LOCUS       NM_018413               5734 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens carbohydrate sulfotransferase 11 (CHST11), transcript
            variant 1, mRNA.
ACCESSION   NM_018413
VERSION     NM_018413.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5734)
  AUTHORS   Hu,W., Chen,Y., Zhang,L., Guo,X., Wei,X., Shao,Y., Wang,D. and
            Wu,B.
  TITLE     Effect of CHST11, a novel biomarker, on the biological
            functionalities of clear cell renal cell carcinoma
  JOURNAL   Sci Rep 14 (1), 7704 (2024)
   PUBMED   38565604
  REMARK    GeneRIF: Effect of CHST11, a novel biomarker, on the biological
            functionalities of clear cell renal cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5734)
  AUTHORS   Chen,X., Lu,T., Cai,Y., Han,Y., Ding,M., Chu,Y., Zhou,X. and
            Wang,X.
  TITLE     KIAA1429-mediated m6A modification of CHST11 promotes progression
            of diffuse large B-cell lymphoma by regulating Hippo-YAP pathway
  JOURNAL   Cell Mol Biol Lett 28 (1), 32 (2023)
   PUBMED   37076815
  REMARK    GeneRIF: KIAA1429-mediated m6A modification of CHST11 promotes
            progression of diffuse large B-cell lymphoma by regulating
            Hippo-YAP pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5734)
  AUTHORS   Zhang,P., Chen,D., Cui,H. and Luo,Q.
  TITLE     High Expression of CHST11 Correlates with Poor Prognosis and Tumor
            Immune Infiltration of Pancreatic Cancer
  JOURNAL   Clin Lab 68 (12) (2022)
   PUBMED   36546737
  REMARK    GeneRIF: High Expression of CHST11 Correlates with Poor Prognosis
            and Tumor Immune Infiltration of Pancreatic Cancer.
REFERENCE   4  (bases 1 to 5734)
  AUTHORS   Li,C.H., Chan,M.H., Chang,Y.C. and Hsiao,M.
  TITLE     The CHST11 gene is linked to lung cancer and pulmonary fibrosis
  JOURNAL   J Gene Med 24 (12), e3451 (2022)
   PUBMED   36181245
  REMARK    GeneRIF: The CHST11 gene is linked to lung cancer and pulmonary
            fibrosis.
REFERENCE   5  (bases 1 to 5734)
  AUTHORS   Kamio,H., Tsuchiya,S., Kuroda,K., Okido,M., Okabe,K., Ohta,Y.,
            Toyama,N. and Hibi,H.
  TITLE     Chondroitin-4-sulfate transferase-1 depletion inhibits formation of
            a proteoglycan-rich layer and alters immunotolerance of bone marrow
            mesenchymal stem cells on titanium oxide surfaces
  JOURNAL   Acta Biomater 114, 460-470 (2020)
   PUBMED   32707405
  REMARK    GeneRIF: Chondroitin-4-sulfate transferase-1 depletion inhibits
            formation of a proteoglycan-rich layer and alters immunotolerance
            of bone marrow mesenchymal stem cells on titanium oxide surfaces.
REFERENCE   6  (bases 1 to 5734)
  AUTHORS   Schmidt,H.H., Dyomin,V.G., Palanisamy,N., Itoyama,T., Nanjangud,G.,
            Pirc-Danoewinata,H., Haas,O.A. and Chaganti,R.S.
  TITLE     Deregulation of the carbohydrate (chondroitin 4) sulfotransferase
            11 (CHST11) gene in a B-cell chronic lymphocytic leukemia with a
            t(12;14)(q23;q32)
  JOURNAL   Oncogene 23 (41), 6991-6996 (2004)
   PUBMED   15273723
REFERENCE   7  (bases 1 to 5734)
  AUTHORS   Mikami,T., Mizumoto,S., Kago,N., Kitagawa,H. and Sugahara,K.
  TITLE     Specificities of three distinct human chondroitin/dermatan
            N-acetylgalactosamine 4-O-sulfotransferases demonstrated using
            partially desulfated dermatan sulfate as an acceptor: implication
            of differential roles in dermatan sulfate biosynthesis
  JOURNAL   J Biol Chem 278 (38), 36115-36127 (2003)
   PUBMED   12847091
  REMARK    GeneRIF: human D4ST-1, C4ST-1, and S4ST-2 have differential roles
            in dermatan sulfate biosynthesis
REFERENCE   8  (bases 1 to 5734)
  AUTHORS   Okuda,T., Mita,S., Yamauchi,S., Matsubara,T., Yagi,F., Yamamori,D.,
            Fukuta,M., Kuroiwa,A., Matsuda,Y. and Habuchi,O.
  TITLE     Molecular cloning, expression, and chromosomal mapping of human
            chondroitin 4-sulfotransferase, whose expression pattern in human
            tissues is different from that of chondroitin 6-sulfotransferase
  JOURNAL   J Biochem 128 (5), 763-770 (2000)
   PUBMED   11056388
REFERENCE   9  (bases 1 to 5734)
  AUTHORS   Hiraoka,N., Nakagawa,H., Ong,E., Akama,T.O., Fukuda,M.N. and
            Fukuda,M.
  TITLE     Molecular cloning and expression of two distinct human chondroitin
            4-O-sulfotransferases that belong to the HNK-1 sulfotransferase
            gene family
  JOURNAL   J Biol Chem 275 (26), 20188-20196 (2000)
   PUBMED   10781601
REFERENCE   10 (bases 1 to 5734)
  AUTHORS   Yamauchi,S., Mita,S., Matsubara,T., Fukuta,M., Habuchi,H.,
            Kimata,K. and Habuchi,O.
  TITLE     Molecular cloning and expression of chondroitin 4-sulfotransferase
  JOURNAL   J Biol Chem 275 (12), 8975-8981 (2000)
   PUBMED   10722746
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA853534.1, AK290923.1 and
            AC073917.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_018413.5.
            
            Summary: The protein encoded by this gene belongs to the
            sulfotransferase 2 family. It is localized to the golgi membrane,
            and catalyzes the transfer of sulfate to position 4 of the
            N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin
            sulfate constitutes the predominant proteoglycan present in
            cartilage, and is distributed on the surfaces of many cells and
            extracellular matrices. A chromosomal translocation involving this
            gene and IgH, t(12;14)(q23;q32), has been reported in a patient
            with B-cell chronic lymphocytic leukemia. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.152693.1,
                                           SRR1163655.19616.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2152568
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303694.6/ ENSP00000305725.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                DA853534.1         35-59
            26-1584             AK290923.1         1-1559
            1585-5734           AC073917.19        34228-38377         c
FEATURES             Location/Qualifiers
     source          1..5734
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.3"
     gene            1..5734
                     /gene="CHST11"
                     /gene_synonym="C4ST; C4ST-1; C4ST1; HSA269537; OCBMD"
                     /note="carbohydrate sulfotransferase 11"
                     /db_xref="GeneID:50515"
                     /db_xref="HGNC:HGNC:17422"
                     /db_xref="MIM:610128"
     exon            1..582
                     /gene="CHST11"
                     /gene_synonym="C4ST; C4ST-1; C4ST1; HSA269537; OCBMD"
                     /inference="alignment:Splign:2.1.0"
     CDS             465..1523
                     /gene="CHST11"
                     /gene_synonym="C4ST; C4ST-1; C4ST1; HSA269537; OCBMD"
                     /EC_number="2.8.2.5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     IgH/CHST11 fusion; C4S-1; chondroitin 4-O-sulfotransferase
                     1; carbohydrate (chondroitin 4) sulfotransferase 11"
                     /codon_start=1
                     /product="carbohydrate sulfotransferase 11 isoform 1"
                     /protein_id="NP_060883.1"
                     /db_xref="CCDS:CCDS9099.1"
                     /db_xref="GeneID:50515"
                     /db_xref="HGNC:HGNC:17422"
                     /db_xref="MIM:610128"
                     /translation="MKPALLEVMRMNRICRMVLATCLGSFILVIFYFQSMLHPVMRRN
                     PFGVDICCRKGSRSPLQELYNPIQLELSNTAVLHQMRRDQVTDTCRANSATSRKRRVL
                     TPNDLKHLVVDEDHELIYCYVPKVACTNWKRLMMVLTGRGKYSDPMEIPANEAHVSAN
                     LKTLNQYSIPEINHRLKSYMKFLFVREPFERLVSAYRNKFTQKYNISFHKRYGTKIIK
                     RQRKNATQEALRKGDDVKFEEFVAYLIDPHTQREEPFNEHWQTVYSLCHPCHIHYDLV
                     GKYETLEEDSNYVLQLAGVGSYLKFPTYAKSTRTTDEMTTEFFQNISSEHQTQLYEVY
                     KLDFLMFNYSVPSYLKLE"
     exon            583..668
                     /gene="CHST11"
                     /gene_synonym="C4ST; C4ST-1; C4ST1; HSA269537; OCBMD"
                     /inference="alignment:Splign:2.1.0"
     exon            669..5734
                     /gene="CHST11"
                     /gene_synonym="C4ST; C4ST-1; C4ST1; HSA269537; OCBMD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5714..5719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHST11"
                     /gene_synonym="C4ST; C4ST-1; C4ST1; HSA269537; OCBMD"
                     /note="hexamer: ATTAAA"
     polyA_site      5734
                     /gene="CHST11"
                     /gene_synonym="C4ST; C4ST-1; C4ST1; HSA269537; OCBMD"
                     /note="major polyA site"
ORIGIN      
        1 atttggtaaa acccagcccc ggaatatata gatcgttgga gcgcaatgaa gtagcctttg
       61 gagagaaggg agagggcccg tcggacagcc acagcggcca gcgcagcggc agcggcggcg
      121 gcaccaccat caccgctcgc accccagccg cccggcccgc gaccaggcag cggcggccgc
      181 cggcgggatc ggaggaggcg gcggagcggc gaggaggagg agcaggagcg cgcagccagc
      241 gggtccacgc atctcagcac ttccagacca actccggcac cttccacacc cctgcccggg
      301 ctgggggctc cgagagcggc cgcgaagcga ctccgatcct ccctctgagc cttgctcagc
      361 tctgccccgc gcctcccggg ctccggtccg cgcggcgggg tccctgctcc tgcgccccgg
      421 gcgcgcttcc cggacacccc ggtccccgca gccaggacaa agccatgaag ccagcgctgc
      481 tggaagtgat gaggatgaac agaatctgcc ggatggtgct ggccacttgc ttgggatcct
      541 ttatcctggt catcttctat ttccaaagta tgttgcaccc agtcatgcgg aggaatccct
      601 ttggtgtgga catctgctgc cggaaggggt cccgaagccc cctgcaggaa ctctacaacc
      661 caatccagct ggagctctca aacactgctg tcctgcacca gatgcggcgg gaccaggtga
      721 cagacacgtg ccgagccaac agcgccacaa gccgtaagcg gagggtgctg acccccaacg
      781 acctgaagca cttggtggtg gatgaggacc acgagctcat ctactgctac gtgcccaagg
      841 tggcctgcac caactggaag cggctcatga tggtcctgac cgggcggggg aagtacagcg
      901 accccatgga gatcccggcc aacgaggcac acgtctccgc caacctgaag accctgaacc
      961 agtacagcat cccagaaatc aaccaccgct tgaaaagcta catgaagttc ctgtttgtcc
     1021 gggagccctt cgagaggcta gtgtccgcct accgcaacaa gttcacccag aagtacaaca
     1081 tctccttcca caagcggtac ggcaccaaga tcatcaaacg ccagcggaag aacgccaccc
     1141 aggaggccct gcgcaaaggg gacgatgtca aattcgagga gtttgtggcc tatctcatcg
     1201 acccacacac ccagcgggag gagcctttca acgaacactg gcaaaccgtc tactcactct
     1261 gccatccctg ccacatccac tatgacctcg tgggcaagta cgagacactg gaagaggatt
     1321 ctaattacgt cctgcagctg gcaggagtgg gcagctacct gaagttcccc acctatgcaa
     1381 agtctacgag aactactgat gaaatgacca cagaattctt ccagaacatc agctcagagc
     1441 accaaacgca gctgtacgaa gtctacaaac tcgatttttt aatgttcaat tactcagtgc
     1501 caagctacct gaaattggaa taaagggggt ggggagaggg agagaatcat gctttttaat
     1561 ttaagatttt tatttgtcaa aagaattata tggatattgg gttattttgt aaattaatat
     1621 ttctttgggg atgatgctgc gagcagcata gtgagaatta tttaaaatcc ttcgtaggga
     1681 aggacagctg tctttgcagg ggaaatagga tgggtcgtcc ttgtctgtag aagtgaatac
     1741 tgcaacactg tctcaaaggt ttcttgtgtt ctggtgaatt ccatgaattg tgcattccat
     1801 aaattctaat taatattatt tatagttatt taaacatggt ctcattattt ctttttgtgg
     1861 cagcaaaatt ctaacatctt tccagaagaa atctatgatt cctgctttgc ttgctacagc
     1921 tcatttgggg gcatgaatgt tctccttact aacctctcat ggagtcatgt gataacagcc
     1981 attgtcatgt gtatggatgc caccattctt gaatttctgc tagaaataag taggttgcta
     2041 ttgcacttag agtcatcttt gcaagggact cattccaaac caattccaat cgacctgaaa
     2101 gtcccttgca ctaaagaaat gtgatttttt tttaacccaa ggagaaagtt ggttgtaaca
     2161 atttttcacc agaattagca atctgataga ataggctttt ttaacaggaa ttttaaactg
     2221 gcggtgccag ttgcagtgaa ggtgaagtgg ctattgcttt atattcgaca aatatttatt
     2281 gagcatctac tatatactag gccctgaaga tagagcgttg aacaaaccca atagtcttgg
     2341 ccctcaaaaa gctttatgtg acatagagca tccagctcga caattagcaa acccctgata
     2401 ttattcatgg acttgacatg aggtttggac tattcatgag caacagcaga aggtccatga
     2461 cccctacaaa tttacatttt tctatggccc atatttgaaa acctcacatt cggagcaggc
     2521 cactttatat tcgtgagtga tcccaagctc actgaccaac agaaaagatg ctaaaaaaat
     2581 gtgtcctatc atgtgcctgc tccaactgat gggtaatgtc tgcctttaag ccccagaatg
     2641 gattctccag gcacagtgtg gaagagtgct gtggttgatt agcaatgtct gccttgggtg
     2701 aggaaagggg aacactcctc aagtgcctcc tactgtcatc tccattcagc ctagcaccac
     2761 atccccatgt agaagtgttg tcttctactg cttgccacgt acaagtgtga aatgccaagg
     2821 tgagactcgt acacttgggg atttgcaatg gtttttaccc ctcatgaagg tcagaggtgg
     2881 actatttgta cacatacaca catgcacacc ctctcacgtc ctccagaggc tgaaagacta
     2941 tcagcatctt ggtaactgcc atgcatgagc agcaaggaca gccttccata atccatgccc
     3001 catttcctct ggaagcctgg aaacttttca tttcctgttc cttgctaatt aacatctaaa
     3061 catgcttctc atttccagcc attgctgatg cttctcagtt gaagtttgag ccacatccct
     3121 cttacagcta gtgaatgagt tggtagcagc tactgtatat aataataata atagttttaa
     3181 taatagggga gggtgggatg gggtgtgggt aagttttgcc ttttgttttg tttttgatgc
     3241 cgtatatagt gaaggggtga ggatattcta aacaaacaaa aattgaataa tttattcaca
     3301 gaaactatta agattgtatt gtaaagctca cagcaagctc agtgggcagc agctgcaaca
     3361 tctcaccggg gaaattattt tatttaacgt gagtgagatg tgggccggag aaggtagctg
     3421 aagctattta taaaacgttg tgtaccttct tccgagctct ctcccctttg tgaagggcgc
     3481 agcaactata cccttgatgg atggagattt acgcaatgtg ttttactggg tagagtgaca
     3541 gaccttggct gtccctggaa ttgagaatct ggaccttatt tccaggcaga gaacactgtc
     3601 ctcagaaatg ggacttctga taatgaaaca ggttgtccaa cattttctaa tacgcattct
     3661 acagaacaca ggttccagga ggcatcaggt tggtgtgatg cagactaagg gttttgtggt
     3721 caaatatcct taagaaacaa agttaagtca gtttcctttc tgcaaggact tttcagcctt
     3781 caatgtgtgc tgtgcatggt gaatccccaa aaataatcct tgagtctgta gcatttcctg
     3841 aacttacatg accaggatac tctattttgc agatcacccc acagagctag ggttccaccg
     3901 agtatacttt gcttaggttg acttagcata tctgaggtct tcaaggataa aaactgccac
     3961 cccaacaccc ttccattaaa aaaaaaatac aaaatagcac cacagtctcc atctggttta
     4021 tagcaacaga ggtactttat ttaatgaagc aatggttcta atcctggata ctgccacgga
     4081 ctacaattct atccctccca gagggagtgg aggaagtctt gggtggtgtg gacagaagga
     4141 agagaggaga gggtgagtgg ggtatagggc ccagggtggc tccctactcc tcaggctcaa
     4201 aaggatgctc agtgggaaca gatgatctct tgatgagtgc ttcttcagtt tcatagtttg
     4261 gaatcgttca ctgtgtgctt tttggggggt tttcaatgga aattcacgtt gctttgcatt
     4321 tctgtgtccg tctttggtca gttgtgcaag cctgctcact gtcatgtgaa gatggccttt
     4381 catctggctt ctctctctta agtgagaaag attgtccttc aggggacatg acatcaatag
     4441 gtttctggaa tgagggactc tttctccccg tgttttgctt tgtgttcaca ttttcttttc
     4501 taatggcatt gaaactttaa aaaaaatgga ttcaactgtt tttgcagaat gtagaaagta
     4561 ttctgtgtcc ttggttaaag aaatccactt gtgaagtgtg cctggaaaat gaaagtttgt
     4621 gttttttaaa gaggaatatt tgaaactgct ttctatgcat gcttagctgg agaaaagtac
     4681 aggcaggcgt cccatctccc agccacttct caaaggtgct gctgtgtttt aaagaccagg
     4741 tacagccagg gcagtatttg caaggacatt cctgcttact ttatcccttt ggttggaaag
     4801 ctctagatga ttcccgcagc tcctccagac cccgcctccc tgccctcccc agctggtctg
     4861 ggaagaggtg gtctgctgac ctgtggtatc tcagagggga cgttcctcct cctccctgtg
     4921 caccaggtgg gctgcaccct cctgcctatt caggatgtgg atgccacagg agagcagcag
     4981 gcagtggaaa cttcagttgc actggttctc ctggtggcaa aggcatgaag cacaggggtc
     5041 gattaatcca ggctactaga aagctccaga gcaaagtgtg cgggtcccac aaatgcttgg
     5101 ctggtggggt ctggatcagt gctgagatag agttggcaga agaagcagag gcactctgct
     5161 tgctttccta gccagtcctc ccctacacac acacacacac acacacacac acacacacac
     5221 aatctcagct gcgccattct gtgcaatccc agtgaccaaa tcccttcctt gcccacctct
     5281 atgtcagcag gactgaccac atcactcccc cgagttccca ccaccagcat ttcctccaac
     5341 ctttttccat cacaaccagt tagaacccta caggcaacaa ggccttctag aatccgctta
     5401 acccttggct gataacaggc aaatttcagt ctgctacact ttgttaggtc cagaaggagc
     5461 tgcccatact actttcttat gagcatgctc agtatggcat atggacatgt aatgtcacat
     5521 ctttgtggag tgtgattttc ttttttcaca tatttgtatg cagtagagag cctgttgtag
     5581 aaaacgctcc ctgtatcttg ctgtactgtt aaagaaagct gaattccaca ttgccaacaa
     5641 aagcgtgaaa atgttcatga accttcctcc aggaaaagcc attcaagcct gattattttt
     5701 ctaagtaact tcaattaaat tgaagaaaaa agaa
//
