LOCUS       NM_001039690            2921 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens chromosome transmission fidelity factor 8 (CHTF8),
            transcript variant 1, mRNA.
ACCESSION   NM_001039690
VERSION     NM_001039690.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2921)
  AUTHORS   Bigaud,E. and Corrales,F.J.
  TITLE     Methylthioadenosine (MTA) Regulates Liver Cells Proteome and
            Methylproteome: Implications in Liver Biology and Disease
  JOURNAL   Mol Cell Proteomics 15 (5), 1498-1510 (2016)
   PUBMED   26819315
REFERENCE   2  (bases 1 to 2921)
  AUTHORS   Murakami,T., Takano,R., Takeo,S., Taniguchi,R., Ogawa,K., Ohashi,E.
            and Tsurimoto,T.
  TITLE     Stable interaction between the human proliferating cell nuclear
            antigen loader complex Ctf18-replication factor C (RFC) and DNA
            polymerase {epsilon} is mediated by the cohesion-specific subunits,
            Ctf18, Dcc1, and Ctf8
  JOURNAL   J Biol Chem 285 (45), 34608-34615 (2010)
   PUBMED   20826785
  REMARK    GeneRIF: Stable interaction between the human proliferating cell
            nuclear antigen loader complex Ctf18-replication factor C (RFC) and
            DNA polymerase {epsilon} is mediated by the cohesion-specific
            subunits, Ctf18, Dcc1, and Ctf8.
REFERENCE   3  (bases 1 to 2921)
  AUTHORS   Green,A.R., Krivinskas,S., Young,P., Rakha,E.A., Paish,E.C.,
            Powe,D.G. and Ellis,I.O.
  TITLE     Loss of expression of chromosome 16q genes DPEP1 and CTCF in
            lobular carcinoma in situ of the breast
  JOURNAL   Breast Cancer Res Treat 113 (1), 59-66 (2009)
   PUBMED   18213475
REFERENCE   4  (bases 1 to 2921)
  AUTHORS   Shiomi,Y., Masutani,C., Hanaoka,F., Kimura,H. and Tsurimoto,T.
  TITLE     A second proliferating cell nuclear antigen loader complex,
            Ctf18-replication factor C, stimulates DNA polymerase eta activity
  JOURNAL   J Biol Chem 282 (29), 20906-20914 (2007)
   PUBMED   17545166
REFERENCE   5  (bases 1 to 2921)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   6  (bases 1 to 2921)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 2921)
  AUTHORS   Bermudez,V.P., Maniwa,Y., Tappin,I., Ozato,K., Yokomori,K. and
            Hurwitz,J.
  TITLE     The alternative Ctf18-Dcc1-Ctf8-replication factor C complex
            required for sister chromatid cohesion loads proliferating cell
            nuclear antigen onto DNA
  JOURNAL   Proc Natl Acad Sci U S A 100 (18), 10237-10242 (2003)
   PUBMED   12930902
  REMARK    GeneRIF: The alternative Ctf18-Dcc1-Ctf8-replication factor C
            complex required for sister chromatid cohesion loads proliferating
            cell nuclear antigen onto DNA.
REFERENCE   8  (bases 1 to 2921)
  AUTHORS   Merkle,C.J., Karnitz,L.M., Henry-Sanchez,J.T. and Chen,J.
  TITLE     Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human
            homologs of a Saccharomyces cerevisiae complex involved in sister
            chromatid cohesion establishment
  JOURNAL   J Biol Chem 278 (32), 30051-30056 (2003)
   PUBMED   12766176
  REMARK    GeneRIF: hCTF18, hCTF8, and hDCC1 interact with each other as well
            as with the p38 subunit of RFC
REFERENCE   9  (bases 1 to 2921)
  AUTHORS   Mayer,M.L., Gygi,S.P., Aebersold,R. and Hieter,P.
  TITLE     Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC
            complex required for sister chromatid cohesion in S. cerevisiae
  JOURNAL   Mol Cell 7 (5), 959-970 (2001)
   PUBMED   11389843
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009027.10.
            
            On Jun 2, 2019 this sequence version replaced NM_001039690.4.
            
            Summary: This gene encodes a short protein that forms part of the
            Ctf18 replication factor C (RFC) complex that occurs in both yeast
            and mammals. The heteroheptameric RFC complex plays a role in
            sister chromatid cohesion and may load the replication clamp PCNA
            (proliferating cell nuclear antigen) onto DNA during DNA
            replication and repair. This gene is ubiquitously expressed and has
            been shown to have reduced expression in renal and prostate tumors.
            Alternatively spliced transcript variants have been described. This
            gene has a pseudogene on chromosome X. [provided by RefSeq, Oct
            2018].
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018700.2, SRR1660803.91557.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155770, SAMEA2156266
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000448552.7/ ENSP00000408367.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AC009027.10        7563-7667
            106-163             AC009027.10        18658-18715
            164-281             AC009027.10        18981-19098
            282-2921            AC009027.10        19502-22141
FEATURES             Location/Qualifiers
     source          1..2921
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..2921
                     /gene="CHTF8"
                     /gene_synonym="CTF8; DERPC"
                     /note="chromosome transmission fidelity factor 8"
                     /db_xref="GeneID:54921"
                     /db_xref="HGNC:HGNC:24353"
                     /db_xref="MIM:613202"
     exon            1..105
                     /gene="CHTF8"
                     /gene_synonym="CTF8; DERPC"
                     /inference="alignment:Splign:2.1.0"
     exon            106..163
                     /gene="CHTF8"
                     /gene_synonym="CTF8; DERPC"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..506
                     /gene="CHTF8"
                     /gene_synonym="CTF8; DERPC"
                     /note="CTF8, chromosome transmission fidelity factor 8
                     homolog; decreased expression in renal and prostate cancer
                     protein"
                     /codon_start=1
                     /product="chromosome transmission fidelity protein 8
                     homolog"
                     /protein_id="NP_001034779.1"
                     /db_xref="CCDS:CCDS42185.1"
                     /db_xref="GeneID:54921"
                     /db_xref="HGNC:HGNC:24353"
                     /db_xref="MIM:613202"
                     /translation="MVQIVISSARAGGLAEWVLMELQGEIEARYSTGLAGNLLGDLHY
                     TTEGIPVLIVGHHILYGKIIHLEKPFAVLVKHTPGDQDCDELGRETGTRYLVTALIKD
                     KILFKTRPKPIITSVPKKV"
     exon            164..281
                     /gene="CHTF8"
                     /gene_synonym="CTF8; DERPC"
                     /inference="alignment:Splign:2.1.0"
     exon            282..2921
                     /gene="CHTF8"
                     /gene_synonym="CTF8; DERPC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2902..2907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHTF8"
                     /gene_synonym="CTF8; DERPC"
                     /note="hexamer: AATAAA"
     polyA_site      2921
                     /gene="CHTF8"
                     /gene_synonym="CTF8; DERPC"
                     /note="major polyA site"
ORIGIN      
        1 agtcggaagt gcgcaggcag tgctcgcggc ggcggcgacg gcggcgggag gttcggttgt
       61 cgcccgttgg ccgcgcggcg ccgcgctcgg cggccgccat tgcagcttgt tttcacttgc
      121 tttttaaaga cagaaagctc atggtgcaaa ttgttatttc cagtgcgagg gctggaggcc
      181 tggcagaatg ggtgctgatg gagctacagg gggagatcga ggctcgctac agcactggat
      241 tagctggaaa cctcctggga gacctacatt acaccactga gggaatccct gtgctgatcg
      301 tggggcatca tatcctgtat gggaaaatca tccacctgga gaaacctttt gcagtccttg
      361 tcaaacacac tcctggggat caggactgtg atgagcttgg ccgcgagact ggcacccggt
      421 acctggtgac agcactcatc aaagacaaga tccttttcaa aacccgcccc aagcccatta
      481 tcaccagcgt ccccaagaaa gtatgaaaga acctcggatt ttccctagag agcggccaac
      541 tccttggact cgtgctccgc tgccacctcg aggacggctc gacggttccc tgggaccaca
      601 ggggggtcct gttctgaaca caggccaccc actgggtgtg aactcggatc ccttccttat
      661 ggcggccggt tctcttggtg gaaatctgac cccatttcca aggaacccat ctccttttcc
      721 agcttcatca ggctcattgg cttcaaatcc agcacctttc ccggctggtg ctcgtgaccc
      781 aagtatggct tcttttccaa gagggatgaa tcccactggc acaggtgcag tttctttccc
      841 aaggcctggt ggcctcttgg ggccaggccc aggcccaggc cccaccctaa accctaggac
      901 aggggctctg ccaggcccag ggcctctgtc taaccccagg ttagggggtc tcccaggacc
      961 aggtcctatg tccaacccaa gggcaggtgg tctcctggga gcaggtcctg accccagagg
     1021 tggtggtccc atgggccctg gatctggacc taacctgaga gccggtgttc tgttaacctc
     1081 tgggaatggt cctcccaatc ctaggccagt tggcctgggc ccaggaccaa accccaatct
     1141 gagatcaggc tttttaggga caaaccctgc ccccaggtca ggtgtgtttc caggcccagg
     1201 ccttgggccc aacccaagac caagtggcct gggcccaggc cctaatctag atgccagagc
     1261 aggtggcctc ttgggcacag gatctggtct taacttaaga atggctggac ctcaaggcct
     1321 cgatcttgcc cccattctaa gagcagcagg tcttttagga gcaaattcag cttctttctc
     1381 acaggcttct ggaaacatgg gcacaagccc atcctccatg gcaagagtac ctggccccat
     1441 gggcccaaac tcgggtccta gctctcgggg aattggcctt ccagggccaa atccatctcc
     1501 catgtcaagg gctcctggcc ccataggccc taattcagct catttctcaa ggccagttgg
     1561 ccccatgggg gtaaatgcca atccctttcc caggggagca ggttcatctg ccttttctca
     1621 gtcttctggc acattggcat caaacccagc taccttccaa aggtccgctg gcctccaggg
     1681 ctcaaatcca accattttcc caagagcctc tgggccactt ggccccaacc cagctaactt
     1741 cccaagggcc actggcctgc agggtccaag tccaactacc ttcccaaggt ctactggccc
     1801 attaggccct ggtcaagtta ctttccccag gccagctgcc gggcatctgg gcccttctcc
     1861 agctggccct gtgggtatca acccagctcc tttcacaagg ccaactggga ccctgggtct
     1921 caacccagct tcctttccaa ggatgaatgg ccctgcaggc aagagtttcg tcccatttcc
     1981 tagagtgggg agcctccctg gcacaaaccc agctgctttc cccagaccag ggggtccaat
     2041 ggctgcaatg tacccaaatg gaatgttgcc cccttaaaca ccattttccc tccaggacca
     2101 ccttggtttc taggcactgt ggttcttggc aggggctgtc ttaggtaaaa gggtagttgt
     2161 ggagctacag tctgaagaac atagcttggg ctcaagttca aatgagccat ctttttcctt
     2221 tgcgtttttc ttgactgaag gtgagatgtt atttgtggca tgtgaactgt ggcaggtggg
     2281 aataatcctg cccttgagag aaaggatctc cagcctccca gaagcctgct gtgctttcgt
     2341 cccacagctt tctgcccatt gtttcttact agtttcttga attgttcttg tggacttttc
     2401 ctcagggata cattggcctg caggtcccag ttcacatgta gtcccctgct caccattgga
     2461 gaatcagctc actgctctct agaaacgtgg cgttggtgaa cggaccatgc ttccgtagct
     2521 ctgacctggg cagcttggac ctggtcatcc tctactgcca tacctttccc tgggggcttg
     2581 aacacagaac agggagatgg acaaccactt caaagaaaga cccaccgaat gcagtttctg
     2641 cttgactgac tgggcctgca gctcccttct cctgggactt agaggtggcc agatttaagg
     2701 cccctctact catccaactc cctcttcact ggtactccca atcaatcaaa gaacctcaaa
     2761 atttaaactg atgtggatgg gaatatggga attagggtgg gggtggggga tgaagggaag
     2821 aaatcactgt gctttgttcg gcctggtgtg caaggatggt tggtggtttt cctgcattgt
     2881 atcttttctt actgtttctt taataaatgg gatgagaggg c
//
