LOCUS       NM_020402               1945 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens cholinergic receptor nicotinic alpha 10 subunit
            (CHRNA10), transcript variant 1, mRNA.
ACCESSION   NM_020402
VERSION     NM_020402.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1945)
  AUTHORS   Gu,S., Knowland,D., Matta,J.A., O'Carroll,M.L., Davini,W.B.,
            Dhara,M., Kweon,H.J. and Bredt,D.S.
  TITLE     Hair cell alpha9alpha10 nicotinic acetylcholine receptor functional
            expression regulated by ligand binding and deafness gene products
  JOURNAL   Proc Natl Acad Sci U S A 117 (39), 24534-24544 (2020)
   PUBMED   32929005
  REMARK    GeneRIF: Hair cell alpha9alpha10 nicotinic acetylcholine receptor
            functional expression regulated by ligand binding and deafness gene
            products.
REFERENCE   2  (bases 1 to 1945)
  AUTHORS   Azam,L. and McIntosh,J.M.
  TITLE     Molecular basis for the differential sensitivity of rat and human
            alpha9alpha10 nAChRs to alpha-conotoxin RgIA
  JOURNAL   J Neurochem 122 (6), 1137-1144 (2012)
   PUBMED   22774872
  REMARK    GeneRIF: A two order of magnitude species difference is reported in
            potency of alpha-conotoxin RgIA for rat versus human alpha9alpha10
            nAChR.
REFERENCE   3  (bases 1 to 1945)
  AUTHORS   Rigbi,A., Yakir,A., Sarner-Kanyas,K., Pollak,Y. and Lerer,B.
  TITLE     Why do young women smoke? VI. A controlled study of nicotine
            effects on attention: pharmacogenetic interactions
  JOURNAL   Pharmacogenomics J 11 (1), 45-52 (2011)
   PUBMED   20231857
  REMARK    GeneRIF: Clinical trial of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   4  (bases 1 to 1945)
  AUTHORS   Saccone,N.L., Schwantes-An,T.H., Wang,J.C., Grucza,R.A.,
            Breslau,N., Hatsukami,D., Johnson,E.O., Rice,J.P., Goate,A.M. and
            Bierut,L.J.
  TITLE     Multiple cholinergic nicotinic receptor genes affect nicotine
            dependence risk in African and European Americans
  JOURNAL   Genes Brain Behav 9 (7), 741-750 (2010)
   PUBMED   20584212
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1945)
  AUTHORS   Ehringer,M.A., McQueen,M.B., Hoft,N.R., Saccone,N.L., Stitzel,J.A.,
            Wang,J.C. and Bierut,L.J.
  TITLE     Association of CHRN genes with 'dizziness' to tobacco
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 153B (2), 600-609 (2010)
   PUBMED   19760673
  REMARK    GeneRIF: CHRNA10 may have a role in 'dizziness' in response to
            tobacco
REFERENCE   6  (bases 1 to 1945)
  AUTHORS   Rigbi,A., Kanyas,K., Yakir,A., Greenbaum,L., Pollak,Y.,
            Ben-Asher,E., Lancet,D., Kertzman,S. and Lerer,B.
  TITLE     Why do young women smoke? V. Role of direct and interactive effects
            of nicotinic cholinergic receptor gene variation on neurocognitive
            function
  JOURNAL   Genes Brain Behav 7 (2), 164-172 (2008)
   PUBMED   17559419
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   7  (bases 1 to 1945)
  AUTHORS   Shi,J., Hattori,E., Zou,H., Badner,J.A., Christian,S.L.,
            Gershon,E.S. and Liu,C.
  TITLE     No evidence for association between 19 cholinergic genes and
            bipolar disorder
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 144B (6), 715-723 (2007)
   PUBMED   17373692
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1945)
  AUTHORS   Peng,H., Ferris,R.L., Matthews,T., Hiel,H., Lopez-Albaitero,A. and
            Lustig,L.R.
  TITLE     Characterization of the human nicotinic acetylcholine receptor
            subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in
            lymphocytes
  JOURNAL   Life Sci 76 (3), 263-280 (2004)
   PUBMED   15531379
REFERENCE   9  (bases 1 to 1945)
  AUTHORS   Sgard,F., Charpantier,E., Bertrand,S., Walker,N., Caput,D.,
            Graham,D., Bertrand,D. and Besnard,F.
  TITLE     A novel human nicotinic receptor subunit, alpha10, that confers
            functionality to the alpha9-subunit
  JOURNAL   Mol Pharmacol 61 (1), 150-159 (2002)
   PUBMED   11752216
REFERENCE   10 (bases 1 to 1945)
  AUTHORS   Lustig,L.R., Peng,H., Hiel,H., Yamamoto,T. and Fuchs,P.A.
  TITLE     Molecular cloning and mapping of the human nicotinic acetylcholine
            receptor alpha10 (CHRNA10)
  JOURNAL   Genomics 73 (3), 272-283 (2001)
   PUBMED   11350119
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF199235.2 and AC060812.15.
            
            On May 17, 2019 this sequence version replaced NM_020402.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF199235.2, AJ278118.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000250699.2/ ENSP00000250699.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-765               AF199235.2         1-765
            766-766             AC060812.15        112762-112762
            767-1902            AF199235.2         767-1902
            1903-1903           AC060812.15        114566-114566
            1904-1945           AF199235.2         1904-1945
FEATURES             Location/Qualifiers
     source          1..1945
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..1945
                     /gene="CHRNA10"
                     /note="cholinergic receptor nicotinic alpha 10 subunit"
                     /db_xref="GeneID:57053"
                     /db_xref="HGNC:HGNC:13800"
                     /db_xref="MIM:606372"
     exon            1..133
                     /gene="CHRNA10"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1425
                     /gene="CHRNA10"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; cholinergic receptor, nicotinic, alpha
                     polypeptide 10; neuronal acetylcholine receptor subunit
                     alpha-10; NACHR alpha-10; nicotinic acetylcholine receptor
                     subunit alpha-10; acetylcholine receptor, nicotinic, alpha
                     10 (neuronal); cholinergic receptor, nicotinic, alpha 10
                     (neuronal); cholinergic receptor, nicotinic alpha 10"
                     /codon_start=1
                     /product="neuronal acetylcholine receptor subunit alpha-10
                     isoform a precursor"
                     /protein_id="NP_065135.2"
                     /db_xref="CCDS:CCDS7745.1"
                     /db_xref="GeneID:57053"
                     /db_xref="HGNC:HGNC:13800"
                     /db_xref="MIM:606372"
                     /translation="MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSA
                     LRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLD
                     AIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAA
                     FPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGC
                     CSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLL
                     ALTVFQLLLAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPA
                     WARALLLGHLARGLCVRERGEPCGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQ
                     EALLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL
                     "
     exon            134..279
                     /gene="CHRNA10"
                     /inference="alignment:Splign:2.1.0"
     exon            280..434
                     /gene="CHRNA10"
                     /inference="alignment:Splign:2.1.0"
     exon            435..967
                     /gene="CHRNA10"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1945
                     /gene="CHRNA10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1922..1927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHRNA10"
                     /note="hexamer: AATAAA"
     polyA_site      1945
                     /gene="CHRNA10"
                     /note="major polyA site"
ORIGIN      
        1 taattttgcc ctaggtctgg ccaggaggcc tcacatccag agacctgccc ccgctcttgc
       61 agtgccaggg ccatggggct ccggagccac cacctcagcc tgggccttct gcttctgttt
      121 ctactccctg cagagtgcct gggagctgag ggccggctgg ctctcaagct gttccgtgac
      181 ctctttgcca actacacaag tgccctgaga cctgtggcag acacagacca gactctgaat
      241 gtgaccctgg aggtgacact gtcccagatc atcgacatgg atgaacggaa ccaggtgctg
      301 accctgtatc tgtggatacg gcaggagtgg acagatgcct acctacgatg ggaccccaat
      361 gcctatggtg gcctggatgc catccgcatc cccagcagtc ttgtgtggcg gccagacatc
      421 gtactctata acaaagccga cgcgcagcct ccaggttccg ccagcaccaa cgtggtcctg
      481 cgccacgatg gcgccgtgcg ctgggacgcg ccggccatca cgcgcagctc gtgccgcgtg
      541 gatgtagcag ccttcccgtt cgacgcccag cactgcggcc tgacgttcgg ctcctggact
      601 cacggcgggc accaactgga tgtgcggccg cgcggcgctg cagccagcct ggcggacttc
      661 gtggagaacg tggagtggcg cgtgctgggc atgccggcgc ggcggcgcgt gctcacctac
      721 ggctgctgct ccgagcccta ccccgacgtc accttcacgc tgctgctgcg ccgccgcgcc
      781 gccgcctacg tgtgcaacct gctgctgccc tgcgtgctca tctcgctgct tgcgccgctc
      841 gccttccacc tgcctgccga ctcaggcgag aaggtgtcgc tgggcgtcac cgtgctgctg
      901 gcgctcaccg tcttccagtt gctgctggcc gagagcatgc caccggccga gagcgtgccg
      961 ctcatcggga agtactacat ggccactatg accatggtca cattctcaac agcactcacc
     1021 atccttatca tgaacctgca ttactgtggt cccagtgtcc gcccagtgcc agcctgggct
     1081 agggccctcc tgctgggaca cctggcacgg ggcctgtgcg tgcgggaaag aggggagccc
     1141 tgtgggcagt ccaggccacc tgagttatct cctagccccc agtcgcctga aggaggggct
     1201 ggccccccag cgggcccttg ccacgagcca cgatgtctgt gccgccagga agccctactg
     1261 caccacgtag ccaccattgc caataccttc cgcagccacc gagctgccca gcgctgccat
     1321 gaggactgga agcgcctggc ccgtgtgatg gaccgcttct tcctggccat cttcttctcc
     1381 atggccctgg tcatgagcct cctggtgctg gtgcaggccc tgtgagggct gggactaagt
     1441 cacagggatc tgctgcagcc acagctcctc cagaaaggga cagccacggc caagtggttg
     1501 ctggtctttg ggccagccag tctctcccca ctgctcctaa gatcctgaga cacttgactt
     1561 cacaatccac aagggagcac tcattgtcta cacaccctaa ctaaaggaag tccagagcct
     1621 gccactcccc taattccaaa aaaaagagga actctacaaa ggccaagatc acagagtaca
     1681 gtcttggagg gacagaattg tttgtgctgg gtattggagc tctcagtggg gagcacatgg
     1741 gttataatga gaaactgaac tgtactgctg catttcctgt cttccttcct aggtggctgc
     1801 tttgcagggc tttggctgtt acctttccct gctgaggggc tcagggaaaa gggtcgggga
     1861 ttctcagtcg agtttccaga gcaggaggcc ctacagacat ttggccccaa atccctgact
     1921 caataaagta agcgtgtacc tagca
//
