LOCUS       NM_007236               3201 bp    mRNA    linear   PRI 19-MAR-2024
DEFINITION  Homo sapiens calcineurin like EF-hand protein 1 (CHP1), mRNA.
ACCESSION   NM_007236
VERSION     NM_007236.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3201)
  AUTHORS   Minoia,M., Quintana-Cordero,J., Jetzinger,K., Kotan,I.E.,
            Turnbull,K.J., Ciccarelli,M., Masser,A.E., Liebers,D., Gouarin,E.,
            Czech,M., Hauryliuk,V., Bukau,B., Kramer,G. and Andreasson,C.
  TITLE     Chp1 is a dedicated chaperone at the ribosome that safeguards eEF1A
            biogenesis
  JOURNAL   Nat Commun 15 (1), 1382 (2024)
   PUBMED   38360885
  REMARK    GeneRIF: Chp1 is a dedicated chaperone at the ribosome that
            safeguards eEF1A biogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3201)
  AUTHORS   Dong,Y., Li,H., Ilie,A., Gao,Y., Boucher,A., Zhang,X.C.,
            Orlowski,J. and Zhao,Y.
  TITLE     Structural basis of autoinhibition of the human NHE3-CHP1 complex
  JOURNAL   Sci Adv 8 (21), eabn3925 (2022)
   PUBMED   35613257
REFERENCE   3  (bases 1 to 3201)
  AUTHORS   Dong,Y., Gao,Y., Ilie,A., Kim,D., Boucher,A., Li,B., Zhang,X.C.,
            Orlowski,J. and Zhao,Y.
  TITLE     Structure and mechanism of the human NHE1-CHP1 complex
  JOURNAL   Nat Commun 12 (1), 3474 (2021)
   PUBMED   34108458
  REMARK    GeneRIF: Structure and mechanism of the human NHE1-CHP1 complex.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3201)
  AUTHORS   Saito,R., Hara,N., Tada,M., Honma,Y., Miyashita,A., Onodera,O.,
            Ikeuchi,T. and Kakita,A.
  TITLE     Novel CHP1 mutation in autosomal-recessive cerebellar ataxia:
            autopsy features of two siblings
  JOURNAL   Acta Neuropathol Commun 8 (1), 134 (2020)
   PUBMED   32787936
  REMARK    GeneRIF: Novel CHP1 mutation in autosomal-recessive cerebellar
            ataxia: autopsy features of two siblings.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3201)
  AUTHORS   Liang,S., Fuchs,S., Mymrikov,E.V., Stulz,A., Kaiser,M.,
            Heerklotz,H. and Hunte,C.
  TITLE     Calcium affects CHP1 and CHP2 conformation and their interaction
            with sodium/proton exchanger 1
  JOURNAL   FASEB J 34 (2), 3253-3266 (2020)
   PUBMED   31912575
REFERENCE   6  (bases 1 to 3201)
  AUTHORS   Pang,T., Su,X., Wakabayashi,S. and Shigekawa,M.
  TITLE     Calcineurin homologous protein as an essential cofactor for Na+/H+
            exchangers
  JOURNAL   J Biol Chem 276 (20), 17367-17372 (2001)
   PUBMED   11350981
REFERENCE   7  (bases 1 to 3201)
  AUTHORS   Lin,X., Sikkink,R.A., Rusnak,F. and Barber,D.L.
  TITLE     Inhibition of calcineurin phosphatase activity by a calcineurin B
            homologous protein
  JOURNAL   J Biol Chem 274 (51), 36125-36131 (1999)
   PUBMED   10593895
REFERENCE   8  (bases 1 to 3201)
  AUTHORS   Lin,X. and Barber,D.L.
  TITLE     A calcineurin homologous protein inhibits GTPase-stimulated Na-H
            exchange
  JOURNAL   Proc Natl Acad Sci U S A 93 (22), 12631-12636 (1996)
   PUBMED   8901634
REFERENCE   9  (bases 1 to 3201)
  AUTHORS   Barroso,M.R., Bernd,K.K., DeWitt,N.D., Chang,A., Mills,K. and
            Sztul,E.S.
  TITLE     A novel Ca2+-binding protein, p22, is required for constitutive
            membrane traffic
  JOURNAL   J Biol Chem 271 (17), 10183-10187 (1996)
   PUBMED   8626580
REFERENCE   10 (bases 1 to 3201)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012652.7.
            
            On Nov 22, 2018 this sequence version replaced NM_007236.4.
            
            Summary: This gene encodes a phosphoprotein that binds to the
            Na+/H+ exchanger NHE1. This protein serves as an essential cofactor
            which supports the physiological activity of NHE family members and
            may play a role in the mitogenic regulation of NHE1. The protein
            shares similarity with calcineurin B and calmodulin and it is also
            known to be an endogenous inhibitor of calcineurin activity.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.250687.1,
                                           SRR1803615.154487.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334660.10/ ENSP00000335632.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AC012652.7         69989-70170
            183-255             AC012652.7         82388-82460
            256-336             AC012652.7         95631-95711
            337-464             AC012652.7         101477-101604
            465-526             AC012652.7         109278-109339
            527-649             AC012652.7         117488-117610
            650-3201            AC012652.7         118057-120608
FEATURES             Location/Qualifiers
     source          1..3201
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..3201
                     /gene="CHP1"
                     /gene_synonym="CHP; p22; p24; Sid470p; SLC9A1BP; SPAX9"
                     /note="calcineurin like EF-hand protein 1"
                     /db_xref="GeneID:11261"
                     /db_xref="HGNC:HGNC:17433"
                     /db_xref="MIM:606988"
     exon            1..182
                     /gene="CHP1"
                     /gene_synonym="CHP; p22; p24; Sid470p; SLC9A1BP; SPAX9"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..703
                     /gene="CHP1"
                     /gene_synonym="CHP; p22; p24; Sid470p; SLC9A1BP; SPAX9"
                     /note="SLC9A1 binding protein; calcineurin homologous
                     protein; calcineurin B homolog; calcium-binding protein
                     p22; calcium-binding protein CHP; calcium binding protein
                     P22; calcineurin B-like protein; EF-hand calcium-binding
                     domain-containing protein p22"
                     /codon_start=1
                     /product="calcineurin B homologous protein 1"
                     /protein_id="NP_009167.1"
                     /db_xref="CCDS:CCDS10073.1"
                     /db_xref="GeneID:11261"
                     /db_xref="HGNC:HGNC:17433"
                     /db_xref="MIM:606988"
                     /translation="MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENG
                     TLSREDFQRIPELAINPLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDV
                     NGPEPLNSRSNKLHFAFRLYDLDKDEKISRDELLQVLRMMVGVNISDEQLGSIADRTI
                     QEADQDGDSAISFTEFVKVLEKVDVEQKMSIRFLH"
     exon            183..255
                     /gene="CHP1"
                     /gene_synonym="CHP; p22; p24; Sid470p; SLC9A1BP; SPAX9"
                     /inference="alignment:Splign:2.1.0"
     exon            256..336
                     /gene="CHP1"
                     /gene_synonym="CHP; p22; p24; Sid470p; SLC9A1BP; SPAX9"
                     /inference="alignment:Splign:2.1.0"
     exon            337..464
                     /gene="CHP1"
                     /gene_synonym="CHP; p22; p24; Sid470p; SLC9A1BP; SPAX9"
                     /inference="alignment:Splign:2.1.0"
     exon            465..526
                     /gene="CHP1"
                     /gene_synonym="CHP; p22; p24; Sid470p; SLC9A1BP; SPAX9"
                     /inference="alignment:Splign:2.1.0"
     exon            527..649
                     /gene="CHP1"
                     /gene_synonym="CHP; p22; p24; Sid470p; SLC9A1BP; SPAX9"
                     /inference="alignment:Splign:2.1.0"
     exon            650..3201
                     /gene="CHP1"
                     /gene_synonym="CHP; p22; p24; Sid470p; SLC9A1BP; SPAX9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3176..3181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHP1"
                     /gene_synonym="CHP; p22; p24; Sid470p; SLC9A1BP; SPAX9"
                     /note="hexamer: AATAAA"
     polyA_site      3201
                     /gene="CHP1"
                     /gene_synonym="CHP; p22; p24; Sid470p; SLC9A1BP; SPAX9"
                     /note="major polyA site"
ORIGIN      
        1 agtggaaaca ctgccctctc ccttcttgac ccctagccct tccttccctc cctccttccc
       61 tcctgtcgcc gtctcttctg gcgccgctgc tcccggagga gctcccggca cggcgatggg
      121 ttctcgggcc tccacgttac tgcgggacga agagctcgag gagatcaaga aggagaccgg
      181 cttttcccac agtcaaatca ctcgcctcta cagccggttc accagcctgg acaaaggaga
      241 gaatgggact ctcagccggg aagatttcca gaggattcca gaacttgcca tcaacccact
      301 gggggaccgg atcatcaatg ccttctttcc agagggagag gaccaggtaa acttccgtgg
      361 attcatgcga actttggctc atttccgccc cattgaggat aatgaaaaga gcaaagatgt
      421 gaatggaccc gaaccactca acagccgaag caacaaactg cactttgctt ttcgactata
      481 tgatttggat aaagatgaaa agatctcccg tgatgagctg ttacaggtgc tacgcatgat
      541 ggtcggagta aatatctcag atgagcagct gggcagcatc gcagacagga ccattcagga
      601 ggctgatcag gatggggaca gtgccatatc tttcacagaa tttgttaagg ttttggagaa
      661 ggtggatgta gaacagaaaa tgagcatccg atttcttcac taaaggagac caaactgttc
      721 cttgcggtct agtatttaag aactggaact tgaaagtcct ccttctacca actccacctc
      781 caccccctca ttccccttct cccaaagtac tactgctgtt gcatgacaac cccaaatatg
      841 ttctgtcaac acaaacctgc ctttggtgta taaacagggc attacagaat ggtacaccct
      901 atatatttct gttcagtatc cattcactag ttcttcattt ataaatatca tcttccccat
      961 tctgctgctg aatgccacac atccatccag tctgagaaag tgagagaggc aatcatgcca
     1021 agaacaagcc agcaaagctc tttcaccaga tgtagactgt agccctgctg ccttccctcc
     1081 agcgagtctg ccagcatgct tcttcatcct ttttatatgt tctttgcttc ctacttccct
     1141 gtcttccaac atactgttca cttactctgg cagtctttct gcttttcatt aagcctcaaa
     1201 atctcctctg ttctacttgg caccacaagc tatgtcctat atatgtattt ctgacttggc
     1261 aggatagttc aggggtctgg cagtttttat ttaccttcat tattaaatgg gcctctggga
     1321 tgttgcctct tcaggagctt tttggtaatc aatacttctc tcagaagtat gagaccatcc
     1381 tctgcactct gctctgtcat caaaggctgc tgggtggaga tacccttttt gaaaggtggc
     1441 cttggtgaga ggtatggagc caagtcttct aggttgcttg cccacatcac tctatctctg
     1501 gcctctgatt ctcaactttg tacctgtgtg gctcctcttg ttagtgcaat gttgactgtt
     1561 gaaaaagcag cagtatgctt acaggtttgc ttagtttggg gacaccgtta ccaccagaat
     1621 ggctgctctg acaatatgcc tagggacttt ctcatggctt ttatttaata aggaggctgg
     1681 gcaccctata aagcctcatg cattcacacc tttgcagcat ggtttatgcc tcagtgttat
     1741 gtgcactgga atgttttcca cttcacattt ccaagtagaa atattagtgt tacggaagtg
     1801 cctaatatcc cagtccaaat tttttttttt tttttttttt ttttttgaga cagagtcttg
     1861 ctctgtcacc caggctggag tgcagtggtg cgatcgctca ctgcaacctc agcctcctgg
     1921 atttaagtga ttctcctgcc tcagcctccc aagtagctgg gattacaggt gtgcaccacc
     1981 atgcccggct aattttttgt atttttagtg gagacagggt ttcaccatgt tggccaggct
     2041 ggtctcgaac tcctgacctc gtgatccgcc tgcctcagcc tcccaaagtg ctgggattac
     2101 aggtgtgagc caccacgcct ggccccagtc caaaatattt aaagattgtt tccttagtgt
     2161 cttgaagttt tgcacaaaat tctttttttt gagatggagt ctcactctgt cacccaggct
     2221 ggagtgcagt ggcgtgatct tggctcactg caacctctgc ctcctgggtt caagcaattc
     2281 tcccacctca gcctcccaag tagctgggat tacagacgtg tgccaccata cctgggtaat
     2341 ttttgcattt ttagtggaga gggagtttca ccatgttggc caggttggtc ttgaactcct
     2401 gacctcaggt gatcctcctg cctcggcctc ccaaagtgct gggattacag gcatgagcca
     2461 ccgtgctcag ccgcaaaatt ctttatgaat tttacacttg gcaaatgtta atgacggaag
     2521 ccatagtctg ctcctaatac atgtccaaag cattgactgt tgtgtcatta gctgcctggt
     2581 tacattagct ccctggcttc ttgtttagac cactgctaat cccttaaaaa caagaggtct
     2641 ggcactagta gcacaaccta aggtggcatt acagatcttt gagcgagcca cagcaacttt
     2701 tctgccaagt cagcttagtt tagacttcag tgaatcaggc tattgctatc ctaatgtatg
     2761 tctctatgag tgtatttagc cacacatctg cccttggttg actttctgac tcattgcttg
     2821 cttgcttgtt tccttgcttt ggaaaactat tgaagattgc taaaaaatac cactgcaaag
     2881 tgatggaaaa gggtggagaa caggggagta gccaggctgg atggctcaaa tataaatgaa
     2941 tgaggaattc tttatgaagt atcagtcaga ttttatgatt aagtgatgta atataggaat
     3001 tatgtaaaag ggaagaatgt ctgatactga tctattagag aggtacttta gaggcttctt
     3061 gattggcata aagttcctaa ggttatagat tttcccccct tttggctgta tagcaaagtg
     3121 ttttaatcca cggttgtgcc ttattgttcc attaaaattg tatcttcgat ccatcaataa
     3181 atacttgtgg ttgaaacaaa a
//
