LOCUS       NM_024533               3554 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens carbohydrate sulfotransferase 5 (CHST5), mRNA.
ACCESSION   NM_024533
VERSION     NM_024533.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3554)
  AUTHORS   Yu,S.Y., Hsiao,C.T., Izawa,M., Yusa,A., Ishida,H., Nakamura,S.,
            Yagi,H., Kannagi,R. and Khoo,K.H.
  TITLE     Distinct substrate specificities of human
            GlcNAc-6-sulfotransferases revealed by mass spectrometry-based
            sulfoglycomic analysis
  JOURNAL   J Biol Chem 293 (39), 15163-15177 (2018)
   PUBMED   30093410
  REMARK    GeneRIF: mRNA transcript analyses on the genes involved in
            synthesizing GlcNAc-6-O-sulfated glycans in human colon cancer
            tissues indicated that GlcNAc6ST-2 (CHST4) is preferentially
            expressed in cancer cells ...  GlcNAc6ST-3 (CHST5) was only
            expressed in nonmalignant epithelial cells, whereas GlcNAc6ST-1
            (CHST2) was expressed equally in both
REFERENCE   2  (bases 1 to 3554)
  AUTHORS   Wolpin,B.M., Rizzato,C., Kraft,P., Kooperberg,C., Petersen,G.M.,
            Wang,Z., Arslan,A.A., Beane-Freeman,L., Bracci,P.M., Buring,J.,
            Canzian,F., Duell,E.J., Gallinger,S., Giles,G.G., Goodman,G.E.,
            Goodman,P.J., Jacobs,E.J., Kamineni,A., Klein,A.P., Kolonel,L.N.,
            Kulke,M.H., Li,D., Malats,N., Olson,S.H., Risch,H.A., Sesso,H.D.,
            Visvanathan,K., White,E., Zheng,W., Abnet,C.C., Albanes,D.,
            Andreotti,G., Austin,M.A., Barfield,R., Basso,D., Berndt,S.I.,
            Boutron-Ruault,M.C., Brotzman,M., Buchler,M.W.,
            Bueno-de-Mesquita,H.B., Bugert,P., Burdette,L., Campa,D.,
            Caporaso,N.E., Capurso,G., Chung,C., Cotterchio,M., Costello,E.,
            Elena,J., Funel,N., Gaziano,J.M., Giese,N.A., Giovannucci,E.L.,
            Goggins,M., Gorman,M.J., Gross,M., Haiman,C.A., Hassan,M.,
            Helzlsouer,K.J., Henderson,B.E., Holly,E.A., Hu,N., Hunter,D.J.,
            Innocenti,F., Jenab,M., Kaaks,R., Key,T.J., Khaw,K.T., Klein,E.A.,
            Kogevinas,M., Krogh,V., Kupcinskas,J., Kurtz,R.C., LaCroix,A.,
            Landi,M.T., Landi,S., Le Marchand,L., Mambrini,A., Mannisto,S.,
            Milne,R.L., Nakamura,Y., Oberg,A.L., Owzar,K., Patel,A.V.,
            Peeters,P.H., Peters,U., Pezzilli,R., Piepoli,A., Porta,M.,
            Real,F.X., Riboli,E., Rothman,N., Scarpa,A., Shu,X.O.,
            Silverman,D.T., Soucek,P., Sund,M., Talar-Wojnarowska,R.,
            Taylor,P.R., Theodoropoulos,G.E., Thornquist,M., Tjonneland,A.,
            Tobias,G.S., Trichopoulos,D., Vodicka,P., Wactawski-Wende,J.,
            Wentzensen,N., Wu,C., Yu,H., Yu,K., Zeleniuch-Jacquotte,A.,
            Hoover,R., Hartge,P., Fuchs,C., Chanock,S.J.,
            Stolzenberg-Solomon,R.S. and Amundadottir,L.T.
  TITLE     Genome-wide association study identifies multiple susceptibility
            loci for pancreatic cancer
  JOURNAL   Nat Genet 46 (9), 994-1000 (2014)
   PUBMED   25086665
REFERENCE   3  (bases 1 to 3554)
  AUTHORS   Liu,C.Y., Wu,M.C., Chen,F., Ter-Minassian,M., Asomaning,K.,
            Zhai,R., Wang,Z., Su,L., Heist,R.S., Kulke,M.H., Lin,X., Liu,G. and
            Christiani,D.C.
  TITLE     A Large-scale genetic association study of esophageal
            adenocarcinoma risk
  JOURNAL   Carcinogenesis 31 (7), 1259-1263 (2010)
   PUBMED   20453000
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3554)
  AUTHORS   Dastani,Z., Pajukanta,P., Marcil,M., Rudzicz,N., Ruel,I.,
            Bailey,S.D., Lee,J.C., Lemire,M., Faith,J., Platko,J., Rioux,J.,
            Hudson,T.J., Gaudet,D., Engert,J.C. and Genest,J.
  TITLE     Fine mapping and association studies of a high-density lipoprotein
            cholesterol linkage region on chromosome 16 in French-Canadian
            subjects
  JOURNAL   Eur J Hum Genet 18 (3), 342-347 (2010)
   PUBMED   19844255
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 3554)
  AUTHORS   Saito,A., Kawamoto,M. and Kamatani,N.
  TITLE     Association study between single-nucleotide polymorphisms in 199
            drug-related genes and commonly measured quantitative traits of 752
            healthy Japanese subjects
  JOURNAL   J Hum Genet 54 (6), 317-323 (2009)
   PUBMED   19343046
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 3554)
  AUTHORS   Akama,T.O., Misra,A.K., Hindsgaul,O. and Fukuda,M.N.
  TITLE     Enzymatic synthesis in vitro of the disulfated disaccharide unit of
            corneal keratan sulfate
  JOURNAL   J Biol Chem 277 (45), 42505-42513 (2002)
   PUBMED   12218059
REFERENCE   7  (bases 1 to 3554)
  AUTHORS   Seko,A., Nagata,K., Yonezawa,S. and Yamashita,K.
  TITLE     Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2,
            in colonic mucinous adenocarcinoma
  JOURNAL   Glycobiology 12 (6), 379-388 (2002)
   PUBMED   12107080
REFERENCE   8  (bases 1 to 3554)
  AUTHORS   Bartes,A., Bhakta,S. and Hemmerich,S.
  TITLE     Sulfation of endothelial mucin by corneal keratan
            N-acetylglucosamine 6-O-sulfotransferase (GST-4beta)
  JOURNAL   Biochem Biophys Res Commun 282 (4), 928-933 (2001)
   PUBMED   11352640
REFERENCE   9  (bases 1 to 3554)
  AUTHORS   Akama,T.O., Nishida,K., Nakayama,J., Watanabe,H., Ozaki,K.,
            Nakamura,T., Dota,A., Kawasaki,S., Inoue,Y., Maeda,N., Yamamoto,S.,
            Fujiwara,T., Thonar,E.J., Shimomura,Y., Kinoshita,S., Tanigami,A.
            and Fukuda,M.N.
  TITLE     Macular corneal dystrophy type I and type II are caused by distinct
            mutations in a new sulphotransferase gene
  JOURNAL   Nat Genet 26 (2), 237-241 (2000)
   PUBMED   11017086
REFERENCE   10 (bases 1 to 3554)
  AUTHORS   Lee,J.K., Bhakta,S., Rosen,S.D. and Hemmerich,S.
  TITLE     Cloning and characterization of a mammalian
            N-acetylglucosamine-6-sulfotransferase that is highly restricted to
            intestinal tissue
  JOURNAL   Biochem Biophys Res Commun 263 (2), 543-549 (1999)
   PUBMED   10491328
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009163.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 14, 2019 this sequence version replaced NM_024533.4.
            
            Summary: The protein encoded by this gene belongs to the
            Gal/GalNAc/GlcNAc 6-O-sulfotransferase (GST) family, members of
            which catalyze the transfer of sulfate to position 6 of galactose
            (Gal), N-acetylgalactosamine (GalNAc), or N-acetylglucosamine
            (GlcNAc) residues within proteoglycans, and sulfation of O-linked
            sugars of mucin-type acceptors. Carbohydrate sulfation plays a
            critical role in many biologic processes. This gene is
            predominantly expressed in colon and small intestine. [provided by
            RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF246718.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1968540,
                                    SAMEA2142348 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336257.8/ ENSP00000338783.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC009163.6         150329-150393       c
            66-348              AC009163.6         149412-149694       c
            349-443             AC009163.6         147374-147468       c
            444-3554            AC009163.6         142815-145925       c
FEATURES             Location/Qualifiers
     source          1..3554
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1"
     gene            1..3554
                     /gene="CHST5"
                     /gene_synonym="glcNAc6ST-3; gn6st-3; hIGn6ST;
                     I-GlcNAc-6-ST; I-GlcNAc6ST"
                     /note="carbohydrate sulfotransferase 5"
                     /db_xref="GeneID:23563"
                     /db_xref="HGNC:HGNC:1973"
                     /db_xref="MIM:604817"
     exon            1..65
                     /gene="CHST5"
                     /gene_synonym="glcNAc6ST-3; gn6st-3; hIGn6ST;
                     I-GlcNAc-6-ST; I-GlcNAc6ST"
                     /inference="alignment:Splign:2.1.0"
     exon            66..348
                     /gene="CHST5"
                     /gene_synonym="glcNAc6ST-3; gn6st-3; hIGn6ST;
                     I-GlcNAc-6-ST; I-GlcNAc6ST"
                     /inference="alignment:Splign:2.1.0"
     exon            349..443
                     /gene="CHST5"
                     /gene_synonym="glcNAc6ST-3; gn6st-3; hIGn6ST;
                     I-GlcNAc-6-ST; I-GlcNAc6ST"
                     /inference="alignment:Splign:2.1.0"
     exon            444..3554
                     /gene="CHST5"
                     /gene_synonym="glcNAc6ST-3; gn6st-3; hIGn6ST;
                     I-GlcNAc-6-ST; I-GlcNAc6ST"
                     /inference="alignment:Splign:2.1.0"
     CDS             1700..2935
                     /gene="CHST5"
                     /gene_synonym="glcNAc6ST-3; gn6st-3; hIGn6ST;
                     I-GlcNAc-6-ST; I-GlcNAc6ST"
                     /EC_number="2.8.2.-"
                     /note="intestinal GlcNAc-6-sulfotransferase; GST4-alpha;
                     N-acetylglucosamine 6-O-sulfotransferase 3;
                     galactose/N-acetylglucosamine/N-acetylglucosamine
                     6-O-sulfotransferase 4-alpha; carbohydrate
                     (N-acetylglucosamine 6-O) sulfotransferase 5"
                     /codon_start=1
                     /product="carbohydrate sulfotransferase 5"
                     /protein_id="NP_078809.2"
                     /db_xref="CCDS:CCDS10919.1"
                     /db_xref="GeneID:23563"
                     /db_xref="HGNC:HGNC:1973"
                     /db_xref="MIM:604817"
                     /translation="MGMRARVPKVAHSTRRPPAARMWLPRFSSKTVTVLLLAQTTCLL
                     LFIISRPGPSSPAGGEDRVHVLVLSSWRSGSSFLGQLFSQHPDVFYLMEPAWHVWTTL
                     SQGSAATLHMAVRDLMRSIFLCDMDVFDAYMPQSRNLSAFFNWATSRALCSPPACSAF
                     PRGTISKQDVCKTLCTRQPFSLAREACRSYSHVVLKEVRFFNLQVLYPLLSDPALNLR
                     IVHLVRDPRAVLRSREAAGPILARDNGIVLGTNGKWVEADPHLRLIREVCRSHVRIAE
                     AATLKPPPFLRGRYRLVRFEDLAREPLAEIRALYAFTGLTLTPQLEAWIHNITHGSGI
                     GKPIEAFHTSSRNARNVSQAWRHALPFTKILRVQEVCAGALQLLGYRPVYSADQQRDL
                     TLDLVLPRGPDHFSWASPD"
     regulatory      3529..3534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHST5"
                     /gene_synonym="glcNAc6ST-3; gn6st-3; hIGn6ST;
                     I-GlcNAc-6-ST; I-GlcNAc6ST"
                     /note="hexamer: AATAAA"
     polyA_site      3554
                     /gene="CHST5"
                     /gene_synonym="glcNAc6ST-3; gn6st-3; hIGn6ST;
                     I-GlcNAc-6-ST; I-GlcNAc6ST"
                     /note="major polyA site"
ORIGIN      
        1 gtctttcaac tcctcccagc tgggacactg caccgggagg cagcacggat tcctgtgtca
       61 tcaagattcg ctctgcctcg agtctccagg agcttccagt ggcttggtta cccccgactc
      121 ttcgtccatg cctcttagag cccctttccc agcctcactg ggtgtccctt aatagtcttg
      181 ggaccttaag gagcaagtca gcccctgcgg aacctcccag tgaagagaaa gagctggctg
      241 tgcggtggaa cttggaagag acgacgtctg ggagcttttg ctgagcccag ggggagaggc
      301 gtccctctgg ctgctgctcc agctctggca gacacgccaa gctttgagaa agctcccagt
      361 gaggaactgg tcttctggag actctgtgtg gcatagagtg attcaaccac cttaagaaga
      421 cctctggctt tcctggaaca cagatgtcga gacatctccc atggatttgt gatcagcgtt
      481 gcagctctcc cagcagccct ggacggtggt gagtcccctc agctggccag gacagtactc
      541 tgctctcacc tctctgcttc ttgggctcca tcccagctcc ccatcaactg atcttcttgc
      601 aaacccacag ggctccagga caccctcctt ctggagccca tgctgcctac agcacttcac
      661 tccccaccag tgatgacaac agttgctgtt ctttgtccac tttatttact tgtttatctt
      721 taatgacaaa agtttttttt ttgttgtttt tttttttttt tttgaaacgg agtctcactc
      781 ttcactcagg ctgcagtgca gtggcgcaat ctcagctcac tgccacctct gcctcccagg
      841 ttcacgccat tctcctgcct cagcctcccg agtagctggg actacaggcg cccaccatca
      901 cgcctggcta attttttgta tttttagtag agatggggtc tcactgtgtt agccaggatg
      961 gtctcgatct cctgacctcg tgatccgccc gcctcggcct cccataatgc tgggattaca
     1021 ggcgtgagcc accgcgcctg gctgacaaaa gttttatacc tgcctgttaa aaaaattata
     1081 taatacagaa gcacaccttg taaaaggtgc aatcctcagt tatgggcatg actgcgtgtt
     1141 cccttccccc atcttcatta taataacccc ccaatccccc cagatcctgt gagccaggta
     1201 ccggaattat ccctctttca cacacgggta aagtgatccg tcacagagag atttaagtga
     1261 tcttcataag caagatcata ggctaggaag tggcagagcc aggattcaac ctcggcgagc
     1321 ctggtggtgc tctgacatcc accgaagccc ccatcaagcc cttttagctc cacaacctaa
     1381 aagggtctct ctaagaggta tcctgaagca aaagacagga gttctctttg aaacatagta
     1441 tttctctcta cagatagata gcctgtaggt atgtaagtag gtgggtgggt gggtaggtag
     1501 acagtttgat gatatcccac attattctgc aactggactt ctgctgtgag cacagactat
     1561 attctggcct atgtcttgac tccgtattcc tgggaaagtg ctcgactgag accttgggag
     1621 tcttgggaag tccaatgggt agggtagccg aatctgaggg ctgatccctg agggcactgg
     1681 gcagtaattg gggcatggga tgggcatgag ggcccgggtc cctaaagttg cccactccac
     1741 ccgaaggccc ccagccgccc gcatgtggct gccacggttc tccagcaaga cagtgacagt
     1801 gctcctcctg gcacagacca cctgcctcct gctcttcatc atctcccggc cagggccctc
     1861 atccccagcc ggcggcgagg atcgtgtgca cgtgctggtg ctgtcctcgt ggcgctcggg
     1921 ctcatccttc ttgggccagc tcttcagcca gcaccccgac gtcttctacc tgatggagcc
     1981 cgcgtggcat gtgtggacca ccctgtcgca gggcagcgcg gcaacgctgc acatggccgt
     2041 gcgcgacctg atgcgctcta tctttttgtg cgacatggac gtgtttgatg cctacatgcc
     2101 acagagccga aacctgtccg cctttttcaa ctgggcaacg agccgcgcgc tgtgctcgcc
     2161 gcccgcctgc agcgcctttc cccgaggcac catcagcaag caggacgtat gcaagacact
     2221 gtgcacgcgg cagccattca gcctggcccg ggaggcctgc cgctcctaca gccacgtggt
     2281 gctcaaggag gtgcgcttct tcaacctgca ggtgctctac ccgctgctca gcgaccccgc
     2341 gctcaacctg cgcatcgtgc acctggtgcg cgacccgcgg gccgtgctgc gctcccggga
     2401 ggcggcgggc ccgatactgg cacgcgacaa cggcatcgtg ctgggcacca acggcaagtg
     2461 ggtggaggcc gaccctcacc tgcgcctgat tcgcgaggtg tgccgcagcc acgtgcgcat
     2521 cgccgaggcc gccacactca agccgccacc cttcctgcgc ggccgctacc gcctggtgcg
     2581 cttcgaggac ctggcgcggg agccgctggc agagatccgc gcactctacg ccttcaccgg
     2641 cctgaccctc acgccacagc tcgaggcctg gatccacaac atcacccacg ggtcggggat
     2701 cggcaagcca atcgaggcct tccatacttc gtctaggaat gcgcgcaacg tctcccaggc
     2761 ctggcgccac gcgttgccct tcactaagat cctgcgcgtg caggaggtgt gcgccggcgc
     2821 gctgcagctg ctgggctacc ggcctgtgta ctctgcggac cagcagcgtg acctcaccct
     2881 ggatctggtg ctgccacgag gcccagacca cttcagctgg gcatcgcctg actgagaact
     2941 ctgggcctta gagcaggccc cgaactgtgg tcgccaggcc caggaggcga ctgcatggtg
     3001 gagagggagc tggggcgcat ggggaagcag gtccctacta tcaaccggga gtttggggtc
     3061 ctcccctgaa gtaggcaagg actgcacgtt tctttctctc ctgattctcg gttttccttt
     3121 gagtcttctg gagctgcctt ctcatcaggt gcactcttca tggaaagcaa ctcttgcccc
     3181 tacctcttct gggcgcaggg agtaagttac tgctaaatta aattaaatgt gtgccaggcc
     3241 gggtgcggtg gctcatgcct gtaatcccag cattttgaga ggctgaggcg ggtggatcac
     3301 ctgaggtcag gagttcgaaa ccagcctggc caacatagtg aaaccccctc tctactaaaa
     3361 atgcaaaaat tagtccggcg tggtggcaca ctcctgtaat cccagctact taggaggctg
     3421 aggtgggaga atcacttgga ctccagaggt ggaggttgca gtaagctgag atcatgccac
     3481 tgcaccctag cttgggtggc agagcaagac tctatcaaaa aaataagtaa taaatttgtt
     3541 caaaagtcct gcaa
//
