtttc
     1681 tatcaaattg gactaacaaa aattgatata atacattcat cacagtattg ttaggagatt
     1741 taaatgaatt agtgaatgta agatacttta gaaagcatgt aaagtactag aaacaatgag
     1801 gtggcttcaa ttagtgctca ttctgagacc taaatttaaa gggtcaggca ttagaaacaa
     1861 aagtgtttct tcatatctag gagatttgga aattctgaac taaggtctta taagaacaag
     1921 aaatgagcaa agtgttcatt gtagatacta gggaaaagct ttgttgaata acagtaatga
     1981 tgataatatc tgagctttat taagtactta ctacatgcta agagcttttt aagcacttat
     2041 ttaatcctca ttaacaaatt cataaggtag gtgctattga tagtttagcc ataaccagat
     2101 atggcttgtt atttgtaagt tatcatgaaa aggtttatat tcactattct ttatttcagt
     2161 gtagcacttt tagagccaaa aaaactcagg cacaaagaag ttaaataact tgccgggtgc
     2221 ggtggctcac ccctgtaatc ccagcacttt gggaggccaa agcaggcgga tcacctgagg
     2281 tcaggagttt gagaccagcc gggccaacat ggtgcaacct cgtctttact aaaaatacaa
     2341 aaacaaaaat tagccagggg tggtggtatg cacctgcagt cccagcaaca tgggaggctg
     2401 aacaggagaa tcgcttgaac ccgcgacagg gaggttgtga tgagccaagg tcatgccact
     2461 gcactccagc ctgggagaca gagcaagact ccatctcaaa aacaaaaaca aaacaaaaca
     2521 acaacaaaaa aagaagttaa ataacttgtt taagatcaca cagctagtgc agttaccccc
     2581 tctcagtaat tatgtttggc aaatatgaaa tacaaggatc tggcaaggtt aggaagaggt
     2641 taagaatatc agtgacagta ctctgaggca tctgggcatg tcagatgaag atttattatt
     2701 cagaaaagtt aagtcagctg ttgcagggat cagttgtttt attcctggaa aatgtttttc
     2761 attttgctgc aaatctatat ctgacctgct gaggaaatcg tttggtgaaa tgaatccaga
     2821 aagcagagaa aatgcttcat tactttaaat agcagcatta agcccattat agcctctgaa
     2881 ttgtcccttc cttgagtttg ctaatgcttc caacttagtc atttgaagcc caagagtcta
     2941 attttatatg ccctgccaat gtcctcatct attgcagaat gtataattat ctatttgttt
     3001 tggactatat gttacaaaaa tttaaaacat aagatcctct ctctatattt cattattggt
     3061 gaacccacat tgtgctgtgt tttgtgatat tttatcattt tctagattct tatgtggatc
     3121 taataacgac cacttgaacc cagtttcaca gaatccttat ttttctgttc aaattaggaa
     3181 ttagggacat ggatgaaatt ggaaatcttc attctcagta aactatcgca aggacaaaaa
     3241 accaaacacc acatgttctc actcatagat aggaattgaa caatgagaac acatggagac
     3301 aggaagggga acatcacact ctagggactg ttgtggggtg aggggagggg tgagggatag
     3361 cattaggaga tatacctgat gctaaatgac gagttagtgg gtgcagcaca ccagcatggc
     3421 acatgtatac gtatgtaact aacctgcaca tcgtgcacat gtaccctaaa acttaaagta
     3481 taataataat aaaataaaaa aaaaggaatt aggcaaaa
//
