LOCUS       NM_019886               2396 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens carbohydrate sulfotransferase 7 (CHST7), mRNA.
ACCESSION   NM_019886
VERSION     NM_019886.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2396)
  AUTHORS   Dong,W., Shi,W., Liu,Y., Li,J., Zhang,Y., Dong,G., Dong,X. and
            Gao,H.
  TITLE     CHST7 Methylation Status Related to the Proliferation and
            Differentiation of Pituitary Adenomas
  JOURNAL   Cells 11 (15), 2400 (2022)
   PUBMED   35954244
  REMARK    GeneRIF: CHST7 Methylation Status Related to the Proliferation and
            Differentiation of Pituitary Adenomas.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2396)
  AUTHORS   Bi,H., Liu,Y., Pu,R., Xia,T., Sun,H., Huang,H., Zhang,L., Zhang,Y.,
            Liu,Y., Xu,J., Rong,J. and Zhao,Y.
  TITLE     CHST7 Gene Methylation and Sex-Specific Effects on Colorectal
            Cancer Risk
  JOURNAL   Dig Dis Sci 64 (8), 2158-2166 (2019)
   PUBMED   30815821
  REMARK    GeneRIF: CHST7 methylation in white blood cells is positively
            associated with CRC risk, especially in females, and may
            potentially serve as a blood-based predictive biomarker for CRC
            risk.
REFERENCE   3  (bases 1 to 2396)
  AUTHORS   Liu,T., Qian,W.J., Gritsenko,M.A., Camp,D.G. 2nd, Monroe,M.E.,
            Moore,R.J. and Smith,R.D.
  TITLE     Human plasma N-glycoproteome analysis by immunoaffinity
            subtraction, hydrazide chemistry, and mass spectrometry
  JOURNAL   J Proteome Res 4 (6), 2070-2080 (2005)
   PUBMED   16335952
REFERENCE   4  (bases 1 to 2396)
  AUTHORS   Thiselton,D.L., McDowall,J., Brandau,O., Ramser,J., d'Esposito,F.,
            Bhattacharya,S.S., Ross,M.T., Hardcastle,A.J. and Meindl,A.
  TITLE     An integrated, functionally annotated gene map of the DXS8026-ELK1
            interval on human Xp11.3-Xp11.23: potential hotspot for
            neurogenetic disorders
  JOURNAL   Genomics 79 (4), 560-572 (2002)
   PUBMED   11944989
  REMARK    Erratum:[Genomics 2002 Jun;79(6):891]
REFERENCE   5  (bases 1 to 2396)
  AUTHORS   Bhakta,S., Bartes,A., Bowman,K.G., Kao,W.M., Polsky,I., Lee,J.K.,
            Cook,B.N., Bruehl,R.E., Rosen,S.D., Bertozzi,C.R. and Hemmerich,S.
  TITLE     Sulfation of N-acetylglucosamine by chondroitin 6-sulfotransferase
            2 (GST-5)
  JOURNAL   J Biol Chem 275 (51), 40226-40234 (2000)
   PUBMED   10956661
REFERENCE   6  (bases 1 to 2396)
  AUTHORS   Uchimura,K., Fasakhany,F., Kadomatsu,K., Matsukawa,T., Yamakawa,T.,
            Kurosawa,N. and Muramatsu,T.
  TITLE     Diversity of N-acetylglucosamine-6-O-sulfotransferases: molecular
            cloning of a novel enzyme with different distribution and
            specificities
  JOURNAL   Biochem Biophys Res Commun 274 (2), 291-296 (2000)
   PUBMED   10913333
REFERENCE   7  (bases 1 to 2396)
  AUTHORS   Kitagawa,H., Fujita,M., Ito,N. and Sugahara,K.
  TITLE     Molecular cloning and expression of a novel chondroitin
            6-O-sulfotransferase
  JOURNAL   J Biol Chem 275 (28), 21075-21080 (2000)
   PUBMED   10781596
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA155923.1, BC045537.1,
            AB037187.1, DA277492.1 and BP250418.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_019886.3.
            
            Summary: This gene is a member of the Gal/GalNAc/GlcNAc
            (galactose/N-acetylgalactosamine/N-acetylglucosamine)
            6-O-sulfotransferase (GST) family. Members of this family encode
            enzymes that catalyze the specific addition of sulfate groups to
            distinct hydroxyl and amino groups of carbohydrates. The encoded
            protein catalyzes the sulfation of 6-hydroxyl group of GalNAc in
            chondroitin. [provided by RefSeq, Aug 2013].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB037187.1, BC045537.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276055.4/ ENSP00000276055.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                DA155923.1         82-100
            20-2101             BC045537.1         1-2082
            2102-2303           AB037187.1         1945-2146
            2304-2384           DA277492.1         492-572
            2385-2396           BP250418.1         570-581
FEATURES             Location/Qualifiers
     source          1..2396
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.3"
     gene            1..2396
                     /gene="CHST7"
                     /gene_synonym="C6ST-2; GST-5"
                     /note="carbohydrate sulfotransferase 7"
                     /db_xref="GeneID:56548"
                     /db_xref="HGNC:HGNC:13817"
                     /db_xref="MIM:300375"
     exon            1..1659
                     /gene="CHST7"
                     /gene_synonym="C6ST-2; GST-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1628
                     /gene="CHST7"
                     /gene_synonym="C6ST-2; GST-5"
                     /EC_number="2.8.2.17"
                     /note="chondroitin 6-sulfotransferase-2; gn6st-4;
                     glcNAc6ST-4; N-acetylglucosamine 6-O-sulfotransferase 4;
                     galactose/N-acetylglucosamine/N-acetylglucosamine
                     6-O-sulfotransferase 5; carbohydrate (N-acetylglucosamine
                     6-O) sulfotransferase 7"
                     /codon_start=1
                     /product="carbohydrate sulfotransferase 7"
                     /protein_id="NP_063939.2"
                     /db_xref="CCDS:CCDS14268.1"
                     /db_xref="GeneID:56548"
                     /db_xref="HGNC:HGNC:13817"
                     /db_xref="MIM:300375"
                     /translation="MKGRRRRRREYCKFALLLVLYTLVLLLVPSVLDGGRDGDKGAEH
                     CPGLQRSLGVWSLEAAAAGEREQGAEARAAEEGGANQSPRFPSNLSGAVGEAVSREKQ
                     HIYVHATWRTGSSFLGELFNQHPDVFYLYEPMWHLWQALYPGDAESLQGALRDMLRSL
                     FRCDFSVLRLYAPPGDPAARAPDTANLTTAALFRWRTNKVICSPPLCPGAPRARAEVG
                     LVEDTACERSCPPVAIRALEAECRKYPVVVIKDVRLLDLGVLVPLLRDPGLNLKVVQL
                     FRDPRAVHNSRLKSRQGLLRESIQVLRTRQRGDRFHRVLLAHGVGARPGGQSRALPAA
                     PRADFFLTGALEVICEAWLRDLLFARGAPAWLRRRYLRLRYEDLVRQPRAQLRRLLRF
                     SGLRALAALDAFALNMTRGAAYGADRPFHLSARDAREAVHAWRERLSREQVRQVEAAC
                     APAMRLLAYPRSGEEGDAEQPREGETPLEMDADGAT"
     exon            1660..2396
                     /gene="CHST7"
                     /gene_synonym="C6ST-2; GST-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2069..2074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHST7"
                     /gene_synonym="C6ST-2; GST-5"
                     /note="hexamer: AATAAT"
     polyA_site      2089
                     /gene="CHST7"
                     /gene_synonym="C6ST-2; GST-5"
                     /note="major polyA site"
     regulatory      2275..2280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHST7"
                     /gene_synonym="C6ST-2; GST-5"
                     /note="hexamer: ATTAAA"
     polyA_site      2308
                     /gene="CHST7"
                     /gene_synonym="C6ST-2; GST-5"
                     /note="major polyA site"
ORIGIN      
        1 agtagcacca ccgccttcca agtttcccct tgtggatgcg cggccccgcg gctctgctcc
       61 tcccggcgca gaggggccgg gagaggccac aggagcggac ctggcacggg atttctgagg
      121 aacgggagaa gactggcgcc cgacccgctc tggagggtcg gtgaacgatg aagggccggc
      181 ggcggcgacg ccgagagtac tgcaagttcg cgctgctgtt ggtgctgtac acgctggtgc
      241 tgttgctcgt cccctccgta ttggacggcg gccgcgacgg ggacaagggc gccgagcact
      301 gccccggcct gcagcgcagc ctgggagtgt ggagcctgga ggcggcggcg gccggcgaac
      361 gcgagcaggg agcggaggcg cgggccgccg aggaaggggg cgcgaaccag tctcctcggt
      421 tcccaagcaa cctcagcggc gctgtcgggg aggcagtgtc tcgcgagaag cagcacatct
      481 acgtgcatgc cacctggcgc accggctcgt ccttcctggg cgaactcttt aaccagcacc
      541 cggacgtttt ctacttgtat gagcccatgt ggcatctatg gcaggcgctg tatccgggcg
      601 acgccgagag cttgcagggc gcgctgcgcg acatgctgcg ttcgctcttc cgctgcgact
      661 tctccgtgct gcggctgtac gcgccgccgg gggaccccgc tgcgcgcgcc ccggacacgg
      721 ccaatcttac cacggccgcc ctcttccgct ggcggactaa caaggtcatc tgctcgccgc
      781 cactgtgtcc tggcgcaccc cgtgcccggg ccgaggtggg cctcgtcgag gacaccgcct
      841 gcgagcgcag ctgcccaccc gtggcgatac gcgccctgga ggccgagtgc cgaaagtacc
      901 cggtggtggt catcaaggac gtgcgcctgc tcgatctggg cgtgctggtg cccctgttgc
      961 gtgatccagg cctcaacctg aaggtggtgc agcttttccg cgacccgagg gcggtgcaca
     1021 actcgcgcct caagtctagg cagggactgc tgcgcgagag catccaggtg ctgcgcaccc
     1081 gccagagggg cgaccgcttc caccgtgtgc tgctggcgca cggcgtgggt gctcgccccg
     1141 ggggccagtc tcgcgcgctg cccgccgcgc cgcgcgccga tttcttcctg accggtgcgc
     1201 tcgaggtgat ctgcgaagcc tggctgcgcg atctgctttt cgcgcgcggc gcgcccgcct
     1261 ggctgcggcg ccgctacctg aggctgcgct atgaggacct ggtgcggcag ccacgcgccc
     1321 agctgcgccg cctgctgcgc ttctccgggc tacgcgcgct cgcagcgctc gatgccttcg
     1381 cgctcaacat gactcgcggc gcggcctacg gcgccgaccg gcccttccac ctgtcagcgc
     1441 gcgacgcccg ggaggcggtg cacgcctggc gcgagcgcct gagccgagag caggtgcgcc
     1501 aggtggaggc cgcctgcgct ccagccatgc gtctgctcgc ctaccctcgc agcggagagg
     1561 agggcgacgc ggagcagccc agggaagggg agacgccgct ggagatggat gccgacggcg
     1621 ccacgtagcc tcccatccct gtccccggca cggatccggg tcagtcacca cgaacagggg
     1681 cactcggcat gctgccccag cactggagaa gcagcgctgt gggggcaatc tgtcacactc
     1741 tcagagtctg ggacttgact tgctaccaac aactgctgtg caattctgct gagcaggaat
     1801 atcatgagct gttcaataat gacggacgca ttggttgaga tgaagtttcc agtaaggaag
     1861 tgacagtgca atgtggatat ttatggctgt aaaataggaa gagctttagt tcccaggctg
     1921 aacctgccac tgctggagcc atttcaacaa ggcatcctca caacaaagaa gagatgtgat
     1981 ttggtaccat ttcacaccag caggtgtctg gacgaaaaca tcaatgtgaa taagggccaa
     2041 gtgcagtcct gtcttgatta aattacttaa taatattatt aaataataat aggtctgggc
     2101 agtattgttt ttaacctgac tcatccagct gtccttcaaa tagctccgtc tccctctacc
     2161 cagaactgat ttttaaaaag aagtaatttt tctccctggg ctgggaaaac cctaatgaac
     2221 tgaaacacac ttttacttta aaatttttct gtctggcgtt tttgtaatca tactattaaa
     2281 tgactctgga gtcatgttaa tgacaggatt tgttttgttt ggatgcagtt caattgcatg
     2341 gtttgggtaa aagctagcct acatacaaag gaatatgaag actgtggaag aaactg
//
