LOCUS       NM_001270764            4809 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens carbohydrate sulfotransferase 15 (CHST15), transcript
            variant 3, mRNA.
ACCESSION   NM_001270764
VERSION     NM_001270764.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4809)
  AUTHORS   Wang,T., Zhang,Y., Wu,J., Feng,H., Wang,R. and Yuan,H.
  TITLE     Association of genetic variants of CircCHST15 with oral squamous
            cell carcinoma in the Chinese Han population
  JOURNAL   Head Neck 45 (4), 806-815 (2023)
   PUBMED   36608057
  REMARK    GeneRIF: Association of genetic variants of CircCHST15 with oral
            squamous cell carcinoma in the Chinese Han population.
REFERENCE   2  (bases 1 to 4809)
  AUTHORS   Chen,Y., Zhang,Y., Wang,Z., Wang,Y., Luo,Y., Sun,N., Zheng,S.,
            Yan,W., Xiao,X., Liu,S., Li,J., Peng,H., Xu,Y., Hu,G., Cheng,Z. and
            Zhang,G.
  TITLE     CHST15 gene germline mutation is associated with the development of
            familial myeloproliferative neoplasms and higher transformation
            risk
  JOURNAL   Cell Death Dis 13 (7), 586 (2022)
   PUBMED   35798703
  REMARK    GeneRIF: CHST15 gene germline mutation is associated with the
            development of familial myeloproliferative neoplasms and higher
            transformation risk.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4809)
  AUTHORS   Gui,C.P., Liao,B., Luo,C.G., Chen,Y.H., Tan,L., Tang,Y.M., Li,J.Y.,
            Hou,Y., Song,H.D., Lin,H.S., Xu,Q.H., Yao,G.S., Yao,H.H., Xi-Liu,
            Luo,J.H., Cao,J.Z. and Wei,J.H.
  TITLE     circCHST15 is a novel prognostic biomarker that promotes clear cell
            renal cell carcinoma cell proliferation and metastasis through the
            miR-125a-5p/EIF4EBP1 axis
  JOURNAL   Mol Cancer 20 (1), 169 (2021)
   PUBMED   34922539
  REMARK    GeneRIF: circCHST15 is a novel prognostic biomarker that promotes
            clear cell renal cell carcinoma cell proliferation and metastasis
            through the miR-125a-5p/EIF4EBP1 axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4809)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4809)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4809)
  AUTHORS   Sekiguchi,T., Hirose,E., Nakashima,N., Ii,M. and Nishimoto,T.
  TITLE     Novel G proteins, Rag C and Rag D, interact with GTP-binding
            proteins, Rag A and Rag B
  JOURNAL   J Biol Chem 276 (10), 7246-7257 (2001)
   PUBMED   11073942
REFERENCE   7  (bases 1 to 4809)
  AUTHORS   Yuki,M., Yoshinaga,K., Yamakawa,H., Sakurada,K., Sato,S., Yajima,A.
            and Horii,A.
  TITLE     Structure, expression and mutational analysis of the hBRAG gene on
            10q in the frequently deleted region in human endometrial cancer
  JOURNAL   Oncol Rep 7 (6), 1339-1342 (2000)
   PUBMED   11032940
REFERENCE   8  (bases 1 to 4809)
  AUTHORS   Verkoczy,L.K., Guinn,Ba. and Berinstein,N.L.
  TITLE     Characterization of the human B cell RAG-associated gene, hBRAG, as
            a B cell receptor signal-enhancing glycoprotein dimer that
            associates with phosphorylated proteins in resting B cells
  JOURNAL   J Biol Chem 275 (28), 20967-20979 (2000)
   PUBMED   10749872
REFERENCE   9  (bases 1 to 4809)
  AUTHORS   Verkoczy,L.K., Marsden,P.A. and Berinstein,N.L.
  TITLE     hBRAG, a novel B cell lineage cDNA encoding a type II transmembrane
            glycoprotein potentially involved in the regulation of
            recombination activating gene 1 (RAG1)
  JOURNAL   Eur J Immunol 28 (9), 2839-2853 (1998)
   PUBMED   9754571
REFERENCE   10 (bases 1 to 4809)
  AUTHORS   Inoue,H., Otsu,K., Suzuki,S. and Nakanishi,Y.
  TITLE     Difference between N-acetylgalactosamine 4-sulfate
            6-O-sulfotransferases from human serum and squid cartilage in
            specificity toward the terminal and interior portion of chondroitin
            sulfate
  JOURNAL   J Biol Chem 261 (10), 4470-4475 (1986)
   PUBMED   3082866
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CR749804.1, BC027908.1,
            AF026477.1 and BC075813.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001270764.1.
            
            Summary: Chondroitin sulfate (CS) is a glycosaminoglycan which is
            an important structural component of the extracellular matrix and
            which links to proteins to form proteoglycans. Chondroitin sulfate
            E (CS-E) is an isomer of chondroitin sulfate in which the C-4 and
            C-6 hydroxyl groups are sulfated. This gene encodes a type II
            transmembrane glycoprotein that acts as a sulfotransferase to
            transfer sulfate to the C-6 hydroxal group of chondroitin sulfate.
            This gene has also been identified as being co-expressed with RAG1
            in B-cells and as potentially acting as a B-cell surface signaling
            receptor. Alternative splicing results in multiple transcript
            variants encoding distinct isoforms. [provided by RefSeq, Jul
            2012].
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1, and encodes isoform (1). Variants 1 and 3 encode the
            same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749804.1, SRR1803611.215705.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000435907.6/ ENSP00000402394.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3301              CR749804.1         93-3393
            3302-4491           BC027908.1         3216-4405
            4492-4493           AF026477.1         4055-4056
            4494-4809           BC075813.1         4159-4474
FEATURES             Location/Qualifiers
     source          1..4809
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.13"
     gene            1..4809
                     /gene="CHST15"
                     /gene_synonym="BRAG; GALNAC4S-6ST"
                     /note="carbohydrate sulfotransferase 15"
                     /db_xref="GeneID:51363"
                     /db_xref="HGNC:HGNC:18137"
                     /db_xref="MIM:608277"
     exon            1..130
                     /gene="CHST15"
                     /gene_synonym="BRAG; GALNAC4S-6ST"
                     /inference="alignment:Splign:2.1.0"
     exon            131..1188
                     /gene="CHST15"
                     /gene_synonym="BRAG; GALNAC4S-6ST"
                     /inference="alignment:Splign:2.1.0"
     CDS             643..2328
                     /gene="CHST15"
                     /gene_synonym="BRAG; GALNAC4S-6ST"
                     /EC_number="2.8.2.33"
                     /note="isoform 1 is encoded by transcript variant 3; B
                     cell RAG associated protein (GALNAC4S-6ST); hBRAG; B-cell
                     RAG-associated gene protein; carbohydrate
                     (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15"
                     /codon_start=1
                     /product="carbohydrate sulfotransferase 15 isoform 1"
                     /protein_id="NP_001257693.1"
                     /db_xref="CCDS:CCDS7638.1"
                     /db_xref="GeneID:51363"
                     /db_xref="HGNC:HGNC:18137"
                     /db_xref="MIM:608277"
                     /translation="MRHCINCCIQLLPDGAHKQQVNCQGGPHHGHQACPTCKGENKIL
                     FRVDSKQMNLLAVLEVRTEGNENWGGFLRFKKGKRCSLVFGLIIMTLVMASYILSGAH
                     QELLISSPFHYGGFPSNPSLMDSENPSDTKEHHHQSSVNNISYMKDYPSIKLIINSIT
                     TRIEFTTRQLPDLEDLKKQELHMFSVIPNKFLPNSKSPCWYEEFSGQNTTDPYLTNSY
                     VLYSKRFRSTFDALRKAFWGHLAHAHGKHFRLRCLPHFYIIGQPKCGTTDLYDRLRLH
                     PEVKFSAIKEPHWWTRKRFGIVRLRDGLRDRYPVEDYLDLFDLAAHQIHQGLQASSAK
                     EQSKMNTIIIGEASASTMWDNNAWTFFYDNSTDGEPPFLTQDFIHAFQPNARLIVMLR
                     DPVERLYSDYLYFASSNKSADDFHEKVTEALQLFENCMLDYSLRACVYNNTLNNAMPV
                     RLQVGLYAVYLLDWLSVFDKQQFLILRLEDHASNVKYTMHKVFQFLNLGPLSEKQEAL
                     MTKSPASNARRPEDRNLGPMWPITQKILRDFYRPFNARLAQVLADEAFAWKTT"
     exon            1189..1528
                     /gene="CHST15"
                     /gene_synonym="BRAG; GALNAC4S-6ST"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1675
                     /gene="CHST15"
                     /gene_synonym="BRAG; GALNAC4S-6ST"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1832
                     /gene="CHST15"
                     /gene_synonym="BRAG; GALNAC4S-6ST"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1989
                     /gene="CHST15"
                     /gene_synonym="BRAG; GALNAC4S-6ST"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2137
                     /gene="CHST15"
                     /gene_synonym="BRAG; GALNAC4S-6ST"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..4809
                     /gene="CHST15"
                     /gene_synonym="BRAG; GALNAC4S-6ST"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4750..4755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHST15"
                     /gene_synonym="BRAG; GALNAC4S-6ST"
                     /note="hexamer: ATTAAA"
     polyA_site      4774
                     /gene="CHST15"
                     /gene_synonym="BRAG; GALNAC4S-6ST"
                     /note="major polyA site"
     polyA_site      4809
                     /gene="CHST15"
                     /gene_synonym="BRAG; GALNAC4S-6ST"
ORIGIN      
        1 aaacttttcc tcccagcgct cggggagtca ggttgacgcg ccctggatgc ggggctagag
       61 gctcggggct gggcgcgctc ccgcggagcc ggagccgcag aggctcccgg gctggactca
      121 ggcttctcag gaaatctggc attttttaaa gtttgcgccc cacaaagagg aaatattcca
      181 aaggtactca ggatgtaaaa ggggagatct tcacagatgc ctccgtggat ggcatggcaa
      241 tccatccatc aatgagaaga ccatgatttc ttttaatttt ctgtgtgttt ccacattccc
      301 cagtgagaat tcttccacct ttttttgtgc catgggaaaa acctgaaggg caggcagagc
      361 tgctcccgaa cttgtgacct tctctgaggt tgcagcggct cttgtagaac atgactctgg
      421 gacatcactt ccttttgttt tctttcggag ctgaaccaaa gaatgtgcac cctctttctc
      481 tagtgctgtg gtgtctgctt atttttgtat ttgtgctttc catccatctt ctgtgatcac
      541 aaggcattct taaggttttc tagcacgact tgcggacatc cagactcgtg gggggcccac
      601 ccatggctcg gtaagccagc agcccagggc actggcacta ccatgaggca ctgcattaat
      661 tgctgcatac agctgttacc cgacggcgca cacaagcagc aggtcaactg ccaagggggc
      721 ccccatcacg gtcaccaggc gtgccccacg tgcaaaggag aaaacaaaat tctgtttcgt
      781 gtggacagta agcagatgaa cttgcttgct gttctcgaag tgaggactga agggaacgaa
      841 aactggggtg ggtttttgcg cttcaaaaag gggaagcgat gtagcctcgt ttttggactg
      901 ataataatga ccttggtaat ggcttcttac atcctttctg gggcccacca agagcttctg
      961 atctcatcac ctttccatta cggaggcttc cccagcaacc ccagcttgat ggacagcgaa
     1021 aacccaagtg acacaaagga gcatcaccac caatcctctg taaataatat ttcatacatg
     1081 aaggactatc caagcattaa attaattatc aacagcatca caactaggat tgagttcacg
     1141 accagacagc tcccagactt agaagacctt aagaagcagg agttgcatat gttttcagtc
     1201 atccccaaca aattccttcc aaacagtaag agcccctgtt ggtacgagga gttctcgggg
     1261 cagaacacca ccgaccccta cctcaccaac tcctacgtgc tctactccaa gcgcttccgc
     1321 tccaccttcg acgccctgcg caaggccttc tggggccacc tggcgcacgc gcacgggaag
     1381 cacttccgcc tgcgctgcct gccgcacttc tacatcatag ggcagcccaa gtgcgggacc
     1441 acagacctct atgaccgcct gcggctgcac cctgaggtca agttctccgc catcaaggag
     1501 ccacactggt ggacccggaa gcgctttgga atcgtccgcc taagagatgg gctgcgagac
     1561 cgctatcccg tggaagatta tctggacctc tttgacctgg ccgcacacca gatccatcaa
     1621 ggactgcagg ccagctctgc aaaggagcag agcaagatga atacaatcat tatcggggag
     1681 gccagtgcct ccacgatgtg ggataataat gcctggacgt tcttctacga caacagcacg
     1741 gatggcgagc caccgtttct gacgcaggac ttcatccacg cctttcagcc aaatgccaga
     1801 ctgattgtca tgctcaggga ccctgtggag aggttgtact cagactatct ctactttgca
     1861 agttcgaata aatccgcgga cgacttccat gagaaagtga cagaagcact gcagctgttt
     1921 gaaaattgca tgcttgatta ttcactgcgc gcctgcgtct acaacaacac cctcaacaac
     1981 gccatgcctg tgaggctcca ggttgggctc tatgctgtgt accttctgga ctggctcagc
     2041 gtttttgaca agcaacagtt tctcattctt cgcctggaag atcatgcatc caacgtcaag
     2101 tacaccatgc acaaggtctt ccagtttctg aacctagggc ccttaagtga gaagcaggag
     2161 gctttgatga ccaagagccc cgcatccaat gcacggcgtc ccgaggaccg gaacctgggg
     2221 cccatgtggc ccatcacaca gaagattctg cgggatttct acaggccctt caacgctagg
     2281 ctggcgcagg tcctcgcgga tgaggcgttt gcgtggaaga cgacgtgaga gctgaattgt
     2341 tgctgcacgt gctgggcccg ccaatgccgt catcatcagg attttacaaa tctctttgcg
     2401 gggaactgtt tcactcatgg tatggaaaac cccaggactc tgccactcta ggcacacatg
     2461 aattataacc attttggaat ttccttcgtg atgttcgaga gctcagcaat ggacccctca
     2521 cagagctcct ctatccgagg ccattggaga ccccagtttc tcaagaattc agctctgctc
     2581 tgagcgtcct ggagcttggg gatgcagcca gctggcctgc actgggtgtg gagagaacac
     2641 ctagggaagg cagcctggcc ctgcccgcct ccgccttctg gagagcctct gggttctgag
     2701 tcagcaagcc agaggtcatg ccacaggcct ggctggaact tacacttcac gttccctttt
     2761 tttcccccta gagatggggt ctcgccgtgt tgcacagact gtctgtattc aatggctatc
     2821 ttcacaggtg tgatcatacc acattcactt ctgaaacact cttgttgcga tcgctaacct
     2881 cactgggaca gagaaccgca gtctttcgag aatggaggct cttcattttt tttttctcct
     2941 ttactccaaa ctcagccctc cagtttcttc agatgtaaac cctgttaacg tcactgtttc
     3001 caaaaggaaa aaaataagtc agtttttggc agcaccttca tctttctgac ctcctcctat
     3061 tctgtccttg tggacttatg tttaacatag aaaatgaatg cgtttaaaac aaaaccactt
     3121 tctgcattta accagtcctg gctctctctc tgctgcctct tcatacgttt tctcaagaac
     3181 ttcagtttat aattggaaga gaaatttttg ctgttaatgc cagaatgagc aacctcaagg
     3241 aattgaacac ttcttggaaa atctaggtaa ttcaagccct catcaggttt acaagatcat
     3301 cagagaaaca gaggatttta atttttagtt ctggccggct acaggctcca tttctctgcc
     3361 ttcccattgg aaatagttta tttccacatt ctccactgcg tgtggtcaaa gttcctcacc
     3421 cagcaaggga ctatagatac tcgtgtccca attccaaaac acaatgcaca agctgaactt
     3481 gggctgaacg tggcgtgttg agatttggaa tgaggtttct aagagccgtg ttcttcatgg
     3541 aattttccag gccacttggc agcttggttt accgatggat gggctagaga tcttgtcgtt
     3601 tcttggaagt cacagggaag attgaagaga acgcttgagc atccttggca acagcccagg
     3661 tgggacctgg atgaagcttt gcactcaagt attgtcaagg gaagcttcct gtgaaccaaa
     3721 gttctcaggc caaggtctcg cccaccaaag ccagaaagtg caagcacccg tctacccagc
     3781 tctaacttgt atgtgtgaga cagaccaggc ttcgggggta ggaggatctg cagttgttca
     3841 gccgtctttc tgctggtgtt gtctttctgc catcagagaa gggacacaca gcccgttcga
     3901 aggtgtgcag agggctctga gcgccaggat ggccagggct gtttttgcta ctgaaggagc
     3961 gtgtgtcctg aactcccact tgcagggaca gtccccacct tctctatagc cggcactggg
     4021 agcagccgcc agcagggaaa tctggcctga gcacaaggat gctttaggga gagatcactt
     4081 cagtgtgtgt gtatatttat ttgcagtaca gtgcgcgcgt gtgtgtgtgt gtacgcgcac
     4141 gtgtgggtga gtgcgtcttc tgagtgggtt ctgttcagtt gctaatgagg ctcctccgct
     4201 ctggacacaa cccttttata gattaatttc tctgccaatt aacttgtcat tttcagtaca
     4261 tattttacta ttccacacca accataatta caacaaggga tttttcttat gcactcctat
     4321 gcatgtgaat aacatgtggt gtaattctgc ttcttacaga agtattactg aaggtattat
     4381 ttccaatatt atttggttta ttatgcggat cttttttata tatgcagtcc catcccttct
     4441 gtgccactca atgccatcca gacatggttt ttccctccag gggcctttct ctccagaggg
     4501 cacttcggct gcctctgctt cctctcattc gaggcccggc tcttgctgac agaataggtt
     4561 ccgttctggg cggtggttct cgagcctgcc attcaaaacc aaagcaaatt ggagcatttc
     4621 tcacaacatg gtattgaagt tcctttttgt tctcaaaagt tgtgaccgtg ttaaattgta
     4681 ctcccttagt cctgtaaggt atgttaagtg aatcgcagtt acgctgtact tttattaata
     4741 tttaacataa ttaaagatgg acccataaga gtgacgcctg tggagcgcgt gctcttcctc
     4801 tgcagccaa
//
