LOCUS       NM_024944               2545 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens chondrolectin (CHODL), transcript variant 1, mRNA.
ACCESSION   NM_024944
VERSION     NM_024944.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2545)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2545)
  AUTHORS   Xie,T., Deng,L., Mei,P., Zhou,Y., Wang,B., Zhang,J., Lin,J.,
            Wei,Y., Zhang,X. and Xu,R.
  TITLE     Genome-wide association study combining pathway analysis for
            typical sporadic amyotrophic lateral sclerosis in Chinese Han
            populations
  JOURNAL   Neurobiol Aging 35 (7), 1778 (2014)
   PUBMED   24529757
REFERENCE   3  (bases 1 to 2545)
  AUTHORS   Wade,T.D., Gordon,S., Medland,S., Bulik,C.M., Heath,A.C.,
            Montgomery,G.W. and Martin,N.G.
  TITLE     Genetic variants associated with disordered eating
  JOURNAL   Int J Eat Disord 46 (6), 594-608 (2013)
   PUBMED   23568457
REFERENCE   4  (bases 1 to 2545)
  AUTHORS   Low,S.K., Chung,S., Takahashi,A., Zembutsu,H., Mushiroda,T.,
            Kubo,M. and Nakamura,Y.
  TITLE     Genome-wide association study of chemotherapeutic agent-induced
            severe neutropenia/leucopenia for patients in Biobank Japan
  JOURNAL   Cancer Sci 104 (8), 1074-1082 (2013)
   PUBMED   23648065
REFERENCE   5  (bases 1 to 2545)
  AUTHORS   Uhlen,M., Oksvold,P., Algenas,C., Hamsten,C., Fagerberg,L.,
            Klevebring,D., Lundberg,E., Odeberg,J., Ponten,F., Kondo,T. and
            Sivertsson,A.
  TITLE     Antibody-based protein profiling of the human chromosome 21
  JOURNAL   Mol Cell Proteomics 11 (3), M111.013458 (2012)
   PUBMED   22042635
REFERENCE   6  (bases 1 to 2545)
  AUTHORS   Claessens,A., Van de Vijver,K., Van Bockstaele,D.R., Wauters,J.,
            Berneman,Z.N., Van Marck,E. and Merregaert,J.
  TITLE     Expression and localization of CHODLDeltaE/CHODLfDeltaE, the
            soluble isoform of chondrolectin
  JOURNAL   Cell Biol Int 31 (11), 1323-1330 (2007)
   PUBMED   17606388
  REMARK    GeneRIF: CHODLDeltaE/CHODLfDeltaE protein variant localizes in the
            late endoplasmic reticulum and is detected in spleen and tonsils;
            the isoform seems to be differentially expressed in thymocytes and
            lymphocytes.
REFERENCE   7  (bases 1 to 2545)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 2545)
  AUTHORS   Weng,L., Van Bockstaele,D.R., Wauters,J., Van Marck,E., Plum,J.,
            Berneman,Z.N. and Merregaert,J.
  TITLE     A novel alternative spliced chondrolectin isoform lacking the
            transmembrane domain is expressed during T cell maturation
  JOURNAL   J Biol Chem 278 (21), 19164-19170 (2003)
   PUBMED   12621022
  REMARK    GeneRIF: study describes the molecular characterization of novel
            members of the chondrolectin family associated with T cell
            maturation and a subcellular localization of chondrolectin f
            isoform in the endoplasmic reticulum-Golgi apparatus
REFERENCE   9  (bases 1 to 2545)
  AUTHORS   Weng,L., Smits,P., Wauters,J. and Merregaert,J.
  TITLE     Molecular cloning and characterization of human chondrolectin, a
            novel type I transmembrane protein homologous to C-type lectins
  JOURNAL   Genomics 80 (1), 62-70 (2002)
   PUBMED   12079284
  REMARK    GeneRIF: cloning and characterization; localized at chromosome
            21q21
REFERENCE   10 (bases 1 to 2545)
  AUTHORS   Reymond,A., Friedli,M., Henrichsen,C.N., Chapot,F., Deutsch,S.,
            Ucla,C., Rossier,C., Lyle,R., Guipponi,M. and Antonarakis,S.E.
  TITLE     From PREDs and open reading frames to cDNA isolation: revisiting
            the human chromosome 21 transcription map
  JOURNAL   Genomics 78 (1-2), 46-54 (2001)
   PUBMED   11707072
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF257472.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_024944.2.
            
            Summary: This gene encodes a type I membrane protein with a
            carbohydrate recognition domain characteristic of C-type lectins in
            its extracellular portion. In other proteins, this domain is
            involved in endocytosis of glycoproteins and exogenous
            sugar-bearing pathogens. This protein localizes predominantly to
            the perinuclear region. Several transcript variants encoding a few
            different isoforms have been found for this gene. [provided by
            RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF257472.1, SRR1803612.105902.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299295.7/ ENSP00000299295.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2545              AF257472.1         1-2545
FEATURES             Location/Qualifiers
     source          1..2545
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q21.1"
     gene            1..2545
                     /gene="CHODL"
                     /gene_synonym="C21orf68; MT75; PRED12"
                     /note="chondrolectin"
                     /db_xref="GeneID:140578"
                     /db_xref="HGNC:HGNC:17807"
                     /db_xref="MIM:607247"
     exon            1..470
                     /gene="CHODL"
                     /gene_synonym="C21orf68; MT75; PRED12"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..1213
                     /gene="CHODL"
                     /gene_synonym="C21orf68; MT75; PRED12"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; transmembrane protein MT75"
                     /codon_start=1
                     /product="chondrolectin isoform a precursor"
                     /protein_id="NP_079220.2"
                     /db_xref="CCDS:CCDS13570.1"
                     /db_xref="GeneID:140578"
                     /db_xref="HGNC:HGNC:17807"
                     /db_xref="MIM:607247"
                     /translation="MSRVVSLLLGAALLCGHGAFCRRVVSGQKVCFADFKHPCYKMAY
                     FHELSSRVSFQEARLACESEGGVLLSLENEAEQKLIESMLQNLTKPGTGISDGDFWIG
                     LWRNGDGQTSGACPDLYQWSDGSNSQYRNWYTDEPSCGSEKCVVMYHQPTANPGLGGP
                     YLYQWNDDRCNMKHNYICKYEPEINPTAPVEKPYLTNQPGDTHQNVVVTEAGIIPNLI
                     YVVIPTIPLLLLILVAFGTCCFQMLHKSKGRTKTSPNQSTLWISKSTRKESGMEV"
     exon            471..780
                     /gene="CHODL"
                     /gene_synonym="C21orf68; MT75; PRED12"
                     /inference="alignment:Splign:2.1.0"
     exon            781..938
                     /gene="CHODL"
                     /gene_synonym="C21orf68; MT75; PRED12"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1025
                     /gene="CHODL"
                     /gene_synonym="C21orf68; MT75; PRED12"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1128
                     /gene="CHODL"
                     /gene_synonym="C21orf68; MT75; PRED12"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..2545
                     /gene="CHODL"
                     /gene_synonym="C21orf68; MT75; PRED12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2520..2525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHODL"
                     /gene_synonym="C21orf68; MT75; PRED12"
                     /note="hexamer: AATAAA"
     polyA_site      2545
                     /gene="CHODL"
                     /gene_synonym="C21orf68; MT75; PRED12"
                     /note="major polyA site"
ORIGIN      
        1 gctgctgctg tgatccagga ccagggcgca ccggctcagc ctctcacttg tcagaggccg
       61 gggaagagaa gcaaagcgca acggtgtggt ccaagccggg gcttctgctt cgcctctagg
      121 acatacacgg gaccccctaa cttcagtccc ccaaacgcgc accctcgaag tcttgaactc
      181 cagccccgca catccacgcg cggcacaggc gcggcaggcg gcaggtcccg gccgaaggcg
      241 atgcgcgcag ggggtcgggc agctgggctc gggcggcggg agtagggccc ggcagggagg
      301 cagggaggct gcagagtcag agtcgcgggc tgcgccctgg gcagaggccg ccctcgctcc
      361 acgcaacacc tgctgctgcc accgcgccgc gatgagccgc gtggtctcgc tgctgctggg
      421 cgccgcgctg ctctgcggcc acggagcctt ctgccgccgc gtggtcagcg gccaaaaggt
      481 gtgttttgct gacttcaagc atccctgcta caaaatggcc tacttccatg aactgtccag
      541 ccgagtgagc tttcaggagg cacgcctggc ttgtgagagt gagggaggag tcctcctcag
      601 ccttgagaat gaagcagaac agaagttaat agagagcatg ttgcaaaacc tgacaaaacc
      661 cgggacaggg atttctgatg gtgatttctg gatagggctt tggaggaatg gagatgggca
      721 aacatctggt gcctgcccag atctctacca gtggtctgat ggaagcaatt cccagtaccg
      781 aaactggtac acagatgaac cttcctgcgg aagtgaaaag tgtgttgtga tgtatcacca
      841 accaactgcc aatcctggcc ttgggggtcc ctacctttac cagtggaatg atgacaggtg
      901 taacatgaag cacaattata tttgcaagta tgaaccagag attaatccaa cagcccctgt
      961 agaaaagcct tatcttacaa atcaaccagg agacacccat cagaatgtgg ttgttactga
     1021 agcaggtata attcccaatc taatttatgt tgttatacca acaatacccc tgctcttact
     1081 gatactggtt gcttttggaa cctgttgttt ccagatgctg cataaaagta aaggaagaac
     1141 aaaaactagt ccaaaccagt ctacactgtg gatttcaaag agtaccagaa aagaaagtgg
     1201 catggaagta taataactca ttgacttggt tccagaattt tgtaattctg gatctgtata
     1261 aggaatggca tcagaacaat agcttggaat ggcttgaaat cacaaaggat ctgcaagatg
     1321 aactgtaagc tcccccttga ggcaaatatt aaagtaattt ttatatgtct attatttcat
     1381 ttaaagaata tgctgtgcta ataatggagt gagacatgct tattttgcta aaggatgcac
     1441 ccaaacttca aacttcaagc aaatgaaatg gacaatgcag ataaagttgt tatcaacacg
     1501 tcgggagtat gtgtgttaga agcaattcct tttatttctt tcacctttca taagttgtta
     1561 tctagtcaat gtaatgtata ttgtattgaa atttacagtg tgcaaaagta ttttaccttt
     1621 gcataagtgt ttgataaaaa tgaactgttc taatatttat ttttatggca tctcattttt
     1681 caatacatgc tcttttgatt aaagaaactt attactgttg tcaactgaat tcacacacac
     1741 acaaatatag taccatagaa aaagtttgtt ttctcgaaat aattcatctt tcagcttctc
     1801 tgcttttggt caatgtctag gaaatctctt cagaaataag aagctatttc attaagtgtg
     1861 atataaacct cctcaaacat tttacttaga ggcaaggatt gtctaatttc aattgtgcaa
     1921 gacatgtgcc ttataattat ttttagctta aaattaaaca gattttgtaa taatgtaact
     1981 ttgttaatag gtgcataaac actaatgcag tcaatttgaa caaaagaagt gacatacaca
     2041 atataaatca tatgtcttca cacgttgcct atataatgag aagcagctct ctgagggttc
     2101 tgaaatcaat gtggtccctc tcttgcccac taaacaaaga tggttgttcg gggtttggga
     2161 ttgacactgg aggcagatag ttgcaaagtt agtctaaggt ttccctagct gtatttagcc
     2221 tctgactata ttagtataca aagaggtcat gtggttgaga ccaggtgaat agtcactatc
     2281 agtgtggaga caagcacagc acacagacat tttaggaagg aaaggaacta cgaaatcgtg
     2341 tgaaaatggg ttggaaccca tcagtgatcg catattcatt gatgagggtt tgcttgagat
     2401 agaaaatggt ggctcctttc tgtcttatct cctagtttct tcaatgctta cgccttgttc
     2461 ttctcaagag aaagttgtaa ctctctggtc ttcatatgtc cctgtgctcc ttttaaccaa
     2521 ataaagagtt cttgtttctg aagaa
//
