LOCUS       NP_000737                502 aa            linear   PRI 12-JUN-2025
DEFINITION  neuronal acetylcholine receptor subunit alpha-7 isoform 1 precursor
            [Homo sapiens].
ACCESSION   NP_000737 XP_942816
VERSION     NP_000737.1
DBSOURCE    REFSEQ: accession NM_000746.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 502)
  AUTHORS   Oz,M., Kury,L.A., Sadek,B. and Mahgoub,M.O.
  TITLE     The role of nicotinic acetylcholine receptors in the
            pathophysiology and pharmacotherapy of autism spectrum disorder:
            Focus on alpha7 nicotinic receptors
  JOURNAL   Int J Biochem Cell Biol 174, 106634 (2024)
   PUBMED   39094731
  REMARK    GeneRIF: The role of nicotinic acetylcholine receptors in the
            pathophysiology and pharmacotherapy of autism spectrum disorder:
            Focus on alpha7 nicotinic receptors.
            Review article
REFERENCE   2  (residues 1 to 502)
  AUTHORS   Di,T., Chen,Y., Zhou,Z., Liu,J., Du,Y., Feng,C., Zhu,B. and Wang,L.
  TITLE     Effect of alpha7 nAChR-autophagy axis of deciduous tooth pulp stem
            cells in regulating IL-1beta in the process of physiological root
            resorption of deciduous teeth
  JOURNAL   J Mol Med (Berl) 102 (9), 1135-1149 (2024)
   PUBMED   39002004
  REMARK    GeneRIF: Effect of alpha7 nAChR-autophagy axis of deciduous tooth
            pulp stem cells in regulating IL-1beta in the process of
            physiological root resorption of deciduous teeth.
REFERENCE   3  (residues 1 to 502)
  AUTHORS   O'Brien,B.C.V., Thao,S., Weber,L., Danielson,H.L., Boldt,A.D.,
            Hueffer,K. and Weltzin,M.M.
  TITLE     The human alpha7 nicotinic acetylcholine receptor is a host target
            for the rabies virus glycoprotein
  JOURNAL   Front Cell Infect Microbiol 14, 1394713 (2024)
   PUBMED   38836054
  REMARK    GeneRIF: The human alpha7 nicotinic acetylcholine receptor is a
            host target for the rabies virus glycoprotein.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 502)
  AUTHORS   George,A.A., John,S.J., Lucero,L.M., Eaton,J.B., Jaiswal,E.,
            Christensen,S.B., Gajewiak,J., Watkins,M., Cao,Y., Olivera,B.M.,
            Im,W., McIntosh,J.M. and Whiteaker,P.
  TITLE     Analogs of alpha-conotoxin PnIC selectively inhibit alpha7beta2-
            over alpha7-only subtype nicotinic acetylcholine receptors via a
            novel allosteric mechanism
  JOURNAL   FASEB J 38 (1), e23374 (2024)
   PUBMED   38161283
REFERENCE   5  (residues 1 to 502)
  AUTHORS   Sluchanko,N.N., Kapitonova,A.A., Shulepko,M.A., Kukushkin,I.D.,
            Kulbatskii,D.S., Tugaeva,K.V., Varfolomeeva,L.A., Minyaev,M.E.,
            Boyko,K.M., Popov,V.O., Kirpichnikov,M.P. and Lyukmanova,E.N.
  TITLE     Crystal structure reveals canonical recognition of the
            phosphorylated cytoplasmic loop of human alpha7 nicotinic
            acetylcholine receptor by 14-3-3 protein
  JOURNAL   Biochem Biophys Res Commun 682, 91-96 (2023)
   PUBMED   37804592
  REMARK    GeneRIF: Crystal structure reveals canonical recognition of the
            phosphorylated cytoplasmic loop of human alpha7 nicotinic
            acetylcholine receptor by 14-3-3 protein.
REFERENCE   6  (residues 1 to 502)
  AUTHORS   Elliott,K.J., Ellis,S.B., Berckhan,K.J., Urrutia,A.,
            Chavez-Noriega,L.E., Johnson,E.C., Velicelebi,G. and Harpold,M.M.
  TITLE     Comparative structure of human neuronal alpha 2-alpha 7 and beta
            2-beta 4 nicotinic acetylcholine receptor subunits and functional
            expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and
            beta 4 subunits
  JOURNAL   J Mol Neurosci 7 (3), 217-228 (1996)
   PUBMED   8906617
REFERENCE   7  (residues 1 to 502)
  AUTHORS   Peng,X., Katz,M., Gerzanich,V., Anand,R. and Lindstrom,J.
  TITLE     Human alpha 7 acetylcholine receptor: cloning of the alpha 7
            subunit from the SH-SY5Y cell line and determination of
            pharmacological properties of native receptors and functional alpha
            7 homomers expressed in Xenopus oocytes
  JOURNAL   Mol Pharmacol 45 (3), 546-554 (1994)
   PUBMED   8145738
REFERENCE   8  (residues 1 to 502)
  AUTHORS   Chini,B., Raimond,E., Elgoyhen,A.B., Moralli,D., Balzaretti,M. and
            Heinemann,S.
  TITLE     Molecular cloning and chromosomal localization of the human alpha
            7-nicotinic receptor subunit gene (CHRNA7)
  JOURNAL   Genomics 19 (2), 379-381 (1994)
   PUBMED   8188270
REFERENCE   9  (residues 1 to 502)
  AUTHORS   van Bon,B.W.M., Mefford,H.C., de Vries,B.B.A. and Schaaf,C.P.
  TITLE     15q13.3 Recurrent Deletion
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   21290787
REFERENCE   10 (residues 1 to 502)
  AUTHORS   Kunsch,C., Ruben,S.M. and Rosen,C.A.
  TITLE     Selection of optimal kappa B/Rel DNA-binding motifs: interaction of
            both subunits of NF-kappa B with DNA is required for
            transcriptional activation
  JOURNAL   Mol Cell Biol 12 (10), 4412-4421 (1992)
   PUBMED   1406630
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292069.1, BC037571.1,
            AC068448.10 and BI789267.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 4, 2006 this sequence version replaced XP_942816.1.
            
            Summary: The nicotinic acetylcholine receptors (nAChRs) are members
            of a superfamily of ligand-gated ion channels that mediate fast
            signal transmission at synapses. The nAChRs are thought to be
            hetero-pentamers composed of homologous subunits. The proposed
            structure for each subunit is a conserved N-terminal extracellular
            domain followed by three conserved transmembrane domains, a
            variable cytoplasmic loop, a fourth conserved transmembrane domain,
            and a short C-terminal extracellular region. The protein encoded by
            this gene forms a homo-oligomeric channel, displays marked
            permeability to calcium ions and is a major component of brain
            nicotinic receptors that are blocked by, and highly sensitive to,
            alpha-bungarotoxin. Once this receptor binds acetylcholine, it
            undergoes an extensive change in conformation that affects all
            subunits and leads to opening of an ion-conducting channel across
            the plasma membrane. This gene is located in a region identified as
            a major susceptibility locus for juvenile myoclonic epilepsy and a
            chromosomal location involved in the genetic transmission of
            schizophrenia. An evolutionarily recent partial duplication event
            in this region results in a hybrid containing sequence from this
            gene and a novel FAM7A gene. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Feb 2012].
            
            Transcript Variant: This variant (1) lacks an in-frame portion of
            the 5' coding region, compared to variant 2. The resulting isoform
            (1) has a shorter N-terminus, compared to isoform 2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.200548.1,
                                           SRR7410571.165085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306901.9/ ENSP00000303727.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..502
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q13.3"
     Protein         1..502
                     /product="neuronal acetylcholine receptor subunit alpha-7
                     isoform 1 precursor"
                     /note="cholinergic receptor, nicotinic, alpha polypeptide
                     7; a7 nicotinic acetylcholine receptor; alpha 7 neuronal
                     nicotinic acetylcholine receptor; alpha-7 nicotinic
                     cholinergic receptor subunit; neuronal acetylcholine
                     receptor protein, alpha-7 chain; neuronal acetylcholine
                     receptor subunit alpha-7; nicotinic acetylcholine receptor
                     subunit alpha-7; cholinergic receptor, nicotinic, alpha 7
                     (neuronal); cholinergic receptor, nicotinic alpha 7"
                     /calculated_mol_wt=54158
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2310
     Region          3..490
                     /region_name="LIC"
                     /note="Cation transporter family protein; TIGR00860"
                     /db_xref="CDD:273305"
     mat_peptide     23..502
                     /product="Neuronal acetylcholine receptor subunit alpha-7.
                     /id=PRO_0000000366"
                     /note="propagated from UniProtKB/Swiss-Prot (P36544.5)"
                     /calculated_mol_wt=54158
     Site            46
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P36544.5)"
     Site            90
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P36544.5)"
     Site            133
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P36544.5)"
     Site            234..254
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P36544.5)"
     Site            259..279
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P36544.5)"
     Region          260..267
                     /region_name="Essential for TMEM35A/NACHO-mediated proper
                     subunit assembly and trafficking to cell membrane.
                     /evidence=ECO:0000250|UniProtKB:P49582"
                     /note="propagated from UniProtKB/Swiss-Prot (P36544.5)"
     Site            292..315
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P36544.5)"
     Site            467..489
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P36544.5)"
     CDS             1..502
                     /gene="CHRNA7"
                     /gene_synonym="CHRNA7-2; nAChR7; NACHRA7"
                     /coded_by="NM_000746.6:81..1589"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS10027.1"
                     /db_xref="GeneID:1139"
                     /db_xref="HGNC:HGNC:1960"
                     /db_xref="MIM:118511"
ORIGIN      
        1 mrcspggvwl alaasllhvs lqgefqrkly kelvknynpl erpvandsqp ltvyfslsll
       61 qimdvdeknq vlttniwlqm swtdhylqwn vseypgvktv rfpdgqiwkp dillynsade
      121 rfdatfhtnv lvnssghcqy lppgifkssc yidvrwfpfd vqhcklkfgs wsyggwsldl
      181 qmqeadisgy ipngewdlvg ipgkrserfy ecckepypdv tftvtmrrrt lyyglnllip
      241 cvlisalall vfllpadsge kislgitvll sltvfmllva eimpatsdsv pliaqyfast
      301 miivglsvvv tvivlqyhhh dpdggkmpkw trvillnwca wflrmkrpge dkvrpacqhk
      361 qrrcslasve msavapppas ngnllyigfr gldgvhcvpt pdsgvvcgrm acspthdehl
      421 lhggqppegd pdlakileev ryianrfrcq deseavcsew kfaacvvdrl clmafsvfti
      481 ictigilmsa pnfveavskd fa
//
