LOCUS       NM_022092               3092 bp    mRNA    linear   PRI 07-MAY-2024
DEFINITION  Homo sapiens chromosome transmission fidelity factor 18 (CHTF18),
            mRNA.
ACCESSION   NM_022092
VERSION     NM_022092.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3092)
  AUTHORS   He,Q., Wang,F., O'Donnell,M.E. and Li,H.
  TITLE     Cryo-EM reveals a nearly complete PCNA loading process and unique
            features of the human alternative clamp loader CTF18-RFC
  JOURNAL   Proc Natl Acad Sci U S A 121 (18), e2319727121 (2024)
   PUBMED   38669181
  REMARK    GeneRIF: Cryo-EM reveals a nearly complete PCNA loading process and
            unique features of the human alternative clamp loader CTF18-RFC.
REFERENCE   2  (bases 1 to 3092)
  AUTHORS   Ahmad,T., Kawasumi,R., Taniguchi,T., Abe,T., Terada,K., Tsuda,M.,
            Shimizu,N., Tsurimoto,T., Takeda,S. and Hirota,K.
  TITLE     The proofreading exonuclease of leading-strand DNA polymerase
            epsilon prevents replication fork collapse at broken template
            strands
  JOURNAL   Nucleic Acids Res 51 (22), 12288-12302 (2023)
   PUBMED   37944988
  REMARK    GeneRIF: The proofreading exonuclease of leading-strand DNA
            polymerase epsilon prevents replication fork collapse at broken
            template strands.
REFERENCE   3  (bases 1 to 3092)
  AUTHORS   Washif,M., Ahmad,T., Hosen,M.B., Rahman,M.R., Taniguchi,T.,
            Okubo,H., Hirota,K. and Kawasumi,R.
  TITLE     CTF18-RFC contributes to cellular tolerance against
            chain-terminating nucleoside analogs (CTNAs) in cooperation with
            proofreading exonuclease activity of DNA polymerase epsilon
  JOURNAL   DNA Repair (Amst) 127, 103503 (2023)
   PUBMED   37099849
  REMARK    GeneRIF: CTF18-RFC contributes to cellular tolerance against
            chain-terminating nucleoside analogs (CTNAs) in cooperation with
            proofreading exonuclease activity of DNA polymerase epsilon.
REFERENCE   4  (bases 1 to 3092)
  AUTHORS   Fujisawa,R., Ohashi,E., Hirota,K. and Tsurimoto,T.
  TITLE     Human CTF18-RFC clamp-loader complexed with non-synthesising DNA
            polymerase epsilon efficiently loads the PCNA sliding clamp
  JOURNAL   Nucleic Acids Res 45 (8), 4550-4563 (2017)
   PUBMED   28199690
  REMARK    GeneRIF: Human CTF18-RFC clamp-loader complexed with
            non-synthesising POLE efficiently loads the PCNA sliding clamp.
REFERENCE   5  (bases 1 to 3092)
  AUTHORS   Kaneko,Y., Daitoku,H., Komeno,C. and Fukamizu,A.
  TITLE     CTF18 interacts with replication protein A in response to
            replication stress
  JOURNAL   Mol Med Rep 14 (1), 367-372 (2016)
   PUBMED   27175616
  REMARK    GeneRIF: CTF18 forms a complex with RPA when replication stress is
            elicited by hydroxyurea treatment or UV exposure during S phase.
            The interaction kinetics between CTF18 and RPA is positively
            associated with the phosphorylation status of Chk1.
REFERENCE   6  (bases 1 to 3092)
  AUTHORS   Bermudez,V.P., Maniwa,Y., Tappin,I., Ozato,K., Yokomori,K. and
            Hurwitz,J.
  TITLE     The alternative Ctf18-Dcc1-Ctf8-replication factor C complex
            required for sister chromatid cohesion loads proliferating cell
            nuclear antigen onto DNA
  JOURNAL   Proc Natl Acad Sci U S A 100 (18), 10237-10242 (2003)
   PUBMED   12930902
  REMARK    GeneRIF: The alternative Ctf18-Dcc1-Ctf8-replication factor C
            complex required for sister chromatid cohesion loads proliferating
            cell nuclear antigen onto DNA.
REFERENCE   7  (bases 1 to 3092)
  AUTHORS   Merkle,C.J., Karnitz,L.M., Henry-Sanchez,J.T. and Chen,J.
  TITLE     Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human
            homologs of a Saccharomyces cerevisiae complex involved in sister
            chromatid cohesion establishment
  JOURNAL   J Biol Chem 278 (32), 30051-30056 (2003)
   PUBMED   12766176
  REMARK    GeneRIF: hCTF18, hCTF8, and hDCC1 interact with each other as well
            as with the p38 subunit of RFC
REFERENCE   8  (bases 1 to 3092)
  AUTHORS   Ohta,S., Shiomi,Y., Sugimoto,K., Obuse,C. and Tsurimoto,T.
  TITLE     A proteomics approach to identify proliferating cell nuclear
            antigen (PCNA)-binding proteins in human cell lysates.
            Identification of the human CHL12/RFCs2-5 complex as a novel
            PCNA-binding protein
  JOURNAL   J Biol Chem 277 (43), 40362-40367 (2002)
   PUBMED   12171929
  REMARK    GeneRIF: identification as proliferating cell nuclear
            antigen-binding protein
REFERENCE   9  (bases 1 to 3092)
  AUTHORS   Naiki,T., Kondo,T., Nakada,D., Matsumoto,K. and Sugimoto,K.
  TITLE     Chl12 (Ctf18) forms a novel replication factor C-related complex
            and functions redundantly with Rad24 in the DNA replication
            checkpoint pathway
  JOURNAL   Mol Cell Biol 21 (17), 5838-5845 (2001)
   PUBMED   11486023
REFERENCE   10 (bases 1 to 3092)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031033.5.
            
            On Nov 23, 2018 this sequence version replaced NM_022092.2.
            
            Summary: This gene encodes a protein which is a component of a
            replication factor C (RFC) complex, which loads proliferating cell
            nuclear antigen (PCNA) on to DNA during the S phase of cell cycle.
            The encoded protein may interact with other proteins, including RFC
            complex 3, to form a clamp loader complex that plays a role in
            sister chromatid cohesion during metaphase-anaphase transition.
            [provided by RefSeq, Jan 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018184.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262315.14/ ENSP00000262315.9
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AL031033.5         4348-4503
            157-351             AL031033.5         4659-4853
            352-502             AL031033.5         4938-5088
            503-671             AL031033.5         5275-5443
            672-764             AL031033.5         5905-5997
            765-817             AL031033.5         6075-6127
            818-959             AL031033.5         6253-6394
            960-1169            AL031033.5         6889-7098
            1170-1267           AL031033.5         7579-7676
            1268-1391           AL031033.5         7952-8075
            1392-1543           AL031033.5         8167-8318
            1544-1637           AL031033.5         8446-8539
            1638-1736           AL031033.5         8694-8792
            1737-1867           AL031033.5         8872-9002
            1868-2015           AL031033.5         9782-9929
            2016-2240           AL031033.5         10860-11084
            2241-2390           AL031033.5         11413-11562
            2391-2521           AL031033.5         11675-11805
            2522-2666           AL031033.5         12445-12589
            2667-2798           AL031033.5         12689-12820
            2799-2856           AL031033.5         13422-13479
            2857-3092           AL031033.5         13567-13802
FEATURES             Location/Qualifiers
     source          1..3092
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..3092
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /note="chromosome transmission fidelity factor 18"
                     /db_xref="GeneID:63922"
                     /db_xref="HGNC:HGNC:18435"
                     /db_xref="MIM:613201"
     exon            1..156
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..2993
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /note="homolog of yeast CHL12; some homology with holliday
                     junction DNA helicase RUVB like; CTF18, chromosome
                     transmission fidelity factor 18 homolog"
                     /codon_start=1
                     /product="chromosome transmission fidelity protein 18
                     homolog"
                     /protein_id="NP_071375.1"
                     /db_xref="CCDS:CCDS45371.1"
                     /db_xref="GeneID:63922"
                     /db_xref="HGNC:HGNC:18435"
                     /db_xref="MIM:613201"
                     /translation="MEDYEQELCGVEDDFHNQFAAELEVLAELEGASTPSPSGVPLFT
                     AGRPPRTFEEALARGDAASSPAPAASVGSSQGGARKRQVDADLQPAGSLPHAPRIKRP
                     RLQVVKRLNFRSEEMEEPPPPDSSPTDITPPPSPEDLAELWGHGVSEAAADVGLTRAS
                     PAARNPVLRRPPILEDYVHVTSTEGVRAYLVLRADPMAPGVQGSLLHVPWRGGGQLDL
                     LGVSLASLKKQVDGERRERLLQEAQKLSDTLHSLRSGEEEAAQPLGAPEEEPTDGQDA
                     SSHCLWVDEFAPRHYTELLSDDFTNRCLLKWLKLWDLVVFGHERPSRKPRPSVEPARV
                     SKEATAPGKWKSHEQVLEEMLEAGLDPSQRPKQKVALLCGPPGLGKTTLAHVIARHAG
                     YSVVEMNASDDRSPEVFRTRIEAATQMESVLGAGGKPNCLVIDEIDGAPVAAINVLLS
                     ILNRKGPQEVGPQGPAVPSGGGRRRRAEGGLLMRPIICICNDQFAPSLRQLKQQAFLL
                     HFPPTLPSRLVQRLQEVSLRQGMRADPGVLAALCEKTDNDIRACINTLQFLYSRGQRE
                     LSVRDVQATRVGLKDQRRGLFSVWQEVFQLPRAQRRRVGQDPALPADTLLLGDGDAGS
                     LTSASQRFYRVLHAAASAGEHEKVVQGLFDNFLRLRLRDSSLGAVCVALDWLAFDDLL
                     AGAAHHSQSFQLLRYPPFLPVAFHVLFASSHTPRITFPSSQQEAQNRMSQMRNLIQTL
                     VSGIAPATRSRATPQALLLDALCLLLDILAPKLRPVSTQLYSTREKQQLASLVGTMLA
                     YSLTYRQERTPDGQYIYRLEPNVEELCRFPELPARKPLTYQTKQLIAREIEVEKMRRA
                     EASARVENSPQVDGSPPGLEGLLGGIGEKGVHRPAPRNHEQRLEHIMRRAAREEQPEK
                     DFFGRVVVRSTAVPSAGDTAPEQDSVERRMGTAVGRSEVWFRFNEGVSNAVRRSLYIR
                     DLL"
     exon            157..351
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /inference="alignment:Splign:2.1.0"
     exon            352..502
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /inference="alignment:Splign:2.1.0"
     exon            503..671
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /inference="alignment:Splign:2.1.0"
     exon            672..764
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /inference="alignment:Splign:2.1.0"
     exon            765..817
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /inference="alignment:Splign:2.1.0"
     exon            818..959
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1169
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1267
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1391
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1543
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1637
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1736
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1867
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2015
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2240
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2390
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2521
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2666
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2798
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2856
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..3092
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3065..3070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /note="hexamer: TATAAA"
     polyA_site      3092
                     /gene="CHTF18"
                     /gene_synonym="C16orf41; C321D2.2; C321D2.3; C321D2.4;
                     CHL12; Ctf18; RUVBL"
                     /note="major polyA site"
ORIGIN      
        1 gggcagtgcg cgacggcggc ggcggcgcgg gaggttcgga gcgggagctc gggctcgcgg
       61 acggtatgga ggactacgag caggagctgt gcggcgtcga ggatgatttc cacaaccagt
      121 tcgcggccga gctggaggtg ctggcagagc tggaaggggc gtcgactccg tcgccctccg
      181 gggtccccct gttcaccgcg ggccgacccc cgcggacgtt cgaggaggcc cttgccagag
      241 gggacgcggc ctccagtccc gccccagccg catctgtggg cagcagccag ggcggcgcca
      301 ggaagaggca ggtggacgcc gacctgcagc cggccgggtc cctgccccac gcccccagga
      361 tcaaacggcc taggctgcag gtggtcaaga ggctgaactt cagatcggag gagatggagg
      421 agccgccccc tcccgactcc tcgccgacgg acatcacccc gccgccgagc cctgaggacc
      481 tcgcagagct ttggggccac ggagtctcag aagctgctgc cgacgtgggt ctcacacggg
      541 cctcaccagc tgcccgcaat cccgtcctga ggcggccccc catcttggag gactacgtcc
      601 acgtgacatc cacggagggc gtccgggctt atctggtgct gcgtgctgac cccatggccc
      661 cgggggtgca gggctctctc ctccacgtcc catggcgagg cggtggccag ctggacctgc
      721 tgggtgtgtc cttagcctcc ctgaagaagc aggtcgacgg cgagcggcgg gagcggctgc
      781 ttcaggaggc ccagaagctt tcagacaccc tgcacagtct caggtcgggg gaggaggagg
      841 cagcccagcc cttgggggcc cctgaggagg agccgactga cggtcaagac gcctccagtc
      901 actgcctctg ggtggatgag tttgcacccc gccactacac ggagctgctc agtgatgact
      961 tcaccaaccg ctgcctgctc aagtggctga agttgtggga cctggtggtg tttggccacg
     1021 agaggccttc ccggaagccc aggcccagtg ttgagccggc ccgggtcagc aaggaggcca
     1081 cagccccagg caagtggaag agccacgaac aggtgctgga ggagatgctg gaggctgggc
     1141 tggacccgag ccagcgaccg aagcagaagg tggcactgct ctgtgggccc ccggggctgg
     1201 ggaagaccac cctggcacac gtgattgcgc gtcacgcggg gtactctgtg gtggagatga
     1261 acgccagtga cgaccgtagc ccggaggtct tccgcacacg catcgaggcg gccacccaga
     1321 tggagtcggt gctgggtgct ggcgggaagc ccaactgcct ggtcatcgat gagatcgacg
     1381 gggcccccgt ggccgccatc aacgtcctcc tgagcatcct gaaccgcaag gggccacagg
     1441 aggtggggcc acagggcccg gctgtgcctt cgggaggcgg ccgacggcgc cgggcagagg
     1501 gggggctcct catgaggccc attatctgca tttgcaatga ccagttcgca ccgtccctgc
     1561 ggcagctgaa gcagcaggcc ttcctgctcc acttcccgcc gactctgccc tcgaggctgg
     1621 tgcagcggct ccaggaggtc tccctgcggc agggcatgag ggccgaccca ggggtgctgg
     1681 ccgccctctg tgagaaaact gacaatgaca tccgggcctg catcaacacc ctgcagttcc
     1741 tgtacagccg gggccagcgg gagctgagcg tgcgggacgt gcaggccaca cgcgtgggcc
     1801 tcaaggacca gcgcagaggg ctcttctcgg tgtggcagga ggtcttccag ctgcctcgag
     1861 cccagaggcg ccgtgtgggc caggaccccg ccctgcctgc tgacacactc ctgctgggtg
     1921 acggggacgc gggctccctc acctccgcct cacagcgatt ctaccgtgtc ctgcatgccg
     1981 ctgcctctgc gggcgagcac gagaaggtgg tccagggctt gtttgacaac ttcctgcgtc
     2041 tgcggctgcg agactccagc ctgggtgctg tgtgtgtggc cctcgactgg ctggccttcg
     2101 atgacctgct ggcgggggct gctcatcaca gccagagctt ccagctgctg cgctacccac
     2161 ccttcctgcc cgtggccttc catgtgctgt ttgcttccag ccacacaccc aggatcacct
     2221 tccccagcag ccagcaggag gcccagaacc ggatgagcca gatgaggaac ctgatccaga
     2281 cgctggtgtc cggcatcgcg ccagccacgc gcagccgggc cacgccccag gccctgctcc
     2341 tcgatgccct ctgcctgctc ctggacattc ttgcacccaa gctccgcccc gtgagcacac
     2401 agctgtacag cacccgtgaa aagcaacagc tggccagcct ggtgggcacg atgctcgctt
     2461 acagcctgac ctaccgccag gagcgcacgc ccgatggcca gtacatctac aggctggagc
     2521 cgaacgtgga ggaactctgc cgcttccctg agctgcctgc ccgcaagccc ctcacctacc
     2581 agacgaagca gctcatcgcc cgcgagatcg aggtggagaa gatgcggcgg gcggaggctt
     2641 ctgcccgggt agagaacagc ccccaggtgg atgggagccc cccagggctc gagggtctgc
     2701 tggggggcat tggggagaaa ggggtgcacc gacctgcccc acgcaaccat gagcagcggc
     2761 tggagcacat catgaggcga gcggcccggg aggaacagcc tgagaaggac ttctttggac
     2821 gtgtggtcgt caggagcaca gcagtcccga gtgcagggga cacggccccg gagcaggact
     2881 cagtggagcg gcgcatgggc acagcggtgg gcaggagcga ggtctggttc cgcttcaacg
     2941 agggtgtctc caacgccgtg cggcgcagcc tgtacatcag ggacttgctc tagttctctg
     3001 agccgcggac atgccctcgc attgcttccc gcagagtgca gagacaggaa gctggagatg
     3061 tctttataaa gtcacacctt tacagactgt aa
//
