LOCUS       NM_004273               6934 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens carbohydrate sulfotransferase 3 (CHST3), mRNA.
ACCESSION   NM_004273
VERSION     NM_004273.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6934)
  AUTHORS   Singh,S., Jacob,P., Patil,S.J., Muranjan,M., Shah,H., Girisha,K.M.
            and Bhavani,G.S.
  TITLE     Indian patients with CHST3-related chondrodysplasia with congenital
            joint dislocations
  JOURNAL   Am J Med Genet A 194 (3), e63422 (2024)
   PUBMED   37876363
  REMARK    GeneRIF: Indian patients with CHST3-related chondrodysplasia with
            congenital joint dislocations.
REFERENCE   2  (bases 1 to 6934)
  AUTHORS   Luo,Y., Lu,X., Ma,W., Xiao,Y., Wei,C., Yuan,X., Wu,Y., Wang,Y.,
            Xiong,Y., Yu,X., Wu,X., He,S., Liu,Y., Wang,J., Wu,Q., Zhou,H. and
            Jiang,Z.
  TITLE     Dampening HOTAIR sensitizes the gastric cancer cells to oxaliplatin
            through miR-195-5p and ABCG2 pathway
  JOURNAL   J Cell Mol Med 27 (22), 3591-3600 (2023)
   PUBMED   37621132
  REMARK    GeneRIF: Dampening HOTAIR sensitizes the gastric cancer cells to
            oxaliplatin through miR-195-5p and ABCG2 pathway.
REFERENCE   3  (bases 1 to 6934)
  AUTHORS   Otaify,G.A., Elhossini,R.M., Abdel-Ghafar,S.F., Sayed,I.M.,
            Abdel-Salam,G.M.H., Aglan,M.S. and Abdel-Hamid,M.S.
  TITLE     CHST3-related skeletal dysplasia in 14 patients: Identification of
            8 novel variants and further expansion of the phenotypic spectrum
  JOURNAL   Am J Med Genet A 191 (8), 2100-2112 (2023)
   PUBMED   37183573
  REMARK    GeneRIF: CHST3-related skeletal dysplasia in 14 patients:
            Identification of 8 novel variants and further expansion of the
            phenotypic spectrum.
REFERENCE   4  (bases 1 to 6934)
  AUTHORS   Kausar,M., Ain,N.U., Hayat,F., Fatima,H., Azim,S., Ullah,H.,
            Mushtaq,M., Khalid,S., Hussain,S., Naz,S., Janjua,J., Amjad,S.B.,
            Baig,R.M., Makitie,O., Qamar,R., Ikegawa,S., Gen,N., Khor,C.C.,
            Foo,J.N. and Siddiqi,S.
  TITLE     Biallelic variants in CHST3 cause Spondyloepiphyseal dysplasia with
            joint dislocations in three Pakistani kindreds
  JOURNAL   BMC Musculoskelet Disord 23 (1), 818 (2022)
   PUBMED   36042462
  REMARK    GeneRIF: Biallelic variants in CHST3 cause Spondyloepiphyseal
            dysplasia with joint dislocations in three Pakistani kindreds.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6934)
  AUTHORS   Kitazawa,K., Nadanaka,S., Kadomatsu,K. and Kitagawa,H.
  TITLE     Chondroitin 6-sulfate represses keratinocyte proliferation in mouse
            skin, which is associated with psoriasis
  JOURNAL   Commun Biol 4 (1), 114 (2021)
   PUBMED   33495490
  REMARK    GeneRIF: Chondroitin 6-sulfate represses keratinocyte proliferation
            in mouse skin, which is associated with psoriasis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6934)
  AUTHORS   Uchimura,K., Kadomatsu,K., Nishimura,H., Muramatsu,H., Nakamura,E.,
            Kurosawa,N., Habuchi,O., El-Fasakhany,F.M., Yoshikai,Y. and
            Muramatsu,T.
  TITLE     Functional analysis of the chondroitin 6-sulfotransferase gene in
            relation to lymphocyte subpopulations, brain development, and
            oversulfated chondroitin sulfates
  JOURNAL   J Biol Chem 277 (2), 1443-1450 (2002)
   PUBMED   11696535
REFERENCE   7  (bases 1 to 6934)
  AUTHORS   Okuda,T., Mita,S., Yamauchi,S., Matsubara,T., Yagi,F., Yamamori,D.,
            Fukuta,M., Kuroiwa,A., Matsuda,Y. and Habuchi,O.
  TITLE     Molecular cloning, expression, and chromosomal mapping of human
            chondroitin 4-sulfotransferase, whose expression pattern in human
            tissues is different from that of chondroitin 6-sulfotransferase
  JOURNAL   J Biochem 128 (5), 763-770 (2000)
   PUBMED   11056388
REFERENCE   8  (bases 1 to 6934)
  AUTHORS   Tsutsumi,K., Shimakawa,H., Kitagawa,H. and Sugahara,K.
  TITLE     Functional expression and genomic structure of human chondroitin
            6-sulfotransferase
  JOURNAL   FEBS Lett 441 (2), 235-241 (1998)
   PUBMED   9883891
REFERENCE   9  (bases 1 to 6934)
  AUTHORS   Fukuta,M., Kobayashi,Y., Uchimura,K., Kimata,K. and Habuchi,O.
  TITLE     Molecular cloning and expression of human chondroitin
            6-sulfotransferase
  JOURNAL   Biochim Biophys Acta 1399 (1), 57-61 (1998)
   PUBMED   9714738
REFERENCE   10 (bases 1 to 6934)
  AUTHORS   Superti-Furga,A. and Unger,S.
  TITLE     Chondrodysplasia with Congenital Joint Dislocations, CHST3-Related
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   21882400
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB017915.1, AC022392.5 and
            AI041015.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004273.4.
            
            Summary: This gene encodes an enzyme which catalyzes the sulfation
            of chondroitin, a proteoglycan found in the extracellular matrix
            and most cells which is involved in cell migration and
            differentiation. Mutations in this gene are associated with
            spondylepiphyseal dysplasia and humerospinal dysostosis. [provided
            by RefSeq, Mar 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB017915.1, AB012192.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373115.5/ ENSP00000362207.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2251              AB017915.1         34-2284
            2252-6456           AC022392.5         27094-31298
            6457-6934           AI041015.1         12-489              c
FEATURES             Location/Qualifiers
     source          1..6934
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.1"
     gene            1..6934
                     /gene="CHST3"
                     /gene_synonym="C6ST; C6ST1; HSD"
                     /note="carbohydrate sulfotransferase 3"
                     /db_xref="GeneID:9469"
                     /db_xref="HGNC:HGNC:1971"
                     /db_xref="MIM:603799"
     exon            1..300
                     /gene="CHST3"
                     /gene_synonym="C6ST; C6ST1; HSD"
                     /inference="alignment:Splign:2.1.0"
     exon            301..547
                     /gene="CHST3"
                     /gene_synonym="C6ST; C6ST1; HSD"
                     /inference="alignment:Splign:2.1.0"
     CDS             408..1847
                     /gene="CHST3"
                     /gene_synonym="C6ST; C6ST1; HSD"
                     /EC_number="2.8.2.17"
                     /EC_number="2.8.2.21"
                     /note="chondroitin 6-O-sulfotransferase 1;
                     galactose/N-acetylglucosamine/N-acetylglucosamine
                     6-O-sulfotransferase 0; GST-0; C6ST-1; carbohydrate
                     (chondroitin 6) sulfotransferase 3; chondroitin 6
                     sulfotransferase 1"
                     /codon_start=1
                     /product="carbohydrate sulfotransferase 3"
                     /protein_id="NP_004264.2"
                     /db_xref="CCDS:CCDS7312.1"
                     /db_xref="GeneID:9469"
                     /db_xref="HGNC:HGNC:1971"
                     /db_xref="MIM:603799"
                     /translation="MEKGLTLPQDCRDFVHSLKMRSKYALFLVFVVIVFVFIEKENKI
                     ISRVSDKLKQIPQALADANSTDPALILAENASLLSLSELDSAFSQLQSRLRNLSLQLG
                     VEPAMEAAGEEEEEQRKEEEPPRPAVAGPRRHVLLMATTRTGSSFVGEFFNQQGNIFY
                     LFEPLWHIERTVSFEPGGANAAGSALVYRDVLKQLFLCDLYVLEHFITPLPEDHLTQF
                     MFRRGSSRSLCEDPVCTPFVKKVFEKYHCKNRRCGPLNVTLAAEACRRKEHMALKAVR
                     IRQLEFLQPLAEDPRLDLRVIQLVRDPRAVLASRMVAFAGKYKTWKKWLDDEGQDGLR
                     EEEVQRLRGNCESIRLSAELGLRQPAWLRGRYMLVRYEDVARGPLQKAREMYRFAGIP
                     LTPQVEDWIQKNTQAAHDGSGIYSTQKNSSEQFEKWRFSMPFKLAQVVQAACGPAMRL
                     FGYKLARDAAALTNRSVSLLEERGTFWVT"
     exon            548..6934
                     /gene="CHST3"
                     /gene_synonym="C6ST; C6ST1; HSD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6905..6910
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHST3"
                     /gene_synonym="C6ST; C6ST1; HSD"
                     /note="hexamer: ATTAAA"
     polyA_site      6934
                     /gene="CHST3"
                     /gene_synonym="C6ST; C6ST1; HSD"
                     /note="major polyA site"
ORIGIN      
        1 gctagccggc tcgggcctga gcggggaggg cgccaggcag gacctctcgc aggctcgctg
       61 cgcaggacgg cgcccgcctg gcgccgcttc ccttccagcg tgccgaccgg ccccgcagcg
      121 cctccatccc tccggcccgc cccggagaag acgcacagct cgggccgcgc gggcgccggg
      181 gccgcggaac cgcttctgcc gggatcttcc aggaggaaag cgaagttgcg agcggatgct
      241 gcccgcgccg gaccccagcc gcggagggtc ggggccgccg gtggagtctc ggcggccggg
      301 gacaagggtg tcccccacct gaagacggca agctgggtcc tgagtgatgc ccctcagctg
      361 agtgtccaag gctggcccga ggagccccca cggccccacc tttccccatg gagaaaggac
      421 tcactttgcc ccaggactgc cgggactttg tgcacagcct gaagatgaga agcaaatacg
      481 cccttttctt ggtttttgtg gtgatagttt ttgtcttcat cgaaaaggaa aataaaatca
      541 tatcaagggt ctcagacaag ctgaagcaga ttccccaagc tctagcagat gccaacagca
      601 ccgacccagc cctgatctta gctgagaacg catctctctt gtccctgagc gagctcgatt
      661 cagccttctc ccagcttcag agccgtctcc gcaacctcag cttgcagctg ggcgtggagc
      721 cagccatgga ggccgcaggg gaggaagagg aagagcagag aaaggaggag gagccgccca
      781 gaccggccgt ggcggggccc cggcgccacg tgctgctcat ggccaccacg cgcaccggct
      841 cctcgttcgt gggcgagttc ttcaaccagc agggcaacat cttctacctc ttcgagccgc
      901 tgtggcacat cgagcgcaca gtgtccttcg agccgggggg cgccaacgcc gcgggctcgg
      961 ccctggtgta ccgcgacgtg ctcaagcagc tcttcctgtg cgacctgtac gtgctggagc
     1021 acttcatcac gccgctgccc gaggaccacc tgactcagtt catgttccgc cggggctcca
     1081 gccgctccct gtgcgaggac cccgtctgta cgcccttcgt caagaaggtc ttcgagaagt
     1141 accactgcaa gaaccgccgc tgcggccccc tcaacgtgac gctggccgca gaggcctgcc
     1201 gccgcaagga gcacatggcc ctcaaggcgg tgcgcatccg gcagctggag ttcctgcagc
     1261 cgctggccga ggacccccgc ctggacctgc gcgtcatcca gctggtgcgc gacccccggg
     1321 ccgtgctggc ctcgcgcatg gtggccttcg ccggcaagta taagacctgg aagaagtggc
     1381 tggacgacga gggccaggac ggcctgaggg aagaggaggt gcagcggctg cggggcaact
     1441 gcgagagcat ccgcctgtcc gcggagctgg ggctgcggca gcccgcctgg ctgcggggcc
     1501 gctacatgct ggtgcgctac gaggacgtgg cacgcgggcc gctgcagaag gcccgcgaga
     1561 tgtaccgctt cgccggcatc cccctgaccc cgcaggtgga agactggatc caaaagaaca
     1621 cgcaggcggc ccacgacggc agcggcatct actccacgca gaagaactcc tcggagcagt
     1681 tcgagaagtg gcgcttcagc atgcccttca agctggccca ggtggtgcag gccgcctgcg
     1741 gccctgccat gcgcctcttc ggctacaaac tggcgcggga cgccgccgcc ctcaccaacc
     1801 gctcagtcag cctgctggag gagaggggca ccttctgggt cacgtagggg ggccggggcc
     1861 ccgtatgccc ctcctcgtga aaggcctgcc ccgtctttct gccgcagccc tcgcagaggg
     1921 cgggtgcaca gcgccatgag cgggcagcgc ctcctgtagc agtagggccc ccagccagcg
     1981 ctccagccaa agcggcggcc ccagggttaa ttgcggagaa caggacagtg cccggtcccc
     2041 ttgagggcca tcacacccag acccaacggg ttgcagcctc ctgagcaggc ctaggcaggc
     2101 ccgggcctgt tggcaagctt cgatctcaca cacacagaaa catacattcg tgcctggaga
     2161 ccctgcaggc cagagtccaa atatttaaca atcagaaggg gcaaggctct gaccagtgac
     2221 agtcagacct cctgctttat ttggtgttaa ccgtttcttg tctggatggt gaagtctgga
     2281 atctgggtgg gtccttggag gaggggctag gacagccgtg ggtgtcaaag gtggcatttg
     2341 aggctcgttt gaggtgacag tggctgttta ccaactagta cagagcgatt cagcgttttc
     2401 atgaatgggt tggctgtgct ggttactgat gaatatgggc cccttataga gctgcaaaac
     2461 acacacatgc gtatagacat acatacatgt acaccataca tagacaagca tcataaaggc
     2521 acaagtgcac acacatctat gcagacaagc ttcctcgctg cttatgccca cagggttttt
     2581 ctgtatgaca cacctcagag gagcctgtgc ttaacatttg taggattatt tcgagggcag
     2641 ggcaggggaa agaaacgcgt taaagggcca tgacatgaca cagttccctg gccgggtttg
     2701 gactgaacag tggattcaga actgcagcgt tcaaagcccc tgcccgcctt agattctcat
     2761 ggctacctcc tctgacccat ccacatcctt gcggctggca ggcaggatgt tttgaaatgg
     2821 tgcagccaaa ggccccgtct agcttggctg gctcccgaac atgtccatat ttgaaggctg
     2881 cctcaggcct ggcaggcaga agcagctgtg gtccctggag gcaaaaggca gctcacgggg
     2941 ccttccattt ccagccaggc ctcatctggg gtagggccaa gaggaaagta cagagtgccc
     3001 gtgggggaga agtcccacca ggatgccccc cctcccctga gaagcccgcc ttctccctcg
     3061 tggacaggag tcagccagtt ggttgctgtg gttacagcca gtgcctggaa ttcctcctta
     3121 gggccctggg aagagtattg cttaacgcag gatgtgctgg gtgttttgtt tcgggctttt
     3181 atttatggct tggtgtcttt cttgtttcat ggctgtgttt ttgcttttgt ttctgtagga
     3241 gcgcctcttc caagcagtgg aggcctgagg gcttgaggga ggctggggaa aaccagcagg
     3301 gagcacttgg ctcctggcag agggagagga caggaggagg agccttcccc aggaggaacg
     3361 aggagaggtg gccacgtggc aggccacagt gccctatggg cttttctgtt tgaaccccat
     3421 gtgggatgaa tctcaaagcc accagcgttc ttgcctagtg tccagagcag cagagatttg
     3481 cagccctcgc ccctccctga gaagaagctg gatttgaaaa tccctcacag gccctaacat
     3541 gtttcctggg tgggcagggg cctcatgaca agcgacaagt gtacccagag tagaaggcct
     3601 tccccactcc cacctcaaac ccaggagcag aactcagtat ccagagctta caaggagctg
     3661 caagggtttg ccgagggctg cccagctctg cttctggttt cctggacaat ttctctgtca
     3721 gatacggccc attgtaaacc cagagggctg cattttgggt tgagtaatat ggacaccatg
     3781 gaagtacagg atctgagtcc aacattgcca tgggggaggg aagagtgtgt cctggcagga
     3841 agccaccatt ggagaaggtg aggccagtaa ccatctcatg ggattcgcta taatcagcct
     3901 atttgagctg ctgggtctct gtcactgtgg actccagtca ttcaaggagg tctccactct
     3961 tgggtttttt ttattttctt ttcttttgct attttgcctg aacaccccaa cactcttggt
     4021 tttagagtcc aagagtaagt tgtgcagaga catggttcta atttggagtt caaaggaaca
     4081 ccagctctga aaacatgacc gtggggccag gatgtttctg gcaggcccag aagtgctggc
     4141 cgttcttccc cagcctcccc actgctccct cctctgttcc ccatgtggag gtcggagggg
     4201 ctgggactgg ggagggggca gccacctcca tccaaggctc ttcctagggg ccctgctaat
     4261 gtggacagta gactttatcc ctccttctta ctctgggcca agacctccca ctccgccctc
     4321 tgaggatggt accaagaatg ggcctttggg acttctcagg acattgacaa tgtgcacact
     4381 gcaggttgac ttaatttatt tattttttga aaagaagaga cagaaaatac cttattatct
     4441 gcagggactc aaagctgtac ccaaatcaag aaagacaaaa taacaataga aaccattcac
     4501 acactccgtt catgcatgga caccagaaga cgattcagaa cacaagagga gaatgagctg
     4561 gagcgccagc accacgatgg ccccaggacg ttgtttaaga tctgagatcc cttggtttct
     4621 ctcttgttga tctgagatgc tacatcaggg cccttgctgc tgtattacct ctgcccgggt
     4681 gtttgagaca ggtcacaagc gcgtggatgt ttcctggaag tgtattcccc tggggctcag
     4741 cgatgctctg ggaacccttg gggtttgggg aaggacagtg tggtgtgact attggcttga
     4801 aacgttatgg atatggttgg agtcacccat gtggatatga ttttcagctt ggagctggga
     4861 tggagaagat ggaagcactg gtggccgggc ctctttttcc agcgaggcca gccctggctt
     4921 ctcctctgtt ccagcttgtc tgccagaagc cttcccctgc aaggtgccca cctgcccgga
     4981 gacagaggga gcagctgagg cctctctcca ctggccgcca gcctccctag cacaagggga
     5041 ccattcagca atgagtgttt actcatgttc tttcttgttg atgagttctg cggcccagca
     5101 tatagaaatg gctcagaacg ttccaggcct tggtgagaca cagcagcgtc caatgctcac
     5161 aggctgtccc cactctgcct gttcccatct tcccctcggg acctgtttat aaattgagga
     5221 atggatgagg gccctggagg gtccttggga gtagttagtg gagggcagga ttctcaggtc
     5281 cccatagaga gggaaagaga agaccagatg tgcatagaag ccagtctctg tcacatacac
     5341 cgcaggtggt caccgagtta ttttccaaaa gctgaggaac ataaagcaaa tttaggcttt
     5401 tgtccttctg caatacatgc acttgaaaat aaacagaaaa gagatgttta ataacaagtt
     5461 tacttccggt ctgctagcac cctcagcctg ggagctactg ccagaggctg gcgtagtggg
     5521 gcagctgctg accaaacccc acagaacaga gggcaccagg catcacacga catctttccc
     5581 tcccatctct gccatctgtc tgtctggcaa tggaaggagc ttcagcagga ggtccttccc
     5641 agaaggttga ttcttggcct gggtggtaga ggagatatcc tgaccctaaa gtcttccagc
     5701 cccgggtcat cctctcctat actagggcct attgaccgta gaggccaggt gcggtggctc
     5761 atacctgtaa tcccagcagt tggggaggcc aaggtgggag gattgcttga gcccaagagt
     5821 tggagaccag cctgggcaac atggtgagac caattgactg tagggcttgt cccttgctaa
     5881 gacaggagca gaagactgga tggctgtgtc ctcaaggcag tcccctccca tccccattcc
     5941 caaagtcaga aagtgaagcc agatctcaag ggctgatacc tgaggcaagg agagctaagg
     6001 ggagagaaat tggggctgag tggaagcaga tgcctgcaca agccaagtgt gtcttattga
     6061 tctgtacaag ctgatagaag gaccatctgc tgaaatccag ggctcctgag ttggtgggtt
     6121 tgcttgtgaa gcttctagga caaggcgcag ccagatggaa gggagagggt ccagggcttc
     6181 ctaaatgcag ccgcatcacc tgtcaactcg ctgcagtttc agagacagtg gaagctgctc
     6241 tttacctcaa aagcacaaag cagaattggc aacttcactt gtctcaagag ctccaagatc
     6301 ctttggtctc gtgtcctttg gcaccccgta actggactgg ggacaaattt gttacgtgtt
     6361 tccaaggcta cagacatggc gccatcctca caggcctagc tcatgtcatg gatcaggtgc
     6421 tttgctgggg ggatacaatg acccatgtgg tctgcgtctt ctgccattgg cttgaactgg
     6481 gcaccccctg aagtctccat ctcagctgta tattctagtc caaattttcc tggctcccct
     6541 gctccctccc aggtcctgca cactgtcttt ttgccaacac ctcagccctg tttgctattt
     6601 catgtctgca tggtacgaga caccccttca cggcatacac tgccatggta tgtacatatg
     6661 catccacgtg tgtgtatgtg tagcatgtag ctcattctgc tcagcctctg gcgccgttcc
     6721 acattgctcc cagccccatt gctgtcactg tcgtcccaga tgtccttgcc atggccacag
     6781 acaatctgcc gtctcctgga aacgctgggg ctgcccttca gagagctggc agccccagca
     6841 gtcagggcct gctttgcaga atagaatgtg aacccaactc ctgatggcct acttgactta
     6901 tttaattaaa gatgaaatca tgcaatgagc aaaa
//
