LOCUS       NM_015607               2079 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens chromatin target of PRMT1 (CHTOP), transcript variant
            1, mRNA.
ACCESSION   NM_015607
VERSION     NM_015607.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2079)
  AUTHORS   Maron,M.I., Casill,A.D., Gupta,V., Roth,J.S., Sidoli,S.,
            Query,C.C., Gamble,M.J. and Shechter,D.
  TITLE     Type I and II PRMTs inversely regulate post-transcriptional intron
            detention through Sm and CHTOP methylation
  JOURNAL   Elife 11, e72867 (2022)
   PUBMED   34984976
  REMARK    GeneRIF: Type I and II PRMTs inversely regulate
            post-transcriptional intron detention through Sm and CHTOP
            methylation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2079)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2079)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 2079)
  AUTHORS   Syed,F., Tersey,S.A., Turatsinze,J.V., Felton,J.L., Kang,N.J.,
            Nelson,J.B., Sims,E.K., Defrance,M., Bizet,M., Fuks,F., Cnop,M.,
            Bugliani,M., Marchetti,P., Ziegler,A.G., Bonifacio,E.,
            Webb-Robertson,B.J., Balamurugan,A.N., Evans-Molina,C.,
            Eizirik,D.L., Mather,K.J., Arslanian,S. and Mirmira,R.G.
  TITLE     Circulating unmethylated CHTOP and INS DNA fragments provide
            evidence of possible islet cell death in youth with obesity and
            diabetes
  JOURNAL   Clin Epigenetics 12 (1), 116 (2020)
   PUBMED   32736653
  REMARK    GeneRIF: Circulating unmethylated CHTOP and INS DNA fragments
            provide evidence of possible islet cell death in youth with obesity
            and diabetes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2079)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2079)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 2079)
  AUTHORS   van Dijk,T.B., Gillemans,N., Pourfarzad,F., van Lom,K., von
            Lindern,M., Grosveld,F. and Philipsen,S.
  TITLE     Fetal globin expression is regulated by Friend of Prmt1
  JOURNAL   Blood 116 (20), 4349-4352 (2010)
   PUBMED   20688955
  REMARK    GeneRIF: The recently identified chromatin factor Friend of Prmt1
            (FOP) is a critical modulator of gamma-globin gene expression.
REFERENCE   8  (bases 1 to 2079)
  AUTHORS   van Dijk,T.B., Gillemans,N., Stein,C., Fanis,P., Demmers,J., van de
            Corput,M., Essers,J., Grosveld,F., Bauer,U.M. and Philipsen,S.
  TITLE     Friend of Prmt1, a novel chromatin target of protein arginine
            methyltransferases
  JOURNAL   Mol Cell Biol 30 (1), 260-272 (2010)
   PUBMED   19858291
  REMARK    GeneRIF: Fop is tightly associated with chromatin, and that it is
            modified by both asymmetric and symmetric arginine methylation in
            vivo. Fop plays an important role in the ligand-dependent
            activation of estrogen receptor target genes, including TFF1 (pS2).
REFERENCE   9  (bases 1 to 2079)
  AUTHORS   Zullo,A.J., Michaud,M., Zhang,W. and Grusby,M.J.
  TITLE     Identification of the small protein rich in arginine and glycine
            (SRAG): a newly identified nucleolar protein that can regulate cell
            proliferation
  JOURNAL   J Biol Chem 284 (18), 12504-12511 (2009)
   PUBMED   19254951
  REMARK    GeneRIF: The reduction in SRAG protein that occurs in proliferating
            cells was mapped with inhibitors to the G(2)/M phase of the cell
            cycle. As expected, the overexpression of SRAG reduced the
            percentage of cells in the G(2)/M phase and increased cell death.
REFERENCE   10 (bases 1 to 2079)
  AUTHORS   Lehner,B., Semple,J.I., Brown,S.E., Counsell,D., Campbell,R.D. and
            Sanderson,C.M.
  TITLE     Analysis of a high-throughput yeast two-hybrid system and its use
            to predict the function of intracellular proteins encoded within
            the human MHC class III region
  JOURNAL   Genomics 83 (1), 153-167 (2004)
   PUBMED   14667819
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF261137.1, BC108721.1 and
            AI929184.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_015607.3.
            
            Summary: This gene encodes a small nuclear protein that is
            characterized by an arginine and glycine rich region. This protein
            may have an important role in the regulation of fetal globin gene
            expression and in the activation of estrogen-responsive genes. A
            recent study reported that this protein binds
            5-hydroxymethylcytosine (5hmC) and associates with an arginine
            methyltransferase complex (methylosome), which promotes methylation
            of arginine 3 of histone H4 (H4R3) and activation of genes involved
            in glioblastomagenesis. Alternatively spliced transcript variants
            encoding different isoforms have been described for this gene.
            [provided by RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1056163.1,
                                           SRR1803611.120178.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368694.8/ ENSP00000357683.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1276              AF261137.1         18-1293
            1277-2062           BC108721.1         999-1784
            2063-2079           AI929184.1         10-26               c
FEATURES             Location/Qualifiers
     source          1..2079
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..2079
                     /gene="CHTOP"
                     /gene_synonym="C10orf77; C1orf77; FL-SRAG; FOP; pp7704;
                     SRAG; SRAG-3; SRAG-5"
                     /note="chromatin target of PRMT1"
                     /db_xref="GeneID:26097"
                     /db_xref="HGNC:HGNC:24511"
                     /db_xref="MIM:614206"
     exon            1..278
                     /gene="CHTOP"
                     /gene_synonym="C10orf77; C1orf77; FL-SRAG; FOP; pp7704;
                     SRAG; SRAG-3; SRAG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            279..360
                     /gene="CHTOP"
                     /gene_synonym="C10orf77; C1orf77; FL-SRAG; FOP; pp7704;
                     SRAG; SRAG-3; SRAG-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..1042
                     /gene="CHTOP"
                     /gene_synonym="C10orf77; C1orf77; FL-SRAG; FOP; pp7704;
                     SRAG; SRAG-3; SRAG-5"
                     /note="isoform 1 is encoded by transcript variant 1; small
                     protein rich in arginine and glycine; friend of PRMT1
                     protein"
                     /codon_start=1
                     /product="chromatin target of PRMT1 protein isoform 1"
                     /protein_id="NP_056422.2"
                     /db_xref="CCDS:CCDS1048.1"
                     /db_xref="GeneID:26097"
                     /db_xref="HGNC:HGNC:24511"
                     /db_xref="MIM:614206"
                     /translation="MAAQSAPKVVLKSTTKMSLNERFTNMLKNKQPTPVNIRASMQQQ
                     QQLASARNRRLAQQMENRPSVQAALKLKQSLKQRLGKSNIQARLGRPIGALARGAIGG
                     RGLPIIQRGLPRGGLRGGRATRTLLRGGMSLRGQNLLRGGRAVAPRMGLRRGGVRGRG
                     GPGRGGLGRGAMGRGGIGGRGRGMIGRGRGGFGGRGRGRGRGRGALARPVLTKEQLDN
                     QLDAYMSKTKGHLDAELDAYMAQTDPETND"
     exon            361..514
                     /gene="CHTOP"
                     /gene_synonym="C10orf77; C1orf77; FL-SRAG; FOP; pp7704;
                     SRAG; SRAG-3; SRAG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            515..698
                     /gene="CHTOP"
                     /gene_synonym="C10orf77; C1orf77; FL-SRAG; FOP; pp7704;
                     SRAG; SRAG-3; SRAG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            699..836
                     /gene="CHTOP"
                     /gene_synonym="C10orf77; C1orf77; FL-SRAG; FOP; pp7704;
                     SRAG; SRAG-3; SRAG-5"
                     /inference="alignment:Splign:2.1.0"
     exon            837..2079
                     /gene="CHTOP"
                     /gene_synonym="C10orf77; C1orf77; FL-SRAG; FOP; pp7704;
                     SRAG; SRAG-3; SRAG-5"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1244
                     /gene="CHTOP"
                     /gene_synonym="C10orf77; C1orf77; FL-SRAG; FOP; pp7704;
                     SRAG; SRAG-3; SRAG-5"
                     /note="major polyA site"
     regulatory      2057..2062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHTOP"
                     /gene_synonym="C10orf77; C1orf77; FL-SRAG; FOP; pp7704;
                     SRAG; SRAG-3; SRAG-5"
                     /note="hexamer: AACAAA"
     polyA_site      2079
                     /gene="CHTOP"
                     /gene_synonym="C10orf77; C1orf77; FL-SRAG; FOP; pp7704;
                     SRAG; SRAG-3; SRAG-5"
                     /note="major polyA site"
ORIGIN      
        1 gtggcggcca ttttgttttg gacaccgagc aggagctggc ggccgctgca gacgaaaggc
       61 aggaaagggc aggccgggtg agcagacgga tcggccgact agacagccaa ccagcaacaa
      121 cgaactgagc tcgcatacta ccgcttacgc atctaaccaa ccgcccatct agctaacccg
      181 agcccctcca ccgtcaactc aggttcggcc ggtccccggc ccgcctgccg gagccgtggt
      241 ggcagccccg ggaggagcac tggcgtctgt ttccttcgat tctcgggatt cgaagatggc
      301 tgcacagtca gcgccgaaag ttgtgctaaa aagcaccacc aagatgtctc taaatgagcg
      361 ctttactaat atgctgaaga acaaacagcc gacgccagtg aatattcggg cttcgatgca
      421 gcaacaacag cagctagcca gtgccagaaa cagaagactg gcccagcaga tggagaatag
      481 accctctgtc caggcagcat taaaacttaa gcagagctta aagcagcgcc tgggtaagag
      541 taacatccag gcacggttag gccgacccat aggggccctg gccaggggag caatcggagg
      601 acgaggccta cccataatcc agagaggctt gcccagagga ggactacgtg ggggacgtgc
      661 caccagaacc ctacttaggg gcgggatgtc actccgaggt caaaacctgc tccgaggtgg
      721 acgagccgta gctccccgaa tgggcttaag aagaggtggt gttcgaggtc gtggaggtcc
      781 tgggagaggg ggcctagggc gtggagctat gggtcgtggc ggaatcggtg gtagaggtcg
      841 gggtatgata ggtcggggaa gagggggctt tggaggccga ggccgaggcc gtggacgagg
      901 gagaggtgcc cttgctcgcc ctgtattgac caaggagcag ctggacaacc aattggatgc
      961 atatatgtcg aaaacaaaag gacacctgga tgctgagttg gatgcctaca tggcgcagac
     1021 agatcccgaa accaatgatt gaagcctgcc catcctccca tgagagactc ttgttagtca
     1081 acacatctgt aaataacctt gagataacag atgagaagaa atctgattga tgctggatgg
     1141 acctatcaca ataggctgtg gacttacttg ccaccagctt gtgcatttag tgtgttcctt
     1201 ttactttttg atactgtgtt gtatgaaacc cttttgtcct ttgatttggt tttttgtttt
     1261 tgttttttta ggggggaggg ggggtttccc ctcctttgcc cagacttctc tttgaacaca
     1321 aatgcattag ccttgtggct agaacaccct cttcctacct ctgtctcccc tcacttgtca
     1381 tatgctctga catgctaaca tttcttttgt tcatccctgt tgcccccaca gaaacatccc
     1441 agaaaaaccg gtcagtgttc cttcctccct gatccttagg tttctgaaat agggttctgt
     1501 tacatcctct tcgatagcct gtttaaaatg tttagaaggt ctggagctca aaaatgcgtt
     1561 cttccacatt gataatttag taaactgaga acattgacat cactacaggg cagcataaga
     1621 ggttgcttac atgtggtagc agctctggtt tgattcaagt tgctaccatg tacattgaca
     1681 gcacatatac cataaccagc gtgttgggtt gaattgcact ttctaccttt gtatgagatt
     1741 tacagacttt ccttctgggt ttgtatcatg accagagggg tactataggg ttggtttata
     1801 ctgcaatata gaggatcaga agccatttga tttggtaggt gtgtcagaag ggagaatgat
     1861 ggcagacgaa ctgctggaag aggtcagaag atagccatgc taaaatgcaa ttatatcctc
     1921 atgtttatcc caaactaatc ttggactttt ccactcatta gctttgtttt gcccttgttt
     1981 cccttgaagg tttaagttca accatattct gtcaactgtt cagtttcagt ggaatcttgt
     2041 atttctggtt cattataaca aactgttcgc ttaaatcca
//
