LOCUS       NM_001278473            1908 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens chordin like 2 (CHRDL2), transcript variant 2, mRNA.
ACCESSION   NM_001278473
VERSION     NM_001278473.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1908)
  AUTHORS   Wang,L., Xu,W., Mei,Y., Wang,X., Liu,W., Zhu,Z. and Ni,Z.
  TITLE     CHRDL2 promotes cell proliferation by activating the YAP/TAZ
            signaling pathway in gastric cancer
  JOURNAL   Free Radic Biol Med 193 (Pt 1), 158-170 (2022)
   PUBMED   36206931
  REMARK    GeneRIF: CHRDL2 promotes cell proliferation by activating the
            YAP/TAZ signaling pathway in gastric cancer.
REFERENCE   2  (bases 1 to 1908)
  AUTHORS   Chen,H., Pan,R., Li,H., Zhang,W., Ren,C., Lu,Q., Chen,H., Zhang,X.
            and Nie,Y.
  TITLE     CHRDL2 promotes osteosarcoma cell proliferation and metastasis
            through the BMP-9/PI3K/AKT pathway
  JOURNAL   Cell Biol Int 45 (3), 623-632 (2021)
   PUBMED   33245175
  REMARK    GeneRIF: CHRDL2 promotes osteosarcoma cell proliferation and
            metastasis through the BMP-9/PI3K/AKT pathway.
REFERENCE   3  (bases 1 to 1908)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1908)
  AUTHORS   Bunyavanich,S., Schadt,E.E., Himes,B.E., Lasky-Su,J., Qiu,W.,
            Lazarus,R., Ziniti,J.P., Cohain,A., Linderman,M., Torgerson,D.G.,
            Eng,C.S., Pino-Yanes,M., Padhukasahasram,B., Yang,J.J.,
            Mathias,R.A., Beaty,T.H., Li,X., Graves,P., Romieu,I., Navarro
            Bdel,R., Salam,M.T., Vora,H., Nicolae,D.L., Ober,C., Martinez,F.D.,
            Bleecker,E.R., Meyers,D.A., Gauderman,W.J., Gilliland,F.,
            Burchard,E.G., Barnes,K.C., Williams,L.K., London,S.J., Zhang,B.,
            Raby,B.A. and Weiss,S.T.
  TITLE     Integrated genome-wide association, coexpression network, and
            expression single nucleotide polymorphism analysis identifies novel
            pathway in allergic rhinitis
  JOURNAL   BMC Med Genomics 7, 48 (2014)
   PUBMED   25085501
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1908)
  AUTHORS   Vasiljevic,A., Champier,J., Figarella-Branger,D., Wierinckx,A.,
            Jouvet,A. and Fevre-Montange,M.
  TITLE     Molecular characterization of central neurocytomas: potential
            markers for tumor typing and progression
  JOURNAL   Neuropathology 33 (2), 149-161 (2013)
   PUBMED   22816789
REFERENCE   6  (bases 1 to 1908)
  AUTHORS   Yerges,L.M., Klei,L., Cauley,J.A., Roeder,K., Kammerer,C.M.,
            Moffett,S.P., Ensrud,K.E., Nestlerode,C.S., Marshall,L.M.,
            Hoffman,A.R., Lewis,C., Lang,T.F., Barrett-Connor,E., Ferrell,R.E.,
            Orwoll,E.S. and Zmuda,J.M.
  CONSRTM   MrOS Research Group
  TITLE     High-density association study of 383 candidate genes for
            volumetric BMD at the femoral neck and lumbar spine among older men
  JOURNAL   J Bone Miner Res 24 (12), 2039-2049 (2009)
   PUBMED   19453261
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1908)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   8  (bases 1 to 1908)
  AUTHORS   Oren,A., Toporik,A., Biton,S., Almogy,N., Eshel,D., Bernstein,J.,
            Savitsky,K. and Rotman,G.
  TITLE     hCHL2, a novel chordin-related gene, displays differential
            expression and complex alternative splicing in human tissues and
            during myoblast and osteoblast maturation
  JOURNAL   Gene 331, 17-31 (2004)
   PUBMED   15094188
  REMARK    GeneRIF: Differential expression of CHL2 variants was observed
            during myoblast and osteoblast differentiation, implying a role for
            this gene in these physiological processes.
REFERENCE   9  (bases 1 to 1908)
  AUTHORS   Nakayama,N., Han,C.Y., Cam,L., Lee,J.I., Pretorius,J., Fisher,S.,
            Rosenfeld,R., Scully,S., Nishinakamura,R., Duryea,D., Van,G.,
            Bolon,B., Yokota,T. and Zhang,K.
  TITLE     A novel chordin-like BMP inhibitor, CHL2, expressed preferentially
            in chondrocytes of developing cartilage and osteoarthritic joint
            cartilage
  JOURNAL   Development 131 (1), 229-240 (2004)
   PUBMED   14660436
  REMARK    GeneRIF: CHL2 expression is restricted to chondrocytes of various
            developing joint cartilage surfaces and connective tissues in
            reproductive organs
REFERENCE   10 (bases 1 to 1908)
  AUTHORS   Wu,I. and Moses,M.A.
  TITLE     BNF-1, a novel gene encoding a putative extracellular matrix
            protein, is overexpressed in tumor tissues
  JOURNAL   Gene 311, 105-110 (2003)
   PUBMED   12853144
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001324.4, BC142623.1 and
            AY279090.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001278473.2.
            
            Summary: This gene encodes a member of the chordin family of
            proteins. Chordin family members are secreted proteins that share a
            cysteine-rich pro-collagen repeat domain and associate with members
            of the transforming growth factor beta superfamily. In vitro assays
            demonstrate a direct interaction between the encoded protein and
            human activin A. This gene is expressed in many tissues including
            osteoblasts, where it is differentially expressed during
            differentiation. In addition, its expression is upregulated in
            human osteoarthritic joint cartilage, suggesting a role in adult
            cartilage regeneration. [provided by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (2) lacks an alternate 3' coding
            exon, which results in a frameshift compared to variant 1. The
            encoded isoform (2) has a shorter and distinct C-terminus compared
            to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC142623.1, AY279090.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376332.8/ ENSP00000365510.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AP001324.4         110518-110558       c
            42-121              BC142623.1         1-80
            122-122             AP001324.4         110437-110437       c
            123-244             BC142623.1         82-203
            245-990             AY279090.1         1-746
            991-991             AP001324.4         87507-87507         c
            992-1624            AY279090.1         748-1380
            1625-1908           BC142623.1         1584-1867
FEATURES             Location/Qualifiers
     source          1..1908
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..1908
                     /gene="CHRDL2"
                     /gene_synonym="BNF1; CHL2"
                     /note="chordin like 2"
                     /db_xref="GeneID:25884"
                     /db_xref="HGNC:HGNC:24168"
                     /db_xref="MIM:613127"
     exon            1..620
                     /gene="CHRDL2"
                     /gene_synonym="BNF1; CHL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             539..1828
                     /gene="CHRDL2"
                     /gene_synonym="BNF1; CHL2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; breast tumor novel factor 1; chordin-like
                     protein 2; chordin-related protein 2"
                     /codon_start=1
                     /product="chordin-like protein 2 isoform 2 precursor"
                     /protein_id="NP_001265402.1"
                     /db_xref="CCDS:CCDS60893.1"
                     /db_xref="GeneID:25884"
                     /db_xref="HGNC:HGNC:24168"
                     /db_xref="MIM:613127"
                     /translation="MVPEVRVLSSLLGLALLWFPLDSHARARPDMFCLFHGKRYSPGE
                     SWHPYLEPQGLMYCLRCTCSEGAHVSCYRLHCPPVHCPQPVTEPQQCCPKCVEPHTPS
                     GLRAPPKSCQHNGTMYQHGEIFSAHELFPSRLPNQCVLCSCTEGQIYCGLTTCPEPGC
                     PAPLPLPDSCCQACKDEASEQSDEEDSVQSLHGVRHPQDPCSSDAGRKRGPGTPAPTG
                     LSAPLSFIPRHFRPKGAGSTTVKIVLKEKHKKACVHGGKTYSHGEVWHPAFRAFGPLP
                     CILCTCEDGRQDCQRVTCPTEYPCRHPEKVAGKCCKICPEDKADPGHSEISSTRCPKA
                     PGRVLVHTSVSPSPDNLRRFALEHEASDLVEIYLWKLVKGIFHLTQIKKVRKQDFQKE
                     AQHFRLLAGPHEGHWNVFLAQTLELKVTASPDKVTKT"
     exon            621..733
                     /gene="CHRDL2"
                     /gene_synonym="BNF1; CHL2"
                     /inference="alignment:Splign:2.1.0"
     exon            734..827
                     /gene="CHRDL2"
                     /gene_synonym="BNF1; CHL2"
                     /inference="alignment:Splign:2.1.0"
     exon            828..970
                     /gene="CHRDL2"
                     /gene_synonym="BNF1; CHL2"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1064
                     /gene="CHRDL2"
                     /gene_synonym="BNF1; CHL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1120
                     /gene="CHRDL2"
                     /gene_synonym="BNF1; CHL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1289
                     /gene="CHRDL2"
                     /gene_synonym="BNF1; CHL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1484
                     /gene="CHRDL2"
                     /gene_synonym="BNF1; CHL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1658
                     /gene="CHRDL2"
                     /gene_synonym="BNF1; CHL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1751
                     /gene="CHRDL2"
                     /gene_synonym="BNF1; CHL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1908
                     /gene="CHRDL2"
                     /gene_synonym="BNF1; CHL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1886..1891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHRDL2"
                     /gene_synonym="BNF1; CHL2"
                     /note="hexamer: AATAAG"
     polyA_site      1908
                     /gene="CHRDL2"
                     /gene_synonym="BNF1; CHL2"
                     /note="major polyA site"
ORIGIN      
        1 cttggcgagc acagccggcc cgcgctcagc ctccctccgc ggccgccgcg ccgccgccgc
       61 tgctgggacc gccgccccgc cgggccccag gcccccgcgg cccgaccccg agcccaccga
      121 gcagggggcg ccggccgcct ctagcccgcg cgcccgcaac acccgctggt cccgcgcgcc
      181 tcgcccggcg ctgcgcgctc ggcagacgcc ggtcctctcc ctgctttctc ctcctctccc
      241 tctcaccttc cccctttctt tgatcgcctc tcccttctgc tggaccttcc ttcgtctctc
      301 catctctccc tcctttcccc gcgttctctt tccacctttc tcttcttccc accttagacc
      361 tcccttcctg ccctcctttc ctgcccaccg ctgcttcctg gcccttctcc gaccccgctc
      421 tagcagcaga cctcctgggg tctgtgggtt gatctgtggc ccctgtgcct ccgtgtcctt
      481 ttcgtctccc ttcctcccga ctccgctccc ggaccagcgg cctgaccctg gggaaaggat
      541 ggttcccgag gtgagggtcc tctcctcctt gctgggactc gcgctgctct ggttccccct
      601 ggactcccac gctcgagccc gcccagacat gttctgcctt ttccatggga agagatactc
      661 ccccggcgag agctggcacc cctacttgga gccacaaggc ctgatgtact gcctgcgctg
      721 tacctgctca gagggcgccc atgtgagttg ttaccgcctc cactgtccgc ctgtccactg
      781 cccccagcct gtgacggagc cacagcaatg ctgtcccaag tgtgtggaac ctcacactcc
      841 ctctggactc cgggccccac caaagtcctg ccagcacaac gggaccatgt accaacacgg
      901 agagatcttc agtgcccatg agctgttccc ctcccgcctg cccaaccagt gtgtcctctg
      961 cagctgcaca gagggccaga tctactgcgg cctcacaacc tgccccgaac caggctgccc
     1021 agcacccctc ccgctgccag actcctgctg ccaggcctgc aaagatgagg caagtgagca
     1081 atcggatgaa gaggacagtg tgcagtcgct ccatggggtg agacatcctc aggatccatg
     1141 ttccagtgat gctgggagaa agagaggccc gggcacccca gcccccactg gcctcagcgc
     1201 ccctctgagc ttcatccctc gccacttcag acccaaggga gcaggcagca caactgtcaa
     1261 gatcgtcctg aaggagaaac ataagaaagc ctgtgtgcat ggcgggaaga cgtactccca
     1321 cggggaggtg tggcacccgg ccttccgtgc cttcggcccc ttgccctgca tcctatgcac
     1381 ctgtgaggat ggccgccagg actgccagcg tgtgacctgt cccaccgagt acccctgccg
     1441 tcaccccgag aaagtggctg ggaagtgctg caagatttgc ccagaggaca aagcagaccc
     1501 tggccacagt gagatcagtt ctaccaggtg tcccaaggca ccgggccggg tcctcgtcca
     1561 cacatcggta tccccaagcc cagacaacct gcgtcgcttt gccctggaac acgaggcctc
     1621 ggacttggtg gagatctacc tctggaagct ggtaaaagga atcttccact tgactcagat
     1681 caagaaagtc aggaagcaag acttccagaa agaggcacag cacttccgac tgctcgctgg
     1741 cccccacgaa ggtcactgga acgtcttcct agcccagacc ctggagctga aggtcacggc
     1801 cagtccagac aaagtgacca agacataaca aagacctaac agttgcagat atgagctgta
     1861 taattgttgt tattatatat taataaataa gaagttgcat taccctca
//
