LOCUS       NM_004854               2854 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens carbohydrate sulfotransferase 10 (CHST10), mRNA.
ACCESSION   NM_004854
VERSION     NM_004854.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2854)
  AUTHORS   Sheikh,M.O., Venzke,D., Anderson,M.E., Yoshida-Moriguchi,T.,
            Glushka,J.N., Nairn,A.V., Galizzi,M., Moremen,K.W., Campbell,K.P.
            and Wells,L.
  TITLE     HNK-1 sulfotransferase modulates alpha-dystroglycan glycosylation
            by 3-O-sulfation of glucuronic acid on matriglycan
  JOURNAL   Glycobiology 30 (10), 817-829 (2020)
   PUBMED   32149355
REFERENCE   2  (bases 1 to 2854)
  AUTHORS   Suzuki-Anekoji,M., Suzuki,A., Wu,S.W., Angata,K., Murai,K.K.,
            Sugihara,K., Akama,T.O., Khoo,K.H., Nakayama,J., Fukuda,M.N. and
            Fukuda,M.
  TITLE     In vivo regulation of steroid hormones by the Chst10
            sulfotransferase in mouse
  JOURNAL   J Biol Chem 288 (7), 5007-5016 (2013)
   PUBMED   23269668
REFERENCE   3  (bases 1 to 2854)
  AUTHORS   Nakagawa,N., Manya,H., Toda,T., Endo,T. and Oka,S.
  TITLE     Human natural killer-1 sulfotransferase (HNK-1ST)-induced sulfate
            transfer regulates laminin-binding glycans on alpha-dystroglycan
  JOURNAL   J Biol Chem 287 (36), 30823-30832 (2012)
   PUBMED   22801424
  REMARK    GeneRIF: novel role for HNK-1ST as a tumor suppressor controlling
            the functional glycans on alpha-DG and the importance of sulfate
            transfer in the glycosylation of alpha-DG.
REFERENCE   4  (bases 1 to 2854)
  AUTHORS   Nakagawa,N., Izumikawa,T., Kitagawa,H. and Oka,S.
  TITLE     Sulfation of glucuronic acid in the linkage tetrasaccharide by
            HNK-1 sulfotransferase is an inhibitory signal for the expression
            of a chondroitin sulfate chain on thrombomodulin
  JOURNAL   Biochem Biophys Res Commun 415 (1), 109-113 (2011)
   PUBMED   22020094
  REMARK    GeneRIF: These results suggest that HNK-1ST is involved in
            3-O-sulfation of the terminal GlcA of the linkage tetrasaccharide
            which acts as an inhibitory signal for the initiation of
            chondroitin sulfate chain biosynthesis on thrombomodulin.
REFERENCE   5  (bases 1 to 2854)
  AUTHORS   Hashiguchi,T., Mizumoto,S., Nishimura,Y., Tamura,J., Yamada,S. and
            Sugahara,K.
  TITLE     Involvement of human natural killer-1 (HNK-1) sulfotransferase in
            the biosynthesis of the GlcUA(3-O-sulfate)-Gal-Gal-Xyl
            tetrasaccharide found in alpha-thrombomodulin from human urine
  JOURNAL   J Biol Chem 286 (38), 33003-33011 (2011)
   PUBMED   21828042
  REMARK    GeneRIF: HNK-1ST may be responsible for regulating the sorting of
            alpha- and beta-TM.
REFERENCE   6  (bases 1 to 2854)
  AUTHORS   Kahler,A.K., Djurovic,S., Rimol,L.M., Brown,A.A., Athanasiu,L.,
            Jonsson,E.G., Hansen,T., Gustafsson,O., Hall,H., Giegling,I.,
            Muglia,P., Cichon,S., Rietschel,M., Pietilainen,O.P., Peltonen,L.,
            Bramon,E., Collier,D., St Clair,D., Sigurdsson,E., Petursson,H.,
            Rujescu,D., Melle,I., Werge,T., Steen,V.M., Dale,A.M.,
            Matthews,R.T., Agartz,I. and Andreassen,O.A.
  TITLE     Candidate gene analysis of the human natural killer-1 carbohydrate
            pathway and perineuronal nets in schizophrenia: B3GAT2 is
            associated with disease risk and cortical surface area
  JOURNAL   Biol Psychiatry 69 (1), 90-96 (2011)
   PUBMED   20950796
  REMARK    GeneRIF: Observational study and meta-analysis of gene-disease
            association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 2854)
  AUTHORS   Zhao,X., Graves,C., Ames,S.J., Fisher,D.E. and Spanjaard,R.A.
  TITLE     Mechanism of regulation and suppression of melanoma invasiveness by
            novel retinoic acid receptor-gamma target gene carbohydrate
            sulfotransferase 10
  JOURNAL   Cancer Res 69 (12), 5218-5225 (2009)
   PUBMED   19470764
  REMARK    GeneRIF: We show that CHST10 is also regulated by RARgamma in a
            significant subset of human melanoma cells, and three-dimensional
            cell culture migration assays suggest that CHST10 functions as a
            suppressor of invasiveness, but not proliferation, in these cells
REFERENCE   8  (bases 1 to 2854)
  AUTHORS   Kang,H.G., Evers,M.R., Xia,G., Baenziger,J.U. and Schachner,M.
  TITLE     Molecular cloning and characterization of
            chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1
            family of sulfotransferases
  JOURNAL   J Biol Chem 277 (38), 34766-34772 (2002)
   PUBMED   12080076
  REMARK    GeneRIF: identification of a novel member of HNK-1 family of
            sulfotransferases
REFERENCE   9  (bases 1 to 2854)
  AUTHORS   Ong,E., Yeh,J.C., Ding,Y., Hindsgaul,O., Pedersen,L.C., Negishi,M.
            and Fukuda,M.
  TITLE     Structure and function of HNK-1 sulfotransferase. Identification of
            donor and acceptor binding sites by site-directed mutagenesis
  JOURNAL   J Biol Chem 274 (36), 25608-25612 (1999)
   PUBMED   10464296
REFERENCE   10 (bases 1 to 2854)
  AUTHORS   Ong,E., Yeh,J.C., Ding,Y., Hindsgaul,O. and Fukuda,M.
  TITLE     Expression cloning of a human sulfotransferase that directs the
            synthesis of the HNK-1 glycan on the neural cell adhesion molecule
            and glycolipids
  JOURNAL   J Biol Chem 273 (9), 5190-5195 (1998)
   PUBMED   9478973
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA732392.1, AF033827.1,
            DA522916.1 and AF070594.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004854.4.
            
            Summary: This protein encoded by this gene transfers sulfate to the
            C-3 hydroxyl of terminal glucuronic acid of protein- and
            lipid-linked oligosaccharides. This protein was first identified as
            a sulfotransferase that acts on the human natural killer-1 (HNK-1)
            glycan; HNK-1 is a carbohydrate involved in neurodevelopment and
            synaptic plasticity.[provided by RefSeq, Feb 2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010441.1, SRR1803617.186617.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264249.8/ ENSP00000264249.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DA732392.1         1-12
            13-307              AF033827.1         1-295
            308-324             DA522916.1         280-296
            325-2854            AF070594.1         1-2530
FEATURES             Location/Qualifiers
     source          1..2854
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..2854
                     /gene="CHST10"
                     /gene_synonym="HNK-1ST; HNK1ST"
                     /note="carbohydrate sulfotransferase 10"
                     /db_xref="GeneID:9486"
                     /db_xref="HGNC:HGNC:19650"
                     /db_xref="MIM:606376"
     exon            1..295
                     /gene="CHST10"
                     /gene_synonym="HNK-1ST; HNK1ST"
                     /inference="alignment:Splign:2.1.0"
     exon            296..366
                     /gene="CHST10"
                     /gene_synonym="HNK-1ST; HNK1ST"
                     /inference="alignment:Splign:2.1.0"
     exon            367..498
                     /gene="CHST10"
                     /gene_synonym="HNK-1ST; HNK1ST"
                     /inference="alignment:Splign:2.1.0"
     CDS             399..1469
                     /gene="CHST10"
                     /gene_synonym="HNK-1ST; HNK1ST"
                     /EC_number="2.8.2.-"
                     /note="HNK-1 sulfotransferase; huHNK-1ST"
                     /codon_start=1
                     /product="carbohydrate sulfotransferase 10"
                     /protein_id="NP_004845.1"
                     /db_xref="CCDS:CCDS2047.1"
                     /db_xref="GeneID:9486"
                     /db_xref="HGNC:HGNC:19650"
                     /db_xref="MIM:606376"
                     /translation="MHHQWLLLAACFWVIFMFMVASKFITLTFKDPDVYSAKQEFLFL
                     TTMPEVRKLPEEKHIPEELKPTGKELPDSQLVQPLVYMERLELIRNVCRDDALKNLSH
                     TPVSKFVLDRIFVCDKHKILFCQTPKVGNTQWKKVLIVLNGAFSSIEEIPENVVHDHE
                     KNGLPRLSSFSDAEIQKRLKTYFKFFIVRDPFERLISAFKDKFVHNPRFEPWYRHEIA
                     PGIIRKYRRNRTETRGIQFEDFVRYLGDPNHRWLDLQFGDHIIHWVTYVELCAPCEIM
                     YSVIGHHETLEDDAPYILKEAGIDHLVSYPTIPPGITVYNRTKVEHYFLGISKRDIRR
                     LYARFEGDFKLFGYQKPDFLLN"
     exon            499..590
                     /gene="CHST10"
                     /gene_synonym="HNK-1ST; HNK1ST"
                     /inference="alignment:Splign:2.1.0"
     exon            591..825
                     /gene="CHST10"
                     /gene_synonym="HNK-1ST; HNK1ST"
                     /inference="alignment:Splign:2.1.0"
     exon            826..931
                     /gene="CHST10"
                     /gene_synonym="HNK-1ST; HNK1ST"
                     /inference="alignment:Splign:2.1.0"
     exon            932..2854
                     /gene="CHST10"
                     /gene_synonym="HNK-1ST; HNK1ST"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2830..2835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHST10"
                     /gene_synonym="HNK-1ST; HNK1ST"
                     /note="hexamer: AATAAA"
     polyA_site      2854
                     /gene="CHST10"
                     /gene_synonym="HNK-1ST; HNK1ST"
                     /note="major polyA site"
ORIGIN      
        1 aggcggcgcg cacggccgga taggcgcgag ggggccgcgt gaggcggtgc cggcgttctg
       61 gcccccaaag ccggtctagc gcgccgggcg tcttccttac ttccgctgcc gccgccgcca
      121 catcccggga cccgacgggc cgcggcgcgg aggcctcggg gcaaggtggg gcgggcctcc
      181 cgagctccca ggaccccgcg cgcttcgccc acaggcccgg cgaagcccga cccgcgcggc
      241 gcccccaggg ccaggggagg agcctaagga cccggacgag cgccgctcca gtaggtgaca
      301 agaggaacca agaacctcag ttcaggggaa acacagcaag gaaatgtgag ccccaggctg
      361 cagaaggaag agtcagtgaa tggctgcggt gtgacaacat gcaccaccag tggcttctgc
      421 tggccgcatg cttttgggtg attttcatgt tcatggtggc tagcaagttc atcacgttga
      481 cctttaaaga cccagatgtg tacagtgcca aacaggagtt tctgttcctg acaaccatgc
      541 cggaagtgag gaagttgcca gaagagaagc acattcctga ggaactgaag ccaactggga
      601 aggagcttcc agacagccag ctcgttcagc ccctggtcta catggagcgc ctggaactca
      661 tcagaaacgt ctgcagggat gatgccctga agaatctctc gcacactcct gtctccaagt
      721 ttgtcctgga ccgaatattt gtctgtgaca agcacaagat tcttttctgc cagactccca
      781 aagtgggcaa cacccagtgg aagaaagtgc tgattgttct aaatggagca ttttcttcca
      841 ttgaggagat ccccgaaaac gtggtgcacg accacgagaa gaacggcctt cctcggctct
      901 cttccttcag tgatgcagaa attcagaagc gattgaaaac atacttcaag ttttttattg
      961 taagagatcc cttcgaaaga cttatttctg catttaagga taaatttgtt cacaatcccc
     1021 ggtttgagcc ttggtacagg catgagattg ctcctggcat catcagaaaa tacaggagga
     1081 accggacaga gacccggggg atccagtttg aagatttcgt gcgctacctc ggcgatccga
     1141 accacagatg gctagacctt cagtttgggg accacatcat tcactgggtg acgtatgtag
     1201 agctctgtgc tccctgtgag ataatgtaca gtgtgattgg acaccacgag accctggagg
     1261 acgatgcccc atacatctta aaagaggctg gcattgacca cctggtgtca tacccgacta
     1321 tccctccggg cattaccgtg tataacagaa ccaaggtgga gcactatttc ctgggcatca
     1381 gcaaacgaga catccgacgc ctgtatgccc gtttcgaagg ggactttaag ctctttgggt
     1441 accagaaacc agactttttg ctaaactaat gcataagacc tatgaattca aatatcttta
     1501 ttagacctgg ggctaaccag gtgaagatct gagcccagaa atgacccttc ctccaccaca
     1561 cccctccttt gaggacgccc ggggtctccc acaggcctgt gagttgcctc ggcatatgac
     1621 gcagaacccc aactgttaca acttagtttg gatgtaagat gctctgagga ccctgcccac
     1681 acccctgcgt gcattaggat gtcgctggcc tttgctcacc tcagagggga gaaaaggcta
     1741 aagatttgca gtttgacagc ccagcaggga ggaagcatca cacagcgtta ggagccgttt
     1801 ccttcaggtg ttaaggaagg ggatgcccct gaggttctcc tggctagtca gggtggcttc
     1861 acccatcact ggtgggttgc aggaacagca cccaggactc tgaggaggga cagagaagca
     1921 agggggctgc tgaaatcgca gagacttttg cagcatcaga tctgaggagt aaaacggcac
     1981 ctctggcctt catcttggtg ctgcgacaat tgtggaggca aagcattctt tctgtgacta
     2041 ttttgttcct gtagacagtc agcgatggcc agagggtggt gtggtgtcca ggggtccatc
     2101 tttccagaat ccatgcctgt gtaatgctgg tccatgcttc tgaacctgtg tctgccaagc
     2161 gcctatttca ttcagcacaa gacatacgat tttagaaggt gaggggaggg gaggcttttt
     2221 ctacctgaga aggggagtgt ctttgagggc cttaaaagga ccatggccca ggaatggggg
     2281 cgctggttgg gcttggagct caggctgctg tggatcccgg cgcatcagtt ctgacttgcc
     2341 ttacctgggt ggacagcagt gaatctccac ctgtcttctc cagggagctc ccatgttggg
     2401 gctgaagacg agcaggggca acctgccagc atcacagaat tcagtgtagt ttatacattt
     2461 cgattccttt catctcagca aaatgggcac tgccagagcc atttctgatc acaccaccat
     2521 cctggaccat gtgactggaa ggtgggtaac caagttcacc agcaataaaa cccagcgccc
     2581 aggtagcctc cagcagtgcg gcttcctggc aacaaggtag gccctggtgc agggcaagcc
     2641 gcagcgacca tttcagatac cgtccacagc caggaccgct gagaactggg acagtttcct
     2701 gggatgagtg ccagcctgag cctgcatggt gccgccgagc ccggggtgga ggagggagcc
     2761 aggcttcgct tcaaggcggc ctctaccttt tctcagaatg gtttcctgat tgtgtcaatg
     2821 tgaaagttaa ataaaattta tgtgccaaac ctga
//
