LOCUS       NM_000738               2646 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens cholinergic receptor muscarinic 1 (CHRM1), mRNA.
ACCESSION   NM_000738
VERSION     NM_000738.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2646)
  AUTHORS   Sabbir,M.G., Speth,R.C. and Albensi,B.C.
  TITLE     Loss of Cholinergic Receptor Muscarinic 1 (CHRM1) Protein in the
            Hippocampus and Temporal Cortex of a Subset of Individuals with
            Alzheimer's Disease, Parkinson's Disease, or Frontotemporal
            Dementia: Implications for Patient Survival
  JOURNAL   J Alzheimers Dis 90 (2), 727-747 (2022)
   PUBMED   36155524
  REMARK    GeneRIF: Loss of Cholinergic Receptor Muscarinic 1 (CHRM1) Protein
            in the Hippocampus and Temporal Cortex of a Subset of Individuals
            with Alzheimer's Disease, Parkinson's Disease, or Frontotemporal
            Dementia: Implications for Patient Survival.
REFERENCE   2  (bases 1 to 2646)
  AUTHORS   Reale,M., Carrarini,C., Russo,M., Dono,F., Ferri,L., Di Pietro,M.,
            Costantini,E., Porreca,A., Di Nicola,M., Onofrj,M. and Bonanni,L.
  TITLE     Muscarinic Receptors Expression in the Peripheral Blood Cells
            Differentiate Dementia with Lewy Bodies from Alzheimer's Disease
  JOURNAL   J Alzheimers Dis 85 (1), 323-330 (2022)
   PUBMED   34806612
  REMARK    GeneRIF: Muscarinic Receptors Expression in the Peripheral Blood
            Cells Differentiate Dementia with Lewy Bodies from Alzheimer's
            Disease.
REFERENCE   3  (bases 1 to 2646)
  AUTHORS   Marce-Grau,A., Elorza-Vidal,X., Perez-Rius,C., Ruiz-Nel Lo,A.,
            Sala-Coromina,J., Gabau,E., Estevez,R. and Macaya,A.
  TITLE     Muscarinic acetylcholine receptor M1 mutations causing
            neurodevelopmental disorder and epilepsy
  JOURNAL   Hum Mutat 42 (10), 1215-1220 (2021)
   PUBMED   34212451
  REMARK    GeneRIF: Muscarinic acetylcholine receptor M1 mutations causing
            neurodevelopmental disorder and epilepsy.
REFERENCE   4  (bases 1 to 2646)
  AUTHORS   Islam,F., Maciukiewicz,M., Freeman,N., Huang,E., Tiwari,A.,
            Mulsant,B.H., Pollock,B.G., Remington,G., Kennedy,J.L., Muller,D.J.
            and Rajji,T.K.
  TITLE     Contributions of cholinergic receptor muscarinic 1 and CYP1A2 gene
            variants on the effects of plasma ratio of
            clozapine/N-desmethylclozapine on working memory in schizophrenia
  JOURNAL   J Psychopharmacol 35 (1), 31-39 (2021)
   PUBMED   33143542
  REMARK    GeneRIF: Contributions of cholinergic receptor muscarinic 1 and
            CYP1A2 gene variants on the effects of plasma ratio of
            clozapine/N-desmethylclozapine on working memory in schizophrenia.
REFERENCE   5  (bases 1 to 2646)
  AUTHORS   Goto,Y., Ando,T., Izumi,H., Feng,X., Arang,N., Gilardi,M., Wang,Z.,
            Ando,K. and Gutkind,J.S.
  TITLE     Muscarinic receptors promote castration-resistant growth of
            prostate cancer through a FAK-YAP signaling axis
  JOURNAL   Oncogene 39 (20), 4014-4027 (2020)
   PUBMED   32205868
  REMARK    GeneRIF: Muscarinic receptors promote castration-resistant growth
            of prostate cancer through a FAK-YAP signaling axis.
REFERENCE   6  (bases 1 to 2646)
  AUTHORS   Arden,J.R., Nagata,O., Shockley,M.S., Philip,M., Lameh,J. and
            Sadee,W.
  TITLE     Mutational analysis of third cytoplasmic loop domains in G-protein
            coupling of the HM1 muscarinic receptor
  JOURNAL   Biochem Biophys Res Commun 188 (3), 1111-1115 (1992)
   PUBMED   1445347
REFERENCE   7  (bases 1 to 2646)
  AUTHORS   Nitsch,R.M., Slack,B.E., Wurtman,R.J. and Growdon,J.H.
  TITLE     Release of Alzheimer amyloid precursor derivatives stimulated by
            activation of muscarinic acetylcholine receptors
  JOURNAL   Science 258 (5080), 304-307 (1992)
   PUBMED   1411529
REFERENCE   8  (bases 1 to 2646)
  AUTHORS   Gutkind,J.S., Novotny,E.A., Brann,M.R. and Robbins,K.C.
  TITLE     Muscarinic acetylcholine receptor subtypes as agonist-dependent
            oncogenes
  JOURNAL   Proc Natl Acad Sci U S A 88 (11), 4703-4707 (1991)
   PUBMED   1905013
REFERENCE   9  (bases 1 to 2646)
  AUTHORS   Chapman,C.G. and Browne,M.J.
  TITLE     Isolation of the human ml (Hml) muscarinic acetylcholine receptor
            gene by PCR amplification
  JOURNAL   Nucleic Acids Res 18 (8), 2191 (1990)
   PUBMED   2336407
REFERENCE   10 (bases 1 to 2646)
  AUTHORS   Goyal,R.K.
  TITLE     Muscarinic receptor subtypes. Physiology and clinical implications
  JOURNAL   N Engl J Med 321 (15), 1022-1029 (1989)
   PUBMED   2674717
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC022984.1.
            
            On Nov 22, 2018 this sequence version replaced NM_000738.2.
            
            Summary: The muscarinic cholinergic receptors belong to a larger
            family of G protein-coupled receptors. The functional diversity of
            these receptors is defined by the binding of acetylcholine and
            includes cellular responses such as adenylate cyclase inhibition,
            phosphoinositide degeneration, and potassium channel mediation.
            Muscarinic receptors influence many effects of acetylcholine in the
            central and peripheral nervous system. The muscarinic cholinergic
            receptor 1 is involved in mediation of vagally-induced
            bronchoconstriction and in the acid secretion of the
            gastrointestinal tract. The gene encoding this receptor is
            localized to 11q13. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022984.1, SRR14038193.3681494.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306960.4/ ENSP00000306490.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2646              BC022984.1         178-2823
FEATURES             Location/Qualifiers
     source          1..2646
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..2646
                     /gene="CHRM1"
                     /gene_synonym="HM1; M1; M1R"
                     /note="cholinergic receptor muscarinic 1"
                     /db_xref="GeneID:1128"
                     /db_xref="HGNC:HGNC:1950"
                     /db_xref="MIM:118510"
     exon            1..146
                     /gene="CHRM1"
                     /gene_synonym="HM1; M1; M1R"
                     /inference="alignment:Splign:2.1.0"
     exon            147..2646
                     /gene="CHRM1"
                     /gene_synonym="HM1; M1; M1R"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1607
                     /gene="CHRM1"
                     /gene_synonym="HM1; M1; M1R"
                     /note="acetylcholine receptor, muscarinic 1"
                     /codon_start=1
                     /product="muscarinic acetylcholine receptor M1"
                     /protein_id="NP_000729.2"
                     /db_xref="CCDS:CCDS8040.1"
                     /db_xref="GeneID:1128"
                     /db_xref="HGNC:HGNC:1950"
                     /db_xref="MIM:118510"
                     /translation="MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNL
                     LVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWL
                     ALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPA
                     ILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENR
                     ARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKE
                     EEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGR
                     DRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCK
                     DCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPG
                     SVHRTPSRQC"
     regulatory      2622..2627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHRM1"
                     /gene_synonym="HM1; M1; M1R"
                     /note="hexamer: AATAAA"
     polyA_site      2646
                     /gene="CHRM1"
                     /gene_synonym="HM1; M1; M1R"
                     /note="major polyA site"
ORIGIN      
        1 atgccaatca ctggctgtgc ctctcccgct gccagcacag ggcgcagctc cccctgggag
       61 ccaggtgttt gggtccctgg agacgccgca ggcccccagg gaggcagtgg ggctgaggac
      121 cctacagacc cctcttcagc cccgtggtga tgactttccc ctgaggaagc cctgtagcgt
      181 gcctggagga aggggctctc caaccccagc cccacctagc caccatgaac acttcagccc
      241 cacctgctgt cagccccaac atcaccgtcc tggcaccagg aaagggtccc tggcaagtgg
      301 ccttcattgg gatcaccacg ggcctcctgt cgctagccac agtgacaggc aacctgctgg
      361 tactcatctc tttcaaggtc aacacggagc tcaagacagt caataactac ttcctgctga
      421 gcctggcctg tgctgacctc atcatcggta ccttctccat gaacctctat accacgtacc
      481 tgctcatggg ccactgggct ctgggcacgc tggcttgtga cctctggctg gccctggact
      541 atgtggccag caatgcctcc gtcatgaatc tgctgctcat cagctttgac cgctacttct
      601 ccgtgactcg gcccctgagc taccgtgcca agcgcacacc ccgccgggca gctctgatga
      661 tcggcctggc ctggctggtt tcctttgtgc tctgggcccc agccatcctc ttctggcagt
      721 acctggtagg ggagcggaca gtgctagctg ggcagtgcta catccagttc ctctcccagc
      781 ccatcatcac ctttggcaca gccatggctg ccttctacct ccctgtcaca gtcatgtgca
      841 cgctctactg gcgcatctac cgggagacag agaaccgagc acgggagctg gcagcccttc
      901 agggctccga gacgccaggc aaagggggtg gcagcagcag cagctcagag aggtctcagc
      961 caggggctga gggctcacca gagactcctc caggccgctg ctgtcgctgc tgccgggccc
     1021 ccaggctgct gcaggcctac agctggaagg aagaagagga agaggacgaa ggctccatgg
     1081 agtccctcac atcctcagag ggagaggagc ctggctccga agtggtgatc aagatgccaa
     1141 tggtggaccc cgaggcacag gcccccacca agcagccccc acggagctcc ccaaatacag
     1201 tcaagaggcc gactaagaaa gggcgtgatc gagctggcaa gggccagaag ccccgtggaa
     1261 aggagcagct ggccaagcgg aagaccttct cgctggtcaa ggagaagaag gcggctcgga
     1321 ccctgagtgc catcctcctg gccttcatcc tcacctggac accgtacaac atcatggtgc
     1381 tggtgtccac cttctgcaag gactgtgttc ccgagaccct gtgggagctg ggctactggc
     1441 tgtgctacgt caacagcacc atcaacccca tgtgctacgc actctgcaac aaagccttcc
     1501 gggacacctt tcgcctgctg ctgctttgcc gctgggacaa gagacgctgg cgcaagatcc
     1561 ccaagcgccc tggctccgtg caccgcactc cctcccgcca atgctgatag tcccctctcc
     1621 tgcatccctc caccccagtc cccgggaaag gccggtggga agagggcagg ggctgcatcc
     1681 tcagccccag ggccctgctc aggcctcacc tggcttccca ggaccctggg tcaccttcct
     1741 gggcagccca gagagaccct gccaactttc cagacttcgc tattcccagg cagggaggga
     1801 aacccgggga actggttttt ctgttccctg ctgggtggga atgcgctctt caccaggaag
     1861 aaggcccggg aggaggatcc gggctttgga ctccttgttt gcctttaggc aggaagtcag
     1921 gagccagcag ggcgggccag gagaaagaag gcttaacatt aagtattcct tggcccagca
     1981 gcggcccaga ttgcggtgtg agatggtgcc ccctgggggg cacagccaga aactgaactg
     2041 gccgctggga gaaaagccag atgacaggga gctggggaat cccctcgctt cataggcaga
     2101 gcccgcccac ctgggcccta ggcatactct ccaggattgt ccacaaatgt cctcagaggg
     2161 tccctaggtg ggtcaactcc aaggcaaatg tccaagcatc agcaagacaa tgacactgga
     2221 agggtccggc ttggctagtc acatatcaag tcccgaggca gcaacaggac caggagccag
     2281 gtgtcctgac tgtcctacaa tatcattttc ctgggagtgg gagtcaagtg tgcctgctat
     2341 ccagccgcaa atccataccc cctgccccag agaagcctca gtccctccct cctggctcac
     2401 agccaccacc tggatggatc tgctccatgc agatctagcc aggcctcccg catgctgcct
     2461 gcctccggcc ctgccccaca caggcctggc ccagccagca ggttctctcc tgtgagctcc
     2521 ccaatccaac ccatgcatgg cctcccagcc acccggatct ccaggcccag cctggcccca
     2581 aatgttcttt cctttcatcc tcagcaagtg ctgagtctgt gaataaagcc acataaccag
     2641 cgggca
//
