LOCUS       NM_022097               1967 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens calcineurin like EF-hand protein 2 (CHP2), mRNA.
ACCESSION   NM_022097
VERSION     NM_022097.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1967)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1967)
  AUTHORS   Xu,L., Qin,Y., Sun,B., Wang,H., Gu,J., Tang,Z., Zhang,W. and
            Feng,J.
  TITLE     Involvement of CHP2 in the Development of Non-Small Cell Lung
            Cancer and Patients' Poor Prognosis
  JOURNAL   Appl Immunohistochem Mol Morphol 28 (9), 678-686 (2020)
   PUBMED   33030853
  REMARK    GeneRIF: Involvement of CHP2 in the Development of Non-Small Cell
            Lung Cancer and Patients' Poor Prognosis.
REFERENCE   3  (bases 1 to 1967)
  AUTHORS   Cottle,W.T., Wallert,C.H., Anderson,K.K., Tran,M.F., Bakker,C.L.,
            Wallert,M.A. and Provost,J.J.
  TITLE     Calcineurin homologous protein isoform 2 supports tumor survival
            via the sodium hydrogen exchanger isoform 1 in non-small cell lung
            cancer
  JOURNAL   Tumour Biol 42 (7), 1010428320937863 (2020)
   PUBMED   32686600
  REMARK    GeneRIF: the data support the tumor-promoting potential of aberrant
            calcineurin B homologous protein 2 expression and position
            calcineurin B homologous protein 2 as a potential therapeutic
            target for the treatment of non-small cell lung cancer.
REFERENCE   4  (bases 1 to 1967)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1967)
  AUTHORS   Liang,S., Fuchs,S., Mymrikov,E.V., Stulz,A., Kaiser,M.,
            Heerklotz,H. and Hunte,C.
  TITLE     Calcium affects CHP1 and CHP2 conformation and their interaction
            with sodium/proton exchanger 1
  JOURNAL   FASEB J 34 (2), 3253-3266 (2020)
   PUBMED   31912575
REFERENCE   6  (bases 1 to 1967)
  AUTHORS   Inoue,H., Nakamura,Y., Nagita,M., Takai,T., Masuda,M., Nakamura,N.
            and Kanazawa,H.
  TITLE     Calcineurin homologous protein isoform 2 (CHP2), Na+/H+
            exchangers-binding protein, is expressed in intestinal epithelium
  JOURNAL   Biol Pharm Bull 26 (2), 148-155 (2003)
   PUBMED   12576672
REFERENCE   7  (bases 1 to 1967)
  AUTHORS   Pang,T., Wakabayashi,S. and Shigekawa,M.
  TITLE     Expression of calcineurin B homologous protein 2 protects serum
            deprivation-induced cell death by serum-independent activation of
            Na+/H+ exchanger
  JOURNAL   J Biol Chem 277 (46), 43771-43777 (2002)
   PUBMED   12226101
REFERENCE   8  (bases 1 to 1967)
  AUTHORS   Wang,Y., Han,K.J., Pang,X.W., Vaughan,H.A., Qu,W., Dong,X.Y.,
            Peng,J.R., Zhao,H.T., Rui,J.A., Leng,X.S., Cebon,J., Burgess,A.W.
            and Chen,W.F.
  TITLE     Large scale identification of human hepatocellular
            carcinoma-associated antigens by autoantibodies
  JOURNAL   J Immunol 169 (2), 1102-1109 (2002)
   PUBMED   12097419
REFERENCE   9  (bases 1 to 1967)
  AUTHORS   Loftus,B.J., Kim,U.J., Sneddon,V.P., Kalush,F., Brandon,R.,
            Fuhrmann,J., Mason,T., Crosby,M.L., Barnstead,M., Cronin,L.,
            Deslattes Mays,A., Cao,Y., Xu,R.X., Kang,H.L., Mitchell,S.,
            Eichler,E.E., Harris,P.C., Venter,J.C. and Adams,M.D.
  TITLE     Genome duplications and other features in 12 Mb of DNA sequence
            from human chromosome 16p and 16q
  JOURNAL   Genomics 60 (3), 295-308 (1999)
   PUBMED   10493829
REFERENCE   10 (bases 1 to 1967)
  AUTHORS   Lin,X. and Barber,D.L.
  TITLE     A calcineurin homologous protein inhibits GTPase-stimulated Na-H
            exchange
  JOURNAL   Proc Natl Acad Sci U S A 93 (22), 12631-12636 (1996)
   PUBMED   8901634
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF146019.1 and BF197519.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022097.3.
            
            Summary: This gene product is a small calcium-binding protein that
            regulates cell pH by controlling plasma membrane-type Na+/H+
            exchange activity. This protein shares sequence similarity with
            calcineurin B and can bind to and stimulate the protein phosphatase
            activity of calcineurin A (CnA) and functions in the
            calcineurin/NFAT (nuclear factor of activated T cells) signaling
            pathway. Another member of the CHP subfamily, Calcineurin B
            homologous protein 1, is located on Chromosome 15 and is an
            inhibitor of calcineurin activity and has a genetic phenotype
            associated with Parkinson's Disease (OMIM:606988). This gene was
            initially identified as a tumor-associated antigen and was
            previously referred to as Hepatocellular carcinoma-associated
            antigen 520. [provided by RefSeq, Jul 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF146019.1, SRR1803612.214828.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300113.3/ ENSP00000300113.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1668              AF146019.1         405-2072
            1669-1967           BF197519.1         24-322              c
FEATURES             Location/Qualifiers
     source          1..1967
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.2"
     gene            1..1967
                     /gene="CHP2"
                     /note="calcineurin like EF-hand protein 2"
                     /db_xref="GeneID:63928"
                     /db_xref="HGNC:HGNC:24927"
     exon            1..91
                     /gene="CHP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..615
                     /gene="CHP2"
                     /note="hepatocellular carcinoma antigen gene 520;
                     hepatocellular carcinoma-associated antigen 520"
                     /codon_start=1
                     /product="calcineurin B homologous protein 2"
                     /protein_id="NP_071380.1"
                     /db_xref="CCDS:CCDS10617.1"
                     /db_xref="GeneID:63928"
                     /db_xref="HGNC:HGNC:24927"
                     /translation="MGSRSSHAAVIPDGDSIRRETGFSQASLLRLHHRFRALDRNKKG
                     YLSRMDLQQIGALAVNPLGDRIIESFFPDGSQRVDFPGFVRVLAHFRPVEDEDTETQD
                     PKKPEPLNSRRNKLHYAFQLYDLDRDGKISRHEMLQVLRLMVGVQVTEEQLENIADRT
                     VQEADEDGDGAVSFVEFTKSLEKMDVEQKMSIRILK"
     exon            92..164
                     /gene="CHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            165..245
                     /gene="CHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            246..376
                     /gene="CHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            377..438
                     /gene="CHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            439..561
                     /gene="CHP2"
                     /inference="alignment:Splign:2.1.0"
     exon            562..1967
                     /gene="CHP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1948..1953
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHP2"
                     /note="hexamer: AATAAA"
     polyA_site      1967
                     /gene="CHP2"
                     /note="major polyA site"
ORIGIN      
        1 ggcccttccg cctccagctc ggccatgggg tcgcgcagct cccacgccgc ggtcattccc
       61 gacggggaca gtattcggcg agagaccggc ttctcccaag ccagcctgct ccgcctgcac
      121 caccggttcc gggcactgga caggaataag aagggctacc tgagccgcat ggatctccag
      181 cagatagggg cgctcgccgt gaaccccctg ggagaccgaa ttatagaaag cttcttcccc
      241 gatgggagcc agcgagtgga tttcccaggc tttgtcaggg tcttggctca ttttcgccct
      301 gtagaagatg aggacacaga aacccaagac cccaagaaac ctgaacctct caacagcaga
      361 aggaacaaac ttcactatgc atttcagctc tatgacctgg atcgcgatgg gaagatctcc
      421 aggcatgaga tgctgcaggt tctccgtctg atggttgggg tacaggtgac agaagagcag
      481 ctggagaaca tcgctgaccg cacggtgcag gaggctgatg aagatgggga tggggctgtg
      541 tccttcgtgg agttcaccaa gtccttagag aagatggacg ttgagcaaaa aatgagcatc
      601 cggatcctga agtgactccg tttgtgcctt gggcttgctc ctgcaaccag tatctccttg
      661 gaattcatcc aaagccccca tggacgcatg gacgcagggc gacaataaac tgtattttcg
      721 tttctaactc tatttagggc caagagaaga aagctggaag gatgtgtact aaagtctagc
      781 tcagcagtcc ccaacctttt tggcatcagg gacagttttt ccacggatgg gtgacagggg
      841 atggttttgg gatgattcaa gtgcattaca tttattgtgc actttatttc tattatgatt
      901 acattgtaat atataatgaa ataattatac aactcaccat aatgtagaat cagcaggagc
      961 cctgagcttg ttttcctgca attagacggt cccatatggg agtgatggga gacagtgaca
     1021 gatcatcagg cattagattc tcataaggag tgcacaatct agatcctttg gtgtgcagtt
     1081 cacagtagga tttgggctcc tatgataatc taatgccact gctgatctga caggaggcag
     1141 agctcaggcg gtaatgcaag caatggggag tggctgtaaa tatagatgaa gcttcagctc
     1201 gcctgccgct caccttgtgc tgtgcagccc ggttcctaac agaccacaga ccccacacca
     1261 ggtctatctc atttggtctc agagctgtga atcagccagc aatattttag ttgcaaatca
     1321 ctgaaaaccc aactcaaagt gacttaagtc agaaagaaat tttatgaatt caggtaatta
     1381 aaaagtccag aagtatctgc ctttaggcac agctggatcc aagggcacaa atgatgtcat
     1441 caggctccag ttattctcca tctcccagct cagctttttc tgtctgtaag cctgattttc
     1501 aggaaggctc tttcctagtg atggagatga ccaccatcag ctccaggctt ctatcctgct
     1561 aacccagtaa cccagtggga agagatttac ttattccaat aattccaagt ggagagtgtc
     1621 attgacccgt ttggggtctc atctctactt ctaggggaat gaaacactct gagtggccag
     1681 gcctgtgtca tgtgctaatt cctagagcca gggaaataag gtctgaggat tcaggatggg
     1741 gtgaaaggtg gttgcttaaa ggaaaatgaa atacaattag cagaataagg ggaaacgagt
     1801 ggtctgctct gctcgggcaa aacaagagat gcccattact gtgagggacc cttgaagtct
     1861 ggactcttaa atgggttttt gctgatttcc tgggtgcatg ctaggatgat ggggcttgat
     1921 gcagtaggga agagacgatg taaaaataat aaacaatata taccttc
//
