LOCUS       NM_017444               2481 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens chromatin accessibility complex subunit 1 (CHRAC1),
            transcript variant 1, mRNA.
ACCESSION   NM_017444
VERSION     NM_017444.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2481)
  AUTHORS   Li,S., Wang,L., Shi,J., Chen,Y., Xiao,A., Huo,B., Tian,W.,
            Zhang,S., Yang,G., Gong,W. and Zhang,H.
  TITLE     Chromatin accessibility complex subunit 1 enhances tumor growth by
            regulating the oncogenic transcription of YAP in breast and
            cervical cancer
  JOURNAL   PeerJ 12, e16752 (2024)
   PUBMED   38223760
  REMARK    GeneRIF: Chromatin accessibility complex subunit 1 enhances tumor
            growth by regulating the oncogenic transcription of YAP in breast
            and cervical cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2481)
  AUTHORS   Wang,M., Li,S., Guo,W., Wang,L., Huang,J., Zhuo,J., Lai,B.,
            Liao,C., Ge,T., Nie,Y., Jin,S., Wang,M., Zhang,Y., Liu,Y., Li,X.
            and Zhang,H.
  TITLE     CHRAC1 promotes human lung cancer growth through regulating YAP
            transcriptional activity
  JOURNAL   Carcinogenesis 43 (3), 264-276 (2022)
   PUBMED   34718437
  REMARK    GeneRIF: CHRAC1 promotes human lung cancer growth through
            regulating YAP transcriptional activity.
REFERENCE   3  (bases 1 to 2481)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2481)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2481)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2481)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   7  (bases 1 to 2481)
  AUTHORS   Kukimoto,I., Elderkin,S., Grimaldi,M., Oelgeschlager,T. and
            Varga-Weisz,P.D.
  TITLE     The histone-fold protein complex CHRAC-15/17 enhances nucleosome
            sliding and assembly mediated by ACF
  JOURNAL   Mol Cell 13 (2), 265-277 (2004)
   PUBMED   14759371
REFERENCE   8  (bases 1 to 2481)
  AUTHORS   Collins,N., Poot,R.A., Kukimoto,I., Garcia-Jimenez,C., Dellaire,G.
            and Varga-Weisz,P.D.
  TITLE     An ACF1-ISWI chromatin-remodeling complex is required for DNA
            replication through heterochromatin
  JOURNAL   Nat Genet 32 (4), 627-632 (2002)
   PUBMED   12434153
REFERENCE   9  (bases 1 to 2481)
  AUTHORS   Bolognese,F., Imbriano,C., Caretti,G. and Mantovani,R.
  TITLE     Cloning and characterization of the histone-fold proteins YBL1 and
            YCL1
  JOURNAL   Nucleic Acids Res 28 (19), 3830-3838 (2000)
   PUBMED   11000277
REFERENCE   10 (bases 1 to 2481)
  AUTHORS   Poot,R.A., Dellaire,G., Hulsmann,B.B., Grimaldi,M.A., Corona,D.F.,
            Becker,P.B., Bickmore,W.A. and Varga-Weisz,P.D.
  TITLE     HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1
            and two novel histone-fold proteins
  JOURNAL   EMBO J 19 (13), 3377-3387 (2000)
   PUBMED   10880450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK023537.1 and AC107375.5.
            
            On Nov 23, 2018 this sequence version replaced NM_017444.5.
            
            Summary: CHRAC1 is a histone-fold protein that interacts with other
            histone-fold proteins to bind DNA in a sequence-independent manner.
            These histone-fold protein dimers combine within larger enzymatic
            complexes for DNA transcription, replication, and
            packaging.[supplied by OMIM, Apr 2004].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK023537.1, SRR1803616.80491.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000220913.10/ ENSP00000220913.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-692               AK023537.1         18-709
            693-2481            AC107375.5         51912-53700         c
FEATURES             Location/Qualifiers
     source          1..2481
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..2481
                     /gene="CHRAC1"
                     /gene_synonym="CHARC1; CHARC15; CHRAC-1; CHRAC-15;
                     CHRAC15; YCL1"
                     /note="chromatin accessibility complex subunit 1"
                     /db_xref="GeneID:54108"
                     /db_xref="HGNC:HGNC:13544"
                     /db_xref="MIM:607268"
     exon            1..325
                     /gene="CHRAC1"
                     /gene_synonym="CHARC1; CHARC15; CHRAC-1; CHRAC-15;
                     CHRAC15; YCL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..574
                     /gene="CHRAC1"
                     /gene_synonym="CHARC1; CHARC15; CHRAC-1; CHRAC-15;
                     CHRAC15; YCL1"
                     /note="histone-fold protein CHRAC15; DNA polymerase
                     epsilon subunit p15; chromatin accessibility complex 15
                     kDa protein"
                     /codon_start=1
                     /product="chromatin accessibility complex protein 1"
                     /protein_id="NP_059140.1"
                     /db_xref="CCDS:CCDS6379.1"
                     /db_xref="GeneID:54108"
                     /db_xref="HGNC:HGNC:13544"
                     /db_xref="MIM:607268"
                     /translation="MADVVVGKDKGGEQRLISLPLSRIRVIMKSSPEVSSINQEALVL
                     TAKATELFVQCLATYSYRHGSGKEKKVLTYSDLANTAQQSETFQFLADILPKKILASK
                     YLKMLKEEKREEDEENDNDNESDHDEADS"
     exon            326..452
                     /gene="CHRAC1"
                     /gene_synonym="CHARC1; CHARC15; CHRAC-1; CHRAC-15;
                     CHRAC15; YCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..2481
                     /gene="CHRAC1"
                     /gene_synonym="CHARC1; CHARC15; CHRAC-1; CHRAC-15;
                     CHRAC15; YCL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2007..2012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHRAC1"
                     /gene_synonym="CHARC1; CHARC15; CHRAC-1; CHRAC-15;
                     CHRAC15; YCL1"
                     /note="hexamer: AATAAA"
     polyA_site      2027
                     /gene="CHRAC1"
                     /gene_synonym="CHARC1; CHARC15; CHRAC-1; CHRAC-15;
                     CHRAC15; YCL1"
                     /note="major polyA site"
     regulatory      2454..2459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHRAC1"
                     /gene_synonym="CHARC1; CHARC15; CHRAC-1; CHRAC-15;
                     CHRAC15; YCL1"
                     /note="hexamer: ATTAAA"
     polyA_site      2481
                     /gene="CHRAC1"
                     /gene_synonym="CHARC1; CHARC15; CHRAC-1; CHRAC-15;
                     CHRAC15; YCL1"
ORIGIN      
        1 ctcacggagc tcgtagtttc ccggacgggc cgctcccggc ctcgcggcct cgcctcccca
       61 cactacaact cccacggggc agcgggcgcg gctccccgta cccaccagct ggccgggcag
      121 ggcagccact tcgcggtcgg gcccgccggc tgcgggcacc cgcgcgacgg gcgggaagat
      181 ggcggacgtg gtcgtgggta aagacaaggg cggggagcag cggctcatct cgctgcctct
      241 atcccgcatc cgggtcatca tgaagagctc ccccgaggtg tccagcatca accaggaggc
      301 gttggtgctc acggccaagg ccacggagct ctttgttcaa tgcctagcca cctattccta
      361 cagacacggc agtggaaagg aaaagaaagt actgacttac agtgatttag caaacactgc
      421 acagcaatca gaaacttttc agtttcttgc agatatatta ccaaagaaga ttttagctag
      481 taaatacctg aaaatgctta aagaggaaaa gagggaagaa gatgaggaga atgacaatga
      541 taatgaaagt gaccatgatg aagctgactc ctaaaccaaa agtgctttaa aaaccagcct
      601 ggcgaggaca gccctggacc cactccactg tctctaagta aacacagcac tgcccgcttt
      661 tagcgtcttc acttcttcac agagttccag tgtgtggtat tctttcgagg tattctttcc
      721 aggccgagat tgagcacctc atgtacctac gccacagaca gccagaggga aagcgaccca
      781 gacagcagcc cctcctcgac aggcccaccc tgcagctcag gcaccaagaa aacagccgat
      841 actggcagcc attgcagctc caaactgcag aggcaaggcc aattttaact tttcaattta
      901 cagtcgattt tgaagagctt ctacatatcg gttatgtaaa ttcatatatg tatattttgg
      961 aatcagttct tataaacagc tcgattcagt tttagctaaa tttatagttt aggtagtatg
     1021 ttacatttga atttttgtct taagaaaagt tgactgttca gatatttttc tactgtaaag
     1081 aaatatactt ttctattaaa gatctgtaca tatttttaca gtaaaatgct ttatggaact
     1141 agttttagag ccctctatgg ctttaaggcc ttgcttactg cctgcaaatt ttgagaaatt
     1201 taaaaataag cattctaaca cttttattcc cacagaaaaa ttccaagtca aattatcaaa
     1261 tcaaatacaa aaataagtct tacctcttgt ataagcatgt tgtactaaaa aaaaattttg
     1321 aaacattttg tatattggag atctctctca tcttactgtt ctttgcttta aattcctggc
     1381 acttcttttt actgtctata agagaaaacc tatcataagc ccaatttttt ttttccactt
     1441 agggtaaatg tttggctcct ctcatttcat tatctttttt tttttttttt taaagacaga
     1501 ttctcactca gttgcccagg ctggattgcg gtggcgctgt ctcagctcac tgcaacctcc
     1561 gcctcccagg ttcaagtgat tctcctgcct catcctcctg agtagctggg attacaggcg
     1621 tgtgccacca tgcccaacct atttttgtat tttttagtag agacggggtt caccatgttg
     1681 gccaggcttg tctcaaactc ctaacctcaa ctgatccacc tgcctcagcc tcccaaagtg
     1741 ccgccgggat tacaggcgtg agccaccatg cctggccttc attatctctt ttttaaaaat
     1801 gaaaaagttt ataatttaca ttcagtaaaa tcaccctttt tagtgtctag tctgtgaatt
     1861 ttgacaaatg catggttttg taaccaatcg ataggacagt tctgccaccc aggacattcc
     1921 cctctgttcc tctgttcctc tcttctcctg ccccctagca accactggtg ttttctgtcc
     1981 ctcttgttca ttgacattta ttttaaaata aaatatttta aaatctactt tttggtgtac
     2041 agttctgagt tttggcaaat gcagtcaagt cactaccacc accacaatta acagctatat
     2101 caccctccag taaattccct gtggtcagct ccttccccac cttttaccgt ggcaaccgtc
     2161 aagctattct ctgtccctat accaggtgtc atcaaatttt tttctggaaa gggccatgca
     2221 gtaaatagtt caagctttgt gggcttttat agtctctgtt gctgctgctg aactcagctg
     2281 ttgtagcacg aaagcagcca ggtaattact agatgaagga atgcaggtgg ctgtgtttca
     2341 atagagcttt atttctgcaa actgaaactt gagttttgtg taattttcat gtgtcatgaa
     2401 atactgtttt ctccaaccat ttaataatgt aaatacttgc tagcttatgt gccattaaaa
     2461 aatgacttga tttggcttac a
//
