LOCUS       NM_152889               1917 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens carbohydrate sulfotransferase 13 (CHST13), mRNA.
ACCESSION   NM_152889
VERSION     NM_152889.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1917)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1917)
  AUTHORS   Lei,J., Yan,S., Zhou,Y., Wang,L., Zhang,J., Guo,X., Lammi,M.J.,
            Han,J. and Qu,C.
  TITLE     Abnormal expression of chondroitin sulfate sulfotransferases in the
            articular cartilage of pediatric patients with Kashin-Beck disease
  JOURNAL   Histochem Cell Biol 153 (3), 153-164 (2020)
   PUBMED   31845005
  REMARK    GeneRIF: Abnormal expression of chondroitin sulfate
            sulfotransferases in the articular cartilage of pediatric patients
            with Kashin-Beck disease.
REFERENCE   3  (bases 1 to 1917)
  AUTHORS   Yorifuji,K., Uemura,Y., Horibata,S., Tsuji,G., Suzuki,Y.,
            Miyagawa,K., Nakayama,K., Hirata,K.I., Kumagai,S. and Emoto,N.
  TITLE     CHST3 and CHST13 polymorphisms as predictors of bosentan-induced
            liver toxicity in Japanese patients with pulmonary arterial
            hypertension
  JOURNAL   Pharmacol Res 135, 259-264 (2018)
   PUBMED   30118797
  REMARK    GeneRIF: We show that the CHST3 and CHST13 alleles are
            significantly more frequent in pulmonary arterial hypertension
            patients with elevated aminotransferases during therapy with
            bosentan than those in patients without liver injury. This is the
            first pharmacogenomics study linking proteoglycan sulfating genes
            to drug-induced liver dysfunction.
            Erratum:[Pharmacol Res. 2019 Jan;139:570. doi:
            10.1016/j.phrs.2018.09.018.. PMID: 30292639]
REFERENCE   4  (bases 1 to 1917)
  AUTHORS   Zhou,H., Li,Y., Song,X., Zhao,Y., Cheng,L., Zhao,L. and Jia,L.
  TITLE     CHST11/13 Regulate the Metastasis and Chemosensitivity of Human
            Hepatocellular Carcinoma Cells Via Mitogen-Activated Protein Kinase
            Pathway
  JOURNAL   Dig Dis Sci 61 (7), 1972-1985 (2016)
   PUBMED   26993826
  REMARK    GeneRIF: These results have demonstrated that CHST11 and CHST13
            negatively modulate metastasis and drug resistance of HCC cells
            probably via oncogenic MAPK signal pathway.
REFERENCE   5  (bases 1 to 1917)
  AUTHORS   Valente,B., Campos,P.A., do Rosario,V.E. and Silveira,H.
  TITLE     Natural frequency of polymorphisms linked to the chondroitin
            4-sulfotransferase genes and its association with placental malaria
  JOURNAL   Trans R Soc Trop Med Hyg 104 (10), 687-689 (2010)
   PUBMED   20580388
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1917)
  AUTHORS   Kang,H.G., Evers,M.R., Xia,G., Baenziger,J.U. and Schachner,M.
  TITLE     Molecular cloning and characterization of
            chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1
            family of sulfotransferases
  JOURNAL   J Biol Chem 277 (38), 34766-34772 (2002)
   PUBMED   12080076
  REMARK    GeneRIF: mol cloning and characterization
REFERENCE   7  (bases 1 to 1917)
  AUTHORS   Hiraoka,N., Nakagawa,H., Ong,E., Akama,T.O., Fukuda,M.N. and
            Fukuda,M.
  TITLE     Molecular cloning and expression of two distinct human chondroitin
            4-O-sulfotransferases that belong to the HNK-1 sulfotransferase
            gene family
  JOURNAL   J Biol Chem 275 (26), 20188-20196 (2000)
   PUBMED   10781601
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC024558.21, DR006930.1 and
            AY120869.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_152889.2.
            
            Summary: The protein encoded by this gene belongs to the
            sulfotransferase 2 family. It is localized to the golgi membrane,
            and catalyzes the transfer of sulfate to the C4 hydroxyl of
            beta-1,4-linked N-acetylgalactosamine (GalNAc) flanked by
            glucuronic acid residue in chondroitin. Chondroitin sulfate
            constitutes the predominant proteoglycan present in cartilage and
            is distributed on the surfaces of many cells and extracellular
            matrices. [provided by RefSeq, Aug 2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY120869.1, BC103895.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319340.7/ ENSP00000317404.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AC024558.21        84784-84916
            134-761             DR006930.1         27-654
            762-1917            AY120869.1         584-1739
FEATURES             Location/Qualifiers
     source          1..1917
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.3"
     gene            1..1917
                     /gene="CHST13"
                     /gene_synonym="C4ST3"
                     /note="carbohydrate sulfotransferase 13"
                     /db_xref="GeneID:166012"
                     /db_xref="HGNC:HGNC:21755"
                     /db_xref="MIM:610124"
     exon            1..275
                     /gene="CHST13"
                     /gene_synonym="C4ST3"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1204
                     /gene="CHST13"
                     /gene_synonym="C4ST3"
                     /EC_number="2.8.2.5"
                     /note="chondroitin 4-O-sulfotransferase 3; C4ST-3;
                     chondroitin 4-sulfotransferase 3; carbohydrate
                     (chondroitin 4) sulfotransferase 13"
                     /codon_start=1
                     /product="carbohydrate sulfotransferase 13"
                     /protein_id="NP_690849.1"
                     /db_xref="CCDS:CCDS3039.1"
                     /db_xref="GeneID:166012"
                     /db_xref="HGNC:HGNC:21755"
                     /db_xref="MIM:610124"
                     /translation="MGRRCCRRRVLAAACLGAALLLLCAAPRSLRPAFGNRALGSSWL
                     GGEKRSPLQKLYDLDQDPRSTLAKVHRQRRDLLNSACSRHSRRQRLLQPEDLRHVLVD
                     DAHGLLYCYVPKVACTNWKRVLLALSGQARGDPRAISAQEAHAPGRLPSLADFSPAEI
                     NRRLRAYLAFLFVREPFERLASAYRNKLARPYSAAFQRRYGARIVQRLRPRALPDARA
                     RGHDVRFAEFLAYLLDPRTRREEPFNEHWERAHALCHPCRLRYDVVGKFETLAEDAAF
                     VLGLAGASDLSFPGPPRPRGAAASRDLAARLFRDISPFYQRRLFDLYKMDFLLFNYSA
                     PSYLRLL"
     exon            276..358
                     /gene="CHST13"
                     /gene_synonym="C4ST3"
                     /inference="alignment:Splign:2.1.0"
     exon            359..1917
                     /gene="CHST13"
                     /gene_synonym="C4ST3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1892..1897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHST13"
                     /gene_synonym="C4ST3"
                     /note="hexamer: AATAAA"
     polyA_site      1917
                     /gene="CHST13"
                     /gene_synonym="C4ST3"
                     /note="major polyA site"
ORIGIN      
        1 agtccccagc gactcgcagg ggctggtggg gctggggtcc agctgccgtg ctcccctgcc
       61 ctgcgccgcg ccgcgcgtct tggtaggcgc tgcgctgccg gggccgggtc ctgggccagt
      121 gcaactccgc ccccagccgt atccagcgga ctgtcctccg ccgcgcgccc ggcacagcat
      181 ggggaggcgc tgctgccggc ggcgcgtgct ggcggccgcc tgtctgggcg ccgcgctcct
      241 gctcctatgc gccgcgcccc gctccctgcg cccggcattt ggaaacagag ccctgggctc
      301 cagctggctt ggtggggaga agagaagccc cctgcagaag ctctatgacc tggatcagga
      361 cccgcgctcg accctggcga aggtgcaccg gcagcggcgc gacctgctga acagcgcctg
      421 tagccgccac tcacgccggc agcgcctgct acagccggag gacctgcggc acgtgctggt
      481 ggacgacgcg catggcctgc tctactgcta cgtgcccaag gtggcctgca ccaactggaa
      541 gcgcgtgctg ctggcgctga gcggccaagc ccgcggcgac ccgcgcgcca tctccgcgca
      601 agaggcgcac gcgcctggcc gcctgccctc actggccgac ttcagccccg ccgagatcaa
      661 ccggcgcctg cgcgcctact tggccttcct gttcgtgcgg gagcccttcg agcgcctggc
      721 atcggcttac cgcaacaagc tcgcgcgccc ctacagcgcc gccttccaga ggcgctacgg
      781 tgcacgcatc gttcagcgcc tgcggccgcg cgcgctcccc gacgcccggg cccgcggcca
      841 cgacgtgcgc ttcgcggagt tcctggccta cctgctggac ccgcgcacgc ggcgtgagga
      901 gcccttcaac gagcactggg agcgcgcgca cgcgctctgc cacccgtgtc gcctccgcta
      961 cgacgtcgtg ggcaagttcg agacgctggc ggaggacgcg gccttcgtgc tgggcctggc
     1021 gggcgcatcc gacctgagct tccctgggcc gccgcggccc cggggagccg ccgcctcccg
     1081 cgacctggca gcgcgcctct tccgggacat cagccccttc taccagcggc gcctcttcga
     1141 cctctacaag atggacttcc tgcttttcaa ctactccgcc ccctcctacc tgcggctgct
     1201 ctagcggtcc tggaggtcct gtggccacgc ggggcaagtg cctttccgac aagacccccg
     1261 gggaatgcag gtgctgccgg ccccaggacc cctcttcaag agccactgcg tgcactcacc
     1321 tggccgccgg gccagcgggc gcagggcaca cctggccagg cttgggggca gcccatctca
     1381 ggtggccctg cacgcgtgtg cctgcctcgg cctgtcgcct gaggcctgct tcctccactt
     1441 gctccagctg acaggcacct ctccaggccc cgtagatggg caaggacttg ataaccaggg
     1501 ttttaggctt ttaaaggcca ttttgggggt cagccctgcc cctgaacctg ttcatggtgc
     1561 atcagaacat aatgctgaca ccggtgtcag tgtggcccga gcctgtgtcc tccccacctc
     1621 gcccaccctg gcaaggacag ctgcggccaa ggacgaaagc cctcccttgg ctggcctcac
     1681 gatggggccg tcccgggagc caggtgggag ctgccttcca ctgccatcgg gtctcctctc
     1741 ctctcccacg cggctggccc tacccaggcg ccaccttcgg tctcagtctg gcaagacgct
     1801 gggtcttcag gctccatgcc aacagagccc ctggtgcaat gcggtcacag gttttatggg
     1861 actttggtga gctgggcggt catggttttg aaataaatgt attttgttac tttctga
//
