LOCUS       XM_017000154           22145 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens cholinergic receptor muscarinic 3 (CHRM3),
            transcript variant X14, mRNA.
ACCESSION   XM_017000154
VERSION     XM_017000154.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017000154.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..22145
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..22145
                     /gene="CHRM3"
                     /gene_synonym="EGBRS; HM3; m3AChR; PBS"
                     /note="cholinergic receptor muscarinic 3; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 7 mRNAs, 3 ESTs, 397 long SRA reads, 24 Proteins, and
                     95% coverage of the annotated genomic feature by RNAseq
                     alignments, including 5 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:1131"
                     /db_xref="HGNC:HGNC:1952"
                     /db_xref="MIM:118494"
     CDS             14147..15919
                     /gene="CHRM3"
                     /gene_synonym="EGBRS; HM3; m3AChR; PBS"
                     /codon_start=1
                     /product="muscarinic acetylcholine receptor M3 isoform X1"
                     /protein_id="XP_016855643.1"
                     /db_xref="GeneID:1131"
                     /db_xref="HGNC:HGNC:1952"
                     /db_xref="MIM:118494"
                     /translation="MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSR
                     AAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTV
                     NNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLL
                     VISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPP
                     GECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAE
                     TENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSS
                     DSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVP
                     EEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKS
                     TATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYN
                     IMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKK
                     KRRKQQYQQRQSVIFHKRAPEQAL"
ORIGIN      
        1 ttttttgcat gtggatgtct ggttgtccca gcaccatttg ttgaagcgat atctttgttc
       61 catagtattg catttgttcc tttgtcaaag atcagttgct atacttagtt attcagtgct
      121 tcttttaggg ctcttttttc tgttcttttg atcaatttat ctagtttttc accaacaccg
      181 ctctgtcttg attagagtag ttttacagta agctttgaag ttgggtaatg ccagtcctcc
      241 aggtttgttc ttcttcaaca tccagtcggc tattctgggt cttttgcctc tctgtataaa
      301 ttatagaatc aagtttgcca gtattataaa atatcttgct gggattctga ttggcattgc
      361 attgaatcaa tagaccaagt tgagaagaac tgacatcttc acaatattga gtcttcctat
      421 ctaggaccat ggaatgtctc tccatttata gttctttgat ttctttcatt ggagttttga
      481 agttaccctt gtgtagatct cgtacatttt tttaagtctt atttctaagt ctgtcatttt
      541 gtagagtgct aatataaatg gtattgtgtt ttaaatttta atttttcctt gttcattgct
      601 ggtttatagg taagcaactg acttttatat attaatctta tatcctgaaa ccttgctaaa
      661 attccagaag ttttgtgttg attctactgg attttctaca tagaaagtca tgccatctac
      721 acaaaaatta agttttattt ctcgcttatc aatctgtatg ccttttattt cactttttgt
      781 ctacctgcat taatgagggt ttccagtacc atgttgaaaa agagtagtag gagggtaaat
      841 ccttgtcttg tttctgaact tagtggtgaa gaaatttgtc atcaagcttc tttttcaagt
      901 ttactgggtt tgtggagttt ccaggtagat aatttaagtg tgttttacat gcctccctta
      961 tctcagtcct ctcattctga ctcctggctg ccgaacttga tctaggagaa aacttgcaga
     1021 caagagatac tttatttgga atgataccat ggtagaagta aaattttgaa atttgaagga
     1081 ctctctcaat gcatcatgta atcctctcta tacccaaatg tcacttccat aaatgaagat
     1141 gaaattagcc cattgaatat ttgataactc acacattttt gtcagcacat atgtcgtata
     1201 tttttgtaga aataacagaa atataagtag agtgctaaat tgtacatcaa aatattctga
     1261 tttttttctc tcaatatgtt ttctcacaga tcatattttt aatatttaac atgtggcctg
     1321 tttggttagt atatatattt ctctagaaat aaactgaata ttcaaatcta aagttcttaa
     1381 aaatgcctaa taaaataaaa tttttgtcta aaaatgcatg gggactgcat gtggcttata
     1441 aatgttatat ttaccttaaa aaaagcatta cgtaaatttt aaaaattata ttagtcaacc
     1501 agaaaatatc tcatatctgt gtaaccttaa taaggcatct agggtaaatt gcaattgttc
     1561 acatgttttt tttgtttttt ttttttttaa ttctggggta aggacactgt taggggaata
     1621 tatattatct aaccttagag aatttcacaa tatttatact tcaagaagag ctgtgtctgt
     1681 tgcaaactaa tttttctgcc ataaacaaag agggaattat ttctgaggac tttaacttat
     1741 ttatttttcc aaaagcttgc cacatggctt caaatgcatt ccacacaaac aattattgtg
     1801 agaaatgaga agtgacaatg catttaactc cttgcatcct gtttttcagc aggcagaaat
     1861 ttgcatctta aatgaataaa atgtgatgga gtatgccaaa ctctgccatc atttggccaa
     1921 aatgatacca aatgattgtg atttatttac ttcacaatag ataaaaataa actaccctta
     1981 gttaaaagtt agatgcctaa aatgtactat attttatgtt tattaagaca aaagctcagt
     2041 aaaaagtctc tgaacttctt aggagcatga gctatgaaat taagactctg ctgacttctg
     2101 gcttcgttgt tgaatgggat tgtaggatat tatacccctg gtaatctatc ttttactatc
     2161 aagagcttag ataactaatg actgctttct ctttctcttt ctctctctct gtctctttct
     2221 cgctctctct catctagatt gccagaaagc tgagcttttt ttttgtgctt acttgcaaca
     2281 accatttgta ggctagtcct gctagtgtaa ttttttttct tcattagcta agatttgaaa
     2341 gaatttatag tatgaacaga ggggtactat tcccaggagg ggagaacatc gtaagcaatt
     2401 atgcaaacac attaaataaa ggaaaagagc tgtatgttaa gaaatttgca aagagtttct
     2461 gaaaccttga aaaaatcatt ttaaagctct gaccttccgc ttctctgtaa aatgggcatc
     2521 acgatactcg caaaaagctg ctatgagaat tagagtagac agtgcatgtg aaggtgttta
     2581 gcacatgaga tagacttagt aaatattaat gacatttcat ctgcctttgg gtattttttg
     2641 agttcctatt cacatatcaa atattttaat actcttatat caaagagtat ggttaaaccc
     2701 agattgtttt ctactagctg tatgagatag caggcgttca cagcctcttg aagcttcagt
     2761 tcctttacgc tgaaatgagg aaaagcagtg catgaatctt gcaggacttc tgggaagatt
     2821 aatgcagggc cccctaaccc tgggccacag ataggtactg gtctgctatg gcctattagg
     2881 aaccaggccg cacagcggga ggtgagtggc agtccagcga gcgaaacgtc tgtatttata
     2941 gctgctccct gttgctcgct ttactgcctg agctctgcct cctgtcagat caacggtggc
     3001 attagattct catagaagca caaaccctat tgtgaactgc acgtgcaaag gatctaggtt
     3061 gcacactcct tatgtgaatc taatgactgg tgatctgtca ctgtctctcc catcacccta
     3121 agatgtgaca atctagttgc aggaaaacag ggtcagggct cccactgatt ctacaccatg
     3181 atgagttgta taattttttc cttctatgtt ataatacaat aataatagaa ataaagtaca
     3241 caataaatgt aatgtacttg aatcatcctg aaaccaccat cctcctgccc ggtccataga
     3301 aaaattgtct tccatgaaat cgatccctgg tgcccaaaag tttggaggcc actggattaa
     3361 aggagacaat gtatgtaaat tttggcttat aataagttct tggaaagtgc tagctgtgtc
     3421 ttatcactga ttatagtatc ccaatcaaac cttgacactt gggttaggat tatttatttc
     3481 cctcaattta taaatgtgaa agcggaggta cagagaggtt aaacagcttg cccaaattca
     3541 cacagcagat atgtgacaaa gcaaaagttc aagctgcccg acttctcaaa cctcactttc
     3601 ccatttattt tacatcactt gccattccta tgtttttcat ttagaccata aacacattag
     3661 caacatgaat ttatcatcaa cgtaatatgg ctaatacagt tgatccggaa tttagtgaag
     3721 catatataat acatgaggtt ttcaattacc agtcattatt gatggtagcc aggtcaaaag
     3781 tatctttcag acattctaga agagtcatgg agttacaaat ttttaacatc tgaaatctga
     3841 atcctttccc cacacccagg cactactttt atctttagaa atgagcattt tttgaaagac
     3901 tcattttagg aagcaagatt ttgattgcct ttgtcttata tattctactt taaaattcag
     3961 tatggtgaac cgggaataaa taatcaatgc ctgtgatgag ataaagacag tttcttccca
     4021 gcactttgag aggctgaggt gggcagatca tgaggtcagg agtttgagac cagcctggca
     4081 aatatggtga aaccccgtgt ctactaaaaa tacaaaaatt agccggacgt ggtggcacgt
     4141 gcctgtagtc ccagctactc aggaggctga ggcagaagaa tcgtttgaac ctgggaggcg
     4201 gaggttgcag tgagccaaaa tcactccact tcactccagc ctgggcaaca gagtgagact
     4261 ccatctgaaa aaacaacgac aacaacaaca acaaccacaa accatttcca cacgttttaa
     4321 tttaattgct ttttaaagag cacgaggaaa gactaagtta ctcaaataca ttttgtagac
     4381 tatctgtaag aagcaaaagt aatcagctca ttaaatatat gcaggagaat agtaaatgta
     4441 atggaagcct ttcacctctt cataagagaa tcaaatgaat gtgagtttga actgaaatcc
     4501 agccttcact taaccccgct gccacctctc ctcaaatcat tctcaacttc acagttaaac
     4561 tgtatgcata ttataagtag gaggctcatt tattggtttc agtgtctctc aaactaaagt
     4621 ccaaggacat atcccacaag atgctctcag tgggggatgg agaaaacaaa tatgaccaaa
     4681 ggtagacaat ttgtcaacct gggttaagac cccttcaatt tttctatagg cttgaaattt
     4741 ttcacactcc acagtttggg agaaaaaagc cagaagctat tgccaatatc ctgatagaaa
     4801 ttaacctagt actataatta agacaatttc aggtcatgat aggaaaatct atacatcagt
     4861 atttattaag ggaaagtttg tgggcggtag ttgcacgtga aatctccttg tctgaaagac
     4921 agaggcatgg tggccaggct accaaggcat cagcagtctg cccaatccca tcccttctcc
     4981 tcctgaattt agcccagtct atatttaata caaagactta gtccacagac tagtgaacta
     5041 atgtatttgc attgtacaaa tttaccttcg aaaagtttta tacatatatt tttgtgtaag
     5101 ttggcatttt tatttaaatt ttgcaaatca tttgttgaca ggatcaaagg gaaaatagca
     5161 tttcacttcc tctttccaga cacctattta caaagtaaaa gtctctattt ttttcagctt
     5221 tacctttctg actttttgga ttactgctat ctaataattt atagtaaaat tggtgtattt
     5281 ttattcctct gtactcagga ttagctactg aaattgacat ctgtttacat aaatttagtt
     5341 taagggtata atttggagat aatttgaatg taattccttc aatgtaaata atataaaaat
     5401 gtagcatgtt atgtacaatc ttctagataa ataaaaattt atacagatgc tcctctagga
     5461 aactaaacta aaattctaaa tttaaactaa aattctaaga ttacatattg tagttgaaat
     5521 caagcatcct ttatgagacg taccaaatat agcctcttct gtatgtttga agacatacca
     5581 agattaactt gcaaaatttg ttgtaatttc ttatttgata atagaaatct ggttttctat
     5641 gattgacaca tcaattgtta gtgattcata agctaatcag ttctttaact gggttaaggc
     5701 aggcacaagt attctctttt ttatcatcaa aagaagatct atcttgaaat gaattgttag
     5761 tagacatatt tttaacacag agaatattca atattaatca aatttatttt tgacttctca
     5821 aatattttat ccataagaga attattctgt ttccttgcca ttacaactta ccttgccatt
     5881 ttcacgtggt taaaaactag ttcttttttt tttttttttt tttttttgag acagagtctc
     5941 gctcagtcac ccaggctaga gtgcagtggc acgatcttgg ctcactgcaa gctccgcctc
     6001 ccgggttcac gccattctcc tgcctcagcc tccctagtag ctgggaccac aggcacccgc
     6061 caccacaccc cgctaatttt ttgtattttt agtagagacg gggtttcccc gtgttagccc
     6121 ggatggtctc gatctcctga cctcgtgatc tgctcgcctc ggcctcccaa agcgtaaaca
     6181 actagttctt actctttcac ttttctgtct cctaaggctc gaaatgtatt gtctcatata
     6241 ccaaatacca aatgtttaac tcaaaatgta ctcagtcatt gctgaggaag aattattttg
     6301 tttaaccctc ataatatatt agtattctta tacccaagaa atacatacag acatttaagt
     6361 tgaaatcagg agtatgtggg gatgagaatg gttgatgtca taagtactcc agtatttaac
     6421 agtgatatag tttgaatatg tgtcctcacc taaatctcgt gttgaattgc aatcctcaaa
     6481 gttggaggtg gggcctggtg ggagatgatc ggatcgtggg ggcggatttc tcatgaatcg
     6541 tttggcacca tctccttggt gctgtcctgg tgatagtgag ttcttatgag acctggctgt
     6601 tgaacggtgt ggcaccccgc ttgctctctc ttgctcccaa tccctccatt tgagacacct
     6661 tctctctggc ttcaccctcc accatgactg agtgcttcat gaggcctccc ctgaagcaga
     6721 cgtctgtgtt atgcttcttg tacatcctgc aaaaccatga gccaattaaa cctcttttct
     6781 ttgtaaattt ccagtctcag gtagttcttt attgcaatgc aggaacagcc caatacaaac
     6841 aggtatagca ggtgtgtcat aatttaagtc aaaccagtga ctaaaatagc attctaacca
     6901 gacccttcca gctcttacag cagtaagctc ccttaggaag atttgatatt gaccctgttt
     6961 tagggaagct ttgatgtatt tgctgaggca tttgttgact ttcaaaagca acttcaattt
     7021 aaggcatttt gtacatacat aacatactgt tagtacaaac ttatgaaggg tttccaatat
     7081 atcctgataa aaatcctctc tctttggagt tacataatta tagagcacag aaaaaaaaat
     7141 ggagtttgac ccaatatgaa cttgaaggaa tcaggattgg cagtgtgtgt aaaaatagac
     7201 atacaaagga aatcttttag aatatatttt attattcaga tttatattaa aatgaattag
     7261 attatggtcc tcccacattt ctgtggcagc atccagaatt ctattatatt tacttccaat
     7321 tactgcagca aacctagact tcaactatta gccaaaggct aaagatgctc ctttgcagtt
     7381 gccaatatat agaccagttt caggctctcc agtggtggac agatggtcat tcccaggcta
     7441 atattgccct atttccatgc aagaggagct attttagacc tttagagtta tggttccagt
     7501 gaaatcagag actttgggaa gacagtgaat ctttgaggat acgagaggac aatagacctt
     7561 cttcattctc ctggaaggca gcttccttcc agaattattc actgaaaatc tctgcttcac
     7621 aaattctctg gaattctcaa gtggtgacat gataatattg gttttctatc attacaatga
     7681 atataaatat gcaatttttt gtttttcact aaatatttca agtgattcct gatgctgaaa
     7741 tacaatacta cgtgaattat gctaagttgt caaaagactt cttgatgcac tggttttata
     7801 gacaggcatg aaatttcatt gcataattgg atgtgggttg tgcacatagg agagggaggt
     7861 acagccagcc ttccataccc acagattaaa ccaatctcag atttagtata ctaaaaaaaa
     7921 ccgcaacaaa ataacgtaca acaataaata atagcacaaa ttcaaaaacc agtgcagtct
     7981 gacaactatt taaatggccg ttacattgta ctagatatta caagtaatct agagatgatt
     8041 taagatacat gggagaatat gcatagggta tatgcaaatt ctatgacatt tcatataagg
     8101 gacatgagca tccaaggatg ttggcattca aggggctcct ggaaccaatg ccccaaggat
     8161 actgagtgat gactgaatat tgttttcttt tcttttcttt tcttttttgc catagtgctc
     8221 ttcttacagg gtgatgaaga aacaccccta tcaaaagatg ggtgtgtgtt ctcatctgtt
     8281 gaatgtaggc agactgttgt aacttcctca tcccataaac agtggtgtgc aatttccaaa
     8341 ccatgtcaca aaagcctttg tgccatcctt cttgctttct tgaattgctt gtaattaggg
     8401 agttgtagat accatgtcat gaggatcttg aagaaaccct ggagagtgag agggtcacat
     8461 ggagacaagt tgtggccgtt ggccaccagc cgtcaccaac ttgccagcca tgtgagtgag
     8521 cctcttggaa gctggggcca gagtcccacc caatccctta gtagatcgtc cgggtctagc
     8581 caacatgtga ctacaactgc atgaaagacc ttaaatgaga cctactcagc caaactcttc
     8641 ctaagtcctg tccaaacaaa accatgaagg ataagaaatg gttattatta ttttaagcta
     8701 ccaccttttg gtgtgattat tatatgcaat aataggtagc agacactggc tttggttgga
     8761 catgtatgtt ctctgcatat tctgcttttg tgcatgtgga gaaatgggct ttctgggctg
     8821 ctgacaatga ggaggtagag atgttgttca ggcagatgcg tttagacttc gagtccactt
     8881 tctccttcca agaactatgt ggccttacaa atgctggggt tggtttaaga aaacagaact
     8941 cttaatgttt gtaaacattc ctgtacgaga gttcatccat catttgtgtc tctctagaaa
     9001 ggtcatacgc agaaaatgta gtggtgtagc aaaattttga acttttcaga gctggcaaaa
     9061 tcctttcttt agtgtatagt attactactc atgtccatta tgaaccatga gcccagggag
     9121 actctgctga gacaggctgc atctcctcca gccttatcct cctaagatca ggcatcctac
     9181 ctaaggggag catagaattt agcccctgtt tgtggggtgg tgtggattct tcccacctgt
     9241 ctaatccacc tgagaaacag tagtgaaaaa aagaagaaaa tgacaaaaat cgagctgatt
     9301 tttgtatcta catatgtaga taatatatgc tatatacaca tgcacataga atgtatacgt
     9361 attatattta tatatgtatg gtcatttttg accactcaca atatacaaga catgataatt
     9421 ttcaacgtgt caagttagaa attaccattc tacctcacta aattatctca aaaatcttga
     9481 tacctagtat ttatatattt tataaattaa gtaacctaag tctaaacaag acgactggtt
     9541 cacagaccac tatcctacat gcaagctgca ataggaaaat aatttctcag cagtgatttt
     9601 ttacaagtga aaataacatt taaaaattac agaaaagccg atgaatggaa ataatcagtg
     9661 acagatgtgg tttaagatat aaaaatgaaa tctgaatcca ttgtccccag tgtgtaaaaa
     9721 tgttttacgt tgtttcttga aaattctcat tggatgaccc tctcttgttg tcatattaat
     9781 tctgaaattc tgattttagt ctattttcat tttcacaaca gaaccaggaa caaaaagtgt
     9841 accctagggg catccaatta acaataagca actattgtat gtttgttgga acatacgtgt
     9901 caggagggcc gaaagcatag ctgacgtgat aagatataca aacaaaatta atgggataaa
     9961 acagtatgat ggcatcaagt aaaacgtttt tgtttacatt tttgtgtagt acagaggtta
    10021 caatcagaaa aggagttgtc agctcaagaa attgaataaa ttaaataata aattaatgaa
    10081 tggaatattt ctgttgggaa atcacacaca gcacattaaa tgaagttcat tagaaagtgg
    10141 gagctacagg atgaaactga caggcaaggg atgctgaatt atggtcgtct tgtaaaattt
    10201 aataccacat ttctcagctt taaagtatta aacctaccaa aaacactaaa cctgcatccc
    10261 acctttgtaa cacttttgaa aaccccataa cctcacctgc tgttaattct agatctttac
    10321 agattcaaag aatatatata tatatatgca cacatatgag tttctcatgt tatttgcctt
    10381 tttagttttt tgagaaatag gccttgtgtg gttttccaaa taagtacaaa ttgtactgac
    10441 agcatatatt tttatctcct caagaagaca gttccttgtc attgttcttt ccagcaactt
    10501 gacattttat ttaggtaacc tgttctccac tttgtaatat gttagctatc atcccagcaa
    10561 aattgttcta tattctacag agtggtagtt tatttttttt ttggaaatac ggacaaagca
    10621 ttcaattatt tgtcgccatg accgctctcg gggttagtta actacatatg caactaaaat
    10681 tggataaatg taattaagaa aattggtatt gtagaggttt cattgttcta tagaattaga
    10741 gaattctacc aactgaattt ataacctgag catgaaaacc agatcctttt tcatatttaa
    10801 atattaacca gagtaagcca tgtactacct taacaataaa aataaaatta aacaaactca
    10861 aaaagtttga agaaataaaa tgataaaagc taagtgaatt ctttgagctg cagctttttt
    10921 accgtgctgc acagttgcct ggcttaggtc agaacctttt caagaaaggt tccatcctgc
    10981 cacggctctt tgaatttttc ttaaatcttt tatgtttaaa gatatctaat tatattctat
    11041 tttaatactt ggataaatta agaattttta aaaattcttc atttttgtaa agtattaata
    11101 aagtaatttt ttaaaagtaa aagaataaat tcaagcattc caatctgtta aaatatcctt
    11161 tacaatgtac taaccggatt atattatcgt gtgtttcgcc tcatttttgt tatacaaatt
    11221 ttcatgtatt aagatgatcc atggcagggc acagtggttc acacctgtaa tctcagctct
    11281 ttgagaggcc aaggagggag gattgcttga gcccaggagt tggagaccag cctgggcaac
    11341 atagggaaaa cctgtctcta caaatatttg taaaatttgc tctcagatac tcaaaaggct
    11401 gaggtgggtg aactgctgga gtctaggagg ctgaggccac agtgggccag tgatcccacc
    11461 actgctctcc agccctggtg acagagagag atgctgtccc caaaaaagaa aaaatccacg
    11521 tgatatttac ttccctagca catgacatca tgttgctgta tcctgatttg actatcagtt
    11581 attgtatttt taaatatttt ggttttcttt ttgtttcttt tttttaaaat tattttaact
    11641 gtaaatcata catagtatga acccctatat acagattagg ctatttactt aggatctgat
    11701 cccaaagttc agcagaagtt gaacaataca aattataaca tattcccaga ttgttcttta
    11761 gagaaaataa atgaatgaac tgacaatata tgcatacatg ttacattctc ccacccactc
    11821 accattttat ataacagctt aattttttta ttttaatgct taaaaataga tttaatttgc
    11881 aactctccaa ctgcttttgc agtgatgcat tttttccaca ggacagtttt cttttttatt
    11941 gttatttgga acaagggcat gtaggcaaaa gatgtaaatg ctttccacag cctgttgctt
    12001 ccccagtggt tctccacctc acctgcatgt tgctgtcaat tcaagaactt taagaaaccc
    12061 tgatgcccag gacaccccaa ttccagttaa atcagagtcc tgggagtgga actcaggcat
    12121 cagtacattt taaagcttct caaatgcttc tatcagccat ccaggtttgg gaatgactca
    12181 tctcaattga tcatggagtc tcagctgggt gtgatgggag attggaagga aaacagtagg
    12241 cttaacttta ttatatgggg caatcggaat taagctgtgt tgtcagcctt cctcccatct
    12301 agtgccctca aacaaaccct tccctggccc tgaatcttct ctcattgcct atgtccttgc
    12361 ctgtcacagt ctttctgcat tgaaacagtc catgaaaaag gtctcctgat ctaaactacc
    12421 ctgtaattag cctgataagt acctcatctc ctacttgtat gctttttctg atctgtttcc
    12481 ctgtagagtg aaatcttact ttctgaacat ccaaatcctg atgaggtttt actgtcaatg
    12541 aacaactgat atttttacgt gaattaagag acacagcaat tccacttcat cccagtgttt
    12601 ttaccagcta cttggacaca ctcgcctact ggatttgacc tctgtgaata ccaatgctgg
    12661 cctgggtgtc agtatttgct agaagcccct gtgtgggttt gtcttccctt agctttagcc
    12721 aggaagacat ctggcctcag caagcacact gctgctgtga ttcttttgct tctattaagt
    12781 gcaaatgaat gcactttatg ttgatggtgt attgcataag actaatttct ggattagcga
    12841 aaaagagctc tttttcattt atcagacatt ttctttctta catcttattt tccttcagct
    12901 tcaaaccatg tctgcctcac ccatatcagt aaccacatta ataatgacga gaataattaa
    12961 ctttcattgc aacctttttc catccttata acataagtca tggctgggtg cagtggctca
    13021 cccctgtaat ctgaacattt gggactacta ggtaggagga tctcttgagc ccagaagttt
    13081 aaggccagtc tgagcaatat agggagaccc tgtctctata aagatattta aaaaattagc
    13141 caggcatagt ggtgcatgcc tgtggtccca gctatacagg aggctgaggt gggaggattg
    13201 cttgagctgg gaggaggtca gagctatagt gagccatgat cacgccactg gattccagcc
    13261 tgtgcgacag ccctgtctca aaaaacaaaa caaaaacaac aaaaacaaga aagccataag
    13321 tcttttacaa atgctgtctc ctttaatttt aacaacctac aaaacagtta ctgtatttat
    13381 ccccagtttt tcagatgaag aaacagtaga ttgaataatg tttattggcc aaggttcaag
    13441 aaatgacaga gctggaggat ttaaacctag cattgcttaa ttcccagagc ctgagctgtt
    13501 gaccatgttt tatgaaaact agatttctta aaaaaaaaat aattgaggcc cttacaaagt
    13561 ctattcctga cctccattta tatccccttt gttcccactc actgccattt ttacctacct
    13621 ttcctcaagc actgctgacc aactgattgt tcctggatct gtgacaactg catgacttgc
    13681 catgtgctgt ttctcaggtc tgagattttt gctctctcct tcaagatatg aacagtaatg
    13741 gcacatattt tggttatgag tcactcagag gactgtggat tgaatgaact gtatccatcc
    13801 ccatcatgat gtacagaacc aagtctcttc actacacttg tgttctgatt agtggccaaa
    13861 taaatgacag tcagaacttc agctaaggta caataaggtt ttgctgtggc gtggcacctg
    13921 gtctctttct agaaggaaag ttcaacatac agcacaattc tggacacatt gtattggttt
    13981 gatgctccta cctggaacag gtggagctgg tctcttgggc agcctgacat ctggtccact
    14041 cctctgtcct atgccgggat catcatgacc gtagagatta tgtcactgtt ttgcatcctt
    14101 gttacataac tcagttcctg gtagattact atgtcagaga gtcacaatga ccttgcacaa
    14161 taacagtaca acctcgcctt tgtttccaaa catcagctcc tcctggatac acagcccctc
    14221 cgatgcaggg ctgcccccgg gaaccgtcac tcatttcggc agctacaatg tttctcgagc
    14281 agctggcaat ttctcctctc cagacggtac caccgatgac cctctgggag gtcataccgt
    14341 ctggcaagtg gtcttcatcg ctttcttaac gggcatcctg gccttggtga ccatcatcgg
    14401 caacatcctg gtaattgtgt catttaaggt caacaagcag ctgaagacgg tcaacaacta
    14461 cttcctctta agcctggcct gtgccgatct gattatcggg gtcatttcaa tgaatctgtt
    14521 tacgacctac atcatcatga atcgatgggc cttagggaac ttggcctgtg acctctggct
    14581 tgccattgac tacgtagcca gcaatgcctc tgttatgaat cttctggtca tcagctttga
    14641 cagatacttt tccatcacga ggccgctcac gtaccgagcc aaacgaacaa caaagagagc
    14701 cggtgtgatg atcggtctgg cttgggtcat ctcctttgtc ctttgggctc ctgccatctt
    14761 gttctggcaa tactttgttg gaaagagaac tgtgcctccg ggagagtgct tcattcagtt
    14821 cctcagtgag cccaccatta cttttggcac agccatcgct gctttttata tgcctgtcac
    14881 cattatgact attttatact ggaggatcta taaggaaact gaaaagcgta ccaaagagct
    14941 tgctggcctg caagcctctg ggacagaggc agagacagaa aactttgtcc accccacggg
    15001 cagttctcga agctgcagca gttacgaact tcaacagcaa agcatgaaac gctccaacag
    15061 gaggaagtat ggccgctgcc acttctggtt cacaaccaag agctggaaac ccagctccga
    15121 gcagatggac caagaccaca gcagcagtga cagttggaac aacaatgatg ctgctgcctc
    15181 cctggagaac tccgcctcct ccgacgagga ggacattggc tccgagacga gagccatcta
    15241 ctccatcgtg ctcaagcttc cgggtcacag caccatcctc aactccacca agttaccctc
    15301 atcggacaac ctgcaggtgc ctgaggagga gctggggatg gtggacttgg agaggaaagc
    15361 cgacaagctg caggcccaga agagcgtgga cgatggaggc agttttccaa aaagcttctc
    15421 caagcttccc atccagctag agtcagccgt ggacacagct aagacttctg acgtcaactc
    15481 ctcagtgggt aagagcacgg ccactctacc tctgtccttc aaggaagcca ctctggccaa
    15541 gaggtttgct ctgaagacca gaagtcagat cactaagcgg aaaaggatgt ccctggtcaa
    15601 ggagaagaaa gcggcccaga ccctcagtgc gatcttgctt gccttcatca tcacttggac
    15661 cccatacaac atcatggttc tggtgaacac cttttgtgac agctgcatac ccaaaacctt
    15721 ttggaatctg ggctactggc tgtgctacat caacagcacc gtgaaccccg tgtgctatgc
    15781 tctgtgcaac aaaacattca gaaccacttt caagatgctg ctgctgtgcc agtgtgacaa
    15841 aaaaaagagg cgcaagcagc agtaccagca gagacagtcg gtcatttttc acaagcgcgc
    15901 acccgagcag gccttgtaga atgaggttgt atcaatagca gtgacaaaac gcacacatca
    15961 acccacagac cttaggagga ggaaggcgag ggcggggtga cttctggtga tgataaaaat
    16021 ggttttatca cccagatgtg aaagaagctg cctgtttact gatccattga ataaacccat
    16081 tttaatagaa aaagtcaata ccaattcagc aaaaagaaaa aaaaaacata ctactgaata
    16141 taaagaaatt tattctgaaa tagactttac gtgttttttt cttaaagagg agaaaaatat
    16201 tgcttgacgg caattatata cccaaagtga tttgcctggg tcctttaatt cccattagct
    16261 ttggaatctc agatgagcat agctgaccca gttcccacat tcttcccaag gatcccaaaa
    16321 gtgggaatcc agaccccaag tggaacactg caggcttacg aatctgtggt tccaaaatta
    16381 tttcatacgt tgcaaagctg aatcttcttg tcccaataga gcttcctgtc ttttctttgg
    16441 tgtgttgtta aactctattt gtggacttga ttcttgattc ttgcaaagta ctgttttgtg
    16501 cagttcaagt ttcgtacaaa taaaaatact taagtatata tatatgtgtg agttctgcac
    16561 gcacacacat agtgtatata atatcatggg aaacactgaa ctggcaaatt attcctgcaa
    16621 catacgcttt cagtactttg gtaactgaag ttctctagga tcctaatgca acattaacgt
    16681 gaaataagcc cagtgtaatg tttttgaaac cagggctgtt ttccacagag agcagccagg
    16741 ccttcccagc aggtctgtgc agagcggaca ggctcgtgag tcagctgagc gccgtggctt
    16801 cgccagactt ggtgttaagc aacctccttt gttgatgtct caacagagct aaatcggggc
    16861 ccctctgagc tcaaagaatg aaccacatcc acacgtttga atttaatcat ctaaatctga
    16921 atgtttcaga acaaaatttc tgctatctaa actgcttgaa actcaataat agtgtcacgt
    16981 ttgaatgtca tacacagcaa tatatatata tgtgtatata tatatatatg gcaaagcaaa
    17041 aaaaaaaaca tggtaagaga gaatgaagga gaacattgtg tttgattctt gctgaatggc
    17101 accttctcaa agaaaatagg gcttgcacct ttgttaatca gctgtggcca gtgctttctg
    17161 gtgttcattg tgtaaccttc acccaggaat aggtgaggtt ttaggaagtt acatgtcctc
    17221 tgaagaaaga attacactct gaaaagtaat gcttcaaatt gatttcctta ccttttggga
    17281 aaaaaaaaaa attgtttttt tgcattctcc cttgaattga ccaaaatgtt aactgtttca
    17341 tttggggagg ggatggggtg ctgccatcat tgtcgttgtt gttgctgctg tagctgttgg
    17401 ggtttctttt cctgttgccg gggctgtttg gggagaggga ggggagggag gtgggagggc
    17461 cgcggagata tcttcccttt gtacagggca ttcgtgttgt gaacccagag ctgggtagaa
    17521 gctgcttttg tattcagtgt gaggtggtgt ttacagacga ctttgacaac agtagaagtg
    17581 tactcagtgg tgtctgtgta tctgaactat ttaatttcgt gttatgttta tatgcagaaa
    17641 tatttatgga tactacacca agtgtttatt taatgttgat aaatatgact cttcagtcgt
    17701 cagccatggt gtcctttcaa agtgattctt taaggtccac ttgagcaatg aatagagtat
    17761 attggagctt tcctgtggct aagaagaaga aacatgtcat cctgttggca tcaccaagca
    17821 cctaactctt tctaggtaat aaaaagtcaa cggtcacttc aacgtaaatg tttaaaacca
    17881 ctctttagtt aaatctgatg ggaactgaac aaagctccac cattgtgtct gaaatcattt
    17941 tacacaggga aaaaaaaaaa caatcagcat aattgtaaga atgatttttt tgggcccaca
    18001 ttcaaccaaa gaacaagaaa gaaacagacg attttctaat atgtacacag caaactacag
    18061 aatgtcatat tatccacctg tgaaacatct agtaagcaat tgcatctata ttttatttct
    18121 caagttggcc tggcactaat aaatatgtga aagcttattc aagtgtccca gtacttcagc
    18181 acttcccatc cttttggaaa ctcctatctt gcctccctcc caaaagggct gtttctttta
    18241 ttaaaaaaaa aaaagaaata gaattaaatt tgagaaaagg agaaaccctg aaatttaaca
    18301 gaactttgag agtcacttcc aatctcctta aacatgatta tctccttatc cttgtccttt
    18361 tgtgatgcta ataatagcag aaaaggaaca aatccaagac tctaggtctc ccttttttgt
    18421 tttactggtt ttattataga attgttttta agcctcttat ggatgaaagc tgcatttaaa
    18481 tactatctac tgattttata gaaaggtatg tccatttctt gggtcacttt cagagaaaga
    18541 aaacaagcaa aataggttct tttgaatatg aataatttaa aagcataatt gaagatgtag
    18601 tgagtattta taattggacc ttagttacac gtgcatttct caaagggctt gtcattacag
    18661 gagatattca gcacttacct aagatcaaaa tgtcttcatc ccaaattggg aatcgaatta
    18721 tttcatgcca tatgcatgag gtttgcagac atttcaagat tagccacttt gcttgaaaga
    18781 agaaaatgat caaacctaaa ataaactaca catggagaat ctctctctct ctctctgcct
    18841 ctctctctct ctttctccct cttcttcctt ctctctctct cacaagcaca cacacacaca
    18901 ctcaatctcc attctccagg cattgccaga tggttaggag aagtgagctc tctctggtcc
    18961 cctagatccc tcggctctgc tctcctttgc ccatcagctc cctgtggcct ctatgctagt
    19021 cctccctatt ctcctagtca ccctttgcct cttaagccca gccttgactc tctacatatt
    19081 tttcatttct ctttaccctt tagtgtacaa tagttgtaga ctctgacgga atgaaaacaa
    19141 acaagaagcc taagcgttag accctgctgt ggctaaagat ctagaaggca tatcagtttt
    19201 ctctgtcagg cttcctacgt tgccctcgtg cagggctcat tgctctgcag agcgctggaa
    19261 gccccttcat gtatcgagag agaagctgga gcacagagct ctgatgcaca gttggctgtt
    19321 tcagctctga ctcagggagg aaagaaggat gccaaggctc tgtcacagcg gagaagtcta
    19381 ataccagagt ggcacagaga aggattccag ggatcagtca gggtgtcctg tacctatctg
    19441 agtagagatg attcaaggat ggggacatat tccaggaaat tgcacaatct tcccctggca
    19501 gcttcagagg acgagtgaaa atagtgcagt atagtcaaag aagcaatgaa tttaggatga
    19561 ggaacctgaa gtttctggac cagtttggtc actgcttagt tacatgtcct taggaatgct
    19621 tgtcacttaa cctaaacttt ctgggtttta tcctcattgc tcaaactaag caacaacacc
    19681 gaagcttctc taatttgcct tctgatgcca aatcggtcaa aactgaggtc agcagctacc
    19741 atgacgaaag taaaatggta tattgggtga atgtttgaaa atttcagatt ttatattctg
    19801 taaagttatt tacttactct atttcaacac cacaaaatct tgaaatttgg aaggtaacca
    19861 aggaagcttt gaaatttgtt ggcaaacccg gagtagtatg gtttcaaata ccactccaac
    19921 ccagcacctg aggtcgggca aactcacaaa atagagtttc taggtagcag gtgtttgctt
    19981 tggttttgca atagcatttc tcataacaga actgaaactg tatagattac aacactccaa
    20041 agttattttt ttttaaccta aagaacccta cttctagcac ctcctctgaa agaatatttt
    20101 gctccaatac cacgtgcaac aaacttattt agacagtatc aactctagcc cttaataggt
    20161 tcaaggacaa gtttactgct tcctttctac acgcttaagt tacactctct tctcctgttc
    20221 tgatgactct aaatcttcag cctctcccag cattaatgtg tgagtcaaca ttgcagacct
    20281 gagaaaggtt tctagaatgg taacccaatg ttctttagaa ctggagaatt ccattttcct
    20341 tttctggctt tagtgttaat gtctgggaag ggaggctcat gataagaaaa taaaaatgag
    20401 aaaagaagat ctagttcata aaatgactat accccacgta agtttgtaac tgcacagtgt
    20461 tttgttgtac ggctcagaaa tgagcaagtg ttagtattat taggcacaca tcacgttcac
    20521 agcttcgcgc agagacggat agtgtatttg gatatatgga agtcatccaa atgcgttgct
    20581 agaatatcag gcctatgttt gttctggtag aaccacagag actcacacaa agttctgacc
    20641 ctaccactct ggtctgggct gagaccaccc caaaaaatca tctagagaat caaaggggct
    20701 cacatctcag ttgcattcta tttaaaagat aaaggggcca tactctccac tgcaaagaag
    20761 cattagtaaa acttcccgca cccaaattat aatccggcaa ccctagcttc agctaaaaag
    20821 attatcccca gaatctaaaa gcttactatt gttctttctt ggagtccaaa atgcttagca
    20881 gttctgcagt tcacatacaa aactcaaaac tctttttatc ctgtattctg tgagttcctt
    20941 gatgatagta attgggtctt attcatcact ctgtatcctg tggctcacac agaatctggc
    21001 aaattgcata tattcaataa atgttgaata tctaataacc tccttattaa tataacaaat
    21061 attatcaaca ttctgtgcac atcaatgtcc catgctgcta ctgtagtcag gagttatttg
    21121 gctgggaagt ggaaagtgtt cacaaacatg atgcttatct aataaaatat cactgagcaa
    21181 taaggagaaa tattttaaat agatttgaag ttgtgaacaa ataatttaga gtccaaagag
    21241 gaaaaagaaa attaactctg ttttttatcc ctagaactca gaaactttac tggattggtc
    21301 aacaaagaca aactttttat tgtataaaac agtagaattc atggaaggga taattctttt
    21361 ggaacaggct tctcggttac ttgccttagt aaaagaagta tctggagggc ctggagagtt
    21421 cataaacata gttttctgtg caagtgaaga tctgtagttt ggcttaaaaa tccttgcatg
    21481 tagttttgct tggcgtggaa agttattagg agacaatcct ttatcctgtt ctgcaagcaa
    21541 tcaaacacat gatctccctt ctagccattc ctcatccagt acatgggcat ttccagcctc
    21601 ctacatgtaa cacttcaaac ttcctctggg cgtctgctta gagctatgtg atggccacag
    21661 tttgggcaaa gcccttcttt cttttaaata taggaactgt taccaagttt ggtgcaggct
    21721 tgaggaataa ttacataaaa atgggcttcc acgatggtga atcagcatgc tgatttctct
    21781 tggcaggaag ctctcaggga aatgtctgtg aatcatttaa agatgctctc tggtggatag
    21841 agaaaccgca gtccaaaaac agatgggtgt atatttgctt tgtaagcaaa gggcatgtat
    21901 catactcgca tctaaaacag tgtccacatc tttgccaaag gcactgaatt ttaccttttt
    21961 ttattacctc gtggccagca cttcctcagt aggcatttca ggtgtgtcac aaaccatgtt
    22021 catttttaat cttgaaaaag tcaatcgtct gtagtctgta ctataaaatg atgcctgcaa
    22081 ctttgtggtg aatattatcc ccaagttaac agtgaaataa gtaaataaaa ctattattga
    22141 acaaa
//
