LOCUS       NM_000748               5857 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens cholinergic receptor nicotinic beta 2 subunit
            (CHRNB2), mRNA.
ACCESSION   NM_000748
VERSION     NM_000748.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5857)
  AUTHORS   Mazzaferro,S., Kang,G., Natarajan,K., Hibbs,R.E. and Sine,S.M.
  TITLE     Structural bases for stoichiometry-selective calcium potentiation
            of a neuronal nicotinic receptor
  JOURNAL   Br J Pharmacol 181 (13), 1973-1992 (2024)
   PUBMED   38454578
REFERENCE   2  (bases 1 to 5857)
  AUTHORS   George,A.A., John,S.J., Lucero,L.M., Eaton,J.B., Jaiswal,E.,
            Christensen,S.B., Gajewiak,J., Watkins,M., Cao,Y., Olivera,B.M.,
            Im,W., McIntosh,J.M. and Whiteaker,P.
  TITLE     Analogs of alpha-conotoxin PnIC selectively inhibit alpha7beta2-
            over alpha7-only subtype nicotinic acetylcholine receptors via a
            novel allosteric mechanism
  JOURNAL   FASEB J 38 (1), e23374 (2024)
   PUBMED   38161283
REFERENCE   3  (bases 1 to 5857)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5857)
  AUTHORS   Weltzin,M.M., George,A.A., Lukas,R.J. and Whiteaker,P.
  TITLE     Sleep-related hypermotor epilepsy associated mutations uncover
            important kinetic roles of alpha4beta2- nicotinic acetylcholine
            receptor intracellular structures
  JOURNAL   PLoS One 16 (3), e0247825 (2021)
   PUBMED   33657187
  REMARK    GeneRIF: Sleep-related hypermotor epilepsy associated mutations
            uncover important kinetic roles of alpha4beta2- nicotinic
            acetylcholine receptor intracellular structures.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5857)
  AUTHORS   Luijerink,L.L.M., Vivekanandarajah,A., Waters,K.A. and
            Machaalani,R.
  TITLE     The alpha7 and beta2 nicotinic acetylcholine receptor subunits
            regulate apoptosis in the infant hippocampus, and in sudden infant
            death syndrome (SIDS)
  JOURNAL   Apoptosis 25 (7-8), 574-589 (2020)
   PUBMED   32577853
  REMARK    GeneRIF: The alpha7 and beta2 nicotinic acetylcholine receptor
            subunits regulate apoptosis in the infant hippocampus, and in
            sudden infant death syndrome (SIDS).
REFERENCE   6  (bases 1 to 5857)
  AUTHORS   Wang,F., Gerzanich,V., Wells,G.B., Anand,R., Peng,X., Keyser,K. and
            Lindstrom,J.
  TITLE     Assembly of human neuronal nicotinic receptor alpha5 subunits with
            alpha3, beta2, and beta4 subunits
  JOURNAL   J Biol Chem 271 (30), 17656-17665 (1996)
   PUBMED   8663494
REFERENCE   7  (bases 1 to 5857)
  AUTHORS   Elliott,K.J., Ellis,S.B., Berckhan,K.J., Urrutia,A.,
            Chavez-Noriega,L.E., Johnson,E.C., Velicelebi,G. and Harpold,M.M.
  TITLE     Comparative structure of human neuronal alpha 2-alpha 7 and beta
            2-beta 4 nicotinic acetylcholine receptor subunits and functional
            expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and
            beta 4 subunits
  JOURNAL   J Mol Neurosci 7 (3), 217-228 (1996)
   PUBMED   8906617
REFERENCE   8  (bases 1 to 5857)
  AUTHORS   Kurahashi,H. and Hirose,S.
  TITLE     Autosomal Dominant Sleep-Related Hypermotor (Hyperkinetic) Epilepsy
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301348
REFERENCE   9  (bases 1 to 5857)
  AUTHORS   Anand,R. and Lindstrom,J.
  TITLE     Chromosomal localization of seven neuronal nicotinic acetylcholine
            receptor subunit genes in humans
  JOURNAL   Genomics 13 (4), 962-967 (1992)
   PUBMED   1505988
REFERENCE   10 (bases 1 to 5857)
  AUTHORS   Anand,R. and Lindstrom,J.
  TITLE     Nucleotide sequence of the human nicotinic acetylcholine receptor
            beta 2 subunit gene
  JOURNAL   Nucleic Acids Res 18 (14), 4272 (1990)
   PUBMED   2377478
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL592078.10, U62437.1 and
            R40506.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_000748.2.
            
            Summary: Neuronal acetylcholine receptors are homo- or
            heteropentameric complexes composed of homologous alpha and beta
            subunits. They belong to a superfamily of ligand-gated ion channels
            which allow the flow of sodium and potassium across the plasma
            membrane in response to ligands such as acetylcholine and nicotine.
            This gene encodes one of several beta subunits. Mutations in this
            gene are associated with autosomal dominant nocturnal frontal lobe
            epilepsy. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.46094.1,
                                           SRR1803616.245182.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368476.4/ ENSP00000357461.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL592078.10        18865-18867         c
            4-2088              U62437.1           1-2085
            2089-5617           AL592078.10        6872-10400          c
            5618-5722           R40506.1           13-117              c
            5723-5857           AL592078.10        6632-6766           c
FEATURES             Location/Qualifiers
     source          1..5857
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..5857
                     /gene="CHRNB2"
                     /gene_synonym="EFNL3; nAChRB2"
                     /note="cholinergic receptor nicotinic beta 2 subunit"
                     /db_xref="GeneID:1141"
                     /db_xref="HGNC:HGNC:1962"
                     /db_xref="MIM:118507"
     exon            1..331
                     /gene="CHRNB2"
                     /gene_synonym="EFNL3; nAChRB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..1776
                     /gene="CHRNB2"
                     /gene_synonym="EFNL3; nAChRB2"
                     /note="cholinergic receptor, nicotinic, beta polypeptide 2
                     (neuronal); neuronal nicotinic acetylcholine receptor beta
                     2; neuronal acetylcholine receptor subunit beta-2;
                     acetylcholine receptor, nicotinic, beta 2 (neuronal);
                     cholinergic receptor, nicotinic beta 2; beta2 human
                     neuronal nicotinic acetylcholine receptor; cholinergic
                     receptor, nicotinic, beta 2 (neuronal)"
                     /codon_start=1
                     /product="neuronal acetylcholine receptor subunit beta-2
                     precursor"
                     /protein_id="NP_000739.1"
                     /db_xref="CCDS:CCDS1070.1"
                     /db_xref="GeneID:1141"
                     /db_xref="HGNC:HGNC:1962"
                     /db_xref="MIM:118507"
                     /translation="MARRCGPVALLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNK
                     LIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNM
                     KKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVK
                     HFPFDQQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDD
                     STYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLAL
                     TVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPW
                     VKVVFLEKLPALLFMQQPRHHCARQRLRLRRRQREREGAGALFFREAPGADSCTCFVN
                     RASVQGLAGAFGAEPAPVAGPGRSGEPCGCGLREAVDGVRFIADHMRSEDDDQSVSED
                     WKYVAMVIDRLFLWIFVFVCVFGTIGMFLQPLFQNYTTTTFLHSDHSAPSSK"
     exon            332..477
                     /gene="CHRNB2"
                     /gene_synonym="EFNL3; nAChRB2"
                     /inference="alignment:Splign:2.1.0"
     exon            478..522
                     /gene="CHRNB2"
                     /gene_synonym="EFNL3; nAChRB2"
                     /inference="alignment:Splign:2.1.0"
     exon            523..632
                     /gene="CHRNB2"
                     /gene_synonym="EFNL3; nAChRB2"
                     /inference="alignment:Splign:2.1.0"
     exon            633..1605
                     /gene="CHRNB2"
                     /gene_synonym="EFNL3; nAChRB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..5857
                     /gene="CHRNB2"
                     /gene_synonym="EFNL3; nAChRB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5705..5710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHRNB2"
                     /gene_synonym="EFNL3; nAChRB2"
                     /note="hexamer: AAGAAA"
     polyA_site      5710
                     /gene="CHRNB2"
                     /gene_synonym="EFNL3; nAChRB2"
     polyA_site      5722
                     /gene="CHRNB2"
                     /gene_synonym="EFNL3; nAChRB2"
                     /note="major polyA site"
ORIGIN      
        1 agactcctcc ccctcaccgt cccaattgta ttccctggaa gagcagccgg aaaagcctcc
       61 gcctgctcat accaggatag gcaagaagct ggtttctcct cgcagccggc tccctgaggc
      121 ccaggaacca ccgcggcggc cggcaccacc tggacccagc tccaggcggg cgcggcttca
      181 gcaccacgga cagcgcccca cccgcggccc tccccccggc ggcgcgctcc agccggtgta
      241 ggcgaggcag cgagctatgc ccgcggcatg gcccggcgct gcggccccgt ggcgctgctc
      301 cttggcttcg gcctcctccg gctgtgctca ggggtgtggg gtacggatac agaggagcgg
      361 ctggtggagc atctcctgga tccttcccgc tacaacaagc ttatccgccc agccaccaat
      421 ggctctgagc tggtgacagt acagcttatg gtgtcactgg cccagctcat cagtgtgcat
      481 gagcgggagc agatcatgac caccaatgtc tggctgaccc aggagtggga agattatcgc
      541 ctcacctgga agcctgaaga gtttgacaac atgaagaaag ttcggctccc ttccaaacac
      601 atctggctcc cagatgtggt cctgtacaac aatgctgacg gcatgtacga ggtgtccttc
      661 tattccaatg ccgtggtctc ctatgatggc agcatcttct ggctgccgcc tgccatctac
      721 aagagcgcat gcaagattga agtaaagcac ttcccatttg accagcagaa ctgcaccatg
      781 aagttccgtt cgtggaccta cgaccgcaca gagatcgact tggtgctgaa gagtgaggtg
      841 gccagcctgg acgacttcac acctagtggt gagtgggaca tcgtggcgct gccgggccgg
      901 cgcaacgaga accccgacga ctctacgtac gtggacatca cgtatgactt catcattcgc
      961 cgcaagccgc tcttctacac catcaacctc atcatcccct gtgtgctcat cacctcgcta
     1021 gccatccttg tcttctacct gccatccgac tgtggcgaga agatgacgtt gtgcatctca
     1081 gtgctgctgg cgctcacggt cttcctgctg ctcatctcca agatcgtgcc tcccacctcc
     1141 ctcgacgtgc cgctcgtcgg caagtacctc atgttcacca tggtgcttgt caccttctcc
     1201 atcgtcacca gcgtgtgcgt gctcaacgtg caccaccgct cgcccaccac gcacaccatg
     1261 gcgccctggg tgaaggtcgt cttcctggag aagctgcccg cgctgctctt catgcagcag
     1321 ccacgccatc attgcgcccg tcagcgcctg cgcctgcggc gacgccagcg tgagcgcgag
     1381 ggcgctggag ccctcttctt ccgcgaagcc ccaggggccg actcctgcac gtgcttcgtc
     1441 aaccgcgcgt cggtgcaggg gttggccggg gccttcgggg ctgagcctgc accagtggcg
     1501 ggccccgggc gctcagggga gccgtgtggc tgtggcctcc gggaggcggt ggacggcgtg
     1561 cgcttcatcg cagaccacat gcggagcgag gacgatgacc agagcgtgag tgaggactgg
     1621 aagtacgtcg ccatggtgat cgaccgcctc ttcctctgga tctttgtctt tgtctgtgtc
     1681 tttggcacca tcggcatgtt cctgcagcct ctcttccaga actacaccac caccaccttc
     1741 ctccactcag accactcagc ccccagctcc aagtgaggcc cttcctcatc tccatgctct
     1801 ttcaccctgc caccctctgc tgcacagtag tgttgggtgg aggatggacg agtgagctac
     1861 caggaagagg ggcgctgccc ccacagatcc atccttttgc ttcatctgga gtccctcctc
     1921 ccccacgcct ccatccacac acagcagctc caacctggag gctggaccaa ctgctttgtt
     1981 ttggctgctc tccatctctt gtaccagccc aggcaatagt gttgaggagg ggagcaaggc
     2041 tgctaagtgg aagacagaga tggcagagcc atccaccctg aggagtgatg ggcaaggggc
     2101 caggaagggg acaggattgt ctgctgcctc caagtcatgg gagaagaggg gtataggaca
     2161 aggggtggaa gggcaggagc tcacaccgca ccgggctggc ctgacacaat ggtagctctg
     2221 aagggagggg aagagagagg cctgggtgtg acctgacacc tgccgctgct tgagtggaca
     2281 gcagctggac tgggtgggcc ccacagtggt cagcgattcc tgccaagtag ggtttagccg
     2341 ggccccatgg tcacagaccc ctgggggagg cttccagctc agtcccacag ccccttgctt
     2401 ctaagggatc cagagacctg ctccagatcc tctttcccca ctgaagaatt ctgcaccctc
     2461 tggacttccc tcttcttcct tcctttctca ggctcaaggt gtggggggca aggctgagta
     2521 ttaggggagc ttctgagttc tgaatctttg ggtgacctgc ttggagtctc aggtccaaat
     2581 acttgaaatc tgtgagaagt ccaagttcat gggcttttgg aactggaaga actttgtaca
     2641 gccatggatt ccaacataag ccatgttgca gatgaagaaa ctgacccaca cggtgagaca
     2701 agcacaggtg ggtctgactc ttcctccctg ccctgagatc catctgtcga gtgccctgtt
     2761 ttttccccac tttgaactga ctggttactc taaggaagtg aactgaggat gttagcttta
     2821 agccaaccca gcctctttgt ccacagcaga gctgaggtga acagctggaa ccctgctaca
     2881 tccgtgctgc tccagtctgt tctgctcatg gctccatcct tctggctgtc actcttcctc
     2941 ttccccttcc caaccaaacc tgagcagctt tgaagcagaa cttgggaagg acagggctgc
     3001 tgctgccagc gacacctcag aaagcatagc ctcggcttcc tgccccatgt gtccctggaa
     3061 gctgtaccct gactctgctt ccagaggcca gcagatggtg ggttacagac gggtcagcct
     3121 gccaagtgca cctgagggac ctgacctgac acaagccatt ttgtccctag agcccagctg
     3181 ggactcctgc ttctctaggc agggcagagg gaggagacac agcacaggca cagagcatgg
     3241 gacagggacc cccgagtctg gattcaagtc ctggccctgc tagtaactca tgtgagccag
     3301 cttgagcaag tcccttcatc ttgctagagc tcagcttcct tgcctataaa acgtaggtgg
     3361 caatgccctc ttcctgaggt tgctgggagg ataaggcagt gcttgtgaaa aagtctagcg
     3421 ctgtacctgg cacagagtag atgcttcatg aatgttgagt ctgacaggca actggagctg
     3481 gtgagaatgg ggtcccctga ctgtcatgcc agcctccctc ccaggcccac tcttcccccc
     3541 tcttccctga ggaaaccaag tctcccttat caggaagagc tgggggagct gggaggaaca
     3601 ttacaggaac accagaggga gtctagcggg tgggcaggct tctctctgca gccccctcag
     3661 cagtttcatt ccattcctgg gctgaaccct tgccctggcc ctgcctccct tctgggtcag
     3721 cacctcctga cacaggtgtg tgctcaggga ccccaggctc tagtcctgta ctggctgtgg
     3781 aagcctatca ctgggacagg aagccagtgg ctgcaggaga caggcctcag cgcatctcgt
     3841 ctgtcaggat gggctcacgg acaccttttc ttggtagcag ggagtgtctc tgcactatgg
     3901 aaactttccc tcttctagag cggattggga gttgcctgta ttatgcctga accctccttg
     3961 aactcatggt cctggggaag gcgtcttgga accagaaaca gcaacaggaa aggagcctcc
     4021 ctctgaaggg taggatgccg gcctgaggcc ctccctcttg gctctcccag ggcctgggct
     4081 accccgaggc cccagcagct gctgctgtgg ctgtacttgc ttttaatatt tcccatacat
     4141 ggctgttgtc caagttaagt caccaaatgg tgctagaggg gatggcagag agcagcttgt
     4201 ccagctcctc tccatgaccc ggttaacaca cgagtaaaca ggcctagagc ttgtctgctg
     4261 tttgacctct tttaagaccc ggctgtgctg catctacaaa atgaagatga cagagctagc
     4321 cgaggtcttc agcaaggaag aaaggggtca gtgtatatga aagggttacc tgggcagtgt
     4381 cattccctcc atctctgtac gcagcccttt gggaaccatc acaataagga agaggtgagg
     4441 gcagaggtga aggatccact gcccaggcaa ggtgctacca tgtggtggga gagtgtgaac
     4501 cctcaagtgc actgggaagc tttggggaac cacagtctct tccacccttg ggtcgtgtgt
     4561 cgtcctcttc tcttgatgtc agggaagccc ctatgcctcc ttcccgtggt ggggctatct
     4621 ctgcagagaa tcgggtgccc agcttaatgc tgggcaagga ctggaggaag ctccagatct
     4681 ggaggtggca gagatactgg atggaaacct ggagcaaggg tttgggaggg gaagtgagga
     4741 aacaggttga gactatctcc atcagagatg gcaaggccac aggtgatctg agaactattt
     4801 ttgtctgaaa agaaggcatg cacaggctct ctgcttttga caggtggcgt tgcagtggga
     4861 ggaaggcagc ttcctggcgg ggagatagaa atactagaac agctggtacc aagttattga
     4921 aaatttaaaa gcaaacaaga cacagcagcc cccaggtggt gtgttctact gaggaaggct
     4981 acggcagagg aagggcaaga ccgtttcccc caatggtctt gaaacggaag aggaaacagg
     5041 gagggctctt tggatggttt ggggacctgg ggctgtttgt atcccagtat tagctcctgt
     5101 tactaagggt ctgctctgcg ccaggtcctc agcatgcgtt gtctttattc cgcgtgacaa
     5161 tcctatggga aggggcctcc acctacgtaa cagaaatgcg gctcagaaag accaagtgac
     5221 agctagtgag tagtgctggg cctgaacccc aaagtccaca ctcttgctat agccgctgag
     5281 gcaggcagaa gagctccttg ggaggaaagt aaggggcatt caaagccttc tctgaatcac
     5341 tccccaagcc agagtagacc tggttccagt tgtccccccc ttgtttccgg gcagagtcag
     5401 gcaggtgtca taccatccct ccccgcccaa ccagtgctgg ccagactccc attcaccgac
     5461 cttgactaga cagcgaacag ccacctttta gtattcatcc caacaggtcc aggcggtcag
     5521 tgtgatagcc acgcagttcc taagggactg taggtctagg aatcattagg acactcactc
     5581 agccaccctc gatgccccca tcttccccac actgcccttg gcctccccgc tctgcacgcc
     5641 tggagtattt gcactggtct agcctactcc aggtcagact cattaggaac tcaagattct
     5701 cgtaaagaaa gttgtttcca aagttgtctt gtcactctat ttgggggttg ggagagagcc
     5761 cgtgggggcc agcgttggcg aatacaggaa aaagggagaa tgctggagaa actggactcg
     5821 tgagagctta aagacatcac aagaatccaa agaaaaa
//
