LOCUS       NM_001143981            3860 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens chordin like 1 (CHRDL1), transcript variant 1, mRNA.
ACCESSION   NM_001143981
VERSION     NM_001143981.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3860)
  AUTHORS   Huang,S., Zhang,J., Qiao,Y., Pathak,J.L., Zou,R., Piao,Z., Xie,S.,
            Liang,J. and Ouyang,K.
  TITLE     CHRDL1 inhibits OSCC metastasis via MAPK signaling-mediated
            inhibition of MED29
  JOURNAL   Mol Med 30 (1), 187 (2024)
   PUBMED   39462350
  REMARK    GeneRIF: CHRDL1 inhibits OSCC metastasis via MAPK
            signaling-mediated inhibition of MED29.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3860)
  AUTHORS   Han,Y., Xia,L., Wang,X., Xiong,H., Zeng,L., Wang,Z., Zhang,T.,
            Xia,K., Hu,X. and Su,T.
  TITLE     Study on the expression and function of chordin-like 1 in oral
            squamous cell carcinoma
  JOURNAL   Oral Dis 29 (5), 2034-2051 (2023)
   PUBMED   35510812
  REMARK    GeneRIF: Study on the expression and function of chordin-like 1 in
            oral squamous cell carcinoma.
REFERENCE   3  (bases 1 to 3860)
  AUTHORS   Yu,J.W., Pang,R., Liu,B., Zhang,L. and Zhang,J.W.
  TITLE     Bioinformatics identify the role of chordin-like 1 in thyroid
            cancer
  JOURNAL   Medicine (Baltimore) 102 (5), e32778 (2023)
   PUBMED   36749222
  REMARK    GeneRIF: Bioinformatics identify the role of chordin-like 1 in
            thyroid cancer.
REFERENCE   4  (bases 1 to 3860)
  AUTHORS   Pei,Y.F., Zhang,Y.J., Lei,Y., Wu,W.D., Ma,T.H. and Liu,X.Q.
  TITLE     Hypermethylation of the CHRDL1 promoter induces proliferation and
            metastasis by activating Akt and Erk in gastric cancer
  JOURNAL   Oncotarget 8 (14), 23155-23166 (2017)
   PUBMED   28423564
  REMARK    GeneRIF: Finally, in vivo experiments confirmed that CHRDL1 acted
            as a tumor suppressor gene in suppressing tumor growth and
            metastasis
            Erratum:[Oncotarget. 2017 Jul 18;8(29):48526. doi:
            10.18632/oncotarget.19303.. Wu, Ding-Wei [corrected to Wu,
            Wei-ding]. PMID: 28753909]
REFERENCE   5  (bases 1 to 3860)
  AUTHORS   Cyr-Depauw,C., Northey,J.J., Tabaries,S., Annis,M.G., Dong,Z.,
            Cory,S., Hallett,M., Rennhack,J.P., Andrechek,E.R. and Siegel,P.M.
  TITLE     Chordin-Like 1 Suppresses Bone Morphogenetic Protein 4-Induced
            Breast Cancer Cell Migration and Invasion
  JOURNAL   Mol Cell Biol 36 (10), 1509-1525 (2016)
   PUBMED   26976638
  REMARK    GeneRIF: Results show that Chrdl1 expression is upregulated in
            numerous breast cancer cells following TGF-beta stimulation and
            demonstrated that Chrdl1 acts as an inhibitor of BMP4-induced
            migration and invasion.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3860)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3860)
  AUTHORS   Chen,D., Zhao,M. and Mundy,G.R.
  TITLE     Bone morphogenetic proteins
  JOURNAL   Growth Factors 22 (4), 233-241 (2004)
   PUBMED   15621726
  REMARK    Review article
REFERENCE   8  (bases 1 to 3860)
  AUTHORS   Sakuta,H., Suzuki,R., Takahashi,H., Kato,A., Shintani,T.,
            Iemura,Si., Yamamoto,T.S., Ueno,N. and Noda,M.
  TITLE     Ventroptin: a BMP-4 antagonist expressed in a double-gradient
            pattern in the retina
  JOURNAL   Science 293 (5527), 111-115 (2001)
   PUBMED   11441185
  REMARK    GeneRIF: reports the cloning of chick ventroptin and its importance
            in topographic retinotectal projection
REFERENCE   9  (bases 1 to 3860)
  AUTHORS   Coffinier,C., Tran,U., Larrain,J. and De Robertis,E.M.
  TITLE     Neuralin-1 is a novel Chordin-related molecule expressed in the
            mouse neural plate
  JOURNAL   Mech Dev 100 (1), 119-122 (2001)
   PUBMED   11118896
REFERENCE   10 (bases 1 to 3860)
  AUTHORS   Chen,J.D., Mackey,D., Fuller,H., Serravalle,S., Olsson,J. and
            Denton,M.J.
  TITLE     X-linked megalocornea: close linkage to DXS87 and DXS94
  JOURNAL   Hum Genet 83 (3), 292-294 (1989)
   PUBMED   2571565
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL591489.11, AK293106.1 and
            AL049176.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001143981.1.
            
            Summary: This gene encodes an antagonist of bone morphogenetic
            protein 4. The encoded protein may play a role in topographic
            retinotectal projection and in the regulation of retinal
            angiogenesis in response to hypoxia. Alternatively spliced
            transcript variants encoding different isoforms have been
            described. [provided by RefSeq, Jan 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Variants 1 and 5
            both encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.11562.1,
                                           SRR1803611.270634.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372042.6/ ENSP00000361112.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AL591489.11        30708-30719         c
            13-1921             AK293106.1         1-1909
            1922-3860           AL049176.3         28358-30296         c
FEATURES             Location/Qualifiers
     source          1..3860
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq23"
     gene            1..3860
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /note="chordin like 1"
                     /db_xref="GeneID:91851"
                     /db_xref="HGNC:HGNC:29861"
                     /db_xref="MIM:300350"
     exon            1..74
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            75..202
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1485
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; ventroptin; neurogenesin-1; chordin-like
                     protein 1; neuralin-1"
                     /codon_start=1
                     /product="chordin-like protein 1 isoform 1 precursor"
                     /protein_id="NP_001137453.1"
                     /db_xref="CCDS:CCDS48149.1"
                     /db_xref="GeneID:91851"
                     /db_xref="HGNC:HGNC:29861"
                     /db_xref="MIM:300350"
                     /translation="MRKKWKMGGMKYIFSLLFFLLLEGGKTEQVKHSETYCMFQDKKY
                     RVGERWHPYLEPYGLVYCVNCICSENGNVLCSRVRCPNVHCLSPVHIPHLCCPRCPED
                     SLPPVNNKVTSKSCEYNGTTYQHGELFVAEGLFQNRQPNQCTQCSCSEGNVYCGLKTC
                     PKLTCAFPVSVPDSCCRVCRGDGELSWEHSDGDIFRQPANREARHSYHRSHYDPPPSR
                     QAGGLSRFPGARSHRGALMDSQQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHP
                     NLRAFGIVECVLCTCNVTKQECKKIHCPNRYPCKYPQKIDGKCCKVCPGKKAKEELPG
                     QSFDNKGYFCGEETMPVYESVFMEDGETTRKIALETERPPQVEVHVWTIRKGILQHFH
                     IEKISKRMFEELPHFKLVTRTTLSQWKIFTEGEAQISQMCSSRVCRTELEDLVKVLYL
                     ERSEKGHC"
     exon            203..315
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            316..409
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            410..555
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            556..649
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            650..717
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            718..886
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1096
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1264
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1354
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..3860
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3834..3839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /note="hexamer: AATAAA"
     polyA_site      3860
                     /gene="CHRDL1"
                     /gene_synonym="CHL; dA141H5.1; MGC1; MGCN; NRLN1; VOPT"
                     /note="major polyA site"
ORIGIN      
        1 agacctcgga cgagagcgcc ccggggagct cggagcgcgt gcacgcgtgg cagacggaga
       61 aggccagtgc ccagcttgaa ggttctgtca ccttttgcag tggtccaaat gagaaaaaag
      121 tggaaaatgg gaggcatgaa atacatcttt tcgttgttgt tctttctttt gctagaagga
      181 ggcaaaacag agcaagtaaa acattcagag acatattgca tgtttcaaga caagaagtac
      241 agagtgggtg agagatggca tccttacctg gaaccttatg ggttggttta ctgcgtgaac
      301 tgcatctgct cagagaatgg gaatgtgctt tgcagccgag tcagatgtcc aaatgttcat
      361 tgcctttctc ctgtgcatat tcctcatctg tgctgccctc gctgcccaga agactcctta
      421 cccccagtga acaataaggt gaccagcaag tcttgcgagt acaatgggac aacttaccaa
      481 catggagagc tgttcgtagc tgaagggctc tttcagaatc ggcaacccaa tcaatgcacc
      541 cagtgcagct gttcggaggg aaacgtgtat tgtggtctca agacttgccc caaattaacc
      601 tgtgccttcc cagtctctgt tccagattcc tgctgccggg tatgcagagg agatggagaa
      661 ctgtcatggg aacattctga tggtgatatc ttccggcaac ctgccaacag agaagcaaga
      721 cattcttacc accgctctca ctatgatcct ccaccaagcc gacaggctgg aggtctgtcc
      781 cgctttcctg gggccagaag tcaccgggga gctcttatgg attcccagca agcatcagga
      841 accattgtgc aaattgtcat caataacaaa cacaagcatg gacaagtgtg tgtttccaat
      901 ggaaagacct attctcatgg cgagtcctgg cacccaaacc tccgggcatt tggcattgtg
      961 gagtgtgtgc tatgtacttg taatgtcacc aagcaagagt gtaagaaaat ccactgcccc
     1021 aatcgatacc cctgcaagta tcctcaaaaa atagacggaa aatgctgcaa ggtgtgtcca
     1081 ggtaaaaaag caaaagaaga acttccaggc caaagctttg acaataaagg ctacttctgc
     1141 ggggaagaaa cgatgcctgt gtatgagtct gtattcatgg aggatgggga gacaaccaga
     1201 aaaatagcac tggagactga gagaccacct caggtagagg tccacgtttg gactattcga
     1261 aagggcattc tccagcactt ccatattgag aagatctcca agaggatgtt tgaggagctt
     1321 cctcacttca agctggtgac cagaacaacc ctgagccagt ggaagatctt caccgaagga
     1381 gaagctcaga tcagccagat gtgttcaagt cgtgtatgca gaacagagct tgaagattta
     1441 gtcaaggttt tgtacctgga gagatctgaa aagggccact gttaggcaag acagacagta
     1501 ttggataggg taaagcaaga aaactcaagc tgcagctgga ctgcaggctt attttgctta
     1561 agtcaacagt gccctaaaac tccaaactca aatgcagtca attattcacg ccatgcacag
     1621 cataatttgc tcctttgtgt ggagtggtgt gtcagccctt gaacatctcc tccaaagaga
     1681 ctagaagagt cttaaattat atgtgggagg aggagggata gaacatcaca acactgctct
     1741 agtttcttgg agaatcacat ttctttacag gttaaagaca aacaagaccc cagggttttt
     1801 atctagaaag ttattcaagt gaaagaaaga gaagggaatt gcttagtagg agttctgcag
     1861 tatagaacaa ttacttgtat gaaattatac ctttgaattt tagaatgtca tgtgttcttt
     1921 taaaaaaatt agctccccat cctccctcct cactccctcc ctccctcctt ctctctctct
     1981 ctctctctcc ctccctctct cacagacaca cacacacaca cacacacaca cacacacacg
     2041 cacgtccaca ctcacattaa acgaaagctt tatttgaagc aaagctagcc aagattctac
     2101 gttacttttc ccttgactgg atcccaagta gcttggaagt ttttgtgccc aggagagtaa
     2161 ataactgtga acaagaggct ctgcccttag gtctttgtgg ctgtttaagt caccaacaat
     2221 agagtcaggg taaagaataa aaacactttc atagcctcat tcattcactt agaagtggta
     2281 ataatttttc cctaatgata ccacttttct tttccccctg tacctatggg acttccagaa
     2341 agaagttaaa ttgagtaaaa tcatcagaaa ctgaatccat gtaagaaaaa ataattgttg
     2401 aagaaagaag ttgatagaat tcaaaaaggc catctttttg ctttcacatc aataaaattt
     2461 accaagtaat agatcagtac tcactaatat ttttgagacc atagttgtct ggtcagaaaa
     2521 attatattaa attagtaaat tctagaagct ctttaaaagg gaagttttcc ttcttctcca
     2581 attataggag ttgattttta ctttgcaaag tggctcggtc ctcatgagca tctgcatgtt
     2641 gactcttcag ttaagaaaat tgttgttcat ttagggaggt ggatattctg atgaagatct
     2701 ttatcctaaa ccttcctact atccttgtct tattcatcaa gcagatattt tagtcaagaa
     2761 ttccagagaa ggctgctcct aaaatgtcta cttgcagccc aataccagag cataaactat
     2821 ccattctggg gtctggcttt agaaatcatc tttgtgggaa gacctaattc ttcacagcaa
     2881 ggatctcagg catgccttct agatttgttc cctctgaggg gcaggaatga actgtagaaa
     2941 tgttttaagg acccagaaac cccatatgtc tcattccatg actataggtg agagaattct
     3001 ttcctaagag ggtttgatac caatagggga aaatgtaaaa tgttcagtct ttatgacaac
     3061 ctggcataaa ggagtcaatt cttatgaaag agacacaagg gccttatggc cagggtttct
     3121 tgggacaaga ctctcaccag cacatcacac acgttctcct tggaagagag aagcagtaca
     3181 tcccggttga gaggtcacaa agcattagtt tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     3241 tgtgtgtgtg tgtgtgtggt aaagggggga aggtgttatg cggctgctcc ctccgtccca
     3301 gaggtggcag tgattccata atgtggagac tagtaactag atcctaaggc aaagaggtgt
     3361 ttctccttct ggatgattca tcccaaagcc ttcccaccca ggtgttctct gaaagcttag
     3421 ccttaagaga acacgcagag agtttcccta gatatactcc tgcctccagg tgctgggaca
     3481 cacctttgca aaatgctgtg ggaagcagga gctggggagc tgtgttaagt caaagtagaa
     3541 accctccagt gtttggtgtt gtgtagagaa taggacatag ggtaaagagg ccaagctgcc
     3601 tgtagttagt agagaagaat ggatgtggtt cttcttgtgt atttatttgt atcataaaca
     3661 cttggaacaa caaagaccat aagcatcatt tagcagttgt agccattttc tagttaactc
     3721 atgtaaacaa gtaagagtaa cataacagta ttaccctttc actgttctca caggacatgt
     3781 acctaattat ggtacttatt tatgtagtca ctgtatttct ggatttttaa attaataaaa
     3841 aagttaattt tgaaaaatca
//
