LOCUS       NM_021615               8370 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens carbohydrate sulfotransferase 6 (CHST6), transcript
            variant 1, mRNA.
ACCESSION   NM_021615
VERSION     NM_021615.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8370)
  AUTHORS   Samulenas,G., Insodaite,R., Kunceviciene,E., Poceviciute,R.,
            Masionyte,L., Zitkeviciute,U., Pilipaityte,L. and Smalinskiene,A.
  TITLE     The Role of Functional Polymorphisms in the Extracellular Matrix
            Modulation-Related Genes on Dupuytren's Contracture
  JOURNAL   Genes (Basel) 13 (5), 743 (2022)
   PUBMED   35627129
  REMARK    GeneRIF: The Role of Functional Polymorphisms in the Extracellular
            Matrix Modulation-Related Genes on Dupuytren's Contracture.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8370)
  AUTHORS   Hao,X.D., Liu,Y.N., Hu,S.H., Pan,X.J. and Chen,P.
  TITLE     Association of macular corneal dystrophy with excessive cell
            senescence and apoptosis induced by the novel mutant CHST6
  JOURNAL   Exp Eye Res 214, 108862 (2022)
   PUBMED   34826417
  REMARK    GeneRIF: Association of macular corneal dystrophy with excessive
            cell senescence and apoptosis induced by the novel mutant CHST6.
REFERENCE   3  (bases 1 to 8370)
  AUTHORS   Li,D., Tian,L., Wang,X. and Chen,M.
  TITLE     Macular corneal dystrophy related to novel mutations of CHST6 in a
            Chinese family and clinical observation after penetrating
            keratoplasty
  JOURNAL   BMC Med Genomics 14 (1), 247 (2021)
   PUBMED   34645431
  REMARK    GeneRIF: Macular corneal dystrophy related to novel mutations of
            CHST6 in a Chinese family and clinical observation after
            penetrating keratoplasty.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8370)
  AUTHORS   Safari,I., Baradaran-Rafii,A., Issazadeh-Navikas,S. and Elahi,E.
  TITLE     CHST6 mutations identified in Iranian MCD patients and CHST6
            mutations reported worldwide identify targets for gene editing
            approaches including the CRISPR/Cas system
  JOURNAL   Int Ophthalmol 40 (9), 2223-2235 (2020)
   PUBMED   32472422
  REMARK    GeneRIF: CHST6 mutations identified in Iranian MCD patients and
            CHST6 mutations reported worldwide identify targets for gene
            editing approaches including the CRISPR/Cas system.
REFERENCE   5  (bases 1 to 8370)
  AUTHORS   Zhang,J., Wu,D., Li,Y., Fan,Y., Dai,Y. and Xu,J.
  TITLE     A comprehensive evaluation of 181 reported CHST6 variants in
            patients with macular corneal dystrophy
  JOURNAL   Aging (Albany NY) 11 (3), 1019-1029 (2019)
   PUBMED   30716718
  REMARK    GeneRIF: vast majority of variants likely to be protein-damaging
REFERENCE   6  (bases 1 to 8370)
  AUTHORS   Liu,N.P., Dew-Knight,S., Rayner,M., Jonasson,F., Akama,T.O.,
            Fukuda,M.N., Bao,W., Gilbert,J.R., Vance,J.M. and Klintworth,G.K.
  TITLE     Mutations in corneal carbohydrate sulfotransferase 6 gene (CHST6)
            cause macular corneal dystrophy in Iceland
  JOURNAL   Mol Vis 6, 261-264 (2000)
   PUBMED   11139648
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 8370)
  AUTHORS   Spiro,M.J. and Spiro,R.G.
  TITLE     Sulfation of the N-linked oligosaccharides of influenza virus
            hemagglutinin: temporal relationships and localization of
            sulfotransferases
  JOURNAL   Glycobiology 10 (11), 1235-1242 (2000)
   PUBMED   11087716
REFERENCE   8  (bases 1 to 8370)
  AUTHORS   Akama,T.O., Nishida,K., Nakayama,J., Watanabe,H., Ozaki,K.,
            Nakamura,T., Dota,A., Kawasaki,S., Inoue,Y., Maeda,N., Yamamoto,S.,
            Fujiwara,T., Thonar,E.J., Shimomura,Y., Kinoshita,S., Tanigami,A.
            and Fukuda,M.N.
  TITLE     Macular corneal dystrophy type I and type II are caused by distinct
            mutations in a new sulphotransferase gene
  JOURNAL   Nat Genet 26 (2), 237-241 (2000)
   PUBMED   11017086
REFERENCE   9  (bases 1 to 8370)
  AUTHORS   Uchimura,K., Fasakhany,F., Kadomatsu,K., Matsukawa,T., Yamakawa,T.,
            Kurosawa,N. and Muramatsu,T.
  TITLE     Diversity of N-acetylglucosamine-6-O-sulfotransferases: molecular
            cloning of a novel enzyme with different distribution and
            specificities
  JOURNAL   Biochem Biophys Res Commun 274 (2), 291-296 (2000)
   PUBMED   10913333
REFERENCE   10 (bases 1 to 8370)
  AUTHORS   Vance,J.M., Jonasson,F., Lennon,F., Sarrica,J., Damji,K.F.,
            Stauffer,J., Pericak-Vance,M.A. and Klintworth,G.K.
  TITLE     Linkage of a gene for macular corneal dystrophy to chromosome 16
  JOURNAL   Am J Hum Genet 58 (4), 757-762 (1996)
   PUBMED   8644739
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009163.6, HY106598.1,
            AF280086.1 and BF510724.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 19, 2018 this sequence version replaced NM_021615.4.
            
            Summary: The protein encoded by this gene is an enzyme that
            catalyzes the transfer of a sulfate group to the GlcNAc residues of
            keratan. Keratan sulfate helps maintain corneal transparency.
            Defects in this gene are a cause of macular corneal dystrophy
            (MCD). [provided by RefSeq, Jan 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.1534729.1,
                                           SRR18074969.1044797.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332272.9/ ENSP00000328983.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC009163.6         109722-109726       c
            6-413               HY106598.1         2-409
            414-3371            AF280086.1         9-2966
            3372-7854           AC009163.6         86853-91335         c
            7855-8370           BF510724.1         18-533              c
FEATURES             Location/Qualifiers
     source          1..8370
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1"
     gene            1..8370
                     /gene="CHST6"
                     /gene_synonym="C-GlcNAc6ST; glcNAc6ST-5; gn6st-5;
                     GST4-beta; hCGn6ST; MCDC1"
                     /note="carbohydrate sulfotransferase 6"
                     /db_xref="GeneID:4166"
                     /db_xref="HGNC:HGNC:6938"
                     /db_xref="MIM:605294"
     exon            1..502
                     /gene="CHST6"
                     /gene_synonym="C-GlcNAc6ST; glcNAc6ST-5; gn6st-5;
                     GST4-beta; hCGn6ST; MCDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            503..577
                     /gene="CHST6"
                     /gene_synonym="C-GlcNAc6ST; glcNAc6ST-5; gn6st-5;
                     GST4-beta; hCGn6ST; MCDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            578..8370
                     /gene="CHST6"
                     /gene_synonym="C-GlcNAc6ST; glcNAc6ST-5; gn6st-5;
                     GST4-beta; hCGn6ST; MCDC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             594..1781
                     /gene="CHST6"
                     /gene_synonym="C-GlcNAc6ST; glcNAc6ST-5; gn6st-5;
                     GST4-beta; hCGn6ST; MCDC1"
                     /EC_number="2.8.2.21"
                     /note="corneal N-acetylglucosamine 6-sulfotransferase;
                     N-acetylglucosamine 6-O-sulfotransferase 5; corneal
                     N-acetylglucosamine-6-O-sulfotransferase; carbohydrate
                     (N-acetylglucosamine 6-O) sulfotransferase 6;
                     galactose/N-acetylglucosamine/N-acetylglucosamine
                     6-O-sulfotransferase 4-beta"
                     /codon_start=1
                     /product="carbohydrate sulfotransferase 6"
                     /protein_id="NP_067628.1"
                     /db_xref="CCDS:CCDS10918.1"
                     /db_xref="GeneID:4166"
                     /db_xref="HGNC:HGNC:6938"
                     /db_xref="MIM:605294"
                     /translation="MWLPRVSSTAVTALLLAQTFLLLFLVSRPGPSSPAGGEARVHVL
                     VLSSWRSGSSFVGQLFNQHPDVFYLMEPAWHVWTTLSQGSAATLHMAVRDLVRSVFLC
                     DMDVFDAYLPWRRNLSDLFQWAVSRALCSPPACSAFPRGAISSEAVCKPLCARQSFTL
                     AREACRSYSHVVLKEVRFFNLQVLYPLLSDPALNLRIVHLVRDPRAVLRSREQTAKAL
                     ARDNGIVLGTNGTWVEADPGLRVVREVCRSHVRIAEAATLKPPPFLRGRYRLVRFEDL
                     AREPLAEIRALYAFTGLSLTPQLEAWIHNITHGSGPGARREAFKTSSRNALNVSQAWR
                     HALPFAKIRRVQELCAGALQLLGYRPVYSEDEQRNLALDLVLPRGLNGFTWASSTASH
                     PRN"
     regulatory      7271..7276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHST6"
                     /gene_synonym="C-GlcNAc6ST; glcNAc6ST-5; gn6st-5;
                     GST4-beta; hCGn6ST; MCDC1"
                     /note="hexamer: AATAAA"
     polyA_site      7298
                     /gene="CHST6"
                     /gene_synonym="C-GlcNAc6ST; glcNAc6ST-5; gn6st-5;
                     GST4-beta; hCGn6ST; MCDC1"
                     /note="major polyA site"
ORIGIN      
        1 acctcgggac cgcagccacg tctgaaagcg cctcattgtg tgcgctcggg cgggctgcac
       61 cgggcagcgc cgagggttgc cggccggcgc gcggggagta gagggcgcgg gccgcagtgc
      121 cgggttccag agggagctct gcgccgggtc cttccctgtg gtagccccag gacaccccca
      181 gcctcaacat cccattctgg gactcctgcc ctgttcccac attcgttcta cctcgagtct
      241 ccaggagctt ccagtggctt ggtcaccgcc aactctcgtc catgcctctt agagcccctt
      301 tcccggcctc accgggtgtc gcttaatagt cttgggacct taaggagcaa gtcagcccct
      361 gcggaccctc ccagtgaaga gaaagagctg gctgtgcggt ggaatttgga agagacgacg
      421 tttgggagcc tttgctgagt ccagggagag aggcgtcccc caccgtgccg ctgcagctcg
      481 ggcagagccg ccaagctttg gggtgctgag gaacctctaa tcatctccca tggatttgtg
      541 atcagcgttg cagctctccc agcagccctg gacagtggcc cccagcagtc agcatgtggc
      601 tgccgcgcgt ctccagcaca gcagtgaccg cgctcctcct ggcgcagacc ttcctcctcc
      661 tctttctggt ttcccggcca gggccctcgt ccccagcagg cggcgaggcg cgcgtgcatg
      721 tgctggtgct gtcctcgtgg cgctcgggct cgtccttcgt gggccaactc ttcaaccagc
      781 accccgacgt cttctaccta atggagcccg cgtggcacgt gtggaccacc ctgtcgcagg
      841 gcagcgccgc aacgctgcac atggctgtgc gcgacctggt gcgctccgtc ttcctgtgcg
      901 acatggacgt gtttgatgcc tatctgcctt ggcgccgcaa cctgtccgac ctcttccagt
      961 gggccgtgag ccgtgcactg tgctcgccac ccgcctgcag tgcctttccc cgaggcgcca
     1021 tcagcagcga ggccgtgtgc aagccactgt gcgcgcggca gtccttcacc ctggcccggg
     1081 aggcctgccg ctcctacagc cacgtggtgc tcaaggaggt gcgcttcttc aacctgcagg
     1141 tgctctaccc gctgctcagc gaccccgcgc tcaacctacg catcgtgcac ctggtgcgcg
     1201 acccgcgggc cgtgctgcgc tcccgggagc agacagccaa ggctctggcg cgtgacaacg
     1261 gcatcgtgct gggcaccaac ggcacgtggg tggaggccga ccccggcctg cgcgtggtgc
     1321 gcgaggtgtg ccgtagccac gtacgcatcg ccgaggccgc cacactcaag ccgccaccct
     1381 ttctgcgcgg ccgctaccgc ctggtgcgct tcgaggacct ggcgcgggag ccgctggcag
     1441 aaatccgtgc gctctacgcc ttcactgggc tcagtctcac gccacagctc gaggcctgga
     1501 tccataacat cacccacgga tctggacctg gtgcgcgccg cgaagccttc aagacttcgt
     1561 ccaggaatgc gctcaacgtc tcccaggcct ggcgccatgc gctgcccttt gccaagatcc
     1621 gccgcgtgca ggaactgtgc gctggtgcgc tgcagctgct gggctaccgg cctgtgtact
     1681 ctgaggacga gcagcgcaac ctcgcccttg atctggtgct gccacgaggc ctgaacggct
     1741 tcacttgggc atcatccacc gcctcgcacc cccgaaatta gtggaggcca cagttgtagc
     1801 aggcgctagg cccgggagga gagtgcatgg tgcagagggg gctggggcgc acggagaagc
     1861 aggtccctat attgaccaag gagtttgtgg tacgacccct ccccctcccc aagtaggcaa
     1921 ggactgcacg tttctttctc tcttgattct tggttttcct ttgagtcctc tggagctgcc
     1981 ttctcatcag gtgcactctt catggaaagc aactcttgcc cctcctcctc tgggcacagg
     2041 gtgtgcgttc agatgacttg gctcctactc aagggctttc ttccccttta actctctcct
     2101 tctggtgaca catcctgcag cagctgaggg ggtgccctgg cactggctgg gagtggagag
     2161 gcactgtggt gaaatggctc cagaggtctg tacatcacat acatatgcac acaggcacac
     2221 atggcaaaac tcggaagtga aaggacttgt ctgaaatcac atggtgagaa ggaggatgaa
     2281 gggaggagag agcttttgct ctgggtctcc agtggatagg agaggacctg cctcctgggt
     2341 gagaagggtc agattttcct attttaattg ctttagggaa gagcaagcag agtcatgacc
     2401 agggacacag ctgagagata gaggaggctg tgaatgctga gaccagagtt tatcatgctg
     2461 gacaagcctg gaaggaggca ataagtggga aaggtaggag gagagaaggc tggggagggc
     2521 tgggcagcaa gccaggcaca gtgagtggca gagcaagagg gggaaagcag gatcagtgcc
     2581 tggaaggcag gtgtgcccgt cagcggggag tggaactcat caggcttgcc aagaggttgg
     2641 aagggaaatg gctctgggct ggaactgtct tcccttggtc cttctggtcc aggccttgga
     2701 ggaaagcaga ggatgatccc tgcctgtgag ccacacctcc tagctctggg ggcaaagggg
     2761 cttagtaaag gaatgctgga tgtgtagagg gtttagtccc gagctcagga aatgagagcc
     2821 tataagtgcc cagtacatgt ttaaaagaag agctcatgga acctctggaa aggacaggga
     2881 agttgagtta gccacataaa tgaacccaag tcacattgga acacagagct ggtctgggaa
     2941 ctgtgttggc tgccaacaga acttctgacc ctgttacctg tgaaatgagg cagtttccct
     3001 cacgttgcca tcagctacca ggagcgatgc tggtggtcac tagcttctga tcctcatcct
     3061 gggtgtggcc acagattggg ggaacctgga ttgtggagtc acatcctccc tgcaaagcaa
     3121 gcagggcaag ggagatctgg cattttctgc tttacgtgga gggagaacag gcacattagc
     3181 cttgaagctg aagctcattt taggttcctt ccaggtttag aagcttcaac caaatgaaac
     3241 ttgaatctgt ccctcgtgac aattatagga ggaaggtatt taaaacccca gatttatgaa
     3301 tgtgtactac atggcttaga gaatgtcttt gttcttgttc aggtggttat aacaaaatac
     3361 cttaagagtg ggtaacttgg ctggatgcag tggctcatgc ctgtaatccc agcactgtgg
     3421 gaggccgagg gggatgaatc acctgaggtc aggcattcaa gaacagcctg gccaacatgg
     3481 cgaagcccct cctctactaa aaatacaaaa ttagcgaggc atggtcgcac atacctgtaa
     3541 tcccagctcc tcgggaagct gaggcaggag aatcgcttga acccaggagg cggaggttgc
     3601 agtgagccaa gatcacgcca ttgcactcca gcctgggtga cagagcaaga ctccatctca
     3661 aaaaaaaaaa aaagactggg taacttataa acaaatgttc ttctcacaag tctggagact
     3721 gggaagtcca agatcaagcc accagtgctg tctgatgagg gcccactttt tcaaagacag
     3781 tgccttctag ctgtgtcctc ttatcgtaga agatgggaga cagctctcca gggccatttt
     3841 tttttttttt tttttttttt tgagatggag tctggctctg tcgcccaggc tggagtgcag
     3901 tggcacaatc tcggctcact gcaacctctg cctctctctg cctcctgagt tcaagcaatt
     3961 ctcctgcctc agcctcctga ggagctggga ctacagggat gcaccaccat gcccagctaa
     4021 tttttgtatt tttgtagaca ctgggtttca ccatattggc caggttggtc tcaaactcct
     4081 gacctcaagt gatctgccca cctcagcctc ccaaagtgct gagattacag gcatgagcca
     4141 ctgtacccag tctccagggc cttttaaaga atgtcactaa tcccattctt gaggtctcca
     4201 ccttcattat ctaatcacct cccaaaggct ccacatccca acaccatcat attgtgggtt
     4261 aagatttcaa ccacaagcca ggcgtggtgg ctcatgcctg taatcccagc attttggaag
     4321 gctgaggcag gtggatcact tgaggtcagg agtttgagac cagcctggcc aacatggtga
     4381 aaccccatct ctactaaaaa taaaaaaaat tagccgggtg tggtggtgca cacctgtaat
     4441 tccagctact caggaggctg aggcaggaga atcccttgaa tccaggaggc ggacagtgca
     4501 gtgagccgag ataatgccac tgcactccag cctggatgac agagcaagac tccatctcat
     4561 gcccagccag catgcccaac aagcttcatt tgcccctgtt taggtcacaa attttattga
     4621 tggctgcaat taatggcctc ttggtatcca agtcctttgt tgtatgaccc atccattctc
     4681 ccctgactcc caaggtgtca ggacatgctt gactggctcc tgaatttgct ctctgcgcat
     4741 gggcagtaca gtcaagcctc acagtgaacc caggtcagct ttcaggacaa agaaagtggc
     4801 ctggctgact aggcacagta aagccagggc tgggtaggta catacttgtg ctgatcacgt
     4861 atgtcttata tctctgtgag agtgcagtcc caacaggaag gtttaatcac tggggactgc
     4921 ccaatgctgt gacagggcac agagctctgg gttgctgtgg gggtgactgc attgaccact
     4981 gttagtggtt tgctgtgttg acactctgtg ctgtgtgacc atggctcctg ccatcaagaa
     5041 gtagagtctg tttctccacc tctgaatcca ggctggtcct gtgacttgct ttgtcctgta
     5101 gacaagtgta gtgcaacttc ctgtgagcca gtttgaagca taggccttgg aagcaaaact
     5161 ttacctccac ctgtcttagg ttttcagctg gggctctgct gtgatttgat tgtgtctccc
     5221 aaagttggaa ccttgatccc cagtgttgtg aggtgaggct tgatggaaag taaattacgc
     5281 cgtgcgggtt atgcccttgt gaatgggtag agaacattat ttctgggcgc aggcatggta
     5341 gctcatgtct gtaatcccag cattttggga ggttgaggtg tgcggattac ttgaggtcag
     5401 gagtttgaga ccagcctggc caacaaggta aaacaccatt tctagttaaa atacaaaaat
     5461 tagccaggtg tggtggcaca tgcctgtaag gccagctact tgggaggctg agacaggaga
     5521 atcgcttgaa cccaggaggc agagattgca gtgagctgag atcgcaccac tgtactccag
     5581 cctgggcaac aaagcgagag tctgtcttaa aaaaaaccac cattatttca ggagtgagtt
     5641 ggttatcctg agagtggtgc cttttaaatg aaggagttca ttctttgtct ttctctcgcc
     5701 ctcactttgc ccttctgcca tatgatgcct tccatcatgc taggacacag caagaaggct
     5761 ctcgctagat gctggctcct tgatcttggg cttcccagcc tccagaactg taagccaata
     5821 cacttctatt tattatatat gacccttgct gggttcagtg gctcacgcct gtaatcccaa
     5881 tactttgcaa ggctgaggca ggaggatcac ttgagaccag gcactcaaga ccagcctggg
     5941 caacatagtg agaccccatc tctacaaagt taaaaaaaaa ttagcagggc atggtgtcgt
     6001 gcacctgtag tcctagctac ttgggaggct gagttgggag gactgcttga ccctgggagg
     6061 ttgaggctac attgaaccat gatcatgcca gtgcactcca gcctgagtga cagagcaaga
     6121 cacctatctc taaataaatg accccatctg tggtattgtt atagcaaaac aaaacagatt
     6181 aagagagact ttttaatgaa aagacagatt cacaaagaaa aacaatgttt ttgtttctgt
     6241 ttttttgagg cagagtcttg ctcttgtccc ccaggctgga gtgcagtggc gccatcttgg
     6301 ctcactgcaa cctccgcctc ccagtttcaa gcgattctcc tgcctcagcc tcccgagtag
     6361 ctgggattac agatgtacac caccacgccc ggctaatttt ttttgtattt ttagtagaga
     6421 tggggtttca ccatgtcgat caggctgggc tggaactcct gacctcaggt gatccacctg
     6481 ccttggcctc ccaatgtgct aggattacag gcatgagcca ctgtacctgg cgaaaaacag
     6541 tttgttaaca caggcagcca acatcactca ggataagcct caatgaaaag taacaaagtg
     6601 atggcttgga acactgtctt acacagcatt tttaaaaaat acaataaatt tgtagagata
     6661 ggatgaccaa ggacaacagt tttaggcttc caaaggtggt aaactatggg atggtaaata
     6721 tccgagagga agctgatgca acaggatttg tctgcagcag cctctggtac cacctctgag
     6781 tcaagggttg tgtccagtga tggagagttt atatcgtgcc tttaggcaga aaaggggagg
     6841 gaaacctgaa cttttcctgc actttctgct tcttaattgc cttcagctga aaatcatttt
     6901 ttatgtgaaa aaggcatagt ctgagctgac gcctctgctt tcctccacct gaagagaacc
     6961 tgcgtgctgc tcctttgctt cggacctccg cctctgcccg ggagaaagcc caggccagcc
     7021 tgctggacaa gcagagacca tgagaaggag agttcagggg tcccaaacca ggccatccta
     7081 gaccagccag ctccagctga tccgcacgca gccacttcgg ctaccttcta ctggccaaag
     7141 ggagtcccag ggctcaccca gattcagagg tggggaaact gagtccacca cttgagaaga
     7201 gtagctataa agacatatga gcgaggccag ctgagcccag cactgcggcc aagtcgaaga
     7261 ctttaggagc aataaaagtg cttattgtgt ttcagtcatt tgagtgttgt ggtggtttgt
     7321 tacgtagcat tgcctaaccg atacacttga gaacggaggg ctcctggcac ctgcagcttc
     7381 caatttccac cagggtccag gctccctccc tgctggtagg gctgtaatta gtgtctcccc
     7441 ttacctgtag gccctgtgat gcagctagaa gtgtctaggc ccagcagtca cccacaatta
     7501 ggggcaggca cgcttgctgc ctctgctctg gctgtgggag ctcagaaggg gcaatcaaag
     7561 cactagatgg gctgatgggt gcatagaaac agtgttgcct ggaataggtc agagaaccca
     7621 cctatcaaga ggctgttggg gaatcaatgg tgggccttat ttttgttatt ttgcatcaag
     7681 aagatatatt atccacatca acactgtatc aactcctcat ggccaccaca gaccctgtgt
     7741 cccctagctt tgtctttgat gtgcctttgt cacccactcc tacagactgc gccccaccac
     7801 tgccacaact gccccatcac ctctacaggg ttaaatcaat ggttttaatt tttgcctacc
     7861 tgatgggtga aaaatgttac ttgatgtttc agtctgcact tctttaattc ctggggcagc
     7921 tgaacatctt ttcatgctta tgactcaact gtattccttt ttcattgttc aaggctgtgc
     7981 ccatgttgct gttgacttac cacagcctct tttgaatatg ctttgttatt tttgttgtgc
     8041 aaatggtttc tcctagcttg tcatctgttt tttgttgttg ttgttttgtt aacttacttt
     8101 atggcatttt cccctcaggc ttcttaaaaa aaaagaagct tcattgagct ataattgata
     8161 tacaacatct gcacataaag tgtaaagttt gattaaacat ttgtatatac ctgtgaaatc
     8221 aaatcaccac ctcatcacaa tcaaatttca aaaagtttca cctagtttat catattgttg
     8281 aatgtgaatc ctttccttat ggccagtgga ttttatgtct tgttgaaacg actttgtcct
     8341 gctacagtga taaaaatggt cttcacgctt
//
