LOCUS       NM_004198               2400 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens cholinergic receptor nicotinic alpha 6 subunit
            (CHRNA6), transcript variant 1, mRNA.
ACCESSION   NM_004198
VERSION     NM_004198.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2400)
  AUTHORS   Zhang,F., Zhang,M., Yuan,X., Tao,Y. and Wang,J.
  TITLE     Involvement of CHRNA6 in the Immune Response in Lung Squamous Cell
            Carcinoma and its Potential as a Drug Target for the Disease
  JOURNAL   Curr Pharm Des 29 (26), 2091-2100 (2023)
   PUBMED   37680128
  REMARK    GeneRIF: Involvement of CHRNA6 in the Immune Response in Lung
            Squamous Cell Carcinoma and its Potential as a Drug Target for the
            Disease.
REFERENCE   2  (bases 1 to 2400)
  AUTHORS   Wen,L., Han,H., Liu,Q., Su,K., Yang,Z., Cui,W., Yuan,W., Ma,Y.,
            Fan,R., Chen,J., Jiang,K., Jiang,X., Payne,T.J., Wang,J. and
            Li,M.D.
  TITLE     Significant association of the CHRNB3-CHRNA6 gene cluster with
            nicotine dependence in the Chinese Han population
  JOURNAL   Sci Rep 7 (1), 9745 (2017)
   PUBMED   28851948
  REMARK    GeneRIF: This study is the first showing that CHRNB3/A6 are highly
            associated with nicotine dependence in a large Chinese Han sample.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2400)
  AUTHORS   Arvaniti,M., Jensen,M.M., Soni,N., Wang,H., Klein,A.B., Thiriet,N.,
            Pinborg,L.H., Muldoon,P.P., Wienecke,J., Imad Damaj,M.,
            Kohlmeier,K.A., Gondre-Lewis,M.C., Mikkelsen,J.D. and Thomsen,M.S.
  TITLE     Functional interaction between Lypd6 and nicotinic acetylcholine
            receptors
  JOURNAL   J Neurochem 138 (6), 806-820 (2016)
   PUBMED   27344019
REFERENCE   4  (bases 1 to 2400)
  AUTHORS   Wen,L., Yang,Z., Cui,W. and Li,M.D.
  TITLE     Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in
            nicotine dependence: update and subjects for future research
  JOURNAL   Transl Psychiatry 6 (6), e843 (2016)
   PUBMED   27327258
  REMARK    GeneRIF: To gain a better understanding of the pathological
            processes underlying ND and ND-related behaviors and to promote the
            development of effective smoking cessation therapies, we here
            present the most recent studies concerning the genetic effects of
            the CHRNB3-CHRNA6 gene cluster in ND.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2400)
  AUTHORS   Zeiger,J.S., Haberstick,B.C., Schlaepfer,I., Collins,A.C.,
            Corley,R.P., Crowley,T.J., Hewitt,J.K., Hopfer,C.J., Lessem,J.,
            McQueen,M.B., Rhee,S.H. and Ehringer,M.A.
  TITLE     The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3)
            are associated with subjective responses to tobacco
  JOURNAL   Hum Mol Genet 17 (5), 724-734 (2008)
   PUBMED   18055561
  REMARK    GeneRIF: CHRNA6 is associated with subjective responses to tobacco.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 2400)
  AUTHORS   Ebihara,M., Ohba,H., Ohno,S.I. and Yoshikawa,T.
  TITLE     Genomic organization and promoter analysis of the human nicotinic
            acetylcholine receptor alpha6 subunit (CHNRA6) gene: Alu and other
            elements direct transcriptional repression
  JOURNAL   Gene 298 (1), 101-108 (2002)
   PUBMED   12406580
REFERENCE   7  (bases 1 to 2400)
  AUTHORS   Bonati,M.T., Combi,R., Asselta,R., Duga,S., Malcovati,M.,
            Oldani,A., Zucconi,M., Ferini-Strambi,L., Dalpra,L. and
            Tenchini,M.L.
  TITLE     Exclusion of linkage of nine neuronal nicotinic acetylcholine
            receptor subunit genes expressed in brain in autosomal dominant
            nocturnal frontal lobe epilepsy in four unrelated families
  JOURNAL   J Neurol 249 (8), 967-974 (2002)
   PUBMED   12195439
REFERENCE   8  (bases 1 to 2400)
  AUTHORS   Graham,A., Court,J.A., Martin-Ruiz,C.M., Jaros,E., Perry,R.,
            Volsen,S.G., Bose,S., Evans,N., Ince,P., Kuryatov,A., Lindstrom,J.,
            Gotti,C. and Perry,E.K.
  TITLE     Immunohistochemical localisation of nicotinic acetylcholine
            receptor subunits in human cerebellum
  JOURNAL   Neuroscience 113 (3), 493-507 (2002)
   PUBMED   12150770
REFERENCE   9  (bases 1 to 2400)
  AUTHORS   Le Novere,N., Zoli,M. and Changeux,J.P.
  TITLE     Neuronal nicotinic receptor alpha 6 subunit mRNA is selectively
            concentrated in catecholaminergic nuclei of the rat brain
  JOURNAL   Eur J Neurosci 8 (11), 2428-2439 (1996)
   PUBMED   8950106
REFERENCE   10 (bases 1 to 2400)
  AUTHORS   Elliott,K.J., Ellis,S.B., Berckhan,K.J., Urrutia,A.,
            Chavez-Noriega,L.E., Johnson,E.C., Velicelebi,G. and Harpold,M.M.
  TITLE     Comparative structure of human neuronal alpha 2-alpha 7 and beta
            2-beta 4 nicotinic acetylcholine receptor subunits and functional
            expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and
            beta 4 subunits
  JOURNAL   J Mol Neurosci 7 (3), 217-228 (1996)
   PUBMED   8906617
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC307404.1 and BC014456.1.
            
            On Dec 3, 2010 this sequence version replaced NM_004198.2.
            
            Summary: This gene encodes an alpha subunit of neuronal nicotinic
            acetylcholine receptors. These receptors consist of five subunits
            and function as ion channels involved in neurotransmission. The
            encoded protein is a subunit of neuronal nicotinic acetylcholine
            receptors that mediate dopaminergic neurotransmission and are
            activated by acetylcholine and exogenous nicotine. Alternatively
            spliced transcript variants have been observed for this gene.
            Single nucleotide polymorphisms in this gene have been associated
            with both nicotine and alcohol dependence. [provided by RefSeq, Dec
            2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014456.1, SRR1803616.215210.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276410.7/ ENSP00000276410.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-310               DC307404.1         3-312
            311-2400            BC014456.1         1-2090
FEATURES             Location/Qualifiers
     source          1..2400
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.21"
     gene            1..2400
                     /gene="CHRNA6"
                     /gene_synonym="CHNRA6"
                     /note="cholinergic receptor nicotinic alpha 6 subunit"
                     /db_xref="GeneID:8973"
                     /db_xref="HGNC:HGNC:15963"
                     /db_xref="MIM:606888"
     exon            1..435
                     /gene="CHRNA6"
                     /gene_synonym="CHNRA6"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..1841
                     /gene="CHRNA6"
                     /gene_synonym="CHNRA6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cholinergic receptor, nicotinic, alpha
                     polypeptide 6; neuronal acetylcholine receptor subunit
                     alpha-6; acetylcholine receptor, nicotinic, alpha 6
                     (neuronal); cholinergic receptor, nicotinic, alpha 6
                     (neuronal); cholinergic receptor, nicotinic alpha 6;
                     alpha(alpha)6 nicotinic acetylcholine receptor (nAChR)
                     subunit"
                     /codon_start=1
                     /product="neuronal acetylcholine receptor subunit alpha-6
                     isoform 1 precursor"
                     /protein_id="NP_004189.1"
                     /db_xref="CCDS:CCDS6135.1"
                     /db_xref="GeneID:8973"
                     /db_xref="HGNC:HGNC:15963"
                     /db_xref="MIM:606888"
                     /translation="MLTSKGQGFLHGGLCLWLCVFTPFFKGCVGCATEERLFHKLFSH
                     YNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEY
                     DGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPM
                     DITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIIDASGYKHDI
                     KYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCI
                     SVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTT
                     HTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLASHGEPRHL
                     KECFHCHKSNELATSKRRLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSHNETK
                     EVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFLQPLLGNTGKS"
     exon            436..575
                     /gene="CHRNA6"
                     /gene_synonym="CHNRA6"
                     /inference="alignment:Splign:2.1.0"
     exon            576..620
                     /gene="CHRNA6"
                     /gene_synonym="CHNRA6"
                     /inference="alignment:Splign:2.1.0"
     exon            621..730
                     /gene="CHRNA6"
                     /gene_synonym="CHNRA6"
                     /inference="alignment:Splign:2.1.0"
     exon            731..1709
                     /gene="CHRNA6"
                     /gene_synonym="CHNRA6"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..2400
                     /gene="CHRNA6"
                     /gene_synonym="CHNRA6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaagatct cagccactca caggtgttca tcctcccggg gtcctgtctg ccccagcatt
       61 tcttttctgc ttttcttccc ctttcttgca tgaagagaca tctaggctgt caggaaatgt
      121 gatgactcat ctgacatcag atcgaatctt ttttattcgc ccttcatgtc tgcctcagtc
      181 tctgatcctg gtaataaccg tgtgaagtcc cggggatgtt ttgatttctg agaagacaca
      241 cacggattgc agtgggcttc tgatgatgtc aaggttggat gcatgtggct gactgatagc
      301 tctttgtttt ccacaatcct ttgcctagga aaaaggaatc caagtgtgtt ttaaccatgc
      361 tgaccagcaa ggggcaggga ttccttcatg ggggcttgtg tctctggctg tgtgtgttca
      421 cacctttctt taaaggctgt gtgggctgtg caactgagga gaggctcttc cacaaactgt
      481 tttctcatta caaccagttc atcaggcctg tggaaaacgt ttccgaccct gtcacggtac
      541 actttgaagt ggccatcacc cagctggcca acgtggatga agtaaaccag atcatggaaa
      601 ccaatttgtg gctgcgtcac atctggaatg attataaatt gcgctgggat ccaatggaat
      661 atgatggcat tgagactctt cgcgttcctg cagataagat ttggaagccc gacattgttc
      721 tctataacaa tgctgttggt gacttccaag tagaaggcaa aacaaaagct cttcttaaat
      781 acaatggcat gataacctgg actccaccag ctatttttaa gagttcctgc cctatggata
      841 tcaccttttt cccttttgat catcaaaact gttccctaaa atttggttcc tggacgtatg
      901 acaaagctga aattgatctt ctaatcattg gatcaaaagt ggatatgaat gatttttggg
      961 aaaacagtga atgggaaatc attgatgcct ctggctacaa acatgacatc aaatacaact
     1021 gttgtgaaga gatatacaca gatataacct attctttcta cattagaaga ttgccgatgt
     1081 tttacacgat taatctgatc atcccttgtc tctttatttc atttctaacc gtgttggtct
     1141 tttaccttcc ttcggactgt ggtgaaaaag tgacgctttg tatttcagtc ctgctttctc
     1201 tgactgtgtt tttgctggtc atcacagaaa ccatcccatc cacatctctg gtggtcccac
     1261 tggtgggtga gtacctgctg ttcaccatga tctttgtcac actgtccatc gtggtgactg
     1321 tgtttgtgtt gaacatacac taccgcaccc caaccacgca cacaatgccc aggtgggtga
     1381 agacagtttt cctgaagctg ctgccccagg tcctgctgat gaggtggcct ctggacaaga
     1441 caaggggcac aggctctgat gcagtgccca gaggccttgc caggaggcct gccaaaggca
     1501 agcttgcaag ccatggggaa cccagacatc ttaaagaatg cttccattgt cacaaatcaa
     1561 atgagcttgc cacaagcaag agaagattaa gtcatcagcc attacagtgg gtggtggaaa
     1621 attcggagca ctcgcctgaa gttgaagatg tgattaacag tgttcagttc atagcagaaa
     1681 acatgaagag ccacaatgaa accaaggagg tagaagatga ctggaaatac gtggccatgg
     1741 tggtggacag agtatttctt tgggtattta taattgtctg tgtatttgga actgcagggc
     1801 tatttctaca gccactactt gggaacacag gaaaatctta aaatgtattt tcttttatgt
     1861 tcagaaattt acagacacca tatttgttct gcattccctg ccacaaggaa aggaaagcaa
     1921 aggcttccca cccaagtccc ccatctgcta aaactgatgg ctacatggaa aaagaggact
     1981 ttcttgcaca ttaggaagca gaatatcctc cagtgtagca cagggggaga agtgagaagt
     2041 gttatgacat tagtgccctg attgggcagc acccacggct acagtatcag gtcaggtttc
     2101 tcgtgtctgt gtgtttggct tctaaagaca agaatgactt acaatacagc ctaattatgt
     2161 aattaacatc aagccacact aaaaagttct gctgtacctc cagtggatgc tgtttctcag
     2221 tattatgaca tgtgacaggt gaactctggg aattggacca tgcaacattt gtgaactgtt
     2281 tgcaacactt tgtgaactat tgcatccttg atttcttgtg catgtctctg taatgtaact
     2341 caccctcctc agcattattt gatacactga ttgttagttt taaaaaaaaa aaaaaaaaaa
//
