LOCUS       NM_012124               3070 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens cysteine and histidine rich domain containing 1
            (CHORDC1), transcript variant 1, mRNA.
ACCESSION   NM_012124
VERSION     NM_012124.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3070)
  AUTHORS   Poggio,P., Rocca,S., Fusella,F., Ferretti,R., Ala,U., D'Anna,F.,
            Giugliano,E., Panuzzo,C., Fontana,D., Palumbo,V., Carra,G.,
            Taverna,D., Gambacorti-Passerini,C., Saglio,G., Fava,C., Piazza,R.,
            Morotti,A., Orso,F. and Brancaccio,M.
  TITLE     miR-15a targets the HSP90 co-chaperone Morgana in chronic myeloid
            leukemia
  JOURNAL   Sci Rep 14 (1), 15089 (2024)
   PUBMED   38956394
  REMARK    GeneRIF: miR-15a targets the HSP90 co-chaperone Morgana in chronic
            myeloid leukemia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3070)
  AUTHORS   Pichlerova,K., Sinsky,J., Kotasek,M., Majerova,P. and Hanes,J.
  TITLE     CHORDC1, the novel interacting partner of tau protein
  JOURNAL   Gen Physiol Biophys 43 (4), 367-370 (2024)
   PUBMED   38953578
  REMARK    GeneRIF: CHORDC1, the novel interacting partner of tau protein.
REFERENCE   3  (bases 1 to 3070)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3070)
  AUTHORS   Fusella,F., Secli,L., Busso,E., Krepelova,A., Moiso,E., Rocca,S.,
            Conti,L., Annaratone,L., Rubinetto,C., Mello-Grand,M., Singh,V.,
            Chiorino,G., Silengo,L., Altruda,F., Turco,E., Morotti,A.,
            Oliviero,S., Castellano,I., Cavallo,F., Provero,P., Tarone,G. and
            Brancaccio,M.
  TITLE     The IKK/NF-kappaB signaling pathway requires Morgana to drive
            breast cancer metastasis
  JOURNAL   Nat Commun 8 (1), 1636 (2017)
   PUBMED   29158506
  REMARK    GeneRIF: NF-kappaB activation in breast cancer cells depends on the
            presence of the CHORDC1 gene product Morgana.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3070)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   6  (bases 1 to 3070)
  AUTHORS   Ferretti,R., Palumbo,V., Di Savino,A., Velasco,S., Sbroggio,M.,
            Sportoletti,P., Micale,L., Turco,E., Silengo,L., Palumbo,G.,
            Hirsch,E., Teruya-Feldstein,J., Bonaccorsi,S., Pandolfi,P.P.,
            Gatti,M., Tarone,G. and Brancaccio,M.
  TITLE     Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication
            and tumorigenesis
  JOURNAL   Dev Cell 18 (3), 486-495 (2010)
   PUBMED   20230755
REFERENCE   7  (bases 1 to 3070)
  AUTHORS   Gano,J.J. and Simon,J.A.
  TITLE     A proteomic investigation of ligand-dependent HSP90 complexes
            reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein
  JOURNAL   Mol Cell Proteomics 9 (2), 255-270 (2010)
   PUBMED   19875381
  REMARK    GeneRIF: A novel ADP-dependent HSP90 interaction with the cysteine-
            and histidine-rich domain (CHORD)-containing protein CHORDC1, is
            characterized.
REFERENCE   8  (bases 1 to 3070)
  AUTHORS   Wu,J., Luo,S., Jiang,H. and Li,H.
  TITLE     Mammalian CHORD-containing protein 1 is a novel heat shock protein
            90-interacting protein
  JOURNAL   FEBS Lett 579 (2), 421-426 (2005)
   PUBMED   15642353
REFERENCE   9  (bases 1 to 3070)
  AUTHORS   Brancaccio,M., Menini,N., Bongioanni,D., Ferretti,R., De Acetis,M.,
            Silengo,L. and Tarone,G.
  TITLE     Chp-1 and melusin, two CHORD containing proteins in vertebrates
  JOURNAL   FEBS Lett 551 (1-3), 47-52 (2003)
   PUBMED   12965203
REFERENCE   10 (bases 1 to 3070)
  AUTHORS   Shirasu,K., Lahaye,T., Tan,M.W., Zhou,F., Azevedo,C. and
            Schulze-Lefert,P.
  TITLE     A novel class of eukaryotic zinc-binding proteins is required for
            disease resistance signaling in barley and development in C.
            elegans
  JOURNAL   Cell 99 (4), 355-366 (1999)
   PUBMED   10571178
  REMARK    GeneRIF: This paper described the cloning of a barley CHORD
            containing protein, but it also described the CHORD containing
            proteins in other species including human and characterized the
            CHORD domains.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK290231.1, BC072461.1, BC002339.2, CB852298.1 and CK300454.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012124.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.179208.1,
                                           SRR1660807.94729.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320585.11/ ENSP00000319255.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AK290231.1         316-351
            37-2050             BC072461.1         1-2014
            2051-2485           BC002339.2         2014-2448
            2486-3066           CB852298.1         18-598              c
            3067-3070           CK300454.1         16-19               c
FEATURES             Location/Qualifiers
     source          1..3070
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.3"
     gene            1..3070
                     /gene="CHORDC1"
                     /gene_synonym="CHP1"
                     /note="cysteine and histidine rich domain containing 1"
                     /db_xref="GeneID:26973"
                     /db_xref="HGNC:HGNC:14525"
                     /db_xref="MIM:604353"
     exon            1..159
                     /gene="CHORDC1"
                     /gene_synonym="CHP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1094
                     /gene="CHORDC1"
                     /gene_synonym="CHP1"
                     /note="isoform a is encoded by transcript variant 1;
                     cysteine and histidine-rich domain (CHORD)-containing,
                     zinc-binding protein 1; chord domain-containing protein 1;
                     cysteine and histidine-rich domain-containing protein 1;
                     CHP-1; CHORD-containing protein 1; protein morgana;
                     cysteine and histidine-rich domain (CHORD) containing 1"
                     /codon_start=1
                     /product="cysteine and histidine-rich domain-containing
                     protein 1 isoform a"
                     /protein_id="NP_036256.2"
                     /db_xref="CCDS:CCDS8289.1"
                     /db_xref="GeneID:26973"
                     /db_xref="HGNC:HGNC:14525"
                     /db_xref="MIM:604353"
                     /translation="MALLCYNRGCGQRFDPETNSDDACTYHPGVPVFHDALKGWSCCK
                     RRTTDFSDFLSIVGCTKGRHNSEKPPEPVKPEVKTTEKKELCELKPKFQEHIIQAPKP
                     VEAIKRPSPDEPMTNLELKISASLKQALDKLKLSSGNEENKKEEDNDEIKIGTSCKNG
                     GCSKTYQGLESLEEVCVYHSGVPIFHEGMKYWSCCRRKTSDFNTFLAQEGCTKGKHMW
                     TKKDAGKKVVPCRHDWHQTGGEVTISVYAKNSLPELSRVEANSTLLNVHIVFEGEKEF
                     DQNVKLWGVIDVKRSYVTMTATKIEITMRKAEPMQWASLELPAAKKQEKQKDATTD"
     exon            160..209
                     /gene="CHORDC1"
                     /gene_synonym="CHP1"
                     /inference="alignment:Splign:2.1.0"
     exon            210..266
                     /gene="CHORDC1"
                     /gene_synonym="CHP1"
                     /inference="alignment:Splign:2.1.0"
     exon            267..424
                     /gene="CHORDC1"
                     /gene_synonym="CHP1"
                     /inference="alignment:Splign:2.1.0"
     exon            425..528
                     /gene="CHORDC1"
                     /gene_synonym="CHP1"
                     /inference="alignment:Splign:2.1.0"
     exon            529..587
                     /gene="CHORDC1"
                     /gene_synonym="CHP1"
                     /inference="alignment:Splign:2.1.0"
     exon            588..658
                     /gene="CHORDC1"
                     /gene_synonym="CHP1"
                     /inference="alignment:Splign:2.1.0"
     exon            659..764
                     /gene="CHORDC1"
                     /gene_synonym="CHP1"
                     /inference="alignment:Splign:2.1.0"
     exon            765..884
                     /gene="CHORDC1"
                     /gene_synonym="CHP1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..947
                     /gene="CHORDC1"
                     /gene_synonym="CHP1"
                     /inference="alignment:Splign:2.1.0"
     exon            948..3070
                     /gene="CHORDC1"
                     /gene_synonym="CHP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2030..2035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHORDC1"
                     /gene_synonym="CHP1"
                     /note="hexamer: AATAAA"
     polyA_site      2050
                     /gene="CHORDC1"
                     /gene_synonym="CHP1"
                     /note="major polyA site"
     regulatory      2462..2467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHORDC1"
                     /gene_synonym="CHP1"
                     /note="hexamer: AATAAA"
     polyA_site      2485
                     /gene="CHORDC1"
                     /gene_synonym="CHP1"
     regulatory      2676..2681
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHORDC1"
                     /gene_synonym="CHP1"
                     /note="hexamer: ATTAAA"
     polyA_site      2695
                     /gene="CHORDC1"
                     /gene_synonym="CHP1"
     regulatory      3036..3041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHORDC1"
                     /gene_synonym="CHP1"
                     /note="hexamer: AATAAA"
     polyA_site      3070
                     /gene="CHORDC1"
                     /gene_synonym="CHP1"
ORIGIN      
        1 agtcgtcaga ccggtgctag cgacacggga gtggcaaacg catcctcttg ccgttcccgg
       61 tgtttgggcc ttgcctgtga cggtgggaaa agaaaatggc cttgctgtgc tacaaccggg
      121 gctgcggtca gcgcttcgat cctgagacca attccgacga tgcttgcaca taccacccag
      181 gtgttccggt ctttcacgat gcattaaagg gttggtcttg ctgtaagaga agaacaactg
      241 atttttctga tttcttaagc attgtaggct gtacaaaagg tagacataat agtgagaagc
      301 cacctgagcc agtcaaacct gaagtcaaga ctactgagaa gaaggagcta tgtgaattaa
      361 aacccaaatt tcaggaacac atcattcaag cccctaagcc agtagaagca ataaaaagac
      421 caagcccaga tgaaccaatg acaaatttgg aattaaaaat atctgcctcc ctaaaacaag
      481 cacttgataa acttaaactg tcatcaggga atgaagaaaa taagaaagaa gaagacaatg
      541 atgaaattaa gattgggacc tcatgtaaga atggagggtg ttcaaagaca taccagggtc
      601 tagagagtct agaagaagtc tgtgtatatc attctggagt acctattttc catgagggga
      661 tgaaatactg gagctgttgt agaagaaaaa cttctgattt taatacattc ttagcccaag
      721 agggctgtac aaaagggaaa cacatgtgga ctaaaaaaga tgctgggaaa aaagttgttc
      781 catgtagaca tgactggcat cagactggag gtgaagttac catttcagta tatgctaaaa
      841 actcacttcc agaacttagc cgagtagaag caaatagcac attgttaaat gtgcatattg
      901 tatttgaagg agagaaggaa tttgatcaaa atgtgaaatt atggggtgtg attgatgtaa
      961 agcgaagtta tgtaactatg actgcaacaa agattgaaat cactatgaga aaagctgaac
     1021 cgatgcagtg ggcaagcctt gaactgcctg cagctaaaaa gcaggaaaaa caaaaagatg
     1081 ccacaacaga ttgagtggga gatggaagga aggctattac attatttccg aatttttaat
     1141 actgtgtgaa gtggtggctt gctgctgtaa tcttttgttt tgttgttgtg ttactgaatg
     1201 tggcatttca gggttaacat taggttctta aaagccaaag tcagtttgtc tttttgtgcc
     1261 tctcatcttt cttttgtgtt atgtaagatt gattattcat ttctccctac tggtaggaac
     1321 catagttgtg tcctatactt gaagaggctg gaaagtagcc cataaccata attgcagtat
     1381 ttctttgtat ttctctgtta agcaaagaaa tattaaggaa catttttttt atgtttttgt
     1441 attattccat aattagtaaa gcaagatgaa atgtcaaatt ttaatcagtt ttttcatgga
     1501 tttgtgttct tacagtactt gaaaatattt aaggaagaga tgaagctctg cagttttttc
     1561 tatgtgggat gattactttt ttaaggagga ttaattctga ggtagtatag taactaaagg
     1621 ggaatatatg aattgtttaa caaattagaa tttgtttaca actacttgaa tttttaaatt
     1681 atgtcaaaac ttacattact tgccaagcag tatgatgtta taggaaacat aaataagatt
     1741 acagaggtat caatttggtt aaaattcacc attttataag actaagcaat aatcttaaca
     1801 acctctttcc tgaatattta aatgtgtttg tatggtgtta tgactaattg ttactgattt
     1861 agagactaag ccctcttaaa acctttagtt aaatataaaa agaaattata tatatcttgc
     1921 ctccctgatg gaaaactata taaaattgta gacttaaaag gtttgtggaa atacattagg
     1981 atatcagaaa actaaatata tggagttgct ttatgactat tacatgttaa ataaaaatag
     2041 cttaattgtt ttggagtttt tttttaaagt catgaagagc ttcacaattc tagtgataca
     2101 atgttgacta tatattgtac tttatattaa atataggtaa tacagaatta gatcgtttgg
     2161 ataggttttg agttagtgca gaactcaaga agaaaaatta ggaaatattc tgaaggccag
     2221 aactctggaa gaacttagaa agtttgggaa taaattaaac ttatgtagat ttaaaattaa
     2281 aaggggttta tttcccaaac cccttgagtc ttttcttttc cttggtattt atggaattct
     2341 tacaaagaaa aatttgcaga agtactattt tcgtgaataa aacatatgta tcattctact
     2401 accattagca aataacttag ttgtagttaa tataattgtt aaaaggttta gctctgttac
     2461 aaataaaaac ataaagatct ggcaaccaga ctttcatgat gttacattac catgacaaga
     2521 aactctgggc agtaaaagtt ggacccacat ggagtacata agcatctgat acctggagat
     2581 gtatttaaaa tttttcaagt tatcttccat gatttaggaa ccatttagag acatgaagtc
     2641 tttatgggtt gggggaaagg ttgataatta gtttgattaa aggtaatgat taatatccct
     2701 ttttgttcat acttccttct gaggctgttt tcccctaaac agtatcttaa tctgttacat
     2761 gtaattgaaa tattatttga agcagtgagt tattgtaacc tcagattagt tacattgatc
     2821 aaaacattga tttatacaca cacacacaca catacatatg tagcttttat atttagtctg
     2881 gttacattag tgaccatggt atttactttc ttcttaagga gcctttgaat ttcttgtcca
     2941 gataaaaatc cgaatatttc tcttagactc atacataaag ggacacagtt atcgttaggt
     3001 agcatatgtt ttactatcgg tttgtcaaaa aagttaataa aaagtgctta ttgatttatt
     3061 tctctagaaa
//
