LOCUS       NM_014918               4662 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens chondroitin sulfate synthase 1 (CHSY1), mRNA.
ACCESSION   NM_014918
VERSION     NM_014918.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4662)
  AUTHORS   Liu,L., Xu,Q., Xiong,Y., Deng,H. and Zhou,J.
  TITLE     LncRNA LINC01094 contributes to glioma progression by modulating
            miR-224-5p/CHSY1 axis
  JOURNAL   Hum Cell 35 (1), 214-225 (2022)
   PUBMED   34716872
  REMARK    GeneRIF: LncRNA LINC01094 contributes to glioma progression by
            modulating miR-224-5p/CHSY1 axis.
REFERENCE   2  (bases 1 to 4662)
  AUTHORS   Liu,J., Tian,Z., Liu,T., Wen,D., Ma,Z., Liu,Y. and Zhu,J.
  TITLE     CHSY1 is upregulated and acts as tumor promotor in gastric cancer
            through regulating cell proliferation, apoptosis, and migration
  JOURNAL   Cell Cycle 20 (18), 1861-1874 (2021)
   PUBMED   34412565
  REMARK    GeneRIF: CHSY1 is upregulated and acts as tumor promotor in gastric
            cancer through regulating cell proliferation, apoptosis, and
            migration.
REFERENCE   3  (bases 1 to 4662)
  AUTHORS   Liu,C.H., Lan,C.T., Chou,J.F., Tseng,T.J. and Liao,W.C.
  TITLE     CHSY1 promotes aggressive phenotypes of hepatocellular carcinoma
            cells via activation of the hedgehog signaling pathway
  JOURNAL   Cancer Lett 403, 280-288 (2017)
   PUBMED   28652022
  REMARK    GeneRIF: CHSY1 overexpression in HCC contributes to the malignant
            behavior of hepatocellular carcinoma cells via activation of the
            hedgehog signaling pathway.
REFERENCE   4  (bases 1 to 4662)
  AUTHORS   Momose,T., Yoshimura,Y., Harumiya,S., Isobe,K., Kito,M.,
            Fukushima,M., Kato,H. and Nakayama,J.
  TITLE     Chondroitin sulfate synthase 1 expression is associated with
            malignant potential of soft tissue sarcomas with myxoid substance
  JOURNAL   Hum Pathol 50, 15-23 (2016)
   PUBMED   26997434
  REMARK    GeneRIF: CHSY1 expression is closely associated with malignant
            potential of soft tissue sarcomas with myxoid substance.
REFERENCE   5  (bases 1 to 4662)
  AUTHORS   Kalathas,D., Theocharis,D.A., Bounias,D., Kyriakopoulou,D.,
            Papageorgakopoulou,N., Stavropoulos,M.S. and Vynios,D.H.
  TITLE     Chondroitin synthases I, II, III and chondroitin sulfate
            glucuronyltransferase expression in colorectal cancer
  JOURNAL   Mol Med Rep 4 (2), 363-368 (2011)
   PUBMED   21468578
  REMARK    GeneRIF: The present study focused on the expression of
            chondroitin-synthesizing enzymes in colorectal cancer.
REFERENCE   6  (bases 1 to 4662)
  AUTHORS   Li,Y., Laue,K., Temtamy,S., Aglan,M., Kotan,L.D., Yigit,G.,
            Canan,H., Pawlik,B., Nurnberg,G., Wakeling,E.L., Quarrell,O.W.,
            Baessmann,I., Lanktree,M.B., Yilmaz,M., Hegele,R.A., Amr,K.,
            May,K.W., Nurnberg,P., Topaloglu,A.K., Hammerschmidt,M. and
            Wollnik,B.
  TITLE     Temtamy preaxial brachydactyly syndrome is caused by
            loss-of-function mutations in chondroitin synthase 1, a potential
            target of BMP signaling
  JOURNAL   Am J Hum Genet 87 (6), 757-767 (2010)
   PUBMED   21129728
  REMARK    GeneRIF: unrestricted Bmp2b signaling or loss of Dan activity leads
            to reduced chsy1 expression and, during epithelial morphogenesis,
            defects similar to those that occur upon Chsy1 inactivation
REFERENCE   7  (bases 1 to 4662)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 4662)
  AUTHORS   Yada,T., Sato,T., Kaseyama,H., Gotoh,M., Iwasaki,H., Kikuchi,N.,
            Kwon,Y.D., Togayachi,A., Kudo,T., Watanabe,H., Narimatsu,H. and
            Kimata,K.
  TITLE     Chondroitin sulfate synthase-3. Molecular cloning and
            characterization
  JOURNAL   J Biol Chem 278 (41), 39711-39725 (2003)
   PUBMED   12907687
REFERENCE   9  (bases 1 to 4662)
  AUTHORS   Kitagawa,H., Izumikawa,T., Uyama,T. and Sugahara,K.
  TITLE     Molecular cloning of a chondroitin polymerizing factor that
            cooperates with chondroitin synthase for chondroitin polymerization
  JOURNAL   J Biol Chem 278 (26), 23666-23671 (2003)
   PUBMED   12716890
  REMARK    GeneRIF: chondroitin polymerizing activity requires concomitant
            expression of a ChPF with ChSy; coexpression of the ChPF and ChSy
            yielded markedly augmented glycosyltransferase activities, whereas
            simple mixing of the two separately expressed proteins did not.
REFERENCE   10 (bases 1 to 4662)
  AUTHORS   Kitagawa,H., Uyama,T. and Sugahara,K.
  TITLE     Molecular cloning and expression of a human chondroitin synthase
  JOURNAL   J Biol Chem 276 (42), 38721-38726 (2001)
   PUBMED   11514575
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC023024.6, AB023207.1,
            BC046247.1, AC019254.12 and BQ007796.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014918.4.
            
            Summary: This gene encodes a member of the chondroitin
            N-acetylgalactosaminyltransferase family. These enzymes possess
            dual glucuronyltransferase and galactosaminyltransferase activity
            and play critical roles in the biosynthesis of chondroitin sulfate,
            a glycosaminoglycan involved in many biological processes including
            cell proliferation and morphogenesis. Decreased expression of this
            gene may play a role in colorectal cancer, and mutations in this
            gene are a cause of temtamy preaxial brachydactyly syndrome.
            [provided by RefSeq, Dec 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046247.1, AY358529.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254190.4/ ENSP00000254190.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AC023024.6         59323-59438         c
            117-553             AB023207.1         1-437
            554-569             BC046247.1         427-442
            570-2913            BC046247.1         461-2804
            2914-4451           AC019254.12        125366-126903       c
            4452-4662           BQ007796.1         22-232              c
FEATURES             Location/Qualifiers
     source          1..4662
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.3"
     gene            1..4662
                     /gene="CHSY1"
                     /gene_synonym="CHSY; ChSy-1; CSS1; TPBS"
                     /note="chondroitin sulfate synthase 1"
                     /db_xref="GeneID:22856"
                     /db_xref="HGNC:HGNC:17198"
                     /db_xref="MIM:608183"
     exon            1..912
                     /gene="CHSY1"
                     /gene_synonym="CHSY; ChSy-1; CSS1; TPBS"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1408
                     /gene="CHSY1"
                     /gene_synonym="CHSY; ChSy-1; CSS1; TPBS"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..4662
                     /gene="CHSY1"
                     /gene_synonym="CHSY; ChSy-1; CSS1; TPBS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4443..4448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHSY1"
                     /gene_synonym="CHSY; ChSy-1; CSS1; TPBS"
                     /note="hexamer: AATAAA"
     polyA_site      4471
                     /gene="CHSY1"
                     /gene_synonym="CHSY; ChSy-1; CSS1; TPBS"
     regulatory      4549..4554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHSY1"
                     /gene_synonym="CHSY; ChSy-1; CSS1; TPBS"
                     /note="hexamer: AATAAA"
     polyA_site      4567
                     /gene="CHSY1"
                     /gene_synonym="CHSY; ChSy-1; CSS1; TPBS"
                     /note="major polyA site"
     regulatory      4643..4648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHSY1"
                     /gene_synonym="CHSY; ChSy-1; CSS1; TPBS"
                     /note="hexamer: AGTAAA"
     polyA_site      4662
                     /gene="CHSY1"
                     /gene_synonym="CHSY; ChSy-1; CSS1; TPBS"
                     /note="major polyA site"
ORIGIN      
        1 attcactttt gcgccaatcg cgcggcgcgg acggatcccg agaggggcca cggctcgccg
       61 ccggcggggc cacttcataa cgcgccgtgc gtgacgtgag gggctcctgt tgcaatggcg
      121 agctaagccg gaggatgtgc agctgcggcg gcggcgccgg ctacgaagag gacggggaca
      181 ggcgccgtgc gaaccgagcc cagccagccg gaggacgcgg gcagggcggg acgggagccc
      241 ggactcgtct gccgccgccg tcgtcgccgt cgtgccggcc ccgcgtcccc gcgcgcgagc
      301 gggaggagcc gccgccacct cgcgcccgag ccgccgctag cgcgcgccgg gcatggtccc
      361 ctcttaaagg cgcaggccgc ggcggcgggg gcgggcgtgc ggaacaaagc gccggcgcgg
      421 ggcctgcggg cggctcgggg gccgcgatgg gcgcggcggg cccgcggcgg cggcggcgct
      481 gcccgggccg ggcctcgcgg cgctagggcg ggctggcctc cgcgggcggg ggcagcgggc
      541 tgagggcgcg cggagcctgc ggcggcggcc cggcgggcgg agcggcgcgg gcatggccgc
      601 gcgcggccgg cgcgcctggc tcagcgtgct gctcgggctc gtcctgggct tcgtgctggc
      661 ctcgcggctc gtcctgcccc gggcttccga gctgaagcga gcgggcccac ggcgccgcgc
      721 cagccccgag ggctgccggt ccgggcaggc ggcggcttcc caggccggcg gggcgcgcgg
      781 cgatgcgcgc ggggcgcagc tctggccgcc cggctcggac ccagatggcg gcccgcgcga
      841 caggaacttt ctcttcgtgg gagtcatgac cgcccagaaa tacctgcaga ctcgggccgt
      901 ggccgcctac agaacatggt ccaagacaat tcctgggaaa gttcagttct tctcaagtga
      961 gggttctgac acatctgtac caattccagt agtgccacta cggggtgtgg acgactccta
     1021 cccgccccag aagaagtcct tcatgatgct caagtacatg cacgaccact acttggacaa
     1081 gtatgaatgg tttatgagag cagatgatga cgtgtacatc aaaggagacc gtctggagaa
     1141 cttcctgagg agtttgaaca gcagcgagcc cctctttctt gggcagacag gcctgggcac
     1201 cacggaagaa atgggaaaac tggccctgga gcctggtgag aacttctgca tgggggggcc
     1261 tggcgtgatc atgagccggg aggtgcttcg gagaatggtg ccgcacattg gcaagtgtct
     1321 ccgggagatg tacaccaccc atgaggacgt ggaggtggga aggtgtgtcc ggaggtttgc
     1381 aggggtgcag tgtgtctggt cttatgagat gcagcagctt ttttatgaga attacgagca
     1441 gaacaaaaag gggtacatta gagatctcca taacagtaaa attcaccaag ctatcacatt
     1501 acaccccaac aaaaacccac cctaccagta caggctccac agctacatgc tgagccgcaa
     1561 gatatccgag ctccgccatc gcacaataca gctgcaccgc gaaattgtcc tgatgagcaa
     1621 atacagcaac acagaaattc ataaagagga cctccagctg ggaatccctc cctccttcat
     1681 gaggtttcag ccccgccagc gagaggagat tctggaatgg gagtttctga ctggaaaata
     1741 cttgtattcg gcagttgacg gccagccccc tcgaagagga atggactccg cccagaggga
     1801 agccttggac gacattgtca tgcaggtcat ggagatgatc aatgccaacg ccaagaccag
     1861 agggcgcatc attgacttca aagagatcca gtacggctac cgccgggtga accccatgta
     1921 tggggctgag tacatcctgg acctgctgct tctgtacaaa aagcacaaag ggaagaaaat
     1981 gacggtccct gtgaggaggc acgcgtattt acagcagact ttcagcaaaa tccagtttgt
     2041 ggagcatgag gagctggatg cacaagagtt ggccaagaga atcaatcagg aatctggatc
     2101 cttgtccttt ctctcaaact ccctgaagaa gctcgtcccc tttcagctcc ctgggtcgaa
     2161 gagtgagcac aaagaaccca aagataaaaa gataaacata ctgattcctt tgtctgggcg
     2221 tttcgacatg tttgtgagat ttatgggaaa ctttgagaag acgtgtctta tccccaatca
     2281 gaacgtcaag ctcgtggttc tgcttttcaa ttctgactcc aaccctgaca aggccaaaca
     2341 agttgaactg atgagagatt accgcattaa gtaccctaaa gccgacatgc agattttgcc
     2401 tgtgtctgga gagttttcaa gagccctggc cctggaagta ggatcctccc agtttaacaa
     2461 tgaatctttg ctcttcttct gcgacgtcga cctcgtgttt actacagaat tccttcagcg
     2521 atgtcgagca aatacagttc tgggccaaca aatatatttt ccaatcatct tcagccagta
     2581 tgacccaaag attgtttata gtgggaaagt tcccagtgac aaccattttg cctttactca
     2641 gaaaactggc ttctggagaa actatgggtt tggcatcacg tgtatttata agggagatct
     2701 tgtccgagtg ggtggctttg atgtttccat ccaaggctgg gggctggagg atgtggacct
     2761 tttcaacaag gttgtccagg caggtttgaa gacgtttagg agccaggaag taggagtagt
     2821 ccacgtccac catcctgtct tttgtgatcc caatcttgac cccaaacagt acaaaatgtg
     2881 cttggggtcc aaagcatcga cctatgggtc cacccagcag ctggctgaga tgtggctgga
     2941 aaaaaatgat ccaagttaca gtaaaagcag caataataat ggctcagtga ggacagccta
     3001 atgtccagct ttgctggaaa agacgttttt aattatctaa tttatttttc aaaaattttt
     3061 tgtatgatca gtttttgaag tccgtataca aggatatatt ttacaagtgg ttttcttaca
     3121 taggactcct ttaagattga gctttctgaa caagaaggtg atcagtgttt gcctttgaac
     3181 acatcttctt gctgaacatt atgtagcaga cctgcttaac tttgacttga aatgtacctg
     3241 atgaacaaaa cttttttaaa aaaatgtttt cttttgagac cctttgctcc agtcctatgg
     3301 cagaaaacgt gaacattcct gcaaagtatt attgtaacaa aacactgtaa ctctggtaaa
     3361 tgttctgttg tgattgttaa cattccacag attctacctt ttgtgttttg tttttttttt
     3421 ttacaattgt tttaaagcca tttcatgttc cagttgtaag ataaggaaat gtgataatag
     3481 ctgtttcatc attgtcttca ggagagcttt ccagagttga tcatttcctc tcatggtact
     3541 ctgctcagca tggccacgta ggttttttgt ttgttttgtt ttgttctttt tttgagacgg
     3601 agtctcactc tgttacccag gctggaatgc agtggcgcaa tcttggctca ctttaacctc
     3661 cacttccctg gttcaagcaa ttcccctgcc tttgcctccc gagtagctgg gattacaggc
     3721 acacaccacc acgcccagct agtttttttg tatttttagt agagacgggg tttcaccatg
     3781 caagcccagc tggccacgta ggttttaaag caaggggcgt gaagaaggca cagtgaggta
     3841 tgtggctgtt ctcgtggtag ttcattcggc ctaaatagac ctggcattaa atttcaagaa
     3901 ggatttggca ttttctcttc ttgacccttc tctttaaagg gtaaaatatt aatgtttaga
     3961 atgacaaaga tgaattatta caataaatct gatgtacaca gactgaaaca tacacacata
     4021 caccctaatc aaaacgttgg ggaaaaatgt atttggtttt gttcctttca tcctgtctgt
     4081 gttatgtggg tggagatggt tttcattctt tcattactgt tttgttttat cctttgtatc
     4141 tgaaatacct ttaatttatt taatatctgt tgttcagagc tctgccattt cttgagtacc
     4201 tgttagttag tattatttat gtgtatcggg agtgtgttta gtctgtttta tttgcagtaa
     4261 accgatctcc aaagatttcc ttttggaaac gctttttccc ctccttaatt tttatattcc
     4321 ttactgtttt actaaatatt aagtgttctt tgacaatttt ggtgctcatg tgttttgggg
     4381 acaaaagtga aatgaatctg tcattatacc agaaagttaa attctcagat caaatgtgcc
     4441 ttaataaatt tgttttcatt tagatttcaa acagtgatag acttgccatt ttaatacacg
     4501 tcattggagg gctgcgtatt tgtaaatagc ctgatgctca tttggaaaaa taaaccagtg
     4561 aacaatattt ttctattgta cttttcgaac cattttgtct cattattcct gttttagctg
     4621 aagaattgta ttacatttgg agagtaaaaa acttaaacac ga
//
