LOCUS       NM_001202559            2894 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens CHURC1-FNTB readthrough (CHURC1-FNTB), transcript
            variant 1, mRNA.
ACCESSION   NM_001202559
VERSION     NM_001202559.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2894)
  AUTHORS   Evans,D.M., Zhu,G., Dy,V., Heath,A.C., Madden,P.A., Kemp,J.P.,
            McMahon,G., St Pourcain,B., Timpson,N.J., Golding,J., Lawlor,D.A.,
            Steer,C., Montgomery,G.W., Martin,N.G., Smith,G.D. and
            Whitfield,J.B.
  TITLE     Genome-wide association study identifies loci affecting blood
            copper, selenium and zinc
  JOURNAL   Hum Mol Genet 22 (19), 3998-4006 (2013)
   PUBMED   23720494
REFERENCE   2  (bases 1 to 2894)
  AUTHORS   van der Harst,P., Zhang,W., Mateo Leach,I., Rendon,A., Verweij,N.,
            Sehmi,J., Paul,D.S., Elling,U., Allayee,H., Li,X.,
            Radhakrishnan,A., Tan,S.T., Voss,K., Weichenberger,C.X.,
            Albers,C.A., Al-Hussani,A., Asselbergs,F.W., Ciullo,M., Danjou,F.,
            Dina,C., Esko,T., Evans,D.M., Franke,L., Gogele,M., Hartiala,J.,
            Hersch,M., Holm,H., Hottenga,J.J., Kanoni,S., Kleber,M.E.,
            Lagou,V., Langenberg,C., Lopez,L.M., Lyytikainen,L.P., Melander,O.,
            Murgia,F., Nolte,I.M., O'Reilly,P.F., Padmanabhan,S., Parsa,A.,
            Pirastu,N., Porcu,E., Portas,L., Prokopenko,I., Ried,J.S.,
            Shin,S.Y., Tang,C.S., Teumer,A., Traglia,M., Ulivi,S., Westra,H.J.,
            Yang,J., Zhao,J.H., Anni,F., Abdellaoui,A., Attwood,A., Balkau,B.,
            Bandinelli,S., Bastardot,F., Benyamin,B., Boehm,B.O., Cookson,W.O.,
            Das,D., de Bakker,P.I., de Boer,R.A., de Geus,E.J., de Moor,M.H.,
            Dimitriou,M., Domingues,F.S., Doring,A., Engstrom,G.,
            Eyjolfsson,G.I., Ferrucci,L., Fischer,K., Galanello,R.,
            Garner,S.F., Genser,B., Gibson,Q.D., Girotto,G., Gudbjartsson,D.F.,
            Harris,S.E., Hartikainen,A.L., Hastie,C.E., Hedblad,B., Illig,T.,
            Jolley,J., Kahonen,M., Kema,I.P., Kemp,J.P., Liang,L.,
            Lloyd-Jones,H., Loos,R.J., Meacham,S., Medland,S.E., Meisinger,C.,
            Memari,Y., Mihailov,E., Miller,K., Moffatt,M.F., Nauck,M.,
            Novatchkova,M., Nutile,T., Olafsson,I., Onundarson,P.T.,
            Parracciani,D., Penninx,B.W., Perseu,L., Piga,A., Pistis,G.,
            Pouta,A., Puc,U., Raitakari,O., Ring,S.M., Robino,A., Ruggiero,D.,
            Ruokonen,A., Saint-Pierre,A., Sala,C., Salumets,A., Sambrook,J.,
            Schepers,H., Schmidt,C.O., Sillje,H.H., Sladek,R., Smit,J.H.,
            Starr,J.M., Stephens,J., Sulem,P., Tanaka,T., Thorsteinsdottir,U.,
            Tragante,V., van Gilst,W.H., van Pelt,L.J., van Veldhuisen,D.J.,
            Volker,U., Whitfield,J.B., Willemsen,G., Winkelmann,B.R.,
            Wirnsberger,G., Algra,A., Cucca,F., d'Adamo,A.P., Danesh,J.,
            Deary,I.J., Dominiczak,A.F., Elliott,P., Fortina,P., Froguel,P.,
            Gasparini,P., Greinacher,A., Hazen,S.L., Jarvelin,M.R., Khaw,K.T.,
            Lehtimaki,T., Maerz,W., Martin,N.G., Metspalu,A., Mitchell,B.D.,
            Montgomery,G.W., Moore,C., Navis,G., Pirastu,M., Pramstaller,P.P.,
            Ramirez-Solis,R., Schadt,E., Scott,J., Shuldiner,A.R., Smith,G.D.,
            Smith,J.G., Snieder,H., Sorice,R., Spector,T.D., Stefansson,K.,
            Stumvoll,M., Tang,W.H., Toniolo,D., Tonjes,A., Visscher,P.M.,
            Vollenweider,P., Wareham,N.J., Wolffenbuttel,B.H., Boomsma,D.I.,
            Beckmann,J.S., Dedoussis,G.V., Deloukas,P., Ferreira,M.A.,
            Sanna,S., Uda,M., Hicks,A.A., Penninger,J.M., Gieger,C.,
            Kooner,J.S., Ouwehand,W.H., Soranzo,N. and Chambers,J.C.
  TITLE     Seventy-five genetic loci influencing the human red blood cell
  JOURNAL   Nature 492 (7429), 369-375 (2012)
   PUBMED   23222517
REFERENCE   3  (bases 1 to 2894)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2894)
  AUTHORS   Ganesh,S.K., Zakai,N.A., van Rooij,F.J., Soranzo,N., Smith,A.V.,
            Nalls,M.A., Chen,M.H., Kottgen,A., Glazer,N.L., Dehghan,A.,
            Kuhnel,B., Aspelund,T., Yang,Q., Tanaka,T., Jaffe,A., Bis,J.C.,
            Verwoert,G.C., Teumer,A., Fox,C.S., Guralnik,J.M., Ehret,G.B.,
            Rice,K., Felix,J.F., Rendon,A., Eiriksdottir,G., Levy,D.,
            Patel,K.V., Boerwinkle,E., Rotter,J.I., Hofman,A., Sambrook,J.G.,
            Hernandez,D.G., Zheng,G., Bandinelli,S., Singleton,A.B., Coresh,J.,
            Lumley,T., Uitterlinden,A.G., Vangils,J.M., Launer,L.J.,
            Cupples,L.A., Oostra,B.A., Zwaginga,J.J., Ouwehand,W.H.,
            Thein,S.L., Meisinger,C., Deloukas,P., Nauck,M., Spector,T.D.,
            Gieger,C., Gudnason,V., van Duijn,C.M., Psaty,B.M., Ferrucci,L.,
            Chakravarti,A., Greinacher,A., O'Donnell,C.J., Witteman,J.C.,
            Furth,S., Cushman,M., Harris,T.B. and Lin,J.P.
  TITLE     Multiple loci influence erythrocyte phenotypes in the CHARGE
            Consortium
  JOURNAL   Nat Genet 41 (11), 1191-1198 (2009)
   PUBMED   19862010
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL135745.5, AK296850.1 and AL139022.4.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring CHURC1 (churchill domain
            containing 1) and FNTB (farnesyltransferase, CAAX box, beta) on
            chromosome 14. The read-through transcript produces a fusion
            protein that shares sequence identity with each individual gene
            product. [provided by RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.69836.1,
                                           SRR1803615.32110.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 2342, 91612
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AL135745.5         4024-4155           c
            133-1600            AK296850.1         1-1468
            1601-2894           AL139022.4         43528-44821         c
FEATURES             Location/Qualifiers
     source          1..2894
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.3"
     gene            1..2894
                     /gene="CHURC1-FNTB"
                     /gene_synonym="FNTB; FTase-beta"
                     /note="CHURC1-FNTB readthrough"
                     /db_xref="GeneID:100529261"
                     /db_xref="HGNC:HGNC:42960"
     exon            1..174
                     /gene="CHURC1-FNTB"
                     /gene_synonym="FNTB; FTase-beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1551
                     /gene="CHURC1-FNTB"
                     /gene_synonym="FNTB; FTase-beta"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Protein farnesyltransferase subunit beta; CAAX
                     farnesyltransferase subunit beta; Ras proteins
                     prenyltransferase subunit beta"
                     /codon_start=1
                     /product="CHURC1-FNTB protein isoform 1"
                     /protein_id="NP_001189488.1"
                     /db_xref="GeneID:100529261"
                     /db_xref="HGNC:HGNC:42960"
                     /translation="MRQPYLSSREVSSSRKRWRTFPVDCVAMCGDCVEKEYPNRGNTC
                     LENGSFLLNFTGCAVCSKRDFMLITNKSLKEEDGEEIVTYDHLCKNCHHVIARHEYTF
                     SIMDEFQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDAS
                     RPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAV
                     NALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTN
                     IITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKRERSLNLKSL
                     LQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFH
                     QQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVLGV
                     PENALQPTHPVYNIGPDKVIQATTYFLQKPVPGFEELKDETSAEPATD"
     exon            175..310
                     /gene="CHURC1-FNTB"
                     /gene_synonym="FNTB; FTase-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            311..381
                     /gene="CHURC1-FNTB"
                     /gene_synonym="FNTB; FTase-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            382..446
                     /gene="CHURC1-FNTB"
                     /gene_synonym="FNTB; FTase-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            447..519
                     /gene="CHURC1-FNTB"
                     /gene_synonym="FNTB; FTase-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            520..611
                     /gene="CHURC1-FNTB"
                     /gene_synonym="FNTB; FTase-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            612..758
                     /gene="CHURC1-FNTB"
                     /gene_synonym="FNTB; FTase-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            759..842
                     /gene="CHURC1-FNTB"
                     /gene_synonym="FNTB; FTase-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            843..929
                     /gene="CHURC1-FNTB"
                     /gene_synonym="FNTB; FTase-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1059
                     /gene="CHURC1-FNTB"
                     /gene_synonym="FNTB; FTase-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1192
                     /gene="CHURC1-FNTB"
                     /gene_synonym="FNTB; FTase-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1304
                     /gene="CHURC1-FNTB"
                     /gene_synonym="FNTB; FTase-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1419
                     /gene="CHURC1-FNTB"
                     /gene_synonym="FNTB; FTase-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..2894
                     /gene="CHURC1-FNTB"
                     /gene_synonym="FNTB; FTase-beta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2870..2875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHURC1-FNTB"
                     /gene_synonym="FNTB; FTase-beta"
                     /note="hexamer: AATAAA"
     polyA_site      2889
                     /gene="CHURC1-FNTB"
                     /gene_synonym="FNTB; FTase-beta"
                     /note="major polyA site"
ORIGIN      
        1 agacttcggc tcggttcccg agacggaata cccaggagtc gagtacttgg gcgcatgcgg
       61 caaccgtatc tcagttctcg cgaggtttcg tcttcccgga agcgttggag gacattccct
      121 gttgactgcg tcgcgatgtg tggcgactgt gtggagaagg aatatcccaa ccggggtaat
      181 acctgcctgg agaatggatc tttcttactg aactttacag gctgtgcagt gtgcagtaag
      241 cgggatttta tgctgatcac aaacaaatcc ttgaaagaag aagatggaga agaaatagtt
      301 acctatgatc atttgtgtaa gaattgtcat catgtaatag ccagacatga gtatacattc
      361 agtatcatgg atgaatttca ggcaaaagta gaagaaaaga tccaagaggt cttcagttct
      421 tacaagttca accaccttgt accaaggctt gttttgcaga gggagaagca cttccattat
      481 ctgaaaagag gccttcgaca actgacagat gcctatgagt gtctggatgc cagccgccca
      541 tggctctgct attggatcct gcacagcttg gaactgctag atgaacccat cccccagata
      601 gtggctacag atgtgtgtca gttcctggag ctgtgtcaga gcccagaagg tggctttgga
      661 ggaggacccg gtcagtatcc acaccttgca cccacatatg cagcagtcaa tgcattgtgc
      721 atcattggca ccgaggaggc ctatgacatc attaacagag agaagcttct tcagtatttg
      781 tactccctga agcaacctga cggctccttt ctcatgcatg tcggaggtga ggtggatgtg
      841 agaagcgcat actgtgctgc ctccgtagcc tcgctgacca acatcatcac tccagacctc
      901 tttgagggca ctgctgaatg gatagcaagg tgtcagaact gggaaggtgg cattggcggg
      961 gtaccaggga tggaagccca tggtggctat accttctgtg gcctggccgc gctggtaatc
     1021 ctcaagaggg aacgttcctt gaacttgaag agcttattac aatgggtgac aagccggcag
     1081 atgcgatttg aaggaggatt tcagggccgc tgcaacaagc tggtggatgg ctgctactcc
     1141 ttctggcagg cggggctcct gcccctgctc caccgcgcac tgcacgccca aggtgaccct
     1201 gcccttagca tgagccactg gatgttccat cagcaggccc tgcaggagta catcctgatg
     1261 tgctgccagt gccctgcggg ggggcttctg gataaacctg gcaagtcgcg tgatttctac
     1321 cacacctgct actgcctgag cggcctgtcc atagcccagc acttcggcag cggagccatg
     1381 ttgcatgatg tggtcctggg tgtgcccgaa aacgctctgc agcccactca cccagtgtac
     1441 aacattggac cagacaaggt gatccaggcc actacatact ttctacagaa gccagtccca
     1501 ggttttgagg agcttaagga tgagacatcg gcagagcctg caaccgacta gaggacctgg
     1561 gtcccggcag ctctttgctc acccatctcc ccagtcagac aaggtttata cgtttcaata
     1621 catactgcat tctgtgctac acaagcctta gcctcagtgg agctgtggtt ctcttggtac
     1681 tttcttgtca aacaaaacca atggctctgg gtttggagaa cacagtggct ggttttaaaa
     1741 attctttcca cacctgtcaa accaaaaatc tatcagccca cgtggtgtgg ttggtgaaca
     1801 gtgcatgcca ggaggaagca gtccctcctc accagctctc cagccaggac gatcacacag
     1861 agatgaatgg catctgagta ttacggcatc cagagccact gctgactccc acttgcacgc
     1921 caccattcag tcaccagact gggtgccctc cgatgggtgg aataagtctg cttcatgcca
     1981 aggctgggct ttgggtccca ccaagatgag ttctctgtaa gactgtggtg gagttgcacc
     2041 aggaggtgcc tctgcctctc gacttgcacc ctggtcattt gtaagggaaa agagctggag
     2101 gtggggagag aaagatctcc ttcagttggg agtccttcca cttcaacact ggagaactga
     2161 gccttgcatc tctccagggt ccaaggccac gcttggtgca caggcaagac ttgcttcagc
     2221 cccaggtgtg gtgacttaga cctaggaaac caattatgag tggaaagtga ccctctagtt
     2281 caactgtgcc agaggaaaca gccctccagt gcccacctgc ctcactcctc cctatcatgt
     2341 accgtgaaaa ccccctctga tggcctcaag gcagtgcctg caggccgagg cccttctggg
     2401 ggtttctatc tttcttccac cagactccaa gcccactctc ctccaagact gtgttgtctt
     2461 ttctcaccaa gagtattaac actactaagt ctttcacctt aacttatgac tcaggattta
     2521 ttcacgtcct gcccactcta ggctcacagg aataaaatca agtgctagac acactggctg
     2581 ctactaaggc actagcctct gtagctggtg gtggcagcgt ggggtgccgc ccagcgtgct
     2641 gggtcctggc agtgcctctg ctgtgctgca cattgagccc tttctcagtc agtggagtat
     2701 caagttgggc catctgtcta ctgacctggc cttcatgtaa gcagctgtgg gctgcgggca
     2761 gacaggagct cagagatgca gcatgaggcg cttagaaaaa cctggccatt tgctgcctct
     2821 aattcccttt tgctttgcca tattgggcta tgtattacct ccttgaaata ataaaagaat
     2881 aacattttct atga
//
