LOCUS       NM_145234               3912 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens chordin like 1 (CHRDL1), transcript variant 3, mRNA.
ACCESSION   NM_145234
VERSION     NM_145234.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3912)
  AUTHORS   Huang,S., Zhang,J., Qiao,Y., Pathak,J.L., Zou,R., Piao,Z., Xie,S.,
            Liang,J. and Ouyang,K.
  TITLE     CHRDL1 inhibits OSCC metastasis via MAPK signaling-mediated
            inhibition of MED29
  JOURNAL   Mol Med 30 (1), 187 (2024)
   PUBMED   39462350
  REMARK    GeneRIF: CHRDL1 inhibits OSCC metastasis via MAPK
            signaling-mediated inhibition of MED29.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3912)
  AUTHORS   Han,Y., Xia,L., Wang,X., Xiong,H., Zeng,L., Wang,Z., Zhang,T.,
            Xia,K., Hu,X. and Su,T.
  TITLE     Study on the expression and function of chordin-like 1 in oral
            squamous cell carcinoma
  JOURNAL   Oral Dis 29 (5), 2034-2051 (2023)
   PUBMED   35510812
  REMARK    GeneRIF: Study on the expression and function of chordin-like 1 in
            oral squamous cell carcinoma.
REFERENCE   3  (bases 1 to 3912)
  AUTHORS   Yu,J.W., Pang,R., Liu,B., Zhang,L. and Zhang,J.W.
  TITLE     Bioinformatics identify the role of chordin-like 1 in thyroid
            cancer
  JOURNAL   Medicine (Baltimore) 102 (5), e32778 (2023)
   PUBMED   36749222
  REMARK    GeneRIF: Bioinformatics identify the role of chordin-like 1 in
            thyroid cancer.
REFERENCE   4  (bases 1 to 3912)
  AUTHORS   Pei,Y.F., Zhang,Y.J., Lei,Y., Wu,W.D., Ma,T.H. and Liu,X.Q.
  TITLE     Hypermethylation of the CHRDL1 promoter induces proliferation and
            metastasis by activating Akt and Erk in gastric cancer
  JOURNAL   Oncotarget 8 (14), 23155-23166 (2017)
   PUBMED   28423564
  REMARK    GeneRIF: Finally, in vivo experiments confirmed that CHRDL1 acted
            as a tumor suppressor gene in suppressing tumor growth and
            metastasis
            Erratum:[Oncotarget. 2017 Jul 18;8(29):48526. doi:
            10.18632/oncotarget.19303.. Wu, Ding-Wei [corrected to Wu,
            Wei-ding]. PMID: 28753909]
REFERENCE   5  (bases 1 to 3912)
  AUTHORS   Cyr-Depauw,C., Northey,J.J., Tabaries,S., Annis,M.G., Dong,Z.,
            Cory,S., Hallett,M., Rennhack,J.P., Andrechek,E.R. and Siegel,P.M.
  TITLE     Chordin-Like 1 Suppresses Bone Morphogenetic Protein 4-Induced
            Breast Cancer Cell Migration and Invasion
  JOURNAL   Mol Cell Biol 36 (10), 1509-1525 (2016)
   PUBMED   26976638
  REMARK    GeneRIF: Results show that Chrdl1 expression is upregulated in
            numerous breast cancer cells following TGF-beta stimulation and
            demonstrated that Chrdl1 acts as an inhibitor of BMP4-induced
            migration and invasion.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3912)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3912)
  AUTHORS   Chen,D., Zhao,M. and Mundy,G.R.
  TITLE     Bone morphogenetic proteins
  JOURNAL   Growth Factors 22 (4), 233-241 (2004)
   PUBMED   15621726
  REMARK    Review article
REFERENCE   8  (bases 1 to 3912)
  AUTHORS   Sakuta,H., Suzuki,R., Takahashi,H., Kato,A., Shintani,T.,
            Iemura,Si., Yamamoto,T.S., Ueno,N. and Noda,M.
  TITLE     Ventroptin: a BMP-4 antagonist expressed in a double-gradient
            pattern in the retina
  JOURNAL   Science 293 (5527), 111-115 (2001)
   PUBMED   11441185
  REMARK    GeneRIF: reports the cloning of chick ventroptin and its importance
            in topographic retinotectal projection
REFERENCE   9  (bases 1 to 3912)
  AUTHORS   Coffinier,C., Tran,U., Larrain,J. and De Robertis,E.M.
  TITLE     Neuralin-1 is a novel Chordin-related molecule expressed in the
            mouse neural plate
  JOURNAL   Mech Dev 100 (1), 119-122 (2001)
   PUBMED   11118896
REFERENCE   10 (bases 1 to 3912)
  AUTHORS   Chen,J.D., Mackey,D., Fuller,H., Serravalle,S., Olsson,J. and
            Denton,M.J.
  TITLE     X-linked megalocornea: close linkage to DXS87 and DXS94
  JOURNAL   Hum Genet 83 (3), 292-294 (1989)
   PUBMED   2571565
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP377491.1, BC002909.2 and
            AL049176.3.
            
            On Jun 1, 2019 this sequence version replaced NM_145234.3.
            
            Summary: This gene encodes an antagonist of bone morphogenetic
            protein 4. The encoded protein may play a role in topographic
            retinotectal projection and in the regulation of retinal
            angiogenesis in response to hypoxia. Alternatively spliced
            transcript variants encoding different isoforms have been
            described. [provided by RefSeq, Jan 2009].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and uses
            alternate in-frame splice sites in the coding region compared to
            variant 1. The resulting protein (isoform 3) is shorter but has the
            identical N- and C-termini compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002909.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BP377491.1         32-83
            53-2523             BC002909.2         1-2471
            2524-3912           AL049176.3         28358-29746         c
FEATURES             Location/Qualifiers
     source          1..3912
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq23"
     gene            1..3912
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /note="chordin like 1"
                     /db_xref="GeneID:91851"
                     /db_xref="HGNC:HGNC:29861"
                     /db_xref="MIM:300350"
     exon            1..132
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            133..260
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1537
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; ventroptin; neurogenesin-1; chordin-like
                     protein 1; neuralin-1"
                     /codon_start=1
                     /product="chordin-like protein 1 isoform 3 precursor"
                     /protein_id="NP_660277.2"
                     /db_xref="CCDS:CCDS14553.1"
                     /db_xref="GeneID:91851"
                     /db_xref="HGNC:HGNC:29861"
                     /db_xref="MIM:300350"
                     /translation="MRKKWKMGGMKYIFSLLFFLLLEGGKTEQVKHSETYCMFQDKKY
                     RVGERWHPYLEPYGLVYCVNCICSENGNVLCSRVRCPNVHCLSPVHIPHLCCPRCPDS
                     LPPVNNKVTSKSCEYNGTTYQHGELFVAEGLFQNRQPNQCTQCSCSEGNVYCGLKTCP
                     KLTCAFPVSVPDSCCRVCRGDGELSWEHSDGDIFRQPANREARHSYHRSHYDPPPSRQ
                     AGGLSRFPGARSHRGALMDSQQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPN
                     LRAFGIVECVLCTCNVTKQECKKIHCPNRYPCKYPQKIDGKCCKVCPGKKAKELPGQS
                     FDNKGYFCGEETMPVYESVFMEDGETTRKIALETERPPQVEVHVWTIRKGILQHFHIE
                     KISKRMFEELPHFKLVTRTTLSQWKIFTEGEAQISQMCSSRVCRTELEDLVKVLYLER
                     SEKGHC"
     exon            261..373
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            374..467
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            468..610
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            611..704
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            705..772
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            773..941
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1151
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1316
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1406
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..3912
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3886..3891
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /note="hexamer: AATAAA"
     polyA_site      3912
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /note="major polyA site"
ORIGIN      
        1 agacctcgga cgagagcgcc ccggggagct cggagcgcgt gcacgcgtgg cagacggaga
       61 aggccagtgc ccaggttagt gagcagtgcc cggcgcccgc ttccctcacc tccttttcca
      121 gcctttgcac agcttgaagg ttctgtcacc ttttgcagtg gtccaaatga gaaaaaagtg
      181 gaaaatggga ggcatgaaat acatcttttc gttgttgttc tttcttttgc tagaaggagg
      241 caaaacagag caagtaaaac attcagagac atattgcatg tttcaagaca agaagtacag
      301 agtgggtgag agatggcatc cttacctgga accttatggg ttggtttact gcgtgaactg
      361 catctgctca gagaatggga atgtgctttg cagccgagtc agatgtccaa atgttcattg
      421 cctttctcct gtgcatattc ctcatctgtg ctgccctcgc tgcccagact ccttaccccc
      481 agtgaacaat aaggtgacca gcaagtcttg cgagtacaat gggacaactt accaacatgg
      541 agagctgttc gtagctgaag ggctctttca gaatcggcaa cccaatcaat gcacccagtg
      601 cagctgttcg gagggaaacg tgtattgtgg tctcaagact tgccccaaat taacctgtgc
      661 cttcccagtc tctgttccag attcctgctg ccgggtatgc agaggagatg gagaactgtc
      721 atgggaacat tctgatggtg atatcttccg gcaacctgcc aacagagaag caagacattc
      781 ttaccaccgc tctcactatg atcctccacc aagccgacag gctggaggtc tgtcccgctt
      841 tcctggggcc agaagtcacc ggggagctct tatggattcc cagcaagcat caggaaccat
      901 tgtgcaaatt gtcatcaata acaaacacaa gcatggacaa gtgtgtgttt ccaatggaaa
      961 gacctattct catggcgagt cctggcaccc aaacctccgg gcatttggca ttgtggagtg
     1021 tgtgctatgt acttgtaatg tcaccaagca agagtgtaag aaaatccact gccccaatcg
     1081 atacccctgc aagtatcctc aaaaaataga cggaaaatgc tgcaaggtgt gtccaggtaa
     1141 aaaagcaaaa gaacttccag gccaaagctt tgacaataaa ggctacttct gcggggaaga
     1201 aacgatgcct gtgtatgagt ctgtattcat ggaggatggg gagacaacca gaaaaatagc
     1261 actggagact gagagaccac ctcaggtaga ggtccacgtt tggactattc gaaagggcat
     1321 tctccagcac ttccatattg agaagatctc caagaggatg tttgaggagc ttcctcactt
     1381 caagctggtg accagaacaa ccctgagcca gtggaagatc ttcaccgaag gagaagctca
     1441 gatcagccag atgtgttcaa gtcgtgtatg cagaacagag cttgaagatt tagtcaaggt
     1501 tttgtacctg gagagatctg aaaagggcca ctgttaggca agacagacag tattggatag
     1561 ggtaaagcaa gaaaactcaa gctgcagctg gactgcaggc ttattttgct taagtcaaca
     1621 gtgccctaaa actccaaact caaatgcagt caattattca cgccatgcac agcataattt
     1681 gctcctttgt gtggagtggt gtgtcagccc ttgaacatct cctccaaaga gactagaaga
     1741 gtcttaaatt atatgtggga ggaggaggga tagaacatca caacactgct ctagtttctt
     1801 ggagaatcac atttctttac aggttaaaga caaacaagac cccagggttt ttatctagaa
     1861 agttattcaa gtgaaagaaa gagaagggaa ttgcttagta ggagttctgc agtatagaac
     1921 aattacttgt atgaaattat acctttgaat tttagaatgt catgtgttct tttaaaaaaa
     1981 ttagctcccc atcctccctc ctcactccct ccctccctcc ttctctctct ctctctctct
     2041 ccctccctct ctcacagaca cacacacaca cacacacaca cacacacaca cgcacgtcca
     2101 cactcacatt aaacgaaagc tttatttgaa gcaaagctag ccaagattct acgttacttt
     2161 tcccttgact ggatcccaag tagcttggaa gtttttgtgc ccaggagagt aaataactgt
     2221 gaacaagagg ctctgccctt aggtctttgt ggctgtttaa gtcaccaaca atagagtcag
     2281 ggtaaagaat aaaaacactt tcatagcctc attcattcac ttagaagtgg taataatttt
     2341 tccctaatga taccactttt cttttccccc tgtacctatg ggacttccag aaagaagtta
     2401 aattgagtaa aatcatcaga aactgaatcc atgtaagaaa aaataattgt tgaagaaaga
     2461 agttgataga attcaaaaag gccatctttt tgctttcaca tcaataaaat ttaccaagta
     2521 atagatcagt actcactaat atttttgaga ccatagttgt ctggtcagaa aaattatatt
     2581 aaattagtaa attctagaag ctctttaaaa gggaagtttt ccttcttctc caattatagg
     2641 agttgatttt tactttgcaa agtggctcgg tcctcatgag catctgcatg ttgactcttc
     2701 agttaagaaa attgttgttc atttagggag gtggatattc tgatgaagat ctttatccta
     2761 aaccttccta ctatccttgt cttattcatc aagcagatat tttagtcaag aattccagag
     2821 aaggctgctc ctaaaatgtc tacttgcagc ccaataccag agcataaact atccattctg
     2881 gggtctggct ttagaaatca tctttgtggg aagacctaat tcttcacagc aaggatctca
     2941 ggcatgcctt ctagatttgt tccctctgag gggcaggaat gaactgtaga aatgttttaa
     3001 ggacccagaa accccatatg tctcattcca tgactatagg tgagagaatt ctttcctaag
     3061 agggtttgat accaataggg gaaaatgtaa aatgttcagt ctttatgaca acctggcata
     3121 aaggagtcaa ttcttatgaa agagacacaa gggccttatg gccagggttt cttgggacaa
     3181 gactctcacc agcacatcac acacgttctc cttggaagag agaagcagta catcccggtt
     3241 gagaggtcac aaagcattag tttgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     3301 tgtgtgtgtg gtaaaggggg gaaggtgtta tgcggctgct ccctccgtcc cagaggtggc
     3361 agtgattcca taatgtggag actagtaact agatcctaag gcaaagaggt gtttctcctt
     3421 ctggatgatt catcccaaag ccttcccacc caggtgttct ctgaaagctt agccttaaga
     3481 gaacacgcag agagtttccc tagatatact cctgcctcca ggtgctggga cacacctttg
     3541 caaaatgctg tgggaagcag gagctgggga gctgtgttaa gtcaaagtag aaaccctcca
     3601 gtgtttggtg ttgtgtagag aataggacat agggtaaaga ggccaagctg cctgtagtta
     3661 gtagagaaga atggatgtgg ttcttcttgt gtatttattt gtatcataaa cacttggaac
     3721 aacaaagacc ataagcatca tttagcagtt gtagccattt tctagttaac tcatgtaaac
     3781 aagtaagagt aacataacag tattaccctt tcactgttct cacaggacat gtacctaatt
     3841 atggtactta tttatgtagt cactgtattt ctggattttt aaattaataa aaaagttaat
     3901 tttgaaaaat ca
//
